5',6'-Nucleoside phosphonate analogues architecture: Synthesis and comparative evaluation towards metabolic enzymes

ChemMedChem

Volumn 6, Issue 6, 2011, Pages 1094-1106

  Gallier, Franck ^a   Alexandre, Julie A C ^b   ElAmri, Chahrazade ^b   Deville Bonne, Dominique ^b   Peyrottes, Suzanne ^a   Périgaud, Christian ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Conformational analysis; NMP kinases; Nucleotides; Phosphonates; Ribonucleosides

Indexed keywords

1 (2',3' O ISOPROPYLIDENE 5',6' DIDEOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBO 5' HEXENOFURANOSYL)CYTOSIL; 1 (2',3' O ISOPROPYLIDENE 5',6' DIDEOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBO 5' HEXENOFURANOSYL)URACIL; 1 (2',3' O ISOPROPYLIDENE 5',6' DIDEOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBO 5' HEXYNOFURANOSYL)URACIL; 1 (2',3' O ISOPROPYLIDENE 5',6' DIDEOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBOFURANOSYL)URACIL; 1 (2',3' O ISOPROPYLIDENE 5',6' DIDEOXY 6',6' DIBROMO BETA DEXTRO RIBO 5' HEXENOFURANOSYL)URACIL; 1 (2',3' O ISOPROPYLIDENE 5',6' EPOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBOFURANOSYL)URACIL; 1 (2',3' O ISOPROPYLIDENE 6' DIETHYLPHOSPHONO BETA DEXTRO RIBO 5',6' HEXOFURANOSYL)URACIL; 1 (5',6' DIDEOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBO 5' HEXENOFURANOSYL)CYTOSIL; 1 (5',6' DIDEOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBO 5' HEXENOFURANOSYL)URACIL; 1 (5',6' DIDEOXY 6' DIETHYLPHOSPHONO BETA DEXTRO RIBOFURANOSYL)URACIL; 1 (5',6' DIDEOXY 6' PHOSPHONO BETA DEXTRO RIBO 5' HEXENOFURANOSYL)CYTOSIL; 1 (5',6' DIDEOXY 6' PHOSPHONO BETA DEXTRO RIBO 5' HEXENOFURANOSYL)URACIL; 1 (5',6' DIDEOXY 6' PHOSPHONO BETA DEXTRO RIBOFURANOSYL)URACIL; 1 (6' DIETHYLPHOSPHONO BETA DEXTRO RIBO 5',6' HEXOFURANOSYL)URACIL; 1 (6' PHOSPHONO BETA DEXTRO RIBO 5',6' HEXOFURANOSYL)URACIL; 2',3' O ISOPROPYLIDENEURIDINE; 5',6' NUCLEOSIDE PHOSPHONATE DERIVATIVE; ANTIVIRUS AGENT; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE MONOPHOSPHATE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CATALYST; CHEMICAL BOND; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NONHUMAN; NUCLEIC ACID METABOLISM; PHOSPHORYLATION; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MODELS, MOLECULAR; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHONIC ACIDS; PROTEIN BINDING; RIBONUCLEOSIDES; SUBSTRATE SPECIFICITY;

EID: 79957618143     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100068     Document Type: Article

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