Changes in the pharmacokinetics of digoxin in polyuria in streptozotocin-induced diabetic mice and lithium carbonate-treated mice

Xenobiotica

Volumn 41, Issue 6, 2011, Pages 486-493

  Ikarashi, Nobutomo ^a   Kagami, Mai ^a   Kobayashi, Yasushi ^a   Ishii, Makoto ^a   Toda, Takahiro ^a   Ochiai, Wataru ^a   Sugiyama, Kiyoshi ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

aquaporin; Digoxin; lithium carbonate; mdr1a; renal clearance; streptozocin induced diabetic mice

Indexed keywords

AQUAPORIN 2; AQUAPORIN 3; DIGOXIN; GLUCOSE; LITHIUM CARBONATE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; POLYURIA; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE VOLUME;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIDEPRESSIVE AGENTS; AQUAPORIN 2; AQUAPORIN 3; CREATININE; DIABETES MELLITUS, EXPERIMENTAL; DIGOXIN; DRUG INTERACTIONS; KIDNEY; LITHIUM CARBONATE; MALE; MICE; MICE, INBRED ICR; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; P-GLYCOPROTEINS; POLYURIA; RNA, MESSENGER; STREPTOZOCIN;

MUS;

EID: 79956353358     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.551848     Document Type: Article

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