Inhibition of xanthine oxidase by thiosemicarbazones, hydrazones and dithiocarbazates derived from hydroxy-substituted benzaldehydes

ChemMedChem

Volumn 6, Issue 6, 2011, Pages 1107-1118

  Leigh, Maria ^a   Raines, Daniel J ^a   Castillo, Carmen E ^a,b   Duhme Klair, Anne K ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF CÁDIZ   (Spain)

Author keywords

Copper complexation; Inhibitors; Molybdenum complexation; Schiff bases; Xanthine oxidase

Indexed keywords

(2,4,6 TRIHYDROXYBENZALDEHYDE)DITHIOCARBAZATE; 1 (3 CYANOPHENYL) 3 [(2,4,6 TRIHYDROXYPHENYL)METHYLIDENE]AMINOTHIOUREA; 1 (4 CHLOROPHENYL) 3 [(3 HYDROXYPHENYL)METHYLIDENE]AMINOTHIOUREA; 1 (4 CYANOPHENYL) 3 [(3 HYDROXYPHENYL)METHYLIDENE]AMINOTHIOUREA; 2 [2 (2 METHOXYETHOXY)ETHOXY] 5 [5 (2 METHYLPYRIDIN 4 YL) 1H [1,2,4]TRIAZOL 3 YL]BENZONITRILE; 3 [(2,4 DIHYDROXYPHENYL)METHYLIDENE]AMINO 1 PHENYLTHIOUREA; 3 [(3 HYDROXYPHENYL)METHYLIDENE]AMINO 1 PHENYLTHIOUREA; 4 BROMO N' [(2,4 DIHYDROXYPHENYL)METHYLIDENE]BENZOHYDRAZIDE; 4 BROMO N' [(3 HYDROXYPHENYL)METHYLIDENE]BENZOHYDRAZIDE; 4 CHLORO N' [(3 HYDROXYPHENYL)METHYLIDENE]BENZOHYDRAZIDE; 4 HYDROXY N' [(3 HYDROXYPHENYL)METHYLIDENE]BENZOHYDRAZIDE; ALLOPURINOL; BENZALDEHYDE DERIVATIVE; COPPER COMPLEX; DITHIOCARBAZIC ACID DERIVATIVE; FEBUXOSTAT; FYX 051; HYDRAZIDE DERIVATIVE; HYDRAZONE DERIVATIVE; LUTEOLIN; MOLYBDENUM COMPLEX; MYRICETIN; N' [(2,4 DIHYDROXYPHENYL)METHYLIDENE] 4 HYDROXYBENZOHYDRAZIDE; PYRANOSTAT; QUERCETIN; SCHIFF BASE; THIOSEMICARBAZIDE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHINE OXIDASE INHIBITOR; Y 700;

ARTICLE; BINDING KINETICS; CHEMICAL REACTION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; HYPERURICEMIA; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

BENZALDEHYDES; COPPER; ENZYME INHIBITORS; HYDRAZINES; HYDRAZONES; MOLYBDENUM; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES; XANTHINE OXIDASE;

EID: 79957587894     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100054     Document Type: Article

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