Tanshinone II A induces apoptosis and s phase cell cycle arrest in activated rat hepatic stellate cells

Basic and Clinical Pharmacology and Toxicology

Volumn 106, Issue 1, 2010, Pages 30-37

  Che, Xian Hua ^a   Park, Eun Jeon ^a   Zhao, Yu Zhe ^a   Kim, Woong Hyun ^a   Sohn, Dong Hwan ^a  

^a Wonkwang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN A; CYCLIN DEPENDENT KINASE 2 INHIBITOR; CYCLIN E; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; TANSHINONE IIA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL TRANSFORMATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DNA FRAGMENTATION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; LIVER CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; STELLATE CELL; TIME;

ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; HEPATIC STELLATE CELLS; MITOCHONDRIA, LIVER; MITOGEN-ACTIVATED PROTEIN KINASES; PHENANTHRENES; RATS; S PHASE;

RATTUS; SALVIA MILTIORRHIZA; SIMIAN VIRUS 40;

EID: 73649107966     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00465.x     Document Type: Article

References (29)

1. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004 126 : 529 540.
2. Friedman SL. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993 328 : 1828 1835.
3. Saxena NK, Titus MA, Ding X, Floyd J, Srinivasan S, Sitaraman SV et al. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB J 2004 18 : 1612 1614.
4. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005 115 : 209 218.
5. Friedman SL, Maher JJ, Bissell DM. Mechanisms and therapy of hepatic fibrosis: report of the AASLD Single Topic Basic Research Conference. Hepatology 2000 32 : 1403 1408.
6. Li JT, Liao ZX, Ping J, Xu D, Wang H. Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J Gastroenterol 2008 43 : 419 428.
7. Cales P. Apoptosis and liver fibrosis: antifibrotic strategies. Biomed Pharmacother 1998 52 : 259 263.
8. Hsu YC, Lin YL, Chiu YT, Shiao MS, Lee CY, Huang YT. Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats. J Biomed Sci 2005 12 : 185 195.
9. Kim JY, Kim KM, Nan JX et al. Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells. Pharmacol Toxicol 2003 92 : 195 200.
10. Ryu SY, Lee CO, Choi SU. In vitro cytotoxicity of tanshinones from Salvia miltiorrhiza. Planta Med 1997 63 : 339 342.
11. Liu JJ, Lin DJ, Liu PQ, Huang M, Li XD, Huang RW. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. J Biomed Sci 2006 13 : 813 823.
12. Wu WL, Chang WL, Chen CF. Cytotoxic activities of tanshinones against human carcinoma cell lines. Am J Chin Med 1991 19 : 207 216.
13. Lian LH, Park EJ, Piao HS, Zhao YZ, Sohn DH. Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway. Basic Clin Pharmacol Toxicol 2005 96 : 495 502.
14. Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett 1997 411 : 77 82.
15. Marchenko ND, Zaika A, Moll UM. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 2000 275 : 16202 16212.
16. French SW, Nash J, Shitabata P et al. Pathology of alcoholic liver disease. VA Cooperative Study Group 119. Semin Liver Dis 1993 13 : 154 169.
17. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998 281 : 1322 1326.
18. Goldin RD, Hunt NC, Clark J, Wickramasinghe SN. Apoptotic bodies in a murine model of alcoholic liver disease: reversibility of ethanol-induced changes. J Pathol 1993 171 : 73 6.
19. Marchetti P, Castedo M, Susin SA et al. Mitochondrial permeability transition is a central coordinating event of apoptosis. J Exp Med 1996 184 : 1155 1160. (Pubitemid 26313572)
20. van LG, Saelens X, van GM, MacFarlane M, Martin SJ, Vandenabeele P. The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ 2002 9 : 1031 1042.
21. Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 2000 290 : 989 992.
22. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol 1998 18 : 6353 6364.
23. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997 326 (Pt 1 1 16.
24. Reed JC. Mechanisms of apoptosis. Am J Pathol 2000 157 : 1415 1430.
25. Strasser A, O'Connor L, Dixit VM. Apoptosis signaling. Annu Rev Biochem 2000 69 : 217 245.
26. Fan M, Chambers TC. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist Updat 2001 4 : 253 267.
27. Moroy T, Geisen C. Cyclin E. Int J Biochem Cell Biol 2004 36 : 1424 1439.
28. Chang ZF, Huang DY, Lai TC. Different regulation of the human thymidine kinase promoter in normal human diploid IMR-90 fibroblasts and HeLa cells. J Biol Chem 1995 270 : 27374 27379.
29. Zinkel S, Gross A, Yang E. BCL2 family in DNA damage and cell cycle control. Cell Death Differ 2006 13 : 1351 1359.