Treatment of preterm labor with the oxytocin antagonist atosiban: A double-blind, randomized, controlled comparison with salbutamol

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 98, Issue 2, 2001, Pages 177-185

  Cabrol, D ^a   Gillet, J Y ^b   Madelenat, P ^c   Lansac, J ^d   Paniel, B ^e   Dellenbach, P ^f   Lemoine, J P ^g   Bronstein, R ^h   Leng, J J ⁱ   Laurent, M C ^j   Mares, P ^k   Hedon, B ^l   Magnin, G ^m   Treisser, A ⁿ   Schumacher, J C ^o   Grosieux, P ^p   Jacquetin, P ^q   Bruhat, M ^q   Segard, L ^r   Puech, F ^s   Engelmann, P ^t   Schweitzer, M ^u   Boog, G ^v   Boubli, L ^w   Duquidt, N ^x   Desroches, A ^y   Blot, P ^z   Milliez, J ^aa   Tabaste, J L ^ab   MacLennan, A H ^ac   Crowther, C ^ac   Dickinson, J E ^ad   Peat, B B ^ae   King, J ^af   Fulcher, I R ^ag   Permezel, J M ^ah   more..

^a université Paris Cité   (France)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^c BICHAT HOSPITAL   (France)

^d HÔPITAL DU BOCAGE   (France)

^e CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

^f Centre Medico Chirurgical Obstetrique   (France)

^g HÔPITAL CHARLES NICOLLE   (France)

^h CHG   (France)

ⁱ HÔPITAL PELLEGRIN   (France)

^j SERVICE DE RHUMATOLOGIE   (France)

^k DEPARTMENT OF NEUROLOGY   (France)

^l HÔPITAL ARNAUD DE VILLENEUVE   (France)

^m POITIERS UNIVERSITY HOSPITAL   (France)

ⁿ HÔPITAL CIVIL   (France)

^o Hopital du Hasenrain CH de Mulhouse   (France)

^p HÔTEL DIEU   (France)

^q HÔTEL DIEU   (France)

^r Centre Hospitalier Intercommunal Jean Rostand   (France)

^s LILLE UNIVERSITY HOSPITAL   (France)

^t HÔPITAL LOUIS MOURIER   (France)

^u Maternite Regionale Universitaire   (France)

^v Hopital Mere Enfant CHU de Nantes   (France)

^w HÔPITAL NORD   (France)

^x Centre Hospitalier Régional Notre Dame de Bon Secours   (France)

^y Rheumatology Orléans Hospital   (France)

^z HÔPITAL ROBERT DEBRÉ   (France)

^aa HÔPITAL SAINT ANTOINE   (France)

^ab DUPUYTREN UNIVERSITY HOSPITAL   (France)

^ac WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^ad KING EDWARD MEMORIAL HOSPITAL   (Australia)

^ae ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^af Mater Mother's Hospital   (Australia)

^ag NEPEAN HOSPITAL   (Australia)

^ah ROYAL WOMEN'S HOSPITAL   (Australia)

more..

Author keywords

Atosiban; Oxytocin antagonists; Preterm labor; Salbutamol; Adrenergic agonist

Indexed keywords

ARGIPRESTOCIN; ATOSIBAN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; HORMONE ANTAGONIST; SALBUTAMOL; UTERUS SPASMOLYTIC AGENT;

ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FETUS DEATH; HUMAN; INFANT MORTALITY; MULTICENTER STUDY; NEWBORN; NEWBORN DISEASE; PREGNANCY; PREMATURE LABOR; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UTERUS CONTRACTION;

ADRENERGIC BETA-AGONISTS; ADULT; ALBUTEROL; DOUBLE-BLIND METHOD; FEMALE; FETAL DEATH; HORMONE ANTAGONISTS; HUMANS; INFANT MORTALITY; INFANT, NEWBORN; INFANT, NEWBORN, DISEASES; OBSTETRIC LABOR, PREMATURE; PREGNANCY; TOCOLYTIC AGENTS; TREATMENT OUTCOME; UTERINE CONTRACTION; VASOTOCIN;

EID: 0035487869     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-2115(01)00331-1     Document Type: Article

References (40)

1. Scottish Stillbirth, Neonatal Death Reports: 1989, 1990, 1991, 1992, 1993, 1994. Edinburgh (Trinity Park House): ISD Publications, 1995.
2. Robertson PA, Sniderman SH, Laros RK, Cowan R, Heilbron D, Goldenberg RL. Neonatal morbidity according to gestational age and birthweight from five tertiary care centers in the United States, 1983 through 1986. Am J Obstet Gynecol 1992;166:1629-41.
3. Hall MH, Danielian P, Lamont RF. The importance of preterm birth. In: Elder MG, Lamont RF, Romero R, editors. Preterm labor. New York: Churchill Livingstone, 1997. p. 1-28.
4. Cole RM, Lamont RF. Current perspectives on drug treatment for preterm labour. J Obstet Gynaecol 1998;18:309-14.
5. Villar J, Ezcurra EJ, Gurtner de la Fuente V, Campodonico L. Preterm delivery syndrome - the unmet need. Res Clin Forums 1994;16(3):9-38.
6. Besinger RE, Iannucci TA. Tocolytic therapy. In: Elder MG, Lamont RF, Romero R, editors. Preterm labor. New York: Churchill Livingstone, 1997. p. 243-97.
7. Melin P. Development of an oxytocin antagonist atosiban. Res Clin Forums 1994;16(3):155-68.
8. Fuchs AR, Husslein P, Fuchs F. Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin. Am J Obstet Gynecol 1981;141:694-7.
9. Fuchs AR, Fuchs F, Husslein P, Soloff MS, Fernström MJ. Oxytocin receptors and human parturition: a direct role for oxytocin in initiation of labor. Science 1982;215:1396-8.
10. Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in pregnant human uterus. Am J Obstet Gynecol 1984;150:734-41.
11. Fuchs AR, Romero R, Keefe D, Parra M, Oyarzun E, Behnke E. Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women. Am J Obstet Gynecol 1991;165:1515-23.
12. Bossmar T, Akerlund M, Fantoni G, Szamatowicz J, Melin P, Maggi M. Receptors for myometrial responses to oxytocin and vasopressin in preterm human pregnancy: effects of the oxytocin antagonist atosiban. Am J Obstet Gynecol 1994;171:1634-42.
13. Kinsler VA, Thornton S, Ashford MLJ, Melin P, Smith SK. The effect of the oxytocin antagonists F314 and F792 in the in vitro contractility of human myometrium. Br J Obstet Gynaecol 1996;103:373-5.
14. Goodwin TM, Paul R, Silver H, et al. The effect of the oxytocin antagonist atosiban on preterm uterine activity in the human. Am J Obstet Gynecol 1994;170:474-78.
15. Goodwin TM, Millar L, North L, Abrams LS, Wegleinn RC, Holland ML. The pharmacokinetics of the oxytocin antagonist atosiban in pregnant women with preterm uterine contractions. Am J Obstet Gynecol 1995;173:913-7.
16. Goodwin TM, Valenzuela G, Silver H, Hayashi R, Creasy GW, Lane R. Treatment of preterm labor with the oxytocin antagonist atosiban. Am J Perinatol 1996;13:143-6.
17. Stokes M, Davis C, Koch H. Categorical data analysis using the SAS system. Cary (NC): SAS Institute Inc., 1995.
18. Canadian Preterm Labor Investigators Group. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. N Engl J Med 1992;327:308-12.
19. Goodwin TM, Valenzuela GJ, Silver H, Creasy G, Atosiban Study Group. Dose ranging study of the oxytocin antagonist atosiban in the treatment of preterm labor. Obstet Gynecol 1996;88:331-36.
20. Romero R, Sibai BM, Sanchez-Ramos L, Valenzuela GJ, et al. An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomised, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol 2000;182:1173-83.
21. Moutquin J-M, Sherman D, Cohen H, Mohide PT, Hochner D, Fejgin M, et al. Double-blind randomized controlled trial of atosiban and ritodrine in the treatment of preterm labor: a multicenter efficacy and safety study. Am J Obstet Gynecol 2000;182:1191-99.
22. The European Atosiban Study Group. The oxytocin antagonist atosiban in the treatment of preterm labour: a randomised, double-blind, controlled study versus terbutaline. Acta Scand Obstet Gynecol, 2000, submitted for publication.
23. The Worldwide Atosiban versus Beta-Agonists Study Group. Analysis of the pooled data from three randomised double-blind controlled trials of the oxytocin antagonist atosiban versus the beta-adrenergic agonists, ritodrine, terbutaline and salbutamol, in the treatment of preterm labour. Br J Obstet Gynaecol, 2000, submitted for publication.
24. Price AH, Clissold SP. Salbutamol in the 1980s. A reappraisal of its clinical efficacy. Drugs 1989;38:77-122.
25. Singh VK, Sharma M, Rohatgi P. Effect of salbutamol on premature labour. J Indian Med Assoc 1990;88:253-4.
26. Ashworth MF, Spooner SF, Verkuyl DA, Waterman R, Ashurst HM. Failure to prevent preterm labour and delivery in twin pregnancy using prophylactic oral salbutamol. Br J Obstet Gynaecol 1990;97:878-82.
27. Jannet D, Abankwa A, Guyard B, Carbonne B, Marpeau L, Milliez J. Nicardipine versus salbutamol in the treatment of premature labor. A prospective randomized study. Eur J Obstet Gynecol Reprod Biol 1997;73:11-6.
28. Watson NA, Morgan B. Pulmonary oedema and salbutamol in preterm labour. Case report and literature review. Br J Obstet Gynaecol 1989;96:1445-8.
29. Milos M, Aberle DR, Parkinson BT, Batra P, Brown K. Maternal pulmonary edema complicating beta-adrenergic therapy of preterm labor. Am J Roentgenol 1988;151:917-8.
30. Gupta RC, Foster S, Romano PM, Thomas HM. Acute pulmonary edema associated with the use of oral ritodrine for preterm labor. Chest 1989;95:479-81.
31. Sylvester J, Fuentes RT, Holmes RA. Discordant radioaerosol/ radioperfusion in drug-induced maternal pulmonary edema. Clin Nucl Med 1989;14:686-8.
32. Lamont RF. The contemporary use of β-agonists. Br J Obstet Gynaecol 1993;100:890-2.
33. Hadi HA, Albazzaz SJ. Cardiac isoenzymes and electrocardiographic changes during ritodrine tocolysis. Am J Obstet Gynecol 1989;161:318-21.
34. King JF, Grant A, Keirse MJNC, Chalmers I. Beta-mimetics in preterm labour: an overview of the randomized controlled trials. Br J Obstet Gynaecol 1988;95:211-22.
35. Cochrane Database of Systematic Reviews. The Cochrane Library, 1995, Issue 2.
36. Mittendorf R, Covert R, Boman J, Khoshnood B, Lee KS, Siegler M. Is tocolytic magnesium sulphate associated with increased total paediatric mortality? Lancet 1997;250:1517-8.
37. Mittendorf R, Pryde P, Khoshnood B, Lee KS. If tocolytic magnesium sulfate is associated with excess total pediatric mortality, what is its impact? Obstet Gynecol 1998;92:308-11.
38. Higby K, Xenakis EM, Pauerstein CJ. Do tocolytic agents stop preterm labor? A critical and comprehensive review of efficacy and safety. Am J Obstet Gynecol 1993;168:1247-56.
39. Lamont RF, Dunlop PD, Crowley P, Levene MI, Elder MG. Comparative mortality and morbidity of infants transferred in utero or post-natally. J Perinat Med 1983;11:200-3.
40. Crowley P, Chalmers I, Keirse MJNC. The effects of corticosteroid administration prior to preterm delivery: an overview from the evidence from controlled trials. Br J Obstet Gynaecol 1990;97:11-25.