Oxytocin antagonists for the management of preterm birth: A review

American Journal of Perinatology

Volumn 28, Issue 6, 2011, Pages 449-459

  Usta, Ihab M ^a   Khalil, Ali ^a   Nassar, Anwar H ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

adverse effects; dose; Oxytocin antagonists; preterm labor; tocolysis

Indexed keywords

ATOSIBAN; BARUSIBAN; BETAMETHASONE; CALCIUM CHANNEL BLOCKING AGENT; HEXOPRENALINE; LABETALOL; NIFEDIPINE; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; PLACEBO; RELCOVAPTAN; RITODRINE; SALBUTAMOL; TERBUTALINE; UTERUS SPASMOLYTIC AGENT; VASOPRESSIN; VASOPRESSIN V1 RECEPTOR; VASOPRESSIN V2 RECEPTOR; VASOPRESSIN V3 RECEPTOR;

ASPHYXIA; BED REST; BIRTH WEIGHT; BRAIN HEMORRHAGE; CARDIOVASCULAR RISK; CENTRAL NERVOUS SYSTEM; CESAREAN SECTION; CLEARANCE; CLINICAL ASSESSMENT; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; FETUS DEATH; FETUS DISTRESS; FETUS HEART RATE; FLUSHING; GASTROINTESTINAL SYMPTOM; GESTATIONAL AGE; HEADACHE; HEART MUSCLE ISCHEMIA; HEART PALPITATION; HEMATOCRIT; HIGH RISK PATIENT; HOSPITAL SERVICE; HUMAN; HYDRATION; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOKALEMIA; HYPOTENSION; INFUSION; INJECTION SITE REACTION; INTRAUTERINE INFECTION; LOADING DRUG DOSE; LONG TERM CARE; LUNG EDEMA; MATERNAL MORTALITY; MULTICENTER STUDY (TOPIC); NAUSEA; NECROTIZING ENTEROCOLITIS; NEUROLOGIC EXAMINATION; NEWBORN INTENSIVE CARE; OBSERVATIONAL STUDY; PATENT DUCTUS ARTERIOSUS; PERINATAL DEATH; PLASMA PROTEIN BINDING; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENCE RISK; RESPIRATORY DISTRESS SYNDROME; REVIEW; SHELF LIFE; SIDE EFFECT; SUDDEN INFANT DEATH SYNDROME; SYNCOPE; TACHYCARDIA; THORAX PAIN; TOCOLYSIS; TREATMENT FAILURE; TREATMENT WITHDRAWAL; TREMOR; TWIN PREGNANCY; UTERINE ATONY; UTERUS BLEEDING; UTERUS CONTRACTION; VAGINA BLEEDING; VASOCONSTRICTION; VASOPRESSIN RELEASE; VERTIGO; VOMITING; WATER ABSORPTION;

FEMALE; HORMONE ANTAGONISTS; HUMANS; INDOLES; NIFEDIPINE; OLIGOPEPTIDES; OXYTOCIN; PREMATURE BIRTH; PYRROLIDINES; SYMPATHOMIMETICS; TOCOLYTIC AGENTS; VASOTOCIN;

EID: 79957577043     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0030-1270111     Document Type: Review

References (56)

1. Hamilton B E., Martin J A., Ventura S J. Births: preliminary data for 2007. Natl Vital Stat Rep 2009 57 1-23
2. Copper R L., Goldenberg R L., Creasy R K. et al. A multicenter study of preterm birth weight and gestational age-specific neonatal mortality. Am J Obstet Gynecol 1993 168 1 Pt 1 78-84 (Pubitemid 23047616)
3. Morrison J C. Preterm birth: a puzzle worth solving. Obstet Gynecol 1990 76 1 Suppl 5S-12S (Pubitemid 20193304)
4. Akerlund M, Carlsson A M., Melin P, Trojnar J. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand 1985 64 499-504 (Pubitemid 15241026)
5. Engstrm T, Bratholm P, Vilhardt H, Christensen N J. Effect of oxytocin receptor and beta2-adrenoceptor blockade on myometrial oxytocin receptors in parturient rats. Biol Reprod 1999 60 322-329 (Pubitemid 29063872)
6. Goodwin T M., Millar L, North L, Abrams L S., Weglein R C., Holland M L. The pharmacokinetics of the oxytocin antagonist atosiban in pregnant women with preterm uterine contractions. Am J Obstet Gynecol 1995 173 3 Pt 1 913-917
7. Lundin S, Broeders A, Melin P. Pharmacokinetic properties of the tocolytic agent [Mpa1, D-Tyr(Et)2, Thr4, Orn8]-oxytocin (antocin) in healthy volunteers. Clin Endocrinol (Oxf) 1993 39 369-374 (Pubitemid 23274438)
8. Valenzuela G J., Craig J, Bernhardt M D., Holland M L. Placental passage of the oxytocin antagonist atosiban. Am J Obstet Gynecol 1995 172 4 Pt 1 1304-1306
9. Rasmussen B B., Larsen L S., Senderovitz T. Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers. BJOG 2005 112 1492-1499 (Pubitemid 43961235)
10. eMC. Tractocile 7.5 mg/ml solution for injection. Available at: http://www.medicines.org.uk/EMC/medicine/4297/SPC/Tractocile+7. 5+mg+ml+Solution+for+Injection/ Accessed June 24, 2010
11. eMC. Tractocile 7.5 mg/ml concentrate for solution for infusion. Available at: http://www.medicines.org.uk/EMC/medicine/4305/SPC/Tractocile+7. 5+mg+ml+Concentrate+for+Solution+for+Infusion/ Accessed June 24, 2010
12. UKMi. New medicines on the market. Available at: http://www.ukmi.nhs.uk/ NewMaterial/html/docs/atosiban.pdf Accessed June 24, 2010
13. Kashanian M, Akbarian A R., Soltanzadeh M. Atosiban and nifedipin for the treatment of preterm labor. Int J Gynaecol Obstet 2005 91 10-14 (Pubitemid 41278553)
14. Goodwin T M., Paul R, Silver H et al. The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human. Am J Obstet Gynecol 1994 170 474-478 (Pubitemid 24089002)
15. Goodwin T M., Valenzuela G J., Silver H, Creasy G, Atosiban Study Group. Dose ranging study of the oxytocin antagonist atosiban in the treatment of preterm labor. Obstet Gynecol 1996 88 331-336 (Pubitemid 26293273)
16. Thornton J G. The quality of randomised trials of tocolysis. BJOG 2006 113 Suppl 3 93-95 (Pubitemid 44934675)
17. Romero R, Sibai B M., Sanchez-Ramos L et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol 2000 182 1173-1183 (Pubitemid 30353308)
18. Romero R, Sirtori M, Oyarzun E et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989 161 817-824 (Pubitemid 19252813)
19. Moutquin J M., Sherman D, Cohen H et al. Double-blind, randomized, controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter effectiveness and safety study. Am J Obstet Gynecol 2000 182 1191-1199 (Pubitemid 30353310)
20. French/Australian Atosiban Investigators Group. Treatment of preterm labor with the oxytocin antagonist atosiban: a double-blind, randomized, controlled comparison with salbutamol. Eur J Obstet Gynecol Reprod Biol 2001 98 177-185
21. European Atosiban Study Group. The oxytocin antagonist atosiban versus the beta-agonist terbutaline in the treatment of preterm labor. A randomized, double-blind, controlled study. Acta Obstet Gynecol Scand 2001 80 413-422
22. Worldwide Atosiban versus Beta-agonists Study Group. Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour. BJOG 2001 108 133-142
23. Papatsonis D, Flenady V, Cole S, Liley H. Oxytocin receptor antagonists for inhibiting preterm labour. Cochrane Database Syst Rev 2005 3 CD004452
24. Al-Omari W R., Al-Shammaa H B., Al-Tikriti E M., Ahmed K W. Atosiban and nifedipine in acute tocolysis: a comparative study. Eur J Obstet Gynecol Reprod Biol 2006 128 129-134 (Pubitemid 44335862)
25. Coomarasamy A, Knox E M., Gee H, Song F, Khan K S. Effectiveness of nifedipine versus atosiban for tocolysis in preterm labour: a meta-analysis with an indirect comparison of randomised trials. BJOG 2003 110 1045-1049 (Pubitemid 37510145)
26. Kim A, Shim J Y. Emerging tocolytics for maintenance therapy of preterm labour: oxytocin antagonists and calcium channel blockers. BJOG 2006 113 Suppl 3 113-115 (Pubitemid 44934680)
27. Thornton J G. Maintenance tocolysis. BJOG 2005 112 Suppl 1 118-121 (Pubitemid 40313996)
28. Norwitz E R., Bahtiyar M O., Sibai B M. Defining standards of care in maternal-fetal medicine. Am J Obstet Gynecol 2004 191 1491-1496 (Pubitemid 39421620)
29. Valenzuela G J., Sanchez-Ramos L, Romero R et al. Maintenance treatment of preterm labor with the oxytocin antagonist atosiban. The Atosiban PTL-098 Study Group. Am J Obstet Gynecol 2000 182 1184-1190 (Pubitemid 30353309)
30. Papatsonis D, Flenady V, Liley H. Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour. Cochrane Database Syst Rev 2009 1 CD005938
31. Helmer H, Brunbauer M, Rohrmeister K. Exploring the role of Tractocile in everyday clinical practice. BJOG 2003 110 Suppl 20 113-115 (Pubitemid 36577398)
32. Goodwin T M., Valenzuela G, Silver H, Hayashi R, Creasy G W., Lane R. Treatment of preterm labor with the oxytocin antagonist atosiban. Am J Perinatol 1996 13 143-146 (Pubitemid 26099267)
33. Lurie S, Sadan O, Ben Aroya Z, Glezerman M. Atosiban treatment for uterine hyperactivity during active labor: a pilot study. J Perinat Med 2004 32 137-139 (Pubitemid 39220534)
34. Afschar P, Schöll W, Bader A, Bauer M, Winter R. A prospective randomised trial of atosiban versus hexoprenaline for acute tocolysis and intrauterine resuscitation. BJOG 2004 111 316-318 (Pubitemid 38446105)
35. de Heus R, Mulder E J., Derks J B., Kurver P H., van Wolfswinkel L, Visser G H. A prospective randomized trial of acute tocolysis in term labour with atosiban or ritodrine. Eur J Obstet Gynecol Reprod Biol 2008 139 139-145
36. Fuchs A R., Fuchs F, Husslein P, Soloff M S., Fernström M J. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science 1982 215 1396-1398 (Pubitemid 12129721)
37. Fuchs A R., Fuchs F, Husslein P, Soloff M S. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol 1984 150 734-741 (Pubitemid 15204655)
38. Richter O N., Dorn C, van de Vondel P, Ulrich U, Schmolling J. Tocolysis with atosiban: experience in the management of premature labor before 24 weeks of pregnancy. Arch Gynecol Obstet 2005 272 26-30 (Pubitemid 40896630)
39. Husslein P, Quartarolo J P. Review of clinical experience with atosiban and the Tractocile Efficacy Assessment Survey in Europe (TREASURE) study protocol. Int J Clin Pract 2003 57 121-127 (Pubitemid 36372567)
40. Husslein P, Roura L C., Dudenhausen J et al, TREASURE study group. Clinical practice evaluation of atosiban in preterm labour management in six European countries. BJOG 2006 113 Suppl 3 105-110 (Pubitemid 44934678)
41. Treschan T A., Peters J. The vasopressin system: physiology and clinical strategies. Anesthesiology 2006 105 599-612 quiz 639-640 (Pubitemid 44310444)
42. Tsatsaris V, Carbonne B, Cabrol D. Atosiban for preterm labour. Drugs 2004 64 375-382 (Pubitemid 38333654)
43. Thornton S. Oxytocin receptor antagonists for inhibiting preterm labour. Available at: http://www.cochranefeedback.com/cf/cda/citation.do?id=9535#9535 Accessed June 24, 2010
44. Food and Drug Administration. Antocin, (atosiban injection) for use in the management of preterm labor. Gaithersburg, MD Centre for Drug Evaluation and Research, Advisory Committee for Reproductive Health Drugs April 20, 1998 Issue-NDA 20-797 83-85
45. Food and Drug Administration. Antocin, (atosiban injection) for use in the management of preterm labor. Gaithersburg, MD Centre for Drug Evaluation and Research, Advisory Committee for Reproductive Health Drugs April 20, 1998 Issue-NDA 20-797 24
46. Papatsonis D N., Kok J H., van Geijn H P., Bleker O P., Adr H J., Dekker G A. Neonatal effects of nifedipine and ritodrine for preterm labor. Obstet Gynecol 2000 95 477-481 (Pubitemid 30139563)
47. Papatsonis D N., Van Geijn H P., Adr H J., Lange F M., Bleker O P., Dekker G A. Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstet Gynecol 1997 90 230-234 (Pubitemid 27318838)
48. Goodwin T MRH, Perry K, Menard M K. et al. A report on infant outcomes up to 24 months of age after the use of atosiban in the management of preterm labour. Abstract presented at: 46th ACOG Annual Meeting May 9-13, 1998 New Orleans, LA
49. Akerlund M, Bossmar T, Brouard R et al. Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women. Br J Obstet Gynaecol 1999 106 1047-1053 (Pubitemid 29457087)
50. Pierzynski P, Lemancewicz A, Reinheimer T, Akerlund M, Laudanski T. Inhibitory effect of barusiban and atosiban on oxytocin-induced contractions of myometrium from preterm and term pregnant women. J Soc Gynecol Investig 2004 11 384-387 (Pubitemid 39179893)
51. Reinheimer T M., Bee W H., Resendez J C., Meyer J K., Haluska G J., Chellman G J. Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor. J Clin Endocrinol Metab 2005 90 2275-2281 (Pubitemid 40586274)
52. Thornton S, Goodwin T M., Greisen G, Hedegaard M, Arce J C. The effect of barusiban, a selective oxytocin antagonist, in threatened preterm labor at late gestational age: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol 2009 200 627 e1-e10
53. Reinheimer T M. Barusiban suppresses oxytocin-induced preterm labour in non-human primates. BMC Pregnancy Childbirth 2007 7 Suppl 1 S15
54. Wilson R J., Allen M J., Nandi M, Giles H, Thornton S. Spontaneous contractions of myometrium from humans, non-human primate and rodents are sensitive to selective oxytocin receptor antagonism in vitro. BJOG 2001 108 960-966 (Pubitemid 32778592)
55. Steinwall M, Bossmar T, Gaud C, Akerlund M. Inhibitory effects of SR 49059 on oxytocin-and vasopressin-induced uterine contractions in non-pregnant women. Acta Obstet Gynecol Scand 2004 83 12-18 (Pubitemid 38121726)
56. Steinwall M, Bossmar T, Brouard R et al. The effect of relcovaptan (SR 49059), an orally active vasopressin V1a receptor antagonist, on uterine contractions in preterm labor. Gynecol Endocrinol 2005 20 104-109 (Pubitemid 40604026)