Ginsenoside Rg1 enhances immune response induced by recombinant Toxoplasma gondii SAG1 antigen

Veterinary Parasitology

Volumn 179, Issue 1-3, 2011, Pages 28-34

  Qu, Dao Feng ^a,b   Yu, Hai Jie ^a,b   Liu, Zhao ^a,b   Zhang, De Fu ^a,b   Zhou, Qian Jin ^a,b   Zhang, Hong Li ^a,b   Du, Ai Fang ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Adjuvant; Ginsenoside Rg1; RSAG1; Toxoplasma gondii

Indexed keywords

CYTOKINE; GINSENOSIDE RG 1; PARASITE ANTIBODY; PARASITE ANTIGEN; RECOMBINANT ANTIGEN; RECOMBINANT SURFACE ANTIGEN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; SURVIVAL TIME; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, PROTOZOAN; GINSENOSIDES; IMMUNOGLOBULIN G; LYMPHOCYTES; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; PROTOZOAN PROTEINS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL;

MUS; PANAX GINSENG; TOXOPLASMA GONDII;

EID: 79957608931     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2011.02.008     Document Type: Article

References (33)

1. Cardona N., de-la-Torre A., Siachoque H., Patarroyo M.A., Gomez-Marin J.E. Toxoplasma gondii: P30 peptides recognition pattern in human toxoplasmosis. Exp. Parasitol. 2009, 123:199-202.
2. Cong H., Gu Q.M., Yin H.E., Wang J.W., Zhao Q.L., Zhou H.Y., Li Y., Zhang J.Q. Multi-epitope DNA vaccine linked to the A2/B subunit of cholera toxin protect mice against Toxoplasma gondii. Vaccine 2008, 26:3913-3921.
3. Debard N., Buzoni-Gatel D., Bout D. Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebral cysts after oral infection. Infect. Immun. 1996, 64:2158-2166.
4. Delibas S.B., Ertabaklar H., Ertug S. Evaluation of antigenic variations between two virulent toxoplasma strains. J. Med. Microbiol. 2006, 55:1333-1335.
5. Du A., Hu S., Wang S. Eimeria tenella: ginsenosides-enhanced immune response to the immunization with recombinant 5401 antigen in chickens. Exp. parasitol. 2005, 111:191-197.
6. El-Malky M., Shaohong L., Kumagai T., Yabu Y., Noureldin M.S., Saudy N., Maruyama H., Ohta N. Protective effect of vaccination with Toxoplasma lysate antigen and CpG as an adjuvant against Toxoplasma gondii in susceptible C57BL/6 mice. Microbiol. Immunol. 2005, 49:639-646.
7. Fang R., Feng H., Nie H., Wang L., Tu P., Song Q., Zhou Y., Zhao J. Construction and immunogenicity of pseudotype baculovirus expressing Toxoplasma gondii SAG1 protein in BALB/c mice model. Vaccine 2010, 28:1803-1807.
8. Hu S., Concha C., Lin F., Persson Waller K. Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle. Vet. Immunol. Immunopathol. 2003, 91:29-37.
9. Ismael A.B., Dimier-Poisson I., Lebrun M., Dubremetz J.F., Bout D., Mevelec M.N. Mic1-3 knockout of Toxoplasma gondii is a successful vaccine against chronic and congenital toxoplasmosis in mice. J. Infect. Dis. 2006, 194:1176-1183.
10. Khan I.A., Ely K.H., Kasper L.H. A purified parasite antigen (p30) mediates CD8+ T cell immunity against fatal Toxoplasma gondii infection in mice. J. Immunol. 1991, 147:3501-3506.
11. Lee J.H., Han Y. Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4+ T cell. Int. Immunopharmacol. 2006, 6:1424-1430.
12. Liu Q., Shang L., Jin H., Wei F., Zhu X.Q., Gao H. The protective effect of a Toxoplasma gondii SAG1 plasmid DNA vaccine in mice is enhanced with IL-18. Res. Vet. Sci. 2010, 89:93-97.
13. Luder C.G., Gross U. Apoptosis and its modulation during infection with Toxoplasma gondii: molecular mechanisms and role in pathogenesis. Curr. Top. Microbiol. Immunol. 2005, 289:219-237.
14. Machado A.V., Caetano B.C., Barbosa R.P., Salgado A.P., Rabelo R.H., Garcia C.C., Bruna-Romero O., Escriou N., Gazzinelli R.T. Prime and boost immunization with influenza and adenovirus encoding the Toxoplasma gondii surface antigen 2 (SAG2) induces strong protective immunity. Vaccine 2010, 28:3247-3256.
15. Peng G.H., Yuan Z.G., Zhou D.H., He X.H., Liu M.M., Yan C., Yin C.C., He Y., Lin R.Q., Zhu X.Q. Toxoplasma gondii microneme protein 6 (MIC6) is a potential vaccine candidate against toxoplasmosis in mice. Vaccine 2009, 27:6570-6574.
16. Petersen E., Nielsen H.V., Christiansen L., Spenter J. Immunization with E. coli produced recombinant T. gondii SAG1 with alum as adjuvant protect mice against lethal infection with Toxoplasma gondii. Vaccine 1998, 16:1283-1289.
17. Qu D., Wang S., Cai W., Du A. Protective effect of a DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice. Vaccine 2008, 26:4541-4548.
18. Qu D., Yu H., Wang S., Cai W., Du A. Induction of protective immunity by multiantigenic DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice. Vet. Parasitol. 2009, 166:220-227.
19. Rivera E., Daggfeldt A., Hu S. Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and Erysipelothrix rhusiopathiae. Vet. Immunol. Immunopathol. 2003, 91:19-27.
20. Rivera E., Hu S., Concha C. Ginseng and aluminium hydroxide act synergistically as vaccine adjuvants. Vaccine 2003, 21:1149-1157.
21. Rosenberg C., De Craeye S., Jongert E., Gargano N., Beghetto E., Del Porto P., Vorup-Jensen T., Petersen E. Induction of partial protection against infection with Toxoplasma gondii genotype II by DNA vaccination with recombinant chimeric tachyzoite antigens. Vaccine 2009, 27:2489-2498.
22. Shang L., Liu Q., Liu W., Men J., Gao S., Jiang L., Wang Z., Zhai Y., Jin H., Lian H., Chen C., Xia Z., Yuan Z., Zhu X.Q. Protection in mice immunized with a heterologous prime-boost regime using DNA and recombinant pseudorabies expressing TgSAG1 against Toxoplasma gondii challenge. Vaccine 2009, 27:2741-2745.
23. Sibley L.D., Adams L.B., Krahenbuhl J.L. Macrophage interactions in toxoplasmosis. Res. Immunol. 1993, 144:38-40.
24. Singh S. Mother-to-child transmission and diagnosis of Toxoplasma gondii infection during pregnancy. Indian J. Med. Microbiol. 2003, 21:69-76.
25. Sloat B.R., Sandoval M.A., Hau A.M., He Y., Cui Z. Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles. J. Controlled Release 2010, 141:93-100.
26. Song X., Bao S., Wu L., Hu S. Ginseng stem-leaf saponins (GSLS) and mineral oil act synergistically to enhance the immune responses to vaccination against foot-and-mouth disease in mice. Vaccine 2009, 27:51-55.
27. Sun H., Pollock K.G., Brewer J.M. Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro. Vaccine 2003, 21:849-855.
28. Sun H., Yang Z., Ye Y. Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng. Int. Immunopharmacol. 2006, 6:14-25.
29. Sun H.X., Pan H.J. Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice. Vaccine 2006, 24:1914-1920.
30. Sun J., Hu S., Song X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine 2007, 25:1114-1120.
31. Sun J., Song X., Hu S. Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice. Clin. Vaccine Immunol. 2008, 15:303-307.
32. Tan T.G., Mui E., Cong H., Witola W.H., Montpetit A., Muench S.P., Sidney J., Alexander J., Sette A., Grigg M.E., Maewal A., McLeod R. Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans. Vaccine 2010.
33. Zhou H., Gu Q., Zhao Q., Zhang J., Cong H., Li Y., He S. Toxoplasma gondii: expression and characterization of a recombinant protein containing SAG1 and GRA2 in Pichia pastoris. Parasitol. Res. 2007, 100:829-835.