Receptor binding of oxytocin and vasopressin antagonists and inhibitory effects on isolated myometrium from preterm and term pregnant women

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 106, Issue 10, 1999, Pages 1047-1053

  Åkerlund, Mats ^a   Bossmar, Thomas ^a   Brouard, Rémi ^d   Kostrzewska, Anna ^c   Laudanski, Tadeusz ^b   Lemancewicz, Adam ^b   Gal, Claudine Secradeil Le ^d   Steinwall, Margareta ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Bialystok University Hospital   (Poland)

^c Department of Biophysics ^*  (Poland)

^d SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; ATOSIBAN; N TERT BUTYL 4 [5' ETHOXY 4 (2 MORPHOLINOETHOXY) 2' OXOSPIRO[CYCLOHEXANE 1,3' INDOLE] 1' SULFONYL] 3 METHOXYBENZAMIDE; OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; RELCOVAPTAN; UNCLASSIFIED DRUG; VASOPRESSIN; VASOPRESSIN ANTAGONIST; VASOPRESSIN RECEPTOR;

ARTICLE; BINDING AFFINITY; CELL LINE; CESAREAN SECTION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; FEMALE; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN TISSUE; MYOMETRIUM; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY;

ARGININE VASOPRESSIN; CELL LINE; CESAREAN SECTION; FEMALE; HORMONE ANTAGONISTS; HUMANS; INDOLES; MORPHOLINES; MYOMETRIUM; OBSTETRIC LABOR, PREMATURE; OXYTOCIN; PREGNANCY; PYRROLIDINES; RECEPTORS, OXYTOCIN; RECEPTORS, VASOPRESSIN; SPIRO COMPOUNDS; VASOPRESSINS;

EID: 0032882688     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.1999.tb08112.x     Document Type: Article

References (18)

1. Fuchs AR, Romero R, Keefe D, Parra M, Oyarzun E, Behnke E. Oxytocin secretion and human parturition: pulse frequence and duration increased during spontaneous labour in women. Am J Obstet Gynecol 1991; 165: 1515-1523.
2. Lefebvre DL, Giaid A, Bennett H et al. Oxytocin gene expression in rat uterus. Science 1992; 256: 1553-1555.
3. Chibbar R, Miller FD, Mitchell BF. Synthesis of oxytocin in amnion chorion and decidua may influence the timing of human parturition. J Clin Invest 1993; 91: 185-192.
4. 1 VP receptors as well as oxytwin receptors. J Clin Endocrinol Metab 1990; 70: 1142-1154.
5. Chard T, Hudson CN, Edwards CRW, Boyd NHR. Release of oxytocin and vasopressin by the human foetus during labour. Nature 1971; 234: 352-354.
6. Bossmar T, Åerlund M, Fantoni G, Szamatowicz J, Melin P, Maggi M. Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human myometrium. Effects of the antagonist atosiban. Am J Obstet Gynecol 1994; 171: 1634-1642.
7. Burbach JPH, Roger AHA, Lolait SJ et al. Molecular neurobiology and pharmacology of the vasopressidoxytocin receptor family. Cell Mol Neurobiol 1995; 15: 573-595.
8. 1a receptor. J Clin Invest 1994; 92: 224-231.
9. 1a receptor antagonist, SR 49059, and its enantiomer, SR 49770, on isolated human myometrium. Acta Obster Gynecol Scand 1996; 75: 516-519.
10. 1a receptor antagonist, SR 49059, on the response of human uterine arteries to vasopressin and other vasoactive substances. Acta Obstet Gynecol Scand 1998; 77: 3-7.
11. Bossmar T, Brouard R, Döberl A, Åkerlund M. Effects of SR 49059, an orally active vasopressin receptor antagonist, on vasopressin-induced uterine contractions. Br J Obstet Gynaecol 1997; 104: 471-477.
12. 2 receptor antagonist. J Clin Invest 1996; 98: 2729-2738.
13. Åkerlund M, Strömberg P, Hauksson et al. Inhibition of uterine contractions of premature labour with an oxytocin analogue. Results from a pilot study. Br J Obstet Gynaecol 1987; 94: 1040-1044.
14. Goodwin TM, Paul R, Silver H et al. The effects of the oxytocin antagonist atosiban on preterm uterine activity in the human. Am J Obstet Gynecol 1994; 170: 474-478.
15. Munson PV, Rodbard D. Ligand: A versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 1980; 107: 220-239.
16. 50) of an enzymatic reaction. Biochim Phannacol 1973; 22: 3099-3108.
17. Allen MJ, Smith JR, Hampton SL, Giles H. Affinity of antagonist and endogenous peptides at human recombinant oxytocin and vasopressin receptors. 1997 Word Congress of Neurohypophyseal Hormones, Montreal, Canada, August 8-12, Abstract No 176.
18. Bossmar T, Åkerlund M, Szamatowicz J, Laudanski T, Fantoni G, Maggi M. Receptor-mediated uterine effects of vasopressin and oxytocin in non-pregnant women. Br J Obstet Gynaecol 1995; 102: 907-912.