In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity

Archives of Toxicology

Volumn 85, Issue 5, 2011, Pages 525-535

  Vávrová, Anna ^a   Popelová, Olga ^b   Štěrba, Martin ^b   Jirkovský, Eduard ^a,b   Hašková, Pavlína ^a   Mertlíková Kaiserová, Helena ^a,c   Geršl, Vladimír ^b   Šimůnek, Tomáš ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Anthracycline cardiotoxicity; Daunorubicin; Glutathione; Glutathione peroxidase; Glutathione reductase

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; ANTHRACYCLINE; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; DAUNORUBICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; TROPONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 79956353957     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-010-0615-8     Document Type: Article

References (47)

1. M Adamcova T Simunek H Kaiserova O Popelova M Sterba A Potacova J Vavrova J Malakova V Gersl 2007 In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity Toxicology 237 218 228 17587482 10.1016/j.tox.2007.05.016 1:CAS:528:DC%2BD2sXnslWnu70%3D (Pubitemid 47031418)
2. ME Anderson 1998 Glutathione: an overview of biosynthesis and modulation Chem Biol Interact 111-112 1 14 9679538 10.1016/S0009-2797(97)00146-4 (Pubitemid 28271929)
3. E Barry JA Alvarez RE Scully TL Miller SE Lipshultz 2007 Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management Expert Opin Pharmacother 8 1039 1058 17516870 10.1517/14656566.8.8. 1039 1:CAS:528:DC%2BD2sXls1agsbc%3D (Pubitemid 46929299)
4. JH Doroshow GY Locker J Baldinger CE Myers 1979 The effect of doxorubicin on hepatic and cardiac glutathione Res Commun Chem Pathol Pharmacol 26 285 295 574979 1:CAS:528:DyaL3cXjsVensQ%3D%3D (Pubitemid 10205994)
5. JH Doroshow GY Locker CE Myers 1980 Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin J Clin Invest 65 128 135 7350193 10.1172/JCI109642 1:CAS:528:DyaL3cXovVyruw%3D%3D (Pubitemid 10214339)
6. JH Doroshow GY Locker I Ifrim CE Myers 1981 Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine J Clin Invest 68 1053 1064 7287901 10.1172/JCI110328 1:CAS:528:DyaL3MXmtFGisrs%3D (Pubitemid 11023534)
7. Dorr RT, Lagel K, McLean S (1996) Cardioprotection of rat heart myocytes with amifostine (Ethyol) and its free thiol, WR-1065, in vitro. Eur J Cancer 32A(Suppl 4):S21-S25
8. AR Dresdale LH Barr RO Bonow DJ Mathisen CE Myers DE Schwartz T d'Angelo SA Rosenberg 1982 Prospective randomized study of the role of N-acetyl cysteine in reversing doxorubicin-induced cardiomyopathy Am J Clin Oncol 5 657 663 7165010 10.1097/00000421-198212000-00015 1:STN:280:DyaL3s7kvFOgsA%3D%3D (Pubitemid 13149997)
9. J Gao Y Xiong YS Ho X Liu CC Chua X Xu H Wang R Hamdy BH Chua 2008 Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity Biochim Biophys Acta 1783 2020 2029 18602426 10.1016/j.bbamcr.2008.05.027 1:CAS:528:DC%2BD1cXhtV2isLrM
10. G Gatta R Capocaccia MP Coleman LA Ries F Berrino 2002 Childhood cancer survival in Europe and the United States Cancer 95 1767 1772 12365026 10.1002/cncr.10833
11. V Gersl R Hrdina 1994 Noninvasive polygraphic cardiac changes in daunorubicin-induced cardiomyopathy in rabbits Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove 37 49 55 7784798 1:STN:280:DyaK2MzgsVaksA%3D%3D
12. V Gersl Y Mazurová J Bajgar M Mělka R Hrdina V Palička 1996 Lack of cardiotoxicity of a new antineoplastic agent, a synthetic derivative of indenoisochinoline: comparison with daunorubicin in rabbits Arch Toxicol 70 645 651 8870958 10.1007/s002040050324 1:CAS:528:DyaK28XltlKmtb8%3D (Pubitemid 26258632)
13. L Gianni EH Herman SE Lipshultz G Minotti N Sarvazyan DB Sawyer 2008 Anthracycline cardiotoxicity: from bench to bedside J Clin Oncol 26 3777 3784 18669466 10.1200/JCO.2007.14.9401
14. Halliwell B, Gutteridge JM (2007) Free radicals in biology and medicine. Oxford University Press, Oxford
15. EH Herman VJ Ferrans CE Myers JF Van Vleet 1985 Comparison of the effectiveness of (±)-1, 2-bis(3, 5-dioxopiperazinyl-1-yl)propane (ICRF-187) and N-acetylcysteine in preventing chronic doxorubicin cardiotoxicity in beagles Cancer Res 45 276 281 3917371 1:CAS:528:DyaL2MXhtVGrsLc%3D (Pubitemid 15196968)
16. EH Herman J Zhang DP Chadwick VJ Ferrans 2000 Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats Cancer Chemother Pharmacol 45 329 334 10755322 10.1007/s002800050048 1:CAS:528:DC%2BD3cXhtlCrtbw%3D (Pubitemid 30151527)
17. A Jemal R Siegel E Ward T Murray J Xu C Smigal MJ Thun 2006 Cancer statistics, 2006 CA Cancer J Clin 56 106 130 16514137 10.3322/canjclin.56.2.106
18. RH Julicher A van der Laarse L Sterrenberg CH Bloys van Treslong A Bast J Noordhoek 1985 The involvement of an oxidative mechanism in the adriamycin induced toxicity in neonatal rat heart cell cultures Res Commun Chem Pathol Pharmacol 47 35 47 3983469 1:CAS:528:DyaL2MXht1Giu7o%3D (Pubitemid 15127519)
19. H Kaiserova GJ den Hartog T Simunek L Schroterova E Kvasnickova A Bast 2006 Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin Br J Pharmacol 149 920 930 17031387 10.1038/sj.bjp.0706930 1:CAS:528:DC%2BD28Xht1ClsrjF (Pubitemid 44851716)
20. HG Keizer HM Pinedo GJ Schuurhuis H Joenje 1990 Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity Pharmacol Ther 47 219 231 2203071 10.1016/0163-7258(90)90088-J 1:CAS:528:DyaK3cXmt1eqsbk%3D (Pubitemid 20228581)
21. BW Kimes BL Brandt 1976 Properties of a clonal muscle cell line from rat heart Exp Cell Res 98 367 381 943302 10.1016/0014-4827(76)90447-X 1:CAS:528:DyaE28Xhs1anu74%3D
22. I Klimtova T Simunek Y Mazurova R Hrdina V Gersl M Adamcova 2002 Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits Hum Exp Toxicol 21 649 657 12540035 10.1191/0960327102ht311oa 1:CAS:528:DC%2BD3sXhtVSru7w%3D (Pubitemid 36124497)
23. Kufe DW, Holland JF, Frei E, American Cancer Society (2003) Cancer medicine 6. BC Decker, Hamilton
24. T Li PK Singal 2000 Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol Circulation 102 2105 2110 11044428 1:CAS:528:DC%2BD3cXotVCqtb4%3D
25. Maines MD (1999) Current protocols in toxicology. Wiley, New York
26. P Menna E Salvatorelli G Minotti 2008 Cardiotoxicity of antitumor drugs Chem Res Toxicol 21 978 989 18376852 10.1021/tx800002r 1:CAS:528: DC%2BD1cXktVGitbc%3D
27. E Mingyan L Hongli L Shufeng Y Bo 2008 Effects of pyrrolidine dithiocarbamate on antioxidant enzymes in cardiomyopathy induced by adriamycin in rats Cardiology 111 119 125 18376123 10.1159/000119699 1:STN:280: DC%2BD1crnsVaquw%3D%3D
28. G Minotti P Menna E Salvatorelli G Cairo L Gianni 2004 Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity Pharmacol Rev 56 185 229 15169927 10.1124/pr.56.2.6 1:CAS:528:DC%2BD2cXltlKgtb0%3D (Pubitemid 38720829)
29. HE Mohamed SE El-Swefy HH Hagar 2000 The protective effect of glutathione administration on adriamycin-induced acute cardiac toxicity in rats Pharmacol Res 42 115 121 10887039 10.1006/phrs.1999.0630 1:CAS:528:DC%2BD3cXks1Wru7w%3D (Pubitemid 30658939)
30. RD Olson PS Mushlin 1990 Doxorubicin cardiotoxicity: analysis of prevailing hypotheses Faseb J 4 3076 3086 2210154 1:CAS:528:DyaK3MXhs12ktA%3D%3D
31. R Paniagua-Pérez E Madrigal-Bujaidar S Reyes-Cadena I Alvarez-González L Sánchez-Chapul J Pérez-Gallaga N Hernández G Flores-Mondragón O Velasco 2008 Cell protection induced by beta-sitosterol: inhibition of genotoxic damage, stimulation of lymphocyte production, and determination of its antioxidant capacity Arch Toxicol 82 615 622 18253721 10.1007/s00204-007-0277-3
32. O Popelova M Sterba P Haskova T Simunek M Hroch I Guncova P Nachtigal M Adamcova V Gersl Y Mazurova 2009 Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death Br J Cancer 101 792 802 19623174 10.1038/sj.bjc.6605192 1:CAS:528:DC%2BD1MXhtVGqu7fL
33. A Russo JB Mitchell 1985 Potentiation and protection of doxorubicin cytotoxicity by cellular glutathione modulation Cancer Treat Rep 69 1293 1296 4092192 1:CAS:528:DyaL28XjsFY%3D (Pubitemid 16217011)
34. K Shinoda K Mitsumori K Yasuhara C Uneyama H Onodera M Hirose M Uehara 1999 Doxorubicin induces male germ cell apoptosis in rats Arch Toxicol 73 274 281 10463394 10.1007/s002040050617 1:CAS:528:DyaK1MXkt1Omurc%3D (Pubitemid 29356692)
35. T Simunek I Klimtova M Adamcova V Gersl R Hrdina M Sterba J Kaplanova Y Mazurova 2003 Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy Cancer Chemother Pharmacol 52 431 434 14618274 10.1007/s00280-003-0675-z 1:CAS:528:DC%2BD3sXotFWmtLw%3D (Pubitemid 37363618)
36. T Simunek I Klimtova J Kaplanova Y Mazurova M Adamcova M Sterba R Hrdina V Gersl 2004 Rabbit model for in vivo study of anthracycline-induced heart failure and for the evaluation of protective agents Eur J Heart Fail 6 377 387 15182761 10.1016/j.ejheart.2003.05.003 1:CAS:528:DC%2BD2cXkslWqsLk%3D (Pubitemid 38746579)
37. T Simunek C Boer RA Bouwman R Vlasblom AM Versteilen M Sterba V Gersl R Hrdina P Ponka JJ de Lange WJ Paulus RJ Musters 2005 SIH-a novel lipophilic iron chelator-protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death J Mol Cell Cardiol 39 345 354 15978614 10.1016/j.yjmcc.2005.05.008 1:CAS:528:DC%2BD2MXmsVOrtL8%3D (Pubitemid 40995024)
38. T Simunek M Sterba O Popelova H Kaiserova M Adamcova M Hroch P Haskova P Ponka V Gersl 2008 Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone Br J Pharmacol 155 138 148 18536744 10.1038/bjp.2008.236 1:CAS:528:DC%2BD1cXhtVagsLfP
39. T Simunek M Sterba O Popelova M Adamcova R Hrdina V Gersl 2009 Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron Pharmacol Rep 61 154 171 19307704 1:CAS:528:DC%2BD1MXhtFCku7%2FN
40. PK Singal N Iliskovic 1998 Doxorubicin-induced cardiomyopathy N Engl J Med 339 900 905 9744975 10.1056/NEJM199809243391307 1:STN:280: DyaK1cvhsVektw%3D%3D (Pubitemid 28446849)
41. PL Takeuchi LM Antunes CS Takahashi 2008 Modulation of doxorubicin-induced clastogenesis in Wistar rat bone marrow cells by vitamin B(6) Arch Toxicol 82 869 873 18488196 10.1007/s00204-008-0308-8 1:CAS:528:DC%2BD1cXhsVKjt7%2FE
42. F Tietze 1969 Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues Anal Biochem 27 502 522 4388022 10.1016/0003-2697(69)90064-5 1:CAS:528:DyaF1MXktVSlt7k%3D
43. van Dalen EC, Caron HN, Dickinson HO, Kremer LC (2008) Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev, CD003917
44. X Wu BB Hasinoff 2005 The antitumor anthracyclines doxorubicin and daunorubicin do not inhibit cell growth through the formation of iron-mediated reactive oxygen species Anticancer Drugs 16 93 99 15613911 10.1097/00001813- 200501000-00014 1:CAS:528:DC%2BD2cXhtFSnsb3I
45. Y Xiong X Liu CP Lee BH Chua YS Ho 2006 Attenuation of doxorubicin-induced contractile and mitochondrial dysfunction in mouse heart by cellular glutathione peroxidase Free Radic Biol Med 41 46 55 16781452 10.1016/j.freeradbiomed.2006.02.024 1:CAS:528:DC%2BD28Xls1arsLo%3D (Pubitemid 43866460)
46. Y Yoda M Nakazawa T Abe Z Kawakami 1986 Prevention of doxorubicin myocardial toxicity in mice by reduced glutathione Cancer Res 46 2551 2556 3697994 1:CAS:528:DyaL28XktVShtLs%3D (Pubitemid 16120729)
47. S Zhou CM Palmeira KB Wallace 2001 Doxorubicin-induced persistent oxidative stress to cardiac myocytes Toxicol Lett 121 151 157 11369469 10.1016/S0378-4274(01)00329-0 1:CAS:528:DC%2BD3MXjsFaku78%3D (Pubitemid 32441771)