Penile erectile activity of dinitrosyl iron complexes with thiol-containing ligands

Nitric Oxide - Biology and Chemistry

Volumn 24, Issue 4, 2011, Pages 217-223

  Andreyev Andriyevsky, Alexander A ^a   Mikoyan, Vasak D ^b   Serezhenkov, Vladimir A ^b   Vanin, Anatoly F ^b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b SEMENOV INSTITUTE OF CHEMICAL PHYSICS   (Russian Federation)

Author keywords

Dinitrosyl iron complexes; Nitric oxide; Papaverine; Penile erection

Indexed keywords

CYSTEINE; DINITROSYL IRON COMPLEX; GLUTATHIONE; IRON COMPLEX; LIGAND; NITRO DERIVATIVE; NITROPRUSSIDE SODIUM; PAPAVERINE; THIOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; DRUG MEGADOSE; ELECTRON SPIN RESONANCE; EXPERIMENTAL DENERVATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PENILE BLOOD VESSEL; PENIS ERECTION; PRIORITY JOURNAL; RAT; TIME; VASODILATATION;

ANIMALS; BLOOD PRESSURE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLUTATHIONE; INJECTIONS; IRON; MALE; NITRIC OXIDE; NITROGEN OXIDES; NITROPRUSSIDE; PAPAVERINE; PENILE ERECTION; PENIS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS;

RATTUS;

EID: 79956355929     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2011.04.008     Document Type: Article

References (30)

1. L.J. Ignarro, Nitric Oxide: Biology and Pharmacology, Academic Press, SanDiego, 2000.
2. A.L. Burnett, C.J. Lowenstein, D.S. Bredt, T.S.K. Chang, S.H. Snyder, Nitric oxide: a physiological mediator of penile erection, Science 257 (1992) 401-403.
3. J. Reifer, W.J. Aronson, P.A. Bush, F.J. Dorey, L.J. Ignarro, Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenoergic, noncholiniergic neurotransmission, N. Engl. Med. J. 326 (1992) 90-94.
4. R. Wang, F.R. Dommer, S.C. Sikka, P.J. Kadowitz, W.J. Hellstrom, Nitric oxide mediates penile erection in cats, J. Urol. 151 (1994) 234-237. (Pubitemid 24046980)
5. A. Fabbri, A. Aversa, A. Isidori, Erectile disfunction: an overreview, Hum. Reprod. Update 3 (1997) 455-466.
6. A.L. Burnett, Nitric oxide regulation of penile erection: biology and therapeutic implications, J. Androl. 23 (2002) S20-S26. (Pubitemid 34977533)
7. R.C. Dean, T.F. Lue, Physiology of penile erection and pathophysiology of erectile disfunction, Urol. Clin. North Am. 32 (2005) 379-395. (Pubitemid 41607527)
8. A.L. Burnett, The role of nitric oxide in erectile disfunction: implications for medical therapy, J. Clin. Hypertens. 8 (2006) 53-62.
9. A.L. Burnett, S.L. Tillman, T.S. Chang, J.I. Epstein, C.J. Lowenstein, D.S. Bredt, S.H. Snyder, P.C. Walsh, Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis, J. Urol. 150 (1993) 73-76. (Pubitemid 23175974)
10. J.P.M. Finberg, S. Levi, Y. Vardi, Inhibition of nerve-stimulation- induced vasodilatation in corpora cavernosa of the pithered rat by blocade of nitric oxide synthase, Br. J. Pharmacol. 108 (1993) 1122-1127.
11. L. Fazio, G. Brock, Erectile disfunction: management update, CMAI 170 (2004) 1429-1437.
12. W.J. Hellstrom, M. Monga, R. Wang, F.R. Dommer, P.J. Kadowitz, J.A. Roberts, Penile erection in the primate: induction with nitric-oxide donors, J. Urol. 151 (1994) 1723-1727. (Pubitemid 24151350)
13. E.I. Veliev, S.V. Kotov, V.K. Shishlo, V.A. Serezhenkov, V.I. Losinskii, A.V. Vanin, Effect of dinitrosyl iron complexes with thiol-containing ligands on penile cavernosum bodies in rats, Biophysika (Rus) 53 (2008) 326-335.
14. E.I. Veliev, A.F. Vanin, S.V. Kotov, V.K. Shishlo, Modern aspects of pathophysiology and prevention of erectile disfunction and cavernous fibrosis after radical prostatectomy, Urologiia (Rus) 2 (2009) 46-51.
15. V.L. Lakomkin, A.F. Vanin, A.A. Timoshin, V.I. Kapel'ko, E.I. Chazov, Long-lasting hypotensive action of stable preparations of dinitrosyl-iron complexes with thiol-containing ligands in conscious normotensive and hypertensive rats, Nitric Oxide, Biol. Chem. 16 (2007) 413-418.
16. A.F. Vanin, V.P. Mokh, V.A. Serezhenkov, E.I. Chazov, Vasorelaxing activity of stable powder preparations of dinitrosyl iron complexes with cysteine or glutathione, Nitric Oxide, Biol. Chem. 16 (2007) 322-330. (Pubitemid 46528770)
17. A.B. Shekhter, T.G. Rudenko, V.A. Serezhenkov, A.F. Vanin, Dinitrosyl-iron complexes with cysteine or glutathione accelerate skin wound healing, Biofizika (Rus) 52 (2007) 534-538.
18. P.I. Mordvintcev, V.G. Rudneva, A.F. Vanin, L.L. Shimkevich, B.I. Khodorov, The inhibitory effect of low-molecular dinitrosyl iron complexes on platelet aggregation, Biokhimiya (Rus) 51 (1986) 1851-1857. (Pubitemid 17213463)
19. A.F. Vanin, A.P. Poltorakov, V.D. Mikoyan, L.N. Kubrina, D.S. Burbaev, Polynuclear water-soluble dinitrosyl iron complexes with cysteine or glutathione: EPR and optical studies, Nitric Oxide, Biol. Chem. 23 (2010) 136-149.
20. M. Seidler, S. Uckert, E. Waldkirch, C.G. Stief, M. Oelke, D. Tsikas, M. Sohn, U. Jonas, In vitro effect of a novel class of nitric oxide donating compounds on an isolated human erectile tissue, Eur. Urol. 42 (2002) 523-528.
21. A. Morelli, L. Vignozzi, S. Filippi, R. Mancina, M. Maggi, Erectile disfunction: molecular biology, pathophysiology and pharmacological treatment, Minerva Urol. Nefrol. 57 (2002) 85-90. (Pubitemid 40979456)
22. K.A. Montorsi, K.E. Andersson, C.G. Stief, Phosphodiesterase inhibitors for the treatment of erectile disfunction, Curr. Opin. Investig. Drugs 3 (2002) 1489-1495.
23. A.L. Burnett, Phosphodiesterase 5 mechanisms and therapeutic applications, Am. J. Cardiol. 96 (2005) 29M-31M.
24. R. Wang, T.R. Huegra, S.C. Sikka, R.K. Minkes, J.A. Bellan, P.J. Kadowitz, F.R. Dommer, W.J. Hellstrom, Penile erection induced by vasoactive intestine peptide and sodium nitroprusside, Urol. Res. 21 (1993) 75-77.
25. F. Trigo-Rocha, L. Martinez-Pineiro, C.F. Donatucci, G.L. Hsu, T.F. Lue, E.A. Tanagho, Sodium nitroprusside: physiological effect as a nitric oxide donor in three species, Int. J. Impot. Res. 7 (1995) 49-56.
26. A.F. Vanin, P.I. Mordvintcev, A.L. Kleschyov, Role of nitric oxide and iron in hypotensive action of nitrosyl iron complexes with various anionic ligands, Studia Biophys. 105 (1985) 93-102.
27. A.F. Vanin, V.A. Serezhenkov, V.D. Mikoyan, M.V. Genkin, The 2.03 signal as an indicator of dinitrosyl-iron complexes with thiol-containing ligands, Nitric Oxide, Biol. Chem. 2 (1998) 224-234. (Pubitemid 29016152)
28. A.A. Timoshin, A.F. Vanin, T.R. Orlova, N.A. Sanina, E.K. Ruuge, S.M. Aldoshin, E.I. Chazov, Protein-bound dinitrosyl-iron complexes in blood of rabbit added with a low-molecular dinitrosyl-iron complex: EPR studies, Nitric Oxide, Biol. Chem. 16 (2007) 286-293. (Pubitemid 46149388)
29. A.F. Vanin, Dinitrosyl iron complexes with thiolate ligands: physico-chemistry, biochemistry and physiology, Nitric Oxide, Bio. Chem. 21 (2009) 1-13.
30. J.N. Bates, M.T. Baker, R. Guerra, D.G. Harrison, Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required, Biochem. Pharmacol. 42 (1991) S157-S165.