Nuclear factor κ-Light chain-enhancer of activated b cells is activated by radiotherapy and is prognostic for overall survival in patients with rectal cancer treated with preoperative fluorouracil-based chemoradiotheraphy

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 3, 2011, Pages 705-711

  O'Neil, Bert H ^a   Funkhouser, William K ^a   Calvo, Benjamin F ^a   Meyers, Michael O ^a   Kim, Hong Jin ^a   Goldberg, Richard M ^a   Bernard, Stephen A ^a   Caskey, Laura ^c   Deal, Allison M ^b   Wright, Fred ^b   Baldwin, Albert S ^c   Tepper, Joel E ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Bcl 2; Chemoradiotherapy; cIAP 2; inducible resistance genes; interleukin 8; NF B; prognostic markers; rectal cancer; TRAF1

Indexed keywords

BCL-2; CHEMORADIOTHERAPY; CIAP-2; INDUCIBLE RESISTANCE GENES; INTERLEUKIN-8; PROGNOSTIC MARKERS; RECTAL CANCER; TRAF1;

BIOPSY; CELL DEATH; GENES; PATHOLOGY; POLYMERASE CHAIN REACTION; RADIOTHERAPY; TRANSCRIPTION; TRANSCRIPTION FACTORS; TUMORS;

DISEASES;

FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 2; INTERLEUKIN 8; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; RECTUM CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR BIOPSY; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; FEMALE; GENES, BCL-2; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTERLEUKIN-8; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NF-KAPPA B; PROGNOSIS; PROSPECTIVE STUDIES; RADIATION TOLERANCE; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; TNF RECEPTOR-ASSOCIATED FACTOR 1; TREATMENT OUTCOME;

EID: 79957556270     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.02.063     Document Type: Article

References (24)

1. American Cancer Society Cancer facts & figures 2008 American Cancer Society New York
2. E. Kapiteijn, E.K. Kranenbarg, W.H. Steup Dutch ColoRectal Cancer Group Total mesorectal excision (TME) with or without preoperative radiotherapy in the treatment of primary rectal cancer: Prospective randomised trial with standard operative and histopathological techniques Eur J Surg 165 1999 410 420 (Pubitemid 29377119)
3. C.H. Crane, J.M. Skibber, and E.H. Birnbaum The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer Int J Radiat Oncol Biol Phys 57 2003 84 89 (Pubitemid 36959742)
4. R. Sauer, H. Becker, and W. Hohenberger Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 2004 1731 1740
5. K.Y. Jen, and V.G. Cheung Transcriptional response of lymphoblastoid cells to ionizing radiation Genome Res 13 2003 2092 2100 (Pubitemid 37161766)
6. S.S. Liu, A.N. Cheung, and H.Y. Ngan Differential gene expression in cervical cancer cell lines before and after ionizing radiation Int J Oncol 22 2003 1091 1099
7. W.Y. Park, C.I. Hwang, and C.N. Im Identification of radiation-specific responses from gene expression profile Oncogene 21 2002 8521 8528
8. A.S. Baldwin Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB J Clin Invest 107 2001 241 246 (Pubitemid 32157954)
9. J.C. Cusack Jr., R. Liu, and M. Houston Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition Cancer Res 61 2001 3535 3540 (Pubitemid 32694955)
10. C.Y. Wang, D.C. Guttridge, and M.W. Mayo NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis Mol Cell Biol 19 1999 5923 5929 (Pubitemid 29399297)
11. L. Vallat, H. Magdelenat, and H. Merle-Beral The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays Blood 101 2003 4598 4606 (Pubitemid 36857833)
12. Z. Li, and J.J. Li Effector genes altered in mcf-7 human breast cancer cells after exposure to fractionated ionizing radiation Radiat Res 155 2001 543 553 (Pubitemid 32260252)
13. C. Didelot, M. Barberi-Heyob, and A. Bianchi Constitutive NF-kappaB activity influences basal apoptosis and radiosensitivity of head-and-neck carcinoma cell lines Int J Radiat Oncol Biol Phys 51 2001 1354 1360 (Pubitemid 33116331)
14. S.M. Russo, J.E. Tepper, and A.S. Baldwin Jr. Enhancement of radiosensitivity by proteasome inhibition: Implications for a role of NF-kappaB Int J Radiat Oncol Biol Phys 50 2001 183 193
15. P.C. Cogswell, D.C. Guttridge, and W.K. Funkhouser Selective activation of NF-kappa B subunits in human breast cancer: Potential roles for NF-kappa B2/p52 and for Bcl-3 Oncogene 19 2000 1123 1131 (Pubitemid 30157541)
16. H. Nakayama, T. Ikebe, and M. Beppu High expression levels of nuclear factor kappaB, IkappaB kinase alpha and Akt kinase in squamous cell carcinoma of the oral cavity Cancer 92 2001 3037 3044 (Pubitemid 33136198)
17. W. Wang, J.L. Abbruzzese, and D.B. Evans The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells Clin Cancer Res 5 1999 119 127 (Pubitemid 29045184)
18. S. Evertsson, and X.F. Sun Protein expression of NF-kappaB in human colorectal adenocarcinoma Int J Mol Med 10 2002 547 550
19. B.H. O'Neil, P. Buzkova, and H. Farrah Expression of nuclear factor-kappaB family proteins in hepatocellular carcinomas Oncology 72 2007 97 104 (Pubitemid 350249136)
20. S.A. Amundson, K.T. Do, and L.C. Vinikoor Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen Cancer Res 68 2008 415 424 (Pubitemid 351380067)
21. S.A. Amundson, R.A. Lee, and C.A. Koch-Paiz Differential responses of stress genes to low dose-rate gamma irradiation Mol Cancer Res 1 2003 445 452 (Pubitemid 36459255)
22. A.J. Fornace Jr., S.A. Amundson, and M. Bittner The complexity of radiation stress responses: Analysis by informatics and functional genomics approaches Gene Expr 7 1999 387 400 (Pubitemid 29372082)
23. A. Debucquoy, K. Haustermans, and A. Daemen Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiotherapy in rectal cancer J Clin Oncol 27 2009 2751 2757
24. M. Scartozzi, I. Bearzi, and C. Pierantoni Nuclear factor-κB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy J Clin Oncol 25 2007 3930 3935 (Pubitemid 47477270)