Design, synthesis and molecular docking studies of novel triazole as antifungal agent

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 3167-3176

  Chai, Xiaoyun ^a   Zhang, Jun ^a   Cao, Yongbing ^a   Zou, Yan ^a   Wu, Qiuye ^a   Zhang, Dazhi ^a   Jiang, Yuanying ^a   Sun, Qingyan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal agents; Molecular docking; Synthesis; Triazole

Indexed keywords

1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [(TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL] PROPAN 2 OL; ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 2,4 DICHLOROBENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 3 (2 CHLOROPHENYL)ACRYLAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 3 (2 FLUOROPHENYL)ACRYLAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 3 (3 FLUOROPHENYL)ACRYLAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 3 (4 FLUOROPHENYL)ACRYLAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 4 (TRIFLUOROMETHOXY)BENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 4 CHLOROBENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 4 ETHYLBENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 4 FLUOROBENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 4 ISOPROPYLBENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 4 METHOXYBENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL] 4 METHYLBENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]ACETAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]BENZAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]BUTYRAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]CINNAMAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]HEPTANAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]HEXANAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]ISOBUTYRAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]OCTANAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]PENTANAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]PIVALAMIDE; N [4 [4 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 3 [1H 1,2,4 TRIAZOL 1 YL]PROPYL]PIPERAZIN 1 YL] 3 [TRIFLUOROMETHYL]PHENYL]PROPIONAMIDE; TRIAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORICONAZOLE; CYTOCHROME P450 INHIBITOR; FUNGAL PROTEIN; PIPERAZINE DERIVATIVE; PROPANOL; STEROL 14ALPHA DEMETHYLASE; TRIAZOLE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CRYPTOCOCCUS NEOFORMANS; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; FONSECAEA; FONSECAEA COMPACTA; MICROSPORUM GYPSEUM INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; TRICHOPHYTON RUBRUM; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

ANTIFUNGAL AGENTS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CATALYTIC DOMAIN; CRYPTOCOCCUS NEOFORMANS; CYTOCHROME P-450 ENZYME INHIBITORS; DRUG DESIGN; FLUCONAZOLE; FUNGAL PROTEINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PIPERAZINES; PROPANOLS; STEROL 14-DEMETHYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; VORICONAZOLE;

EID: 79957515466     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.022     Document Type: Article

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