A novel class of trans-methylpyrazoline analogs of combretastatins: Synthesis and in-vitro biological testing

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 3099-3104

  Lee, Megan ^a   Brockway, Olivia ^a   Dandavati, Armaan ^a   Tzou, Samuel ^a   Sjoholm, Robert ^a   Satam, Vijay ^a   Westbrook, Cara ^b   Mooberry, Susan L ^b   Zeller, Matthias ^c   Babu, Balaji ^a   Lee, Moses ^a  

^a HOPE COLLEGE   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c YOUNGSTOWN STATE UNIVERSITY   (United States)

Author keywords

Combretastatins; Cytotoxicity; Lymphoma; Melanoma; Microtubules; Pyrazolines; Tubulins

Indexed keywords

COLCHICINE; COMBRETASTATIN A4; METHYLPYRAZOLINE DERIVATIVE; PYRAZOLE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIBENZYL DERIVATIVE; COMBRETASTATIN; COMBRETASTATIN A4 PHOSPHATE; STILBENE DERIVATIVE; TUBULIN MODULATOR;

ARTICLE; CYTOTOXICITY; DEPOLYMERIZATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LYMPHOMA CELL; MELANOMA CELL; MICROTUBULE; MOLECULAR MODEL; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; IC50; LEUKEMIA L1210; MELANOMA, EXPERIMENTAL; METABOLISM; MOLECULAR DOCKING; MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIBENZYLS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA L1210; MELANOMA, EXPERIMENTAL; MICE; MICROTUBULES; MOLECULAR DOCKING SIMULATION; PYRAZOLES; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 79957466365     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.064     Document Type: Article

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