The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow

Journal of Endocrinological Investigation

Volumn 34, Issue 2, 2011, Pages 106-110

  Somjen, D ^a   Katzburg, S ^a   Kohen, F ^b   Gayer, B ^b   Posner, G H ^c   Yoles, I ^a   Livne, E ^d  

^a TEL AVIV UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Bone marrow; Estradiol 17 ; Fat cells; Phytoestrogens; Vitamin D analogs

Indexed keywords

CALCITRIOL DERIVATIVE; DAIDZEIN; ESTRADIOL; ESTRADIOL RECEPTOR; ESTROGEN DERIVATIVE; GENISTEIN; PHYTOESTROGEN; RALOXIFENE; VITAMIN D DERIVATIVE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CONTROLLED STUDY; FAT CONTENT; FEMALE; LONG BONE; NONHUMAN; OSSIFICATION; OVARIECTOMY; RAT;

ADIPOCYTES; ANIMALS; BONE MARROW CELLS; CALCITRIOL; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; ESTROGENS; FEMALE; GENISTEIN; ISOFLAVONES; OVARIECTOMY; PHYTOESTROGENS; RALOXIFENE; RATS; RATS, WISTAR;

EID: 79956363538     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/7108     Document Type: Article

References (34)

1. Burkhardt R, Kettner G, Bohm W, et al. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone 1987, 8: 157-64. (Pubitemid 17111858)
2. Meunier P, Aaron J, Edouard C, Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 1971, 80: 147-54.
3. Wronski TJ, Dann LM, Scott KS, Cintrón M. Long-term effects of ovariectomy and aging on the rat skeleton. Calcif Tissue Int 1989, 45: 360-6. (Pubitemid 20028364)
4. David V, Martin A, Lafage-Proust MH, et al. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 2007, 148: 2553-62. (Pubitemid 47007541)
5. Rozman C, Feliu E, Berga L, Reverter JC, Climent C, Ferrán MJ. Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study. Exp Hematol 1989, 17: 34-7. (Pubitemid 19036773)
6. Compston JE. Bone marrow and bone: a functional unit. J Endocrinol 2002, 173: 387-94. (Pubitemid 34704710)
7. Martin RB, Zissimos SL Relationships between marrow fat and bone turnover in ovariectomized and intact rats. Bone 1991, 12: 123-31.
8. Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 2000, 16: 145-71. (Pubitemid 32037503)
9. Chan GK, Duque G. Age-related bone loss: old bone, new facts. Gerontology 2002, 48: 62-71. (Pubitemid 34195721)
10. Pacifici R. Cytokines, estrogen and postmenopausal osteoporosis-the second decade. Endocrinology 1998, 139: 2659-61.
11. Riggs BL, Khosla S, Melton III LJ. A unitary model for involutional osteoporosis: Estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 1998, 13: 763-73. (Pubitemid 28224192)
12. rd. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 2002, 23: 279-302.
13. Somjen D, Yoles I. DT56a (Tofupill/Femarelle) selectively stimulates creatine kinase specific activity in skeletal tissues of rats but not in the uterus. J Steroid Biochem Mol Biol 2003, 86: 93-8. (Pubitemid 37025753)
14. Somjen D, Katzburg S, Livne E, Yoles I. DT56a (Femarelle) stimulates bone formation in female rats. BJOG 2005, 112: 981-5. (Pubitemid 40896969)
15. Somjen D, Katzburg S, Posner GH, Livne E, Kaye AM. Systemic treatments with the low-calcemic 1,25(OH)(2)D(3) analogs JKF or QW increaseboth the morphological and biochemical responses to estradiol-17β in rat tibiae. J Cell Biochem 2007, 100: 1406-14.
16. Somjen D, Katzburg S, Kohen F, Gayer B, Livne E. Daidzein unlike other isolated isoflavones, preserves bone architecture in ovariectomized female rats in vivo. J Cell Biochem 2007, 103: 1826-32. (Pubitemid 351501913)
17. Sato M, Rippy MK, Bryant HU. Raloxifene, tamoxifen, nafoxidine or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J 1996, 10: 905-12. (Pubitemid 26184169)
18. Sharp JC, Copps JC, Liu Q, et al. Analysis of ovariectomy and estrogen effects on body composition in rats by X-ray and magnetic resonance imaging techniques. J Bone Miner Res 2000, 15: 138-46. (Pubitemid 30026941)
19. Benayahu D, Shur I, Ben-Eliyahu S. Hormonal changes affect the boneand bone marrow cells in a rat model. J Cell Biochem 79, 2000: 407-15.
20. Somjen D. Vitamin D modulation of the activity of estrogenic compounds in bone cells in vitro and in vivo. Crit Rev Eukaryot Gene Expr 2007, 17: 115-47. (Pubitemid 46847186)
21. Kajkenova O, Lecka-Czernik B, Gubrij I, et al. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res 1997, 12: 1772-9. (Pubitemid 27500188)
22. Moore SG, Dawson KL. Red and yellow marrow in the femur: age-related changes in appearance at MR imaging. Radiology 1990, 175: 219-23. (Pubitemid 20108569)
23. Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell 2004, 3: 379-89. (Pubitemid 40246708)
24. Gazit D, Zilberman Y, Ebner R, Kahn A. Bone loss (osteopenia) in old male mice results from diminished activity and availability of TGF-β. J Cell Biochem 1998, 70: 478-88. (Pubitemid 28357958)
25. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 2002, 143: 2376-84.
26. Gimble JM, Robinson CE, Wu X, Kelly KA. The function of adipocytes in the bone marrow stroma: an update. Bone 1996, 19: 421-8.
27. Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I. Adipogenesis and aging: does aging make fat go MAD? Exp Gerontol 2002, 37: 757-67.
28. Elbaz A, Rivas D, Duque G. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BI76J mice. Biogerontology 2009, March 31 [Epub ahead of print); doi: 10.1007/s10522-009-9221-7.
29. Dang ZC, van Bezooijen RL, Karperien M, Papapoulos SE, Löwik CW. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res 2002, 17: 394-405. (Pubitemid 34171754)
30. Dang ZC, Lowik CW. Differential effects of PD98059 and U0126 on osteogenesis and adipogenesis. J Cell Biochem 2004, 92: 525-33.
31. Heim M, Frank O, Kampmann G, et al. The phytoestrogen genistein enhances osteogenesis and represses adipogenic differentiation of human primary bone marrow stromal cells. Endocrinology 2004, 145: 848-59. (Pubitemid 38183829)
32. Somjen D, Katzburg S, Kohen F, et al. Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a "less- calcemic" analog of 1,25 dihydroxyvitamin D(3): JK 1624F(2)-2 (JKF). J Steroid Biochem Mol Biol 2006, 98: 139-46.
33. Fanti P, Monier-Faugere MC, Geng Z, et al. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos Int 1998, 8: 274-81. (Pubitemid 28427078)
34. Ishimi Y, Miyaura C, Ohmura M, et al. selective effects of genistein, a soybean isoflavone, on b-lymphopoiesis and bone loss caused by estrogen deficiency. Endocrinology 1999, 140: 1893-900. (Pubitemid 29149263)