Characterization of cases of Clostridium difficile infection (CDI) presenting at an emergency room: Molecular and clinical features differentiate community-onset hospital-associated and community-associated CDI in a tertiary care hospital

Journal of Clinical Microbiology

Volumn 49, Issue 6, 2011, Pages 2161-2165

  Shin, Bo Moon ^a   Moon, Se Jin ^a   Kim, You Sun ^a   Shin, Won Chang ^a   Yoo, Hyeon Mi ^a  

^a Inje University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL TOXIN; CEPHALOSPORIN; PROTEIN TCDA; PROTEIN TCDB; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BACTERIUM CULTURE; BACTERIUM ISOLATE; BACTERIUM ISOLATION; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DIABETES MELLITUS; DIARRHEA; EMERGENCY WARD; FECES ANALYSIS; FECES CULTURE; FEMALE; GENETIC VARIABILITY; GENOTYPE; HOSPITAL DISCHARGE; HOSPITAL INFECTION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SYMPTOMATOLOGY; TERTIARY HEALTH CARE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; EMERGENCY SERVICE, HOSPITAL; ENTEROTOXINS; FECES; FEMALE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; REPETITIVE SEQUENCES, NUCLEIC ACID; YOUNG ADULT;

CLOSTRIDIUM DIFFICILE;

EID: 79957460628     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02330-10     Document Type: Article

References (24)

1. Bauer, M. P., et al. 2009. Clinical and microbiological characteristics of community-onset Clostridium difficile infection in The Netherlands. Clin. Microbiol. Infect. 15:1087-1092.
2. Byun, T. J., et al. 2009. Clinical characteristics and changing epidemiology of Clostridium difficile-associated disease (CDAD). Korean J. Gastroenterol. 54:13-19.
3. Chang, H. T., et al. 2007. Onset of symptoms and time to diagnosis of Clostridium difficile-associated disease following discharge from an acute care hospital. Infect. Control Hosp. Epidemiol. 28:926-931.
4. Dubberke, E. R., et al. 2009. Multicenter study of the impact of community-onset Clostridium difficile infection on surveillance for C. difficile infection. Infect. Control Hosp. Epidemiol. 30:518-525.
5. Hirschhorn, L. R., Y. Trnka, A. Onderdonk, M. L. Lee, and R. Platt. 1994. Epidemiology of community-acquired Clostridium difficile-associated diarrhea. J. Infect. Dis. 169:127-133.
6. Kato, H., et al. 1998. Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J. Clin. Microbiol. 36:2178-2182.
7. Kutty, P. K., et al. 2010. Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Emerg. Infect. Dis. 16:197-204.
8. Lee, J. H., et al. 2010. The incidence and clinical features of Clostridium difficile infection; single center study. Korean J. Gastroenterol. 55:175-182.
9. Limbago, B. M., et al. 2009. Clostridium difficile strains from community-associated infections. J. Clin. Microbiol. 47:3004-3007.
10. McDonald, L. C., et al. 2007. Recommendations for surveillance of Clostridium difficile-associated disease. Infect. Control Hosp. Epidemiol. 28:140-145.
11. Naggie, S., et al. 2010. Community-associated Clostridium difficile infection: experience of a veteran affairs medical center in southeastern USA. Infection 38:297-300.
12. Noren, T., et al. 2004. Molecular epidemiology of hospital-associated and community-acquired Clostridium difficile infection in a Swedish county. J. Clin. Microbiol. 42:3635-3643.
13. O'Neill, G. L., F. T. Ogunsola, J. S. Brazier, and B. I. Duerden. 1996. Modification of a PCR ribotyping method for application as a routine typing scheme for Clostridium difficile. Anaerobe 2:205-209.
14. Pasanen, T., et al. 2010. Comparison of repetitive extragenic palindromic sequence-based PCR with PCR ribotyping and pulsed-field gel electrophoresis in studying the clonality of Clostridium difficile. Clin. Microbiol. Infect. 17:166-175.
15. Pawlowski, S. W., C. A. Warren, and R. Guerrant. 2009. Diagnosis and treatment of acute or persistent diarrhea. Gastroenterology 136:1874-1886.
16. + variant strain of Clostridium difficile responsible for pseudomembranous colitis at a tertiary care hospital in Korea. Diagn. Microbiol. Infect. Dis. 60:333-337.
17. Shin, B. M., et al. 2008. Multicentre study of the prevalence of toxigenic Clostridium difficile in Korea: results of a retrospective study 2000-2005. J. Med. Microbiol. 57:697-701.
18. Shin, B. M., E. Y. Kuak, E. J. Lee, and J. G. Songer. 2009. Algorithm combining toxin immunoassay and stool culture for diagnosis of Clostridium difficile infection. J. Clin. Microbiol. 47:2952-2956.
19. + C. difficile prevalent area. Anaerobe 15:266-269.
20. Simor, A. E., S. F. Bradley, L. J. Strausbaugh, K. Crossley, and L. E. Nicolle. 2002. Clostridium difficile in long-term-care facilities for the elderly. Infect. Control Hosp. Epidemiol. 23:696-703.
21. Stabler, R. A., et al. 2006. Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains. J. Clin. Microbiol. 188:7297-7305.
22. Stubbs, S. L., et al. 2000. Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile. FEMS Microbiol. Lett. 186:307-312.
23. Stubbs, S. L., J. S. Brazier, G. L. O'Neill, and B. I. Duerden. 1999. PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J. Clin. Microbiol. 37:461-463.
24. Wilcox, M. H., L. Mooney, R. Bendall, C. D. Settle, and W. N. Fawley. 2008. A case-control study of community-associated Clostridium difficile infection. J. Antimicrob. Chemother. 62:388-396.