Mechanism of action of pentostatin and cladribine in hairy cell leukemia

Leukemia and Lymphoma

Volumn 52, Issue SUPPL. 2, 2011, Pages 43-45

  Johnston, James B ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b CANCERCARE MANITOBA   (Canada)

Author keywords

chronic lymphocytic leukemia; cladribine; hairy cell leukemia; Pentostatin

Indexed keywords

ADENOSINE; APOPTOSIS INDUCING FACTOR; CLADRIBINE; CYTOCHROME C; DEOXYADENOSINE; DEOXYADENOSINE PHOSPHATE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE KINASE; DNA DIRECTED DNA POLYMERASE BETA; FLUDARABINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PENTOSTATIN; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; DNA STRAND BREAKAGE; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HAIRY CELL LEUKEMIA; HUMAN; LEUKEMIA CELL; LYMPHOCYTE; MITOCHONDRION; PRIORITY JOURNAL; TREATMENT RESPONSE;

APOPTOSIS; CLADRIBINE; DNA BREAKS; HUMANS; LEUKEMIA, HAIRY CELL; PENTOSTATIN;

EID: 79957465550     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.570394     Document Type: Article

References (8)

1. Mitchell BS, Kelley WN. Purinogenic immunodeficiency diseases: clinical features and molecular mechanisms. Ann Intern Med 1980;92:826-831. (Pubitemid 10124373)
2. Johnston JB, Begleiter A, Pugh L, et al. Biochemical changes induced in hairy-cell leukemia following treatment with the adenosine deaminase inhibitor 20-deoxycoformycin. Cancer Res 1986;46:2179-2184. (Pubitemid 16117928)
3. Begleiter A, Glazer RI, Israels LG, et al. Induction of DNA strand breaks in chronic lymphocytic leukemia following treatment with 20-deoxycoformycin in vivo and in vitro. Cancer Res 1987;47:2498-2503. (Pubitemid 17099220)
4. Pastor-Anglada M, Molina-Arcas M, Casado FJ, et al. Nucleoside transporters in chronic lymphocytic leukaemia. Leukemia 2004;18:385-393. (Pubitemid 38425849)
5. Seto S, Carrera CJ, Kubota M, Wasson B, Carson DA. Mechanism of dAdo and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J Clin Invest 1985;75:377-382.
6. Begleiter A, Pugh L, Israels LG, Johnston JB. Enhanced cytotoxicity and inhibition of DNA damage repair in irradiated murine L5178Y lymphoblasts and human chronic lymphocytic leukemia cells treated with 20-deoxycoformcyin and dAdo in vitro. Cancer Res 1988;48:3981-3986.
7. Genini D, Adachi S, Chao Q, et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 2000;96:3537-3543.
8. Pettitt AR, Sherrington PD, Cawley JC. Role of poly(ADPribosyl) ation in the killing of chronic lymphocytic leukemia cells by purine analogues. Cancer Res 2000;60:4187-4193. (Pubitemid 30636603)