The paf gene product modulates asexual development in Penicillium chrysogenum

Journal of Basic Microbiology

Volumn 51, Issue 3, 2011, Pages 253-262

  Hegedüs, Nikoletta ^a,c   Sigl, Claudia ^b   Zadra, Ivo ^b   Pócsi, Istvan ^c   Marx, Florentine ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Antifungal protein PAF; Asexual development; Conidiation; Penicillium chrysogenum

Indexed keywords

FUNGAL PROTEIN; PAF PROTEIN, PENICILLIUM CHRYSOGENUM;

ARTICLE; FUNGUS SPORE; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PENICILLIUM CHRYSOGENUM;

FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; PENICILLIUM CHRYSOGENUM; RECOMBINATION, GENETIC; SPORES, FUNGAL;

EMERICELLA NIDULANS; FUNGI; PENICILLIUM CHRYSOGENUM;

EID: 79957503827     PISSN: 0233111X     EISSN: 15214028     Source Type: Journal    
DOI: 10.1002/jobm.201000321     Document Type: Article

References (54)

1. Adams, T., Wieser, J., Yu, J., 1998. Asexual sporulation in Aspergillus nidulans. Microbiol. Mol. Biol. Rev., 62, 35-54.
2. Aerts, A., François, I., Cammue, B., Thevissen, K., 2008. The mode of antifungal action of plant, insect and human defensins. Cell. Mol. Life Sci., 65, 2069-2079.
3. Alex, L., Borkovich, K., Simon, M., 1996. Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase. Proc. Natl. Acad. Sci. USA, 93, 3416-3421.
4. Baker, B., Zambryski, P., Staskawicz, B., Dinesh-Kumar, S., 1997. Signaling in plant-microbe interactions. Science., 276, 726-733.
5. Barna, B., Leiter, E., Hegedus, N., Bíró, T., Pócsi, I., 2008. Effect of the Penicillium chrysogenum antifungal protein (PAF) on barley powdery mildew and wheat leaf rust pathogens. J. Basic Microbiol., 48, 516-520.
6. Batta, G., Barna, T., Gáspári, Z., Sándor, S. et al., 2009. Functional aspects of the solution structure and dynamics of PAF a highly-stable antifungal protein from Penicillium chrysogenum. FEBS. J., 276, 2875-2890.
7. Berrocal-Lobo, M., Segura, A., Moreno, M., López, G., García-Olmedo, F., Molina, A., 2002. Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection. Plant Physiol., 128, 951-961.
8. Cantoral, J.M., Diez, B., Barredo, J.L., Alvarez, E., Martin, J.E., 1987. High frequency transformation of Penicillium chrysogenum. Biotechnol., 5, 494-497.
9. Champe, S., el-Zayat, A., 1989. Isolation of a sexual sporulation hormone from Aspergillus nidulans. J. Bacteriol., 171, 3982-3988.
10. Chang, Y., Timberlake, W., 1993. Identification of Aspergillus brlA response elements (BREs) by genetic selection in yeast. Genetics, 133, 29-38.
11. Chiang, C., Hadwiger, L., 1991. The Fusarium solani -induced expression of a pea gene family encoding high cysteine content proteins. Mol. Plant Microbe Interact., 4, 324-331.
12. Fritig, B., Heitz, T., Legrand, M. 1998. Antimicrobial proteins in induced plant defense. Curr. Opin. Immunol., 10, 16-22.
13. Galgóczy, L., Papp, T., Pócsi, I., Hegedus, N., Vágvölgyi, C., 2008. In vitro activity of Penicillium chrysogenum antifungal protein (PAF) and its combination with fluconazole against different dermatophytes. Anton. Leeuw. Int. J. G., 94, 463-470.
14. Hadley, G., Harrold, C.E., 1958. The sporulation of Penicillium notatum Westling in submerged liquid culture. I. The effect of calcium and nutrients on sporulation. J. Exp. Bot., 9, 408-417.
15. Hoff, B., Kamerewerd, J., Sigl, C., Mitterbauer, R., Zadra, I., Kürnsteiner, H., Kück, U., 2010. Two components of a velvet -like complex control hyphal morphogenesis, conidiophore development and penicillin biosynthesis in Penicillium chrysogenum. Eukaryot. Cell, 9, 1236-1250.
16. Hoff, B., Kamerewerd, J., Sigl, C., Zadra, I., Kück, U., 2009. Homologous recombination in the antibiotic producer Penicillium chrysogenum: strain DeltaPcku70 shows up-regulation of genes from the HOG pathway. Appl. Microbiol. Biotechnol., 210, 1081-1094.
17. Kaiserer, L., Oberparleiter, C., Weiler-Görz, R., Burgstaller, W., Leiter, E., Marx, F., 2003. Characterization of the Penicillium chrysogenum antifungal protein PAF. Arch. Microbiol., 180, 204-210.
18. Kolar, M., Punt, P., van den Hondel, C., Schwab, H., 1988. Transformation of Penicillium chrysogenum using dominant selection markers and expression of an Escherichia coli lacZ fusion gene. Gene, 62, 127-134.
19. Kück, U., Hoff, B., 2006. Application of the nourseothricin acetyltransferase gene (nat1) as dominant marker for the transformation of filamentous fungi. Fungal Genet. Newsl., 53, 9-11.
20. Lee, B., Adams, T., 1994. The Aspergillus nidulans fluG gene is required for production of an extracellular developmental signal and is related to prokaryotic glutamine synthetase I. Genes. Dev., 8, 641-651.
21. Lehrer, R., Ganz, T., 1999. Antimicrobial peptides in mammalian and insect host defence. Curr. Opin. Immunol., 11, 23-27.
22. Leiter, E., Szappanos, H., Oberparleiter, C., Kaiserer, L. et al., 2005. Antifungal protein PAF severely affects the integrity of the plasma membrane of Aspergillus nidulans and induces an apoptosis-like phenotype. Antimicrob. Agents. Chemother., 49, 2445-2453.
23. Marx, F., 2004. Small, basic antifungal proteins secreted from filamentous ascomycetes: a comparative study regarding expression, structure, function and potential application. Appl. Microbiol. Biotechnol., 65, 133-142.
24. Marx, F., Binder, U., Leiter, E., Pócsi, I., 2008. The Penicillium chrysogenum antifungal protein PAF, a promising tool for the development of new antifungal therapies and fungal cell biology studies. Cell. Mol. Life. Sci., 65, 445-454.
25. Meyer, V., 2008. A small protein that fights fungi: AFP as a new promising antifungal agent of biotechnological value. Appl. Microbiol. Biotechnol., 78, 17-28.
26. Meyer, V., Spielvogel, A., Funk, L., Tilburn, J., Arst, H.J., Stahl, U., 2005. Alkaline pH-induced up-regulation of the afp gene encoding the antifungal protein (AFP) of Aspergillus giganteus is not mediated by the transcription factor PacC: possible involvement of calcineurin. Mol. Genet. Genomics, 274, 295-306.
27. Meyer, V., Stahl, U., 2003. The influence of co-cultivation on expression of the antifungal protein in Aspergillus giganteus. J. Basic Microbiol., 43, 68-74.
28. Meyer, V., Wedde, M., Stahl, U., 2002. Transcriptional regulation of the antifungal protein in Aspergillus giganteus. Mol. Genet. Genomics, 266, 747-757.
29. Mirabito, P., Adams, T., Timberlake, W., 1989. Interactions of three sequentially expressed genes control temporal and spatial specificity in Aspergillus development. Cell, 57, 859-868.
30. Mooney, J., Yager, L., 1990. Light is required for conidiation in Aspergillus nidulans. Genes Dev., 4, 1473-1482.
31. Morton, A.G., 1961. The induction of sporulation in mould fungi. Proc. R. Microscop. Soc. B., 153, 548-569.
32. Nielsen, M., Albertsen, L., Lettier, G., Nielsen, J., Mortensen, U., 2006. Efficient PCR-based gene targeting with a recyclable marker for Aspergillus nidulans. Fungal Genet. Biol., 43, 54-64.
33. Paris, S., Debeaupuis, J., Crameri, R., Carey, M. et al., 2003. Conidial hydrophobins of Aspergillus fumigatus. Appl. Environ. Microbiol., 69, 1581-1588.
34. Parta, M., Chang, Y., Rulong, S., Pinto-DaSilva, P., Kwon-Chung, K., 1994. HYP1, a hydrophobin gene from Aspergillus fumigatus, complements the rodletless phenotype in Aspergillus nidulans. Infect. Immun., 62, 4389-4395.
35. Penninckx, I., Eggermont, K., Terras, F., Thomma, B. et al., 1996. Pathogen-induced systemic activation of a plant defensin gene in Arabidopsis follows a salicylic acid-independent pathway. Plant. Cell, 8, 2309-2323.
36. Prost, I., Dhondt, S., Rothe, G., Vicente, J. et al., 2005. Evaluation of the antimicrobial activities of plant oxylipins supports their involvement in defense against pathogens. Plant. Physiol., 139, 1902-1913.
37. Rohlfs, M., Albert, M., Keller, N., Kempken, F., 2007. Secondary chemicals protect mould from fungivory. Biol. Lett., 3, 523-525.
38. Roncal, T., Cordobés, S., Sterner, O., Ugalde, U., 2002. Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene. Eukaryot. Cell, 1, 823-829.
39. Roncal, T., Ugalde, U., 2003. Conidiation induction in Penicillium. Res. Microbiol., 154, 539-546.
40. Sigl, C., Haas, H., Specht, T., Pfaller, K., Kürnsteiner, H., Zadra, I., 2010. Among development regulators StuA but not BrlA is essential for Penicillin V production in Penicillium chrysogenum. Appl. Environ. Microbiol., doi:10.1128/AEM.01557-10.
41. Skromne, I., Sánchez, O., Aguirre, J., 1995. Starvation stress modulates the expression of the Aspergillus nidulans brlA regulatory gene. Microbiology, 141, (Pt 1) 21-28.
42. Springer, M., 1993. Genetic control of fungal differentiation: the three sporulation pathways of Neurospora crassa. Bioessays, 15, 365-374.
43. Stringer, M., Dean, R., Sewall, T., Timberlake, W., 1991. Rodletless, a new Aspergillus developmental mutant induced by directed gene inactivation. Genes. Dev., 5, 1161-1171.
44. Swift, S., Throup, J.P., Williams, P., Salmond, G.P., Stewart, G.S., 1996. Quorum sensing: a population-density component in the determination of bacterial phenotype. Trends. Biochem. Sci., 21, 214-219.
45. Thevissen, K., Ferket, K., François, I., Cammue, B., 2003. Interactions of antifungal plant defensins with fungal membrane components. Peptides, 24, 1705-1712.
46. Thomma, B., Cammue, B., Thevissen, K., 2002. Plant defensins. Planta, 216, 193-202.
47. Tilburn, J., Sarkar, S., Widdick, D., Espeso, E., Orejas, M., Mungroo, J., Peñalva, M., Arst, H.J., 1995. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J., 14, 779-790.
48. Tsitsigiannis, D., Kowieski, T., Zarnowski, R., Keller, N., 2004. Endogenous lipogenic regulators of spore balance in Aspergillus nidulans. Eukaryot. Cell, 3, 1398-1411.
49. Tsitsigiannis, D.I., Keller, N.P., 2007. Oxylipins as developmental and host-fungal communication signals. Trends Microbiol., 15, 109-118.
50. Twumasi-Boateng, K., Yu, Y., Chen, D., Gravelat, F., Nierman, W., Sheppard, D., 2009. Transcriptional profiling identifies a role for BrlA in the response to nitrogen depletion and for StuA in the regulation of secondary metabolite clusters in Aspergillus fumigatus. Eukaryot. Cell, 8, 104-115.
51. Ugalde, U., Pitt, D., 1983. Morphology and calcium-induced conidiation of Penicillium cyclopium in submerged culture. Trans. Br. Mycol. Soc., 80, 319-325.
52. Virginia, M., Appleyard, C., McPheat, W., Stark, M., 2000. A novel 'two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans. Curr. Genet., 37, 364-372.
53. Wnendt, S., Ulbrich, N., Stahl, U., 1994. Molecular cloning, sequence analysis and expression of the gene encoding an antifungal-protein from Aspergillus giganteus. Curr. Genet., 25, 519-523.
54. Wösten, H., de Vocht, M., 2000. Hydrophobins, the fungal coat unravelled. Biochim. Biophys. Acta, 1469, 79-86.