Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

Cardiovascular Research

Volumn 90, Issue 3, 2011, Pages 538-545

  Zhang, Chi ^a,b   Feng, Yansheng ^a   Qu, Shunlin ^a,b   Wei, Xing ^a,b   Zhu, Honglin ^a   Luo, Qi ^a   Liu, Meidong ^a   Chen, Guangwen ^a   Xiao, Xianzhong ^a  

^a Central South University   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Apoptosis; Doxorubicin; p53; Resveratrol; SIRT1

Indexed keywords

CARBONYL DERIVATIVE; CYTOCHROME C; DOXORUBICIN; LACTATE DEHYDROGENASE; MALONALDEHYDE; PROTEIN BAX; PROTEIN P53; RESVERATROL; SIRTUIN 1; SODIUM CHLORIDE;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DEACETYLATION; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; HEART FUNCTION; HEART MUSCLE CELL; HEART WEIGHT; IMMUNOPRECIPITATION; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; UPREGULATION; WESTERN BLOTTING;

ACETYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BODY WEIGHT; CYTOCHROMES C; DOXORUBICIN; GENE EXPRESSION; MALE; MICE; MICE, INBRED BALB C; MYOCARDIUM; MYOCYTES, CARDIAC; ORGAN SIZE; OXIDATIVE STRESS; SIRTUIN 1; STILBENES; TUMOR SUPPRESSOR PROTEIN P53; VENTRICULAR DYSFUNCTION, LEFT;

EID: 79957532361     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr022     Document Type: Article

References (27)

1. Chua CC, Liu X, Gao J, Hamdy RC, Chua BH. Multiple actions of pifithrin-a on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells. Am J Physiol Heart Circ Physiol 2006;290:H2606-H2613. (Pubitemid 43846092)
2. Nakamura T, Ueda Y, Juan Y, Katsuda S, Takahashi H, Koh E. Fas-mediated apoptosis in adriamycin-induced cardiomyopathy in rats: In vivo study. Circulation 2000;102:572-578. (Pubitemid 30639976)
3. Das DK, Maulik N. Resveratrol in cardioprotection: A therapeutic promise of alternative medicine. Mol Interv 2006;6:36-47. (Pubitemid 43327521)
4. Mukherjee S, Lekli I, Gurusamy N, Bertelli AA, Das DK. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med 2009;46:573-578.
5. Danz EDB, Skramsted J, Henry N, Bennett JA, Keller RS. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med 2009;46:1589-1597.
6. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425:191-196. (Pubitemid 37150899)
7. Liu L, Zhang X, Qian B, Min X, Gao X, Li C et al. Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice. Eur J Heart Fail 2007;9:762-769. (Pubitemid 47214666)
8. Elberry AA, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM et al. Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats. Food Chem Toxicol 2010;48:1178-1184.
9. Kawamura N, Kubota T, Kawano S, Monden Y, Feldman AM, Tsutsui H et al. Blockade of NF-kB improves cardiac function and survival without affecting inflammation in TNF-a-induced cardiomyopathy. Cardiovasc Res 2005;66:520-529. (Pubitemid 40725764)
10. Ivanov GS, Ivanova T, Kurash J, Ivanov A, Chuikov S, Gizatullin F et al. Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol 2007;27:6756-6769. (Pubitemid 47483627)
11. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov 2006;5:493-506. (Pubitemid 44136961)
12. Kumar D, Kirshenbaum LA, Li T, Danelisen I, Singal PK. Apoptosis in adriamycin cardiomyopathy and its modulation by probucol. Antioxid Redox Signal 2001;3:135-145. (Pubitemid 32240636)
13. Ueno M, Kakinuma Y, Yuhki K, Murakoshi N, Iemitsu M, Miyauchi T et al. Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo. J Pharmacol Sci 2006;101:151-158. (Pubitemid 43938766)
14. Li K, Sung RY, Huang WZ, Yang M, Pong NH, Lee SM et al. Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin. Circulation 2006; 113:2211-2220.
15. Nozaki N, Shishido T, Takeishi Y, Kubota I. Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice. Circulation 2004;110: 2869-2874. (Pubitemid 39473611)
16. Chen CJ, YuW, Fu YC,Wang X, Li JL,WangW. Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway. Biochem Biophys Res Commun 2009;378:389-393.
17. Lekli I, Szabo G, Juhasz B, Das S, Das M, Varga E et al. Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: The role of GLUT-4 and endothelin. Am J Physiol Heart Circ Physiol 2008;294:H859-H866. (Pubitemid 351253297)
18. El-Mowafy AM, White RE. Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: Reversal of endothelin-1 stimulatory effects. FEBS Lett 1999;451:63-67. (Pubitemid 29236173)
19. Hall SS. Longevity research. In vino vitalis? Compounds activate life-extending genes. Science 2003;301:1165. (Pubitemid 37052181)
20. Yamamoto H, Schoonjans K, Auwerx J. Sirtuin functions in health and disease. Mol Endocrinol 2007;21:1745-1755. (Pubitemid 47173788)
21. Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A et al. Negative control of p53 by Sir2a promotes cell survival under stress. Cell 2001;107:137-148. (Pubitemid 33035941)
22. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001;107:149-159. (Pubitemid 33035942)
23. Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001;268:2764-2772. (Pubitemid 32862957)
24. Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation. Curr Opin Cell Biol 2003;15:164-171. (Pubitemid 36332191)
25. Liu X, Chua CC, Gao J, Chen Z, Landy CL, Hamdy R et al. Pifithrin-a protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. Am J Physiol Heart Circ Physiol 2004;286:H933-H939. (Pubitemid 38248606)
26. Nithipongvanitch R, Ittarat W, Cole MP, Tangpong J, Clair DK, Oberley TD. Mitochondrial and nuclear p53 localization in cardiomyocytes: Redox modulation by doxorubicin (Adriamycin)? Antioxid Redox Signal 2007;9:1001-1008. (Pubitemid 46919601)
27. Erster S, Moll UM. Stress-induced p53 runs a transcription-independent death program. Biochem Biophys Res Commun 2005;331:843-850. (Pubitemid 40615515)