Helper-dependent adenovirus is superior to first-generation adenovirus for expressing transgenes in atherosclerosis-prone arteries

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 6, 2011, Pages 1317-1325

  Jiang, Bo ^a   Qian, Kun ^a   Du, Liang ^a   Luttrell, Ian ^b   Chitaley, Kanchan ^b   Dichek, David A ^a,c  

^a Division of Cardiology   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

atherosclerosis; carotid arteries; gene therapy; vasodilation

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; FIRST GENERATION ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; HELPER DEPENDENT ADENOVIRUS VECTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UROKINASE; VASCULAR CELL ADHESION MOLECULE 1;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA; ARTICLE; CAROTID ATHEROSCLEROSIS; CHOLESTEROL DIET; COMMON CAROTID ARTERY; CONTROLLED STUDY; DISEASE PREDISPOSITION; FIRST GENERATION ADENOVIRUS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HELPER DEPENDENT ADENOVIRUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID STORAGE; MALE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTECTION; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; ARTERIES; ATHEROSCLEROSIS; HELPER VIRUSES; INTERCELLULAR ADHESION MOLECULE-1; LIPID METABOLISM; MACROPHAGES; MALE; RABBITS; TRANSGENES; TUNICA INTIMA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 79957497629     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.225516     Document Type: Article

References (33)

1. Lindemann D, Schnittler H. Genetic manipulation of endothelial cells by viral vectors. Thromb Haemost. 2009;102:1135-1143.
2. Melo LG, Gnecchi M, Pachori AS, Kong D, Wang K, Liu X, Pratt RE, Dzau VJ. Endothelium-targeted gene and cell-based therapies for cardiovascular disease. Arterioscler Thromb Vasc Biol. 2004;24:1761-1774. (Pubitemid 39350290)
3. Yla-Herttuala S, Martin JF. Cardiovascular gene therapy. Lancet. 2000; 355:213-222. (Pubitemid 30068227)
4. Gaffney MM, Hynes SO, Barry F, O'Brien T. Cardiovascular gene therapy: current status and therapeutic potential. Br J Pharmacol. 2007; 152:175-188. (Pubitemid 47517600)
5. Newman KD, Dunn PF, Owens JW, Schulick AH, Virmani R, Sukhova G, Libby P, Dichek DA. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest. 1995;96:2955-2965.
6. Channon KM, Qian H, Youngblood SA, Olmez E, Shetty GA, Neplioueva V, Blazing MA, George SE. Acute host-mediated endothelial injury after adenoviral gene transfer in normal rabbit arteries: impact on transgene expression and endothelial function. Circ Res. 1998;82: 1253-1262. (Pubitemid 28294744)
7. Gruchala M, Bhardwaj S, Pajusola K, Roy H, Rissanen TT, Kokina I, Kholova I, Markkanen JE, Rutanen J, Heikura T, Alitalo K, Bueler H, Yla-Herttuala S. Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors. J Gene Med. 2004;6:545-554. (Pubitemid 40228070)
8. Baker AH. Development and use of gene transfer for treatment of cardiovascular disease. J Card Surg. 2002;17:543-548. (Pubitemid 36308371)
9. Parks RJ, Chen L, Anton M, Sankar U, Rudnicki MA, Graham FL. A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci USA. 1996;93:13565-13570. (Pubitemid 26424159)
10. Sandig V, Youil R, Bett AJ, Franlin LL, Oshima M, Maione D, Wang F, Metzker ML, Savino R, Caskey CT. Optimization of the helperdependent adenovirus system for production and potency in vivo. Proc Natl Acad Sci USA. 2000;97:1002-1007. (Pubitemid 30080802)
11. Suzuki M, Cela R, Clarke C, Bertin TK, Mourino S, Lee B. Large-scale production of high-quality helper-dependent adenoviral vectors using adherent cells in cell factories. Hum Gene Ther. 2010;21:120-126.
12. Palmer DJ, Ng P. Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther. 2005;16:1-16. (Pubitemid 40250327)
13. Oka K, Belalcazar LM, Dieker C, Nour EA, Nuno-Gonzalez P, Paul A, Cormier S, Shin JK, Finegold M, Chan L. Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helperdependent adenovirus vector. Gene Ther. 2007;14:191-202. (Pubitemid 46152622)
14. Brunetti-Pierri N, Stapleton GE, Law M, Breinholt J, Palmer DJ, Zuo Y, Grove NC, Finegold MJ, Rice K, Beaudet AL, Mullins CE, Ng P. Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates. Mol Ther. 2009;17:327-333.
15. Wen S, Graf S, Massey PG, Dichek DA. Improved vascular gene transfer with a helper-dependent adenoviral vector. Circulation. 2004;110: 1484-1491. (Pubitemid 39238028)
16. Feldman LJ, Steg PG, Zheng LP, Chen D, Kearney M, McGarr SE, Barry JJ, Dedieu JF, Perricaudet M, Isner JM. Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit. J Clin Invest. 1995;95:2662-2671.
17. Schneider DB, Vassalli G, Wen S, Driscoll RM, Sassani AB, DeYoung MB, Linnemann R, Virmani R, Dichek DA. Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol. 2000;20:298-308. (Pubitemid 30086084)
18. Falkenberg M, Tom C, DeYoung MB, Wen S, Linnemann R, Dichek DA. Increased expression of urokinase during atherosclerotic lesion development causes arterial constriction and lumen loss, and accelerates lesion growth. Proc Natl Acad Sci USA. 2002;99:10665-10670.
19. Vassalli G, Agah R, Qiao R, Aguilar C, Dichek DA. A mouse model of arterial gene transfer. Antigen-specific immunity is a minor determinant of the early loss of adenovirus-mediated transgene expression. Circ Res. 1999;85:e25-e32.
20. Flynn R, Buckler JM, Tang C, Kim F, Dichek D. Helper-dependent adenoviral vectors are superior in vitro to first-generation vectors for endothelial cell-targeted gene therapy. Mol Ther. 2010;18:2121-2129.
21. Chen L, Anton M, Graham FL. Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre. Somat Cell Mol Genet. 1996;22:477-488. (Pubitemid 27194364)
22. Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol. 1996;70: 7498-7509. (Pubitemid 26339054)
23. Cybulsky MI, Gimbrone MA Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991;251: 788-791.
24. Cozen AE, Moriwaki H, Kremen M, DeYoung MB, Dichek HL, Slezicki KI, Young SG, Veniant M, Dichek DA. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation. 2004;109:2129-2135. (Pubitemid 38620223)
25. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3:1101-1108. (Pubitemid 351818697)
26. Luttrell IP, Swee M, Starcher B, Parks WC, Chitaley K. Erectile dysfunction in the type II diabetic db/db mouse: impaired venoocclusion with altered cavernosal vasoreactivity and matrix. Am J Physiol Heart Circ Physiol. 2008;294:H2204-H2211.
27. Du L, Dronadula N, Tanaka S, Dichek DA. A helper-dependent adenoviral vector achieves prolonged, stable expression of IL-10 in rabbit carotid arteries but does not limit early atherogenesis. Hum Gen Ther. 2011 [Epub ahead of print].
28. Ooboshi H, Rios CD, Chu Y, Christenson SD, Faraci FM, Davidson BL, Heistad DD. Augmented adenovirus-mediated gene transfer to atherosclerotic vessels. Arterioscler Thromb Vasc Biol. 1997;17:1786-1792. (Pubitemid 27424002)
29. Dronadula N, Du L, Flynn R, Buckler J, Kho J, Jiang Z, Tanaka S, Dichek DA. Construction of a novel expression cassette for increasing transgene expression in vivo in endothelial cells of large blood vessels. Gene Ther. 2011 [Epub ahead of print].
30. Yang Y, Li Q, Ertl HCJ, Wilson JM. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol. 1995;69:2004-2015.
31. Lafont A, Loirand G, Pacaud P, Vilde F, Lemarchand P, Escande D. Vasomotor dysfunction early after exposure of normal rabbit arteries to an adenoviral vector. Hum Gene Ther. 1997;8:1033-1040. (Pubitemid 27308201)
32. Qian HS, Channon K, Neplioueva V, Wang Q, Finer M, Tsui L, George SE, McArthur J. Improved adenoviral vector for vascular gene therapy: beneficial effects on vascular function and inflammation. Circ Res. 2001; 88:911-917. (Pubitemid 32441469)
33. Sato J-I, Mohacsi T, Noel A, Jost C, Gloviczki P, Mozes G, Katusic ZS, O'Brien T. In vivo gene transfer of endothelial nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits enhances endotheliumdependent relaxations. Stroke. 2000;31:968-975. (Pubitemid 30198447)