-
1
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward J, (2003) Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3: 11-22.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
3
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, et al. (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
-
4
-
-
0037805547
-
RAS oncogenes: the first 30 years
-
Malumbres M, Barbacid M, (2003) RAS oncogenes: the first 30 years. Nat Rev Cancer 3: 459-465.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 459-465
-
-
Malumbres, M.1
Barbacid, M.2
-
5
-
-
55849105589
-
Quantitative phosphoproteomics--an emerging key technology in signal-transduction research
-
Schreiber TB, Mausbacher N, Breitkopf SB, Grundner-Culemann K, Daub H, (2008) Quantitative phosphoproteomics--an emerging key technology in signal-transduction research. Proteomics 8: 4416-4432.
-
(2008)
Proteomics
, vol.8
, pp. 4416-4432
-
-
Schreiber, T.B.1
Mausbacher, N.2
Breitkopf, S.B.3
Grundner-Culemann, K.4
Daub, H.5
-
6
-
-
52949123622
-
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS
-
Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, et al. (2008) Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proc Natl Acad Sci U S A 105: 14112-14117.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 14112-14117
-
-
Guha, U.1
Chaerkady, R.2
Marimuthu, A.3
Patterson, A.S.4
Kashyap, M.K.5
-
7
-
-
33845329203
-
Functional and quantitative proteomics using SILAC
-
Mann M, (2006) Functional and quantitative proteomics using SILAC. Nat Rev Mol Cell Biol 7: 952-958.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 952-958
-
-
Mann, M.1
-
8
-
-
34848822499
-
Quantitative profile of five murine core proteomes using label-free functional proteomics
-
Cutillas PR, Vanhaesebroeck B, (2007) Quantitative profile of five murine core proteomes using label-free functional proteomics. Mol Cell Proteomics 6: 1560-1573.
-
(2007)
Mol Cell Proteomics
, vol.6
, pp. 1560-1573
-
-
Cutillas, P.R.1
Vanhaesebroeck, B.2
-
9
-
-
10844284696
-
Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
-
Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, et al. (2004) Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res 64: 9027-9034.
-
(2004)
Cancer Res
, vol.64
, pp. 9027-9034
-
-
Ramirez, R.D.1
Sheridan, S.2
Girard, L.3
Sato, M.4
Kim, Y.5
-
10
-
-
33644507072
-
Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
-
Sato M, Vaughan MB, Girard L, Peyton M, Lee W, et al. (2006) Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 66: 2116-2128.
-
(2006)
Cancer Res
, vol.66
, pp. 2116-2128
-
-
Sato, M.1
Vaughan, M.B.2
Girard, L.3
Peyton, M.4
Lee, W.5
-
11
-
-
51349126833
-
CD44 engagement promotes matrix-derived survival through the CD44-SRC-integrin axis in lipid rafts
-
Lee JL, Wang MJ, Sudhir PR, Chen JY, (2008) CD44 engagement promotes matrix-derived survival through the CD44-SRC-integrin axis in lipid rafts. Molecular and Cellular Biology 28: 5710-5723.
-
(2008)
Molecular and Cellular Biology
, vol.28
, pp. 5710-5723
-
-
Lee, J.L.1
Wang, M.J.2
Sudhir, P.R.3
Chen, J.Y.4
-
12
-
-
29244464778
-
Tube-gel digestion: a novel proteomic approach for high throughput analysis of membrane proteins
-
Lu X, Zhu H, (2005) Tube-gel digestion: a novel proteomic approach for high throughput analysis of membrane proteins. Mol Cell Proteomics 4: 1948-1958.
-
(2005)
Mol Cell Proteomics
, vol.4
, pp. 1948-1958
-
-
Lu, X.1
Zhu, H.2
-
13
-
-
55249116044
-
Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics
-
Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, et al. (2008) Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics. J Proteome Res 7: 4058-4069.
-
(2008)
J Proteome Res
, vol.7
, pp. 4058-4069
-
-
Tsai, C.F.1
Wang, Y.T.2
Chen, Y.R.3
Lai, C.Y.4
Lin, P.Y.5
-
14
-
-
76649139789
-
IDEAL-Q, an automated tool for label-free quantitation analysis using an efficient peptide alignment approach and spectral data validation
-
Tsou CC, Tsai CF, Tsui YH, Sudhir PR, Wang YT, et al. (2010) IDEAL-Q, an automated tool for label-free quantitation analysis using an efficient peptide alignment approach and spectral data validation. Mol Cell Proteomics 9: 131-144.
-
(2010)
Mol Cell Proteomics
, vol.9
, pp. 131-144
-
-
Tsou, C.C.1
Tsai, C.F.2
Tsui, Y.H.3
Sudhir, P.R.4
Wang, Y.T.5
-
15
-
-
57149092133
-
Inferring pathway activity toward precise disease classification
-
Lee E, Chuang HY, Kim JW, Ideker T, Lee D, (2008) Inferring pathway activity toward precise disease classification. PLoS Comput Biol 4: e1000217.
-
(2008)
PLoS Comput Biol
, vol.4
-
-
Lee, E.1
Chuang, H.Y.2
Kim, J.W.3
Ideker, T.4
Lee, D.5
-
16
-
-
0029989103
-
An analysis of statistical term strength and its use in the indexing and retrieval of molecular biology texts
-
Wilbur WJ, Yang Y, (1996) An analysis of statistical term strength and its use in the indexing and retrieval of molecular biology texts. Computers in Biology and Medicine 26: 209-222.
-
(1996)
Computers in Biology and Medicine
, vol.26
, pp. 209-222
-
-
Wilbur, W.J.1
Yang, Y.2
-
18
-
-
70549087467
-
GAP: A graphical environment for matrix visualization and cluster analysis
-
Wu H, Tein Y, Chen C, (2009) GAP: A graphical environment for matrix visualization and cluster analysis. Computational Statistics & Data Analysis 54: 767-778.
-
(2009)
Computational Statistics & Data Analysis
, vol.54
, pp. 767-778
-
-
Wu, H.1
Tein, Y.2
Chen, C.3
-
19
-
-
27944499451
-
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets
-
Schwartz D, Gygi SP, (2005) An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets. Nature Biotechnology 23: 1391-1398.
-
(2005)
Nature Biotechnology
, vol.23
, pp. 1391-1398
-
-
Schwartz, D.1
Gygi, S.P.2
-
20
-
-
34250743173
-
Systematic discovery of in vivo phosphorylation networks
-
Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jorgensen C, et al. (2007) Systematic discovery of in vivo phosphorylation networks. Cell 129: 1415-1426.
-
(2007)
Cell
, vol.129
, pp. 1415-1426
-
-
Linding, R.1
Jensen, L.J.2
Ostheimer, G.J.3
van Vugt, M.A.4
Jorgensen, C.5
-
21
-
-
55749111058
-
Linear motif atlas for phosphorylation-dependent signaling
-
Miller ML, Jensen LJ, Diella F, Jorgensen C, Tinti M, et al. (2008) Linear motif atlas for phosphorylation-dependent signaling. Sci Signal 1: ra2.
-
(2008)
Sci Signal
, vol.1
-
-
Miller, M.L.1
Jensen, L.J.2
Diella, F.3
Jorgensen, C.4
Tinti, M.5
-
22
-
-
67849106825
-
Phosphorylation dynamics during early differentiation of human embryonic stem cells
-
Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, et al. (2009) Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 5: 214-226.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 214-226
-
-
Van Hoof, D.1
Munoz, J.2
Braam, S.R.3
Pinkse, M.W.4
Linding, R.5
-
23
-
-
0027959781
-
Identification of multiple, novel, protein kinase C-related gene products
-
Palmer RH, Ridden J, Parker PJ, (1994) Identification of multiple, novel, protein kinase C-related gene products. FEBS Letters 356: 5-8.
-
(1994)
FEBS Letters
, vol.356
, pp. 5-8
-
-
Palmer, R.H.1
Ridden, J.2
Parker, P.J.3
-
24
-
-
0034680838
-
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
-
Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, et al. (2000) Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. Journal of Biological Chemistry 275: 36108-36115.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 36108-36115
-
-
Obata, T.1
Yaffe, M.B.2
Leparc, G.G.3
Piro, E.T.4
Maegawa, H.5
-
25
-
-
54249115942
-
Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells
-
Castro-Rivera E, Ran S, Brekken RA, Minna JD, (2008) Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer Res 68: 8295-8303.
-
(2008)
Cancer Res
, vol.68
, pp. 8295-8303
-
-
Castro-Rivera, E.1
Ran, S.2
Brekken, R.A.3
Minna, J.D.4
-
26
-
-
70349795274
-
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
-
Kosako H, Yamaguchi N, Aranami C, Ushiyama M, Kose S, et al. (2009) Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport. Nat Struct Mol Biol 16: 1026-1035.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 1026-1035
-
-
Kosako, H.1
Yamaguchi, N.2
Aranami, C.3
Ushiyama, M.4
Kose, S.5
-
27
-
-
63649083462
-
Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma
-
Old WM, Shabb JB, Houel S, Wang H, Couts KL, et al. (2009) Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Molecular Cell 34: 115-131.
-
(2009)
Molecular Cell
, vol.34
, pp. 115-131
-
-
Old, W.M.1
Shabb, J.B.2
Houel, S.3
Wang, H.4
Couts, K.L.5
-
28
-
-
30944447568
-
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions
-
Yoon S, Seger R, (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24: 21-44.
-
(2006)
Growth Factors
, vol.24
, pp. 21-44
-
-
Yoon, S.1
Seger, R.2
-
29
-
-
65349107082
-
KRAS mutations in non-small cell lung cancer
-
Riely GJ, Marks J, Pao W, (2009) KRAS mutations in non-small cell lung cancer. Proc Am Thorac Soc 6: 201-205.
-
(2009)
Proc Am Thorac Soc
, vol.6
, pp. 201-205
-
-
Riely, G.J.1
Marks, J.2
Pao, W.3
-
30
-
-
42649125571
-
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
-
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, et al. (2008) Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nature Genetics 40: 600-608.
-
(2008)
Nature Genetics
, vol.40
, pp. 600-608
-
-
Haigis, K.M.1
Kendall, K.R.2
Wang, Y.3
Cheung, A.4
Haigis, M.C.5
-
31
-
-
0033546419
-
Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility
-
Voice JK, Klemke RL, Le A, Jackson JH, (1999) Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. Journal of Biological Chemistry 274: 17164-17170.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 17164-17170
-
-
Voice, J.K.1
Klemke, R.L.2
Le, A.3
Jackson, J.H.4
-
32
-
-
0031737627
-
Signal transduction as a drug-discovery platform
-
Persidis A, (1998) Signal transduction as a drug-discovery platform. Nature Biotechnology 16: 1082-1083.
-
(1998)
Nature Biotechnology
, vol.16
, pp. 1082-1083
-
-
Persidis, A.1
-
33
-
-
65249161129
-
Pathway-based biomarker search by high-throughput proteomics profiling of secretomes
-
Lawlor K, Nazarian A, Lacomis L, Tempst P, Villanueva J, (2009) Pathway-based biomarker search by high-throughput proteomics profiling of secretomes. J Proteome Res 8: 1489-1503.
-
(2009)
J Proteome Res
, vol.8
, pp. 1489-1503
-
-
Lawlor, K.1
Nazarian, A.2
Lacomis, L.3
Tempst, P.4
Villanueva, J.5
-
34
-
-
44049086689
-
Identification of dominant signaling pathways from proteomics expression data
-
Zubarev RA, Nielsen ML, Fung EM, Savitski MM, Kel-Margoulis O, et al. (2008) Identification of dominant signaling pathways from proteomics expression data. J Proteomics 71: 89-96.
-
(2008)
J Proteomics
, vol.71
, pp. 89-96
-
-
Zubarev, R.A.1
Nielsen, M.L.2
Fung, E.M.3
Savitski, M.M.4
Kel-Margoulis, O.5
|