New concepts in acute pain management: Strategies to prevent chronic postsurgical pain, opioid-induced hyperalgesia, and outcome measures

Anesthesiology Clinics

Volumn 29, Issue 2, 2011, Pages 311-327

  Grosu, Irina ^a   de Kock, Marc ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Anesthesia; Chronic postsurgical pain; Hyperalgesia; Pain

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ASCORBIC ACID; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; GABAPENTIN; KETAMINE; LOCAL ANESTHETIC AGENT; MAGNESIUM; MANNITOL; MEMANTINE; MINOXIDIL; NITROUS OXIDE; OMEGA 3 FATTY ACID; OPIATE DERIVATIVE; PREGABALIN; PROPENTOFYLLINE;

ADULT; ANESTHESIA; ANESTHESIST; CASE REPORT; CHRONIC PAIN; FEMALE; FOLLOW UP; HUMAN; HYPERALGESIA; INCIDENCE; POSTOPERATIVE PAIN; PREOPERATIVE CARE; PROPHYLAXIS; REVIEW; SURGICAL STRESS;

ACUTE DISEASE; ANALGESIA; ANALGESICS, OPIOID; ANESTHESIA; CHRONIC DISEASE; HUMANS; HYPERALGESIA; PAIN; PAIN, POSTOPERATIVE;

EID: 79956367055     PISSN: 19322275     EISSN: 22103538     Source Type: Journal    
DOI: 10.1016/j.anclin.2011.04.001     Document Type: Review

References (91)

1. Macrae W.A., Davies H.T. Epidemiology of pain 1999, 125-142. IASP Press, Seattle (WA). I.K. Crombie (Ed.).
2. Dajczman E., Gordon A., Kreisman H., et al. Long-term post-thoracotomy pain. Chest 1991, 99:270-274.
3. Kelhet H., Jensen T., Woolf C. Persistent post surgical pain: risk factors and prevention. Lancet 2006, 367:1618-1625.
4. Gerbershagen H.J., Dagtekin O., Rothe T., et al. Risk factors for acute and chronic postoperative pain in patients with benign and malignant renal disease after nephrectomy. Eur J Pain 2009, 13:853-860.
5. Gerbershagen H., Ozgur E., Dagtekin O., et al. Preoperative pain as a risk factor for chronic post-surgical pain-six month follow up after radical prostatectomy. Eur J Pain 2009, 13:1054-1061.
6. De Kock M., Lavand'homme P., Waterloos H. "Balanced analgesia" in the perioperative period: is there a place for ketamine?. Pain 2001, 92:373-380.
7. Crombie I.K., Davies H.T., Macrae W.A. Cut and thrust: antecedent surgery and trauma among patients attending a chronic pain clinic. Pain 1998, 76:167-171.
8. American Academy of Allergy, Asthma & Immunology Asthma statistics Available at:, Accessed April 4, 2011. http://www.aaai.org/media/resources/media_kit/astma_statistics.stm.
9. Schaffler A., Scholmerich J. Innate immunity and adipose tissue biology. Trends Immunol 2010, 31:226-235.
10. Eisenach J.C. Preventing chronic pain after surgery: who, how, and when?. Reg Anesth Pain Med 2006, 31:1-3.
11. Milligan E., Watkins L. Pathological and protective role of glia in chronic pain. Nat Rev Neurosci 2009, 10:22-36.
12. Angst M.S., Clark J.D. Opioid-induced hyperalgesia: a qualitative systemic review. Anesthesiology 2006, 104:570-587.
13. Matta J.A., Cornett P.M., Miyares R.L., et al. General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci U S A 2008, 105:8784-8789.
14. Woolf C.J., Salter M.W. Neuronal plasticity: increasing the gain in pain. Science 2000, 288:1765-1769.
15. Woolf C.J., Thompson S.W. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of postinjury hypersensitivity states. Pain 1991, 44:293-299.
16. Coderre T.Z., Katz J., Vaccario A.L., et al. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993, 52:259-285.
17. Lavand'homme P., De Kock M., Waterloos H. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery. Anesthesiology 2005, 103:813-820.
18. Lavand'homme P., Roelants F., Waterloos H., et al. Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery. Anesthesiology 2007, 106:1220-1225.
19. De Kock M., Lavand'homme P., Waterloos H. The short-lasting analgesia and long-term antihyperalgesic effect of intrathecal clonidine in patients undergoing colonic surgery. Anesth Analg 2005, 101:566-572.
20. Steegers M., Snik D., Verhagen A., et al. One half of the chronic pain after thoracic surgery shows a neuropathic component. J Pain 2008, 10:955-961.
21. Jaaskelainen S.K., Teerijoki-Osaka T., Virtanen A., et al. Sensory regeneration following intraoperatively verified trigeminal nerve injury. Neurology 2004, 62:1951-1957.
22. Omoigui S. The biochemical origin of pain-proposing a new law of pain: the origin of all pain is inflammation and the inflammatory response-a unifying law of pain. Med Hypotheses 2007, 69:70-82.
23. Hollins M., Harper D., Gallagher S., et al. Perceived intensity and unpleasantness of cutaneous and auditory stimuli: an evaluation of the generalized hypervigilance hypothesis. Pain 2009, 141:215-221.
24. White K.P., Carette S., Harth M., et al. Trauma and fibromyalgesia: is there an association and what does it means?. Semin Arthritis Rheum 2000, 29:200-216.
25. Stefano G.B., Kream R. Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors. Semin Cancer Biol 2008, 18:190-198.
26. Perkins F.M., Kelhet H. Chronic pain as an outcome from surgery. A review of predictive factors. Anesthesiology 2000, 93:1123-1133.
27. Buvanendran A., Kroin J.S., Kerns J.M., et al. Characterization of a new animal model for evaluation of persistent post-thoracotomy pain. Anesth Analg 2004, 99:1453-1460.
28. Tegeder I., Costigan M., Griffin R.S., et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 2006, 12:1269-1277.
29. France C.R., Taddio A., Shah V.S., et al. Maternal family history of hypertension attenuates neonatal pain. Pain 2009, 142:189-193.
30. Murthy B., Narayan B., Nayagam S. Reduced perception of pain in schizophrenia; its relevance to the clinical diagnosis of compartment syndrome. Injury 2004, 35:1192-1193.
31. Lazarev M., Lamb J., Barmada M.M., et al. Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?. Mol Pain 2008, 4:58-62.
32. Granot M., Ferber S.G. The roles of pain catastrophizing and anxiety in the prediction of postoperative pain intensity: a prospective study. Clin J Pain 2005, 21:439-445.
33. Chatterjee S., Nan R., Fleshner N., et al. Permanent flank bulge is a consequence of flank incision for radical nephrectomy in one half of the patients. Urol Oncol 2004, 22:36-39.
34. Miller F.K., Merritt S.A., Klauber-dermore N., et al. Acute and persistent postoperative pain after breast surgery. Pain Med 2009, 10:708-715.
35. Okifuji A., Donaldson G., Barck L., et al. Relationship between fibromyalgia and obesity in pain, function, mood, and sleep. J Pain 2010, 11:1329-1337.
36. Joshi I., Ogunnaike B.O. Consequences of inadequate pain relief and chronic persistent postoperative pain. Anesthesiol Clin North America 2005, 23:21-36.
37. Peters J., Schouw R., Anand K., et al. Does neonatal surgery lead to increased pain sensitivity in later childhood. Pain 2005, 114:444-454.
38. Katz J., Jackson M., Kavanagh B., et al. Acute pain after thoracic surgery predicts long term post-thoracotomy pain. Clin J Pain 1996, 12:50-55.
39. Gotoda Y., Kambara N., Skai T., et al. The morbidity, time course and predictive factors for persistent post-thoracotomy pain. Eur J Pain 2001, 5:89-96.
40. Gehling M., Scheidt C.E., Niebergall H., et al. Persistent pain after elective trauma surgery. Acute Pain 1999, 2:110-114.
41. Dolin S.J., Cashman J.N., Bland J.M. Effectiveness of acute postoperative pain management: I. Evidence from published data. Br J Anaesth 2002, 89:409-423.
42. Apfelbaum J.L., Chen C., metha S.S., et al. Postoperative pain experience from a national survey suggests postoperative pain continues to be undermanaged. Anesth Analg 2003, 97:534-540.
43. Kalkman C.J., Visser K., Moen J., et al. Preoperative prediction of severe postoperative pain. Pain 2003, 105:415-423.
44. Janssen K., Kalkman C.J., Grobbee D.E., et al. The risk of severe postoperative pain: modification and validation of a clinical prediction rule. Anesth Analg 2008, 107:1330-1339.
45. Granot M., Lowenstein L., Yarnitsky D., et al. Postcaeseraen section pain prediction by experimental pain assessment. Anesthesiology 2003, 98:1422-1426.
46. Yarnitsky D., Crispel Y., Eisenberg E., et al. Prediction of chronic post-operative pain: pre-operative DNIC testing identifies patients at risk. Pain 2008, 138:22-28.
47. Restif A.S. Self-hypnosis, a resource for children undergoing painful treatment. Soins Pediatr Pueric 2010, 254:37-39.
48. Carli F., Charlebois P., Stein B., et al. Randomized clinical trial of prehabilitation in colorectal surgery. Br J Surg 2010, 97:1187-1197.
49. Stefano G., Esch T., Bilfinger T., et al. Proinflammation and preconditioning protection are part of a common nitric oxide mediated process. Med Sci Monit 2010, 16:RA125-RA130.
50. Aasvang E., Kelhet H. Chronic postoperative pain: the case of inguinal herniorrhaphy. Br J Anaesth 2005, 95:69-76.
51. Oefelein M., Bayazit Y. Chronic pain syndrome after laparoscopic radical nephrectomy. J Urol 2003, 170:1939-1940.
52. Aubrun F., Valade N., Coriat P., et al. predictive factors of severe postoperative pain in the postanesthetic care unit. Anesth Analg 2008, 106:1535-1541.
53. Chia Y.T., Liu K., Wang J.J., et al. Intraoperative high dose of fentanyl induces postoperative fentanyl tolerance. Can J Anaesth 1999, 48:872-877.
54. Lowenstein E., Hallowell P., Levine F.H., et al. Cardiovascular response to large doses of intravenous morphine in man. N Engl J Med 1969, 281:1389-1393.
55. Celerier E., Rivat C., Jun Y., et al. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000, 92:465-472.
56. Suzuki M., Haraguiti S., Sugimoto K., et al. Low-dose ketamine potentiates epidural analgesia after thoracotomy. Anesthesiology 2006, 105:111-119.
57. Stubhaug A., Breivik H., Eide P.K., et al. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 1997, 41:1124-1132.
58. Dahl J.B., Mathiesen O., Moiniche S. "Protective premedication": an option with gabapentin and related drugs? A review of gabapentin and pregabalin in the treatment of postoperative pain. Acta Anaesthesiol Scand 2004, 48:1130-1136.
59. Bromley L. Pre-emptive analgesia and protective premedication: what is the difference?. Biomed Pharmacother 2006, 60:336-340.
60. Senturk M., Ozcan P.E., Talu G.K., et al. The effects of 3 different analgesic techniques on long-term postthoracotomy pain. Anesth Analg 2002, 94:11-15.
61. Bong C.L., Samuel M., Ng J.M., et al. Effects of preemptive epidural analgesia on post-thoracotomy pain. J Cardiothorac Vasc Anesth 2005, 19:786-793.
62. Ashburn M.A., Caplan R.A., Caert D.B., et al. Practice guidelines for acute pain management in the perioperative setting. An updated report by the American Society of Anesthesiologist Task Force on Acute Pain Management. Anesthesiology 2004, 100:1573-1581.
63. Samad T.A., Sapirstein A., Woolf C.J. Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol Med 2000, 8:390-396.
64. Richardson J., Sabanathan S., Mearns A.J., et al. Post-thoracotomy neuralgia. Pain Clin 1994, 7:87-97.
65. Wong G., Gavva N. Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: recent advances and setbacks. Brain Res Rev 2009, 60:267-277.
66. Di Marzo V., Blumberg P., Szallasi A. Endovanilloid signaling in pain. Curr Opin Neurobiol 2002, 12:372-379.
67. Kissin I. Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with low level of potential neurotoxicity. Anesth Analg 2008, 107:271-281.
68. Aasvang E.K., Hansen J.B., Malmstrom J., et al. The effect of wound instillation of a novel purified capsaicin formulation on postherniotomy pain: a double-blind randomised, placebo-controlled study. Anesth Analg 2008, 107:282-291.
69. Aasvang E.K., Hansen J.B., Kelhet H. Late sensory function after intraoperative capsaicin wound instillation. Acta Anaesthesiol Scand 2010, 54:224-231.
70. Zahn P.K., Brennan T.J. Primary and secondary hyperalgesia in a rat model for human postoperative pain. Anesthesiology 1999, 90:863-872.
71. Kawamata M., Watanabe H., Nishikawa K., et al. Different mechanisms of development and maintenance of experimental incision-induced hyperalgesia in human skin. Anesthesiology 2002, 97:550-559.
72. Joly V., Richebe P., Guignard B., et al. Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 2005, 103:147-155.
73. Stefano G.B., Cadet P., Kream R., et al. The presence of endogenous morphine signaling in animals. Neurochem Res 2008, 33:1933-1939.
74. Murphy G.L., Szokol J.W., Marymont J.H., et al. Morphine-based cardiac anesthesia provides superior early recovery compared to fentanyl in elective cardiac surgery patients. Anesth Analg 2009, 109:311-319.
75. Remerand F., Tendre Ch Le, Baud A., et al. The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesth Analg 2009, 109:1963-1967.
76. Oye I. Ketamine analgesia, NMDA receptors and the gates of perception. Acta Anaesthesiol Scand 1998, 42:747-749.
77. Rabben T., Skjelbred P., Oye I. Prolonged analgesic effect of ketamine, an N-methyl-D-aspartate receptor inhibitor, in patients with chronic pain. J Pharmacol Exp Ther 1999, 289:1060-1066.
78. Mazar J., Rogachev B., Shaked G., et al. Involvement of adenosine in the antiinflammatory action of ketamine. Anesthesiology 2005, 102:1174-1181.
79. Shibakawa Y.S., Sasaki Y., Goshima Y., et al. Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharide. Br J Anaesth 2005, 95:803-810.
80. Czura C., Rosas-ballina M., Tracey K. Cholinergic regulation of inflammation. Psychoneuroimmunology 2006, 85-95. Elsevier, Rochester (NY). R. Adler (Ed.).
81. Lysakowski C., Dumont L., Czarnetsky C., et al. Magnesium as an adjuvant to postoperative analgesia: a systematic review of randomized trials. Anesth Analg 2007, 104:1532-1539.
82. McCartney C., Sinha A., Katz J. A qualitative systemic review of the role of NMDA antagonists in preventive analgesia. Anesth Analg 2004, 98:1385-1400.
83. Bell R.F., Dahl J.B., Moore R.A., et al. Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anaesthesiol Scand 2005, 49:1405-1428.
84. Gilron I. Is gabapentin a "broad spectrum" analgesic. Anesthesiology 2002, 97:537-539.
85. Fassoulaki A., Triga A., Melemeni A., et al. Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. Anesth Analg 2005, 101:1427-1432.
86. Buvanedran A., Kroin J.S., Della Valle C.J., et al. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective randomised, controlled trial. Anesth Analg 2010, 110:199-207.
87. Arm Y., Yousef A. Evaluation of efficacy of the perioperative administration of venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain 2010, 26:31-35.
88. Meert T., De Kock M. Potentiation of the analgesic properties of fentanyl-like opioids with α2-adrenoceptor agonists in rats. Anesthesiology 1994, 81:678-688.
89. Eisenach J., De Kock M., Klimscha W. α2-adrenergic agonists for regional anesthesia: a clinical review of clonidine (1984-1995). Anesthesiology 1996, 85:655-674.
90. Raghavendra V., Tanga F., Rutkowski M., et al. Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and pro-inflammatory cytokines. Pain 2003, 104:655-664.
91. Song P., Zhao Z. The involvement of glial cells in the development of morphine tolerance. Neurosci Res 2001, 39:281-286.