메뉴 건너뛰기




Volumn 16, Issue 4, 2011, Pages 457-462

Effects of low dose Methotrexate on relapsing-remitting multiple sclerosis in comparison to Interferon β-1α: A randomized controlled trial

Author keywords

Interferon Beta; Methotrexate; Multiple Sclerosis

Indexed keywords

BETA1A INTERFERON; CINNOVEX; METHOTREXATE; UNCLASSIFIED DRUG;

EID: 79957566355     PISSN: 17351995     EISSN: 17357136     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (20)

References (39)
  • 1
    • 0034124984 scopus 로고    scopus 로고
    • The management of multiple sclerosis patients
    • Clanet MG, Brassat D. The management of multiple sclerosis patients. Curr Opin Neurol 2000; 13(3): 263-70.
    • (2000) Curr Opin Neurol , vol.13 , Issue.3 , pp. 263-270
    • Clanet, M.G.1    Brassat, D.2
  • 2
    • 79957558572 scopus 로고    scopus 로고
    • Multiple sclerosis
    • (Online), Aug 15; 2007
    • Nicholas R, Chataway J. Multiple sclerosis. Clin Evid (Online). 2007 Aug 15; 2007. pii: 1202.
    • (2007) Clin Evid , pp. 1202
    • Nicholas, R.1    Chataway, J.2
  • 3
    • 0036091948 scopus 로고    scopus 로고
    • A review of the natural history and epidemiology of multiple sclerosis: Implications for resource allocation and health economic models
    • Richards RG, Sampson FC, Beard SM, Tappenden P. A review of the natural history and epidemiology of multiple sclerosis: implications for resource allocation and health economic models. Health Technol Assess 2002; 6(10): 1-73.
    • (2002) Health Technol Assess , vol.6 , Issue.10 , pp. 1-73
    • Richards, R.G.1    Sampson, F.C.2    Beard, S.M.3    Tappenden, P.4
  • 4
    • 0034522161 scopus 로고    scopus 로고
    • Drug treatment of multiple sclerosis
    • Polman CH, Uitdehaag BM. Drug treatment of multiple sclerosis. West J Med 2000; 173(6): 398-402.
    • (2000) West J Med , vol.173 , Issue.6 , pp. 398-402
    • Polman, C.H.1    Uitdehaag, B.M.2
  • 5
    • 16244368038 scopus 로고    scopus 로고
    • US FDA-approved disease-modifying treatments for multiple sclerosis: Review of adverse effect profiles
    • Galetta SL, Markowitz C. US FDA-approved disease-modifying treatments for multiple sclerosis: review of adverse effect profiles. CNS Drugs 2005; 19(3): 239-52.
    • (2005) CNS Drugs , vol.19 , Issue.3 , pp. 239-252
    • Galetta, S.L.1    Markowitz, C.2
  • 6
    • 0030944188 scopus 로고    scopus 로고
    • Current and investigational therapies used to alter the course of disease in multiple sclerosis
    • Miller A. Current and investigational therapies used to alter the course of disease in multiple sclerosis. South Med J 1997; 90(4): 367-75.
    • (1997) South Med J , vol.90 , Issue.4 , pp. 367-375
    • Miller, A.1
  • 7
    • 77950345358 scopus 로고    scopus 로고
    • Pharmacological treatment of multiple sclerosis
    • [In Spanish]
    • Myhr KM. Pharmacological treatment of multiple sclerosis. Tidsskr Nor Laegeforen 2010; 130(5): 490-2. [In Spanish].
    • (2010) Tidsskr Nor Laegeforen , vol.130 , Issue.5 , pp. 490-492
    • Myhr, K.M.1
  • 8
    • 76649114323 scopus 로고    scopus 로고
    • PML risk and natalizumab: More questions than answers
    • Ransohoff RM. PML risk and natalizumab: more questions than answers. Lancet Neurol 2010; 9(3): 231-3.
    • (2010) Lancet Neurol , vol.9 , Issue.3 , pp. 231-233
    • Ransohoff, R.M.1
  • 9
    • 2442496353 scopus 로고    scopus 로고
    • Mitoxantrone: A review of its use in multiple sclerosis
    • Scott LJ, Figgitt DP. Mitoxantrone: a review of its use in multiple sclerosis. CNS Drugs 2004; 18(6): 379-96.
    • (2004) CNS Drugs , vol.18 , Issue.6 , pp. 379-396
    • Scott, L.J.1    Figgitt, D.P.2
  • 10
    • 37749016994 scopus 로고    scopus 로고
    • Mitoxantrone as induction treatment in aggressive relapsing remitting multiple sclerosis: Treatment response factors in a 5 year follow-up observational study of 100 consecutive patients
    • Le Page E, Leray E, Taurin G, Coustans M, Chaperon J, Morrissey SP. Mitoxantrone as induction treatment in aggressive relapsing remitting multiple sclerosis: treatment response factors in a 5 year follow-up observational study of 100 consecutive patients. J Neurol Neurosurg Psychiatry 2008; 79(1): 52-6.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , Issue.1 , pp. 52-56
    • le Page, E.1    Leray, E.2    Taurin, G.3    Coustans, M.4    Chaperon, J.5    Morrissey, S.P.6
  • 11
    • 76649135489 scopus 로고    scopus 로고
    • Use of natalizumab in multiple sclerosis patients
    • O'Connor PW. Use of natalizumab in multiple sclerosis patients. Can J Neurol Sci 2010; 37(1): 98-104.
    • (2010) Can J Neurol Sci , vol.37 , Issue.1 , pp. 98-104
    • O'Connor, P.W.1
  • 12
    • 56549105235 scopus 로고    scopus 로고
    • Disease-modifying agents for multiple sclerosis: Recent advances and future prospects
    • Menge T, Weber MS, Hemmer B, Kieseier BC, von Budingen HC, Warnke C. Disease-modifying agents for multiple sclerosis: recent advances and future prospects. Drugs 2008; 68(17): 2445-68.
    • (2008) Drugs , vol.68 , Issue.17 , pp. 2445-2468
    • Menge, T.1    Weber, M.S.2    Hemmer, B.3    Kieseier, B.C.4    von Budingen, H.C.5    Warnke, C.6
  • 13
    • 67650463349 scopus 로고    scopus 로고
    • Oral laquinimod therapy in relapsing multiple sclerosis
    • Preiningerova J. Oral laquinimod therapy in relapsing multiple sclerosis. Expert Opin Investig Drugs 2009; 18(7): 985-9.
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.7 , pp. 985-989
    • Preiningerova, J.1
  • 15
    • 33646781553 scopus 로고    scopus 로고
    • Intensive immunosuppression in multiple sclerosis
    • Zaffaroni M, Ghezzi A, Comi G. Intensive immunosuppression in multiple sclerosis. Neurol Sci 2006; 27(Suppl 1): S13-7.
    • (2006) Neurol Sci , vol.27 , Issue.SUPPL. 1
    • Zaffaroni, M.1    Ghezzi, A.2    Comi, G.3
  • 16
    • 0029854588 scopus 로고    scopus 로고
    • Low-dose oral methotrexate in chronic progressive multiple sclerosis: Analyses of serial MRIs
    • Goodkin DE, Rudick RA, VanderBrug MS, Daughtry MM, Van Dyke C. Low-dose oral methotrexate in chronic progressive multiple sclerosis: Analyses of serial MRIs. Neurology 1996; 47(5): 1153-7.
    • (1996) Neurology , vol.47 , Issue.5 , pp. 1153-1157
    • Goodkin, D.E.1    Rudick, R.A.2    VanderBrug, M.S.3    Daughtry, M.M.4    van Dyke, C.5
  • 17
    • 0034791382 scopus 로고    scopus 로고
    • Low-dose oral methotrexate treatment in chronic progressive multiple sclerosis
    • Lugaresi A, Caporale C, Farina D, Marzoli F, Bonanni L, Muraro PA, et al. Low-dose oral methotrexate treatment in chronic progressive multiple sclerosis. Neurol Sci 2001; 22(2): 209-10.
    • (2001) Neurol Sci , vol.22 , Issue.2 , pp. 209-210
    • Lugaresi, A.1    Caporale, C.2    Farina, D.3    Marzoli, F.4    Bonanni, L.5    Muraro, P.A.6
  • 18
    • 33746488183 scopus 로고    scopus 로고
    • A systematic review of oral methotrexate for multiple sclerosis
    • Gray OM, McDonnell GV, Forbes RB. A systematic review of oral methotrexate for multiple sclerosis. Mult Scler 2006; 12(4): 507-10.
    • (2006) Mult Scler , vol.12 , Issue.4 , pp. 507-510
    • Gray, O.M.1    McDonnell, G.V.2    Forbes, R.B.3
  • 19
    • 11444251484 scopus 로고    scopus 로고
    • The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules
    • Johnston A, Gudjonsson JE, Sigmundsdottir H, Ludviksson BR, Valdimarsson H. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules. Clin Immunol 2005; 114(2): 154-63.
    • (2005) Clin Immunol , vol.114 , Issue.2 , pp. 154-163
    • Johnston, A.1    Gudjonsson, J.E.2    Sigmundsdottir, H.3    Ludviksson, B.R.4    Valdimarsson, H.5
  • 20
    • 10944271463 scopus 로고    scopus 로고
    • Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis
    • Jeffery DR. Use of combination therapy with immunomodulators and immunosuppressants in treating multiple sclerosis. Neurology 2004; 63(12 Suppl 6): S41-6.
    • (2004) Neurology , vol.63 , Issue.12 SUPPL. 6
    • Jeffery, D.R.1
  • 21
    • 0036200216 scopus 로고    scopus 로고
    • Results of an international questionnaire on immunosuppressive treatment of multiple sclerosis
    • Hommes OR, Weiner HL. Results of an international questionnaire on immunosuppressive treatment of multiple sclerosis. Mult Scler 2002; 8(2): 139-41.
    • (2002) Mult Scler , vol.8 , Issue.2 , pp. 139-141
    • Hommes, O.R.1    Weiner, H.L.2
  • 22
    • 3142514312 scopus 로고    scopus 로고
    • Azathioprine and methotrexate in multiple sclerosis
    • Fernandez O, Fernandez V, De Ramon E. Azathioprine and methotrexate in multiple sclerosis. J Neurol Sci 2004; 223(1): 29-34.
    • (2004) J Neurol Sci , vol.223 , Issue.1 , pp. 29-34
    • Fernandez, O.1    Fernandez, V.2    De Ramon, E.3
  • 23
    • 0035036833 scopus 로고    scopus 로고
    • Systematic review of immunomodulatory drugs for the treatment of people with multiple sclerosis: Is there good quality evidence on effectiveness and cost?
    • Bryant J, Clegg A, Milne R. Systematic review of immunomodulatory drugs for the treatment of people with multiple sclerosis: Is there good quality evidence on effectiveness and cost? J Neurol Neurosurg Psychiatry 2001; 70(5): 574-9.
    • (2001) J Neurol Neurosurg Psychiatry , vol.70 , Issue.5 , pp. 574-579
    • Bryant, J.1    Clegg, A.2    Milne, R.3
  • 24
    • 22444447949 scopus 로고    scopus 로고
    • Primary progressive multiple sclerosis: Current and future treatment options
    • Leary SM, Thompson AJ. Primary progressive multiple sclerosis: current and future treatment options. CNS Drugs 2005; 19(5): 369-76.
    • (2005) CNS Drugs , vol.19 , Issue.5 , pp. 369-376
    • Leary, S.M.1    Thompson, A.J.2
  • 25
    • 0020686503 scopus 로고
    • New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
    • Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13(3): 227-31.
    • (1983) Ann Neurol , vol.13 , Issue.3 , pp. 227-231
    • Poser, C.M.1    Paty, D.W.2    Scheinberg, L.3    McDonald, W.I.4    Davis, F.A.5    Ebers, G.C.6
  • 26
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33(11): 1444-52.
    • (1983) Neurology , vol.33 , Issue.11 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 27
    • 0028906384 scopus 로고
    • Low-dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis
    • Goodkin DE, Rudick RA, VanderBrug MS, Daughtry MM, Schwetz KM, Fischer, J et al. Low-dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis. Ann Neurol 1995; 37(1): 30-40.
    • (1995) Ann Neurol , vol.37 , Issue.1 , pp. 30-40
    • Goodkin, D.E.1    Rudick, R.A.2    VanderBrug, M.S.3    Daughtry, M.M.4    Schwetz, K.M.5    Fischer, J.6
  • 28
    • 52449099194 scopus 로고    scopus 로고
    • Discontinuation of methotrexate therapy in older patients with newly diagnosed rheumatoid arthritis: Analysis of administrative health databases in Quebec, Canada
    • Bernatsky S, Ehrmann FD. Discontinuation of methotrexate therapy in older patients with newly diagnosed rheumatoid arthritis: analysis of administrative health databases in Quebec, Canada. Drugs Aging 2008; 25(10): 879-84.
    • (2008) Drugs Aging , vol.25 , Issue.10 , pp. 879-884
    • Bernatsky, S.1    Ehrmann, F.D.2
  • 29
    • 54549111090 scopus 로고    scopus 로고
    • Rheumatoid arthritis and pregnancy
    • Florea A, Job-Deslandre C. [Rheumatoid arthritis and pregnancy]. Presse Med 2008; 37(11): 1644-51.
    • (2008) Presse Med , vol.37 , Issue.11 , pp. 1644-1651
    • Florea, A.1    Job-Deslandre, C.2
  • 30
    • 49549124746 scopus 로고    scopus 로고
    • Use of nonbiologic disease-modifying antirheumatic drugs and risk of infection in patients with rheumatoid arthritis
    • Lacaille D, Guh DP, Abrahamowicz M, Anis AH, Esdaile JM. Use of nonbiologic disease-modifying antirheumatic drugs and risk of infection in patients with rheumatoid arthritis. Arthritis Rheum 2008; 59(8): 1074-81.
    • (2008) Arthritis Rheum , vol.59 , Issue.8 , pp. 1074-1081
    • Lacaille, D.1    Guh, D.P.2    Abrahamowicz, M.3    Anis, A.H.4    Esdaile, J.M.5
  • 31
    • 0027482084 scopus 로고
    • Low dose oral methotrexate treatment of multiple sclerosis: A pilot study
    • Currier RD, Haerer AF, Meydrech EF. Low dose oral methotrexate treatment of multiple sclerosis: a pilot study. J Neurol Neurosurg Psychiatry 1993; 56(11): 1217-8.
    • (1993) J Neurol Neurosurg Psychiatry , vol.56 , Issue.11 , pp. 1217-1218
    • Currier, R.D.1    Haerer, A.F.2    Meydrech, E.F.3
  • 32
    • 0037154138 scopus 로고    scopus 로고
    • An open-label trial of combination therapy with interferon beta-1a and oral methotrexate in MS
    • Calabresi PA, Wilterdink JL, Rogg JM, Mills P, Webb A, Whartenby KA. An open-label trial of combination therapy with interferon beta-1a and oral methotrexate in MS. Neurology 2002; 58(2): 314-7.
    • (2002) Neurology , vol.58 , Issue.2 , pp. 314-317
    • Calabresi, P.A.1    Wilterdink, J.L.2    Rogg, J.M.3    Mills, P.4    Webb, A.5    Whartenby, K.A.6
  • 33
    • 0033231305 scopus 로고    scopus 로고
    • Assessment of animal models for MS and demyelinating disease in the design of rational therapy
    • Steinman L. Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron 1999; 24(3): 511-4.
    • (1999) Neuron , vol.24 , Issue.3 , pp. 511-514
    • Steinman, L.1
  • 34
    • 5144222298 scopus 로고    scopus 로고
    • Specific antigen vaccination to treat autoimmune disease
    • McDevitt H. Specific antigen vaccination to treat autoimmune disease. Proc Natl Acad Sci U S A 2004; 101(Suppl 2): 14627-30.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.SUPPL. 2 , pp. 14627-14630
    • McDevitt, H.1
  • 35
    • 0029315079 scopus 로고
    • Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Olsson T. Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis. Neurology 1995; 45(6 Suppl 6): S11-5.
    • (1995) Neurology , vol.45 , Issue.6 SUPPL. 6
    • Olsson, T.1
  • 36
    • 0029150012 scopus 로고
    • Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease
    • Cua DJ, Hinton DR, Stohlman SA. Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease. J Immunol 1995; 155(8): 4052-9.
    • (1995) J Immunol , vol.155 , Issue.8 , pp. 4052-4059
    • Cua, D.J.1    Hinton, D.R.2    Stohlman, S.A.3
  • 37
    • 0028202792 scopus 로고
    • Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
    • Weiner HL, Friedman A, Miller A, Khoury SJ, Al Sabbagh A, Santos L, et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 1994; 12: 809-37.
    • (1994) Annu Rev Immunol , vol.12 , pp. 809-837
    • Weiner, H.L.1    Friedman, A.2    Miller, A.3    Khoury, S.J.4    Al Sabbagh, A.5    Santos, L.6
  • 38
    • 0036498604 scopus 로고    scopus 로고
    • The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis
    • Zhang GX, Xu H, Kishi M, Calida D, Rostami A. The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J Immunol 2002; 168(5): 2501-7.
    • (2002) J Immunol , vol.168 , Issue.5 , pp. 2501-2507
    • Zhang, G.X.1    Xu, H.2    Kishi, M.3    Calida, D.4    Rostami, A.5
  • 39
    • 14844286978 scopus 로고    scopus 로고
    • A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis
    • Zhang GX, Yu S, Li Y, Ventura ES, Gran B, Rostami A. A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J Neuroimmunol 2005; 161(1-2): 101-12.
    • (2005) J Neuroimmunol , vol.161 , Issue.1-2 , pp. 101-112
    • Zhang, G.X.1    Yu, S.2    Li, Y.3    Ventura, E.S.4    Gran, B.5    Rostami, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.