The role of aldehyde reductase AKR1A1 in the metabolism of gamma-hydroxybutyrate in 1321N1 human astrocytoma cells

Chemico-Biological Interactions

Volumn 191, Issue 1-3, 2011, Pages 303-307

  Alzeer, Samar ^a   Ellis, Elizabeth M ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

AKR1A1; Aldehyde reductase; Gamma hydroxybutyrate

Indexed keywords

4 HYDROXYBUTYRIC ACID; ALDEHYDE REDUCTASE; DOUBLE STRANDED RNA; SUCCINIC SEMIALDEHYDE;

ASTROCYTE; BIOSYNTHESIS; CELL GROWTH; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MASS FRAGMENTOGRAPHY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALDEHYDE REDUCTASE; ASTROCYTOMA; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYDROXYBUTYRATE DEHYDROGENASE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; SODIUM OXYBATE;

EID: 79957557701     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.01.018     Document Type: Conference Paper

References (32)

1. O.C. Snead 3rd, Gamma hydroxybutyrate, Life Sci. 20 (1977) 1935-1943.
2. C.D. Cash, J.F. Rumigny, P. Mandel, M. Maitre, Enzymology of the alternative reductive pathway of GABA catabolism leading to the biosynthesis of gamma-hydroxybutyrate, Adv. Biochem. Psychopharmacol. 29 (1981) 527-535.
3. J. Park, Y. Osei, J. Churchich, Isolation and characterization of recombinant mitochondrial 4-aminobutyrate aminotransferase, J. Biol. Chem. 268 (1993) 7636-7639.
4. C.D. Cash, M. Maitre, P. Mandel, Purification from human brain and some properties of two NADPH-linked aldehyde reductases which reduce succinic semialdehyde to 4-hydroxybutyrate, J. Neurochem. 33 (1979) 1169-1175. (Pubitemid 10133860)
5. M. Mamelak, Gammahydroxybutyrate: an endogenous regulator of energy metabolism, Neurosci. Biobehav. Rev. 13 (1989) 187-198. (Pubitemid 20039607)
6. M. Mamelak, Alzheimer' s disease, oxidative stress and gammahydroxybutyrate, Neurobiol. Aging 28 (2007) 1340-1360. (Pubitemid 47081231)
7. M. Maitre, C. Andriamampandry, V. Kemmel, C. Schmidt, Y. Hode, V. Hechler, S. Gobaille, Gamma-hydroxybutyric acid as a signalling molecule in brain, Alcohol 20 (2000) 277-283. (Pubitemid 30408577)
8. C. Muller, S. Viry, M. Miche, C. Andriamampandry, D. Aunis, M. Maitre, Evidence for a gamma-hydroxybutyrate (GHB) uptake by rat brain synaptic vesicles, J. Neurochem. 80 (2002) 899-904. (Pubitemid 34809243)
9. V. Hechler, S. Gobaille, M. Maitre, Selective distribution pattern of gamma-hydroxybutyrate receptors in the rat forebrain and midbrain as revealed by quantitative autoradiography, Brain Res. 572 (1992) 345-348.
10. O.C. Snead, Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor, J. Neurochem. 75 (2000) 1986-1996.
11. M. Schaller, M. Schaffhauser, N. Sans, B. Wermuth, Cloning and expression of succinic semialdehyde reductase fromhumanbrain, Eur. J. Biochem. 265 (1999) 1056-1060.
12. R.C. Lyon, S.M. Johnston, D.G. Watson, G. McGarvie, E.M. Ellis, Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2, J. Biol. Chem. 282 (2007) 25986-25992.
13. P. Hoffman, B. Wermuth, J.-P. von Wartburg, Human brain aldehyde reductases: relationship to succinic semialdehyde reductase and aldose reductase, J. Neurochem. 35 (1980) 354-366. (Pubitemid 10034409)
14. E.E. Kaufman, T. Nelson, C. Goochee, L. Sokoloff, Purification and characterization of an NADP+-linked alcohol oxido-reductase which catalyzes the interconversion of gamma-hydroxybutyrate and succinic semialdehyde, J. Neurochem. 32 (1979) 699-712. (Pubitemid 9134404)
15. S.R. Whittle, A.J. Turner, Biogenic aldehyde metabolism in rat brain. Differential sensitivity of aldehyde reductase isoenzymes to sodium valproate, Biochim. Biophys. Acta 657 (1981) 94-105. (Pubitemid 11181771)
16. B. Tabakoff, J.-P. Wartburg, Separation of aldehyde reductases and alcohol dehydrogenase from brain by affinity chromatography: metabolism of succinic semialdehyde and ethanol, Biochem. Biophys. Res. Commun. 63 (1975) 957-966.
17. A.J. Rivett, K.F. Tipton, Kinetic studies of the reduction of succinic semialdehyde by rat-brain aldehyde reductase, Eur. J. Biochem. 118 (1981) 635-639.
18. M aldehyde reductase and aldose reductase, carbonyl reductase, and succinic semialdehyde reductase, J. Neurochem. 44 (1985) 1485-1493.
19. R.C. Lyon, S.M. Johnston, A. Panopoulos, S. Alzeer, G. McGarvie, E.M. Ellis, Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1, Chem. Biol. Interact. 178 (2009) 283-287.
20. E.A. Struys, N.M. Verhoeven, H.J. Ten Brink, W.V. Wickenhagen, K.M. Gibson, C. Jakobs, Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias, J. Inherit. Metab. Dis. 28 (2005) 921-930. (Pubitemid 43168928)
21. O.A. Barski, S.M. Tipparaju, A. Bhatnagar, The aldo-keto reductase superfamily and its role in drug metabolism and detoxification, Drug Metab. Rev. 40 (2008) 553-624.
22. K.H. Gabbay, K.M. Bohren, R. Morello, T. Bertin, J. Liu, P. Vogel, Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis, J. Biol. Chem. 285 (2010) 19510-19520.
23. T. O'Connor, L.S. Ireland, D.J. Harrison, J.D. Hayes, Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members, Biochem. J. 343 (Pt 2) (1999) 487-504. (Pubitemid 29511786)
24. H. Jiang, D.K. Vudathala, I.A. Blair, T.M. Penning, Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction, Chem. Res. Toxicol. 19 (2006) 68-78.
25. O.A. Barski, K.H. Gabbay, K.M. Bohren, Characterization of the human aldehyde reductase gene and promoter, Genomics 60 (1999) 188-198. (Pubitemid 29463677)
26. O.A. Barski, K.H. Gabbay, C.E. Grimshaw, K.M. Bohren, Mechanism of human aldehyde reductase: characterization of the active site pocket, Biochemistry 34 (1995) 11264-11275.
27. R.B. Clark, Y.F. Su, R. Ortmann, L. Cubeddu, G.L. Johnson, J.P. Perkins, Factors influencing the effect of hormones on the accumulation of cyclic AMP in cultured human astrocytoma cells, Metabolism 24 (1975) 343-358.
28. E.A. Newman, New roles for astrocytes: regulation of synaptic transmission, Trends Neurosci. 26 (2003) 536-542. (Pubitemid 37176908)
29. M.M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72 (1976) 248-254.
30. M. Villain, V. Cirimele, B. Ludes, P. Kintz, Ultra-rapid procedure to test for gamma-hydroxybutyric acid in blood and urine by gas chromatography-mass spectrometry, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 792 (2003) 83-87. (Pubitemid 36773804)
31. E.A. Struys, E.E. Jansen, K.M. Gibson, C. Jakobs, Determination of the GABA analogue succinic semialdehyde in urine and cerebrospinal fluid by dinitrophenylhydrazine derivatization and liquid chromatography-tandem mass spectrometry: application to SSADH deficiency, J. Inherit. Metab. Dis. 28 (2005) 913-920. (Pubitemid 43168927)
32. Y.G. Kim, S. Lee, O.S. Kwon, S.Y. Park, S.J. Lee, B.J. Park, K.J. Kim, Redox-switch modulation of human SSADH by dynamic catalytic loop, EMBO J. 28 (2009) 959-968.