Mechanisms of the protective effects of BMSCs promoted by TMDR with heparinized bFGF-incorporated stent in pig model of acute myocardial ischemia

Journal of Cellular and Molecular Medicine

Volumn 15, Issue 5, 2011, Pages 1075-1086

  Zhang, Guang Wei ^a   Liu, Xiao Cheng ^a,b   Li Ling, Jesse ^c   Luan, Yun ^b   Ying, Yuan Ning ^d   Wu, Xue Sheng ^d   Zhao, Chun Hua ^b   Liu, Tian Jun ^e   Lü, Feng ^e  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

^d TEDA INTERNATIONAL CARDIOVASCULAR HOSPITAL   (China)

^e INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

Author keywords

Coronary artery disease; Fibroblast growth factor 2; Stem cell transplantation; Stent; Ventricular remodelling

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; HEPARIN; SIGNAL PEPTIDE;

ACUTE CORONARY SYNDROME; ANIMAL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; HEART MUSCLE REVASCULARIZATION; HEART VENTRICLE REMODELING; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; PATHOLOGY; STENT; SWINE;

ACUTE CORONARY SYNDROME; ANIMALS; APOPTOSIS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTOR 2; HEPARIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MYOCARDIAL REVASCULARIZATION; STENTS; SWINE; VENTRICULAR REMODELING;

SUIDAE;

EID: 79957607066     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2010.01070.x     Document Type: Article

References (20)

1. Schächinger V, Erbs S, Elsässer A, et al Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006; 355: 1210-21.
2. Wollert KC, Meyer GP, Lotz J, et al Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004; 364: 141-8.
3. Assmus B, Honold J, Schächinger V, et al Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med. 2006; 355: 1222-32.
4. Uemura R, Xu M, Ahmad N, Ashraf M. Bone marrow stem cell prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. 2006; 98: 1414-21.
5. Nygren JM, Jovinge S, Breitbach M, et al Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med. 2004; 10: 494-501.
6. Lunde K, Solheim S, Aakhus S, et al Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med. 2006; 355: 1199-209.
7. Meyer GP, Wollert KC, Lotz J, et al Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation. 2006; 113: 1287-94.
8. + stem cell survival and engraftment in the infarcted heart: dual role for preconditioning-induced connexin-43. Circulation. 2009; 119: 2587-96.
9. Miyahara Y, Nagaya N, Kataoka M, et al Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med. 2006; 12: 459-65.
10. Liu XC, Zhao J, Wang Y, et al Heparin- and basic fibroblast growth factor-incorporated stent: a new promising method for myocardial revascularization. J Surg Res. DOI.
11. Wang Y, Liu XC, Zhang GW, et al A new transmyocardial degradable stent combined with growth Factor, heparin, and stem cells in acute myocardial infarction. Cardiovasc Res. 2009; 84: 461-9.
12. Nagaya N, Kangawa K, Itoh T, et al Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation. 2005; 112: 1128-35.
13. Rota M, Kajstura J, Hosoda T, et al Bone marrow cells adopt the cardiomyogenic fatein vivo. Proc Natl Acad Sci USA. 2007; 104: 17783-8.
14. Oswald J, Boxberger S, Jørgensen B, et al Mesenchymal stem cells can be differentiated into endothelial cellsin vitro. Stem Cells. 2004; 22: 377-84.
15. Kinnaird T, Stabile E, Burnett MS, et al Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation. 2004; 109: 1543-9.
16. Yoon YS, Wecker A, Heyd L, et al Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest. 2005; 115: 326-38.
17. + cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest. 2006; 116: 1865-77.
18. Takehara N, Tsutsumi Y, Tateishi K, et al Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction. J Am Coll Cardiol. 2008; 52: 1858-65.
19. Choi SC, Kim SJ, Choi JH, et al Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways. Stem Cells Dev. 2008; 17: 725-36.
20. Langer HF, Stellos K, Steingen C, et al Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cellsin vitro. J Mol Cell Cardiol. 2009; 47: 315-25.