SCOPUS 정보 검색 플랫폼

Volumn 19, Issue 11, 2011, Pages 3394-3401

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1

(7) Greiner, Christine a Zettl, Heiko b Koeberle, Andreas a Pergola, Carlo c Northoff, Hinnak d Schubert Zsilavecz, Manfred b Werz, Oliver c

a UNIVERSITY OF TÜBINGEN (Germany)

b GOETHE UNIVERSITY (Germany)

c FRIEDRICH SCHILLER UNIVERSITY JENA (Germany)

d UNIVERSITY HOSPITAL TÜBINGEN (Germany)

Author keywords

5 Lipoxygenase; Inflammation; Leukotriene; Neutrophils; Prostaglandin

Indexed keywords

2 MERCAPTOHEXANOIC ACID DERIVATIVE; 2[4 (3 BIPHENYLOXYPROPOXY)PHENYLTHIO]HEXANOIC ACID; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 5 LIPOXYGENASE; BWA 4C; CALCIMYCIN; ENZYME INHIBITOR; MICROSOMAL PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN E2 DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; OXYGENATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ARACHIDONATE 5-LIPOXYGENASE; CELL LINE, TUMOR; HEXANOIC ACIDS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOXYGENASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957492550 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.04.034 Document Type: Article

Times cited : (19)

References (39)

1
- 0035976575
- C.D. Funk Science 294 2001 1871
- (2001) Science , vol.294 , pp. 1871
- Funk, C.D.¹

2
- 0024558198
- W.L. Smith Biochem. J. 259 1989 315
- (1989) Biochem. J. , vol.259 , pp. 315
- Smith, W.L.¹

3
- 34748817976
- B. Samuelsson, R. Morgenstern, and P.J. Jakobsson Pharmacol. Rev. 59 2007 207
- (2007) Pharmacol. Rev. , vol.59 , pp. 207
- Samuelsson, B.¹ Morgenstern, R.² Jakobsson, P.J.³

4
- 34547598278
- K.D. Rainsford Subcell. Biochem. 42 2007 3
- (2007) Subcell. Biochem. , vol.42 , pp. 3
- Rainsford, K.D.¹

5
- 0025078185
- J.L. Wallace, C.M. Keenan, and D.N. Granger Am. J. Physiol. 259 1990 G462
- (1990) Am. J. Physiol. , vol.259 , pp. 462
- Wallace, J.L.¹ Keenan, C.M.² Granger, D.N.³

6
- 0035584272
- S. Fiorucci, R. Meli, M. Bucci, and G. Cirino Biochem. Pharmacol. 62 2001 1433
- (2001) Biochem. Pharmacol. , vol.62 , pp. 1433
- Fiorucci, S.¹ Meli, R.² Bucci, M.³ Cirino, G.⁴

7
- 47749092391
- R.W. Friesen, and J.A. Mancini J. Med. Chem. 51 2008 4059
- (2008) J. Med. Chem. , vol.51 , pp. 4059
- Friesen, R.W.¹ Mancini, J.A.²

8
- 20644467057
- D. Riendeau, R. Aspiotis, D. Ethier, Y. Gareau, E.L. Grimm, J. Guay, S. Guiral, H. Juteau, J.A. Mancini, N. Methot, J. Rubin, and R.W. Friesen Bioorg. Med. Chem. Lett. 15 2005 3352
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3352
- Riendeau, D.¹ Aspiotis, R.² Ethier, D.³ Gareau, Y.⁴ Grimm, E.L.⁵ Guay, J.⁶ Guiral, S.⁷ Juteau, H.⁸ Mancini, J.A.⁹ Methot, N.¹⁰ Rubin, J.¹¹ Friesen, R.W.¹²

9
- 71849110338
- A. Koeberle, E.M. Haberl, A. Rossi, C. Pergola, F. Dehm, H. Northoff, R. Troschuetz, L. Sautebin, and O. Werz Bioorg. Med. Chem. 17 2009 7924
- (2009) Bioorg. Med. Chem. , vol.17 , pp. 7924
- Koeberle, A.¹ Haberl, E.M.² Rossi, A.³ Pergola, C.⁴ Dehm, F.⁵ Northoff, H.⁶ Troschuetz, R.⁷ Sautebin, L.⁸ Werz, O.⁹

10
- 35848954713
- B. Cote, L. Boulet, C. Brideau, D. Claveau, D. Ethier, R. Frenette, M. Gagnon, A. Giroux, J. Guay, S. Guiral, J. Mancini, E. Martins, F. Masse, N. Methot, D. Riendeau, J. Rubin, D. Xu, H. Yu, Y. Ducharme, and R.W. Friesen Bioorg. Med. Chem. Lett. 17 2007 6816
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 6816
- Cote, B.¹ Boulet, L.² Brideau, C.³ Claveau, D.⁴ Ethier, D.⁵ Frenette, R.⁶ Gagnon, M.⁷ Giroux, A.⁸ Guay, J.⁹ Guiral, S.¹⁰ Mancini, J.¹¹ Martins, E.¹² Masse, F.¹³ Methot, N.¹⁴ Riendeau, D.¹⁵ Rubin, J.¹⁶ Xu, D.¹⁷ Yu, H.¹⁸ Ducharme, Y.¹⁹ Friesen, R.W.²⁰ more..

11
- 77449125422
- A. Bruno, L. Di Francesco, I. Coletta, G. Mangano, M.A. Alisi, L. Polenzani, C. Milanese, P. Anzellotti, E. Ricciotti, M. Dovizio, A. Di Francesco, S. Tacconelli, M.L. Capone, and P. Patrignani Biochem. Pharmacol. 79 2010 974
- (2010) Biochem. Pharmacol. , vol.79 , pp. 974
- Bruno, A.¹ Di Francesco, L.² Coletta, I.³ Mangano, G.⁴ Alisi, M.A.⁵ Polenzani, L.⁶ Milanese, C.⁷ Anzellotti, P.⁸ Ricciotti, E.⁹ Dovizio, M.¹⁰ Di Francesco, A.¹¹ Tacconelli, S.¹² Capone, M.L.¹³ Patrignani, P.¹⁴

12
- 58149097590
- A. Koeberle, H. Zettl, C. Greiner, M. Wurglics, M. Schubert-Zsilavecz, and O. Werz J. Med. Chem. 51 2008 8068
- (2008) J. Med. Chem. , vol.51 , pp. 8068
- Koeberle, A.¹ Zettl, H.² Greiner, C.³ Wurglics, M.⁴ Schubert-Zsilavecz, M.⁵ Werz, O.⁶

13
- 70450202964
- A. Koeberle, and O. Werz Curr. Med. Chem. 16 2009 4274
- (2009) Curr. Med. Chem. , vol.16 , pp. 4274
- Koeberle, A.¹ Werz, O.²

14
- 68549088901
- A.J. Liedtke, P.R. Keck, F. Lehmann, A. Koeberle, O. Werz, and S.A. Laufer J. Med. Chem. 52 2009 4968
- (2009) J. Med. Chem. , vol.52 , pp. 4968
- Liedtke, A.J.¹ Keck, P.R.² Lehmann, F.³ Koeberle, A.⁴ Werz, O.⁵ Laufer, S.A.⁶

15
- 77953526527
- O. Radmark, and B. Samuelsson J. Intern. Med. 268 2010 5
- (2010) J. Intern. Med. , vol.268 , pp. 5
- Radmark, O.¹ Samuelsson, B.²

16
- 67650628023
- A. Koeberle, F. Pollastro, H. Northoff, and O. Werz Br. J. Pharmacol. 156 2009 952
- (2009) Br. J. Pharmacol. , vol.156 , pp. 952
- Koeberle, A.¹ Pollastro, F.² Northoff, H.³ Werz, O.⁴

17
- 78650176358
- J. Bauer, A. Koeberle, F. Dehm, F. Pollastro, G. Appendino, H. Northoff, A. Rossi, L. Sautebin, and O. Werz Biochem. Pharmacol. 81 2011 259
- (2011) Biochem. Pharmacol. , vol.81 , pp. 259
- Bauer, J.¹ Koeberle, A.² Dehm, F.³ Pollastro, F.⁴ Appendino, G.⁵ Northoff, H.⁶ Rossi, A.⁷ Sautebin, L.⁸ Werz, O.⁹

18
- 63149106084
- A. Koeberle, H. Northoff, and O. Werz Biochem. Pharmacol. 77 2009 1513
- (2009) Biochem. Pharmacol. , vol.77 , pp. 1513
- Koeberle, A.¹ Northoff, H.² Werz, O.³

19
- 68849095477
- A. Koeberle, H. Northoff, and O. Werz Mol. Cancer Ther. 8 2009 2348
- (2009) Mol. Cancer Ther. , vol.8 , pp. 2348
- Koeberle, A.¹ Northoff, H.² Werz, O.³

20
- 66749107378
- E.M. Karg, S. Luderer, C. Pergola, U. Buhring, A. Rossi, H. Northoff, L. Sautebin, R. Troschutz, and O. Werz J. Med. Chem. 52 2009 3474
- (2009) J. Med. Chem. , vol.52 , pp. 3474
- Karg, E.M.¹ Luderer, S.² Pergola, C.³ Buhring, U.⁴ Rossi, A.⁵ Northoff, H.⁶ Sautebin, L.⁷ Troschutz, R.⁸ Werz, O.⁹

21
- 63849222744
- A. Rossi, R. Di Paola, E. Mazzon, T. Genovese, R. Caminiti, P. Bramanti, C. Pergola, A. Koeberle, O. Werz, L. Sautebin, and S. Cuzzocrea J. Pharmacol. Exp. Ther. 329 2009 76
- (2009) J. Pharmacol. Exp. Ther. , vol.329 , pp. 76
- Rossi, A.¹ Di Paola, R.² Mazzon, E.³ Genovese, T.⁴ Caminiti, R.⁵ Bramanti, P.⁶ Pergola, C.⁷ Koeberle, A.⁸ Werz, O.⁹ Sautebin, L.¹⁰ Cuzzocrea, S.¹¹

22
- 67649965623
- H. Zettl, R. Steri, M. Lammerhofer, and M. Schubert-Zsilavecz Bioorg. Med. Chem. Lett. 19 2009 4421
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4421
- Zettl, H.¹ Steri, R.² Lammerhofer, M.³ Schubert-Zsilavecz, M.⁴

23
- 74049088627
- M. Lammerhofer, R. Pell, M. Mahut, M. Richter, S. Schiesel, H. Zettl, M. Dittrich, M. Schubert-Zsilavecz, and W. Lindner J. Chromatogr., A 1217 2010 1033
- (2010) J. Chromatogr., A , vol.1217 , pp. 1033
- Lammerhofer, M.¹ Pell, R.² Mahut, M.³ Richter, M.⁴ Schiesel, S.⁵ Zettl, H.⁶ Dittrich, M.⁷ Schubert-Zsilavecz, M.⁸ Lindner, W.⁹

24
- 79957485987
- A. Koeberle, U. Siemoneit, U. Buehring, H. Northoff, S. Laufer, W. Albrecht, and O.J. Werz Pharmacol. Exp. Ther. 326 2008 982
- (2008) Pharmacol. Exp. Ther. , vol.326 , pp. 982
- Koeberle, A.¹ Siemoneit, U.² Buehring, U.³ Northoff, H.⁴ Laufer, S.⁵ Albrecht, W.⁶ Werz, O.J.⁷

25
- 0033594963
- P.J. Jakobsson, S. Thoren, R. Morgenstern, and B. Samuelsson Proc. Natl. Acad. Sci. U.S.A. 96 1999 7220
- (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 7220
- Jakobsson, P.J.¹ Thoren, S.² Morgenstern, R.³ Samuelsson, B.⁴

26
- 0019227390
- J. Maclouf, H. Kindahl, E. Granstrom, and B. Samuelsson Eur. J. Biochem. 109 1980 561
- (1980) Eur. J. Biochem. , vol.109 , pp. 561
- MacLouf, J.¹ Kindahl, H.² Granstrom, E.³ Samuelsson, B.⁴

27
- 51849122463
- O. Werz, C. Greiner, A. Koeberle, C. Hoernig, S. George, L. Popescu, I. Syha, M. Schubert-Zsilavecz, and D. Steinhilber J. Med. Chem. 51 2008 5449
- (2008) J. Med. Chem. , vol.51 , pp. 5449
- Werz, O.¹ Greiner, C.² Koeberle, A.³ Hoernig, C.⁴ George, S.⁵ Popescu, L.⁶ Syha, I.⁷ Schubert-Zsilavecz, M.⁸ Steinhilber, D.⁹

28
- 0242584866
- D. Claveau, M. Sirinyan, J. Guay, R. Gordon, C.C. Chan, Y. Bureau, D. Riendeau, and J.A. Mancini J. Immunol. 170 2003 4738
- (2003) J. Immunol. , vol.170 , pp. 4738
- Claveau, D.¹ Sirinyan, M.² Guay, J.³ Gordon, R.⁴ Chan, C.C.⁵ Bureau, Y.⁶ Riendeau, D.⁷ Mancini, J.A.⁸

29
- 0023774933
- J.E. Tateson, R.W. Randall, C.H. Reynolds, W.P. Jackson, P. Bhattacherjee, J.A. Salmon, and L.G. Garland Br. J. Pharmacol. 94 1988 528
- (1988) Br. J. Pharmacol. , vol.94 , pp. 528
- Tateson, J.E.¹ Randall, R.W.² Reynolds, C.H.³ Jackson, W.P.⁴ Bhattacherjee, P.⁵ Salmon, J.A.⁶ Garland, L.G.⁷

30
- 77649172085
- C. Pergola, and O. Werz Expert Opin. Ther. Patents 20 2010 355
- (2010) Expert Opin. Ther. Patents , vol.20 , pp. 355
- Pergola, C.¹ Werz, O.²

31
- 0030875291
- O. Werz, N. Schneider, M. Brungs, E.R. Sailer, H. Safayhi, H.P.T. Ammon, and D. Steinhilber Naunyn-Schmiedebergs Arch. Pharmacol. 356 1997 441
- (1997) Naunyn-Schmiedebergs Arch. Pharmacol. , vol.356 , pp. 441
- Werz, O.¹ Schneider, N.² Brungs, M.³ Sailer, E.R.⁴ Safayhi, H.⁵ Ammon, H.P.T.⁶ Steinhilber, D.⁷

32
- 0038661167
- L. Fischer, D. Szellas, O. Radmark, D. Steinhilber, and O. Werz FASEB J. 17 2003 949
- (2003) FASEB J. , vol.17 , pp. 949
- Fischer, L.¹ Szellas, D.² Radmark, O.³ Steinhilber, D.⁴ Werz, O.⁵

33
- 34347397335
- O. Radmark, O. Werz, D. Steinhilber, and B. Samuelsson Trends Biochem. Sci. 32 2007 332
- (2007) Trends Biochem. Sci. , vol.32 , pp. 332
- Radmark, O.¹ Werz, O.² Steinhilber, D.³ Samuelsson, B.⁴

34
- 33846360266
- R.K. Shirumalla, K.S. Naruganahalli, S.G. Dastidar, V. Sattigeri, G. Kaur, C. Deb, J.B. Gupta, M. Salman, and A. Ray Inflamm. Res. 55 2006 517
- (2006) Inflamm. Res. , vol.55 , pp. 517
- Shirumalla, R.K.¹ Naruganahalli, K.S.² Dastidar, S.G.³ Sattigeri, V.⁴ Kaur, G.⁵ Deb, C.⁶ Gupta, J.B.⁷ Salman, M.⁸ Ray, A.⁹

35
- 0031822546
- O. Werz, D. Szellas, M. Henseler, and D. Steinhilber Mol. Pharmacol. 54 1998 445
- (1998) Mol. Pharmacol. , vol.54 , pp. 445
- Werz, O.¹ Szellas, D.² Henseler, M.³ Steinhilber, D.⁴

36
- 3442881705
- L. Fischer, D. Steinhilber, and O. Werz Br. J. Pharmacol. 142 2004 861
- (2004) Br. J. Pharmacol. , vol.142 , pp. 861
- Fischer, L.¹ Steinhilber, D.² Werz, O.³

37
- 77249133243
- A. Koeberle, A. Rossi, H. Zettl, C. Pergola, F. Dehm, J. Bauer, C. Greiner, S. Reckel, C. Hoernig, H. Northoff, F. Bernhard, V. Dotsch, L. Sautebin, M. Schubert-Zsilavecz, and O. Werz J. Pharmacol. Exp. Ther. 332 2010 840
- (2010) J. Pharmacol. Exp. Ther. , vol.332 , pp. 840
- Koeberle, A.¹ Rossi, A.² Zettl, H.³ Pergola, C.⁴ Dehm, F.⁵ Bauer, J.⁶ Greiner, C.⁷ Reckel, S.⁸ Hoernig, C.⁹ Northoff, H.¹⁰ Bernhard, F.¹¹ Dotsch, V.¹² Sautebin, L.¹³ Schubert-Zsilavecz, M.¹⁴ Werz, O.¹⁵

38
- 58149398605
- C. Pergola, G. Dodt, A. Rossi, E. Neunhoeffer, B. Lawrenz, H. Northoff, B. Samuelsson, O. Radmark, L. Sautebin, and O. Werz Proc. Natl. Acad. Sci. U.S.A. 105 2008 19881
- (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 19881
- Pergola, C.¹ Dodt, G.² Rossi, A.³ Neunhoeffer, E.⁴ Lawrenz, B.⁵ Northoff, H.⁶ Samuelsson, B.⁷ Radmark, O.⁸ Sautebin, L.⁹ Werz, O.¹⁰

39
- 0036464591
- O. Werz, E. Burkert, B. Samuelsson, O. Radmark, and D. Steinhilber Blood 99 2002 1044
- (2002) Blood , vol.99 , pp. 1044
- Werz, O.¹ Burkert, E.² Samuelsson, B.³ Radmark, O.⁴ Steinhilber, D.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.