Neurophysiological evidence for muscle tone reduction by intrathecal baclofen at the brainstem level

Clinical Neurophysiology

Volumn 122, Issue 6, 2011, Pages 1229-1237

  Kumru, Hatice ^a   Stetkarova, Ivana ^b   Schindler, Christian ^c   Vidal, Joan ^a   Kofler, Markus ^a  

^a University Institute affiliated with the Autonomous University of Barcelona   (Spain)

^b NA HOMOLCE HOSPITAL   (Czech Republic)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Blink reflex; Brainstem; H reflex; Intrathecal baclofen; Prepulse inhibition; Spasticity; Spinal cord lesion

Indexed keywords

BACLOFEN;

ADOLESCENT; ADULT; ARTICLE; BICEPS BRACHII MUSCLE; BRAIN STEM; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; EYELID REFLEX; FEMALE; HUMAN; HYPERREFLEXIA; MALE; MODIFIED ASHWORTH SCALE; MUSCLE TONE; MUSCLE TONE REDUCTION; NEUROPHYSIOLOGY; PREPULSE INHIBITION; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; SPASTICITY;

ADOLESCENT; ADULT; BACLOFEN; BRAIN STEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; FEMALE; H-REFLEX; HUMANS; INJECTIONS, SPINAL; MALE; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; MUSCLE TONUS; MUSCLE, SKELETAL; NEURAL INHIBITION; NEURAL PATHWAYS; PARAPARESIS, SPASTIC; REACTION TIME; SEVERITY OF ILLNESS INDEX; TIME FACTORS; YOUNG ADULT;

EID: 79956352353     PISSN: 13882457     EISSN: 18728952     Source Type: Journal    
DOI: 10.1016/j.clinph.2010.09.010     Document Type: Article

References (47)

1. Albright A.L., Cervi A., Singletary J. Intrathecal baclofen for spasticity in cerebral palsy. JAMA 1991, 265:1418-1422.
2. Albright A.L., Thompson K., Carlos S., Minnigh M.B. Cerebrospinal fluid baclofen concentrations in patients undergoing continuous intrathecal baclofen therapy. Dev Med Child Neurol 2007, 49:423-425.
3. Allerton C.A., Boden P.R., Hill R.G. Actions of the GABAB agonist, (-)-baclofen, on neurones in deep dorsal horn of the rat spinal cord in vitro. Br J Pharmacol 1989, 96:29-38.
4. Ashworth B. Preliminary trial of carisoprodol in multiple sclerosis. Practitioner 1964, 192:540-542.
5. Aymard C., Katz R., Lafitte C., Lo E., Pénicaud A., Pradat-Diehl P., Raoul S. Presynaptic inhibition and homosynaptic depression - a comparison between lower and upper limbs in normal human subjects and patients with hemiplegia. Brain 2000, 123:1688-1702.
6. Azouvi P., Roby-Brami A., Biraben A., Thiebaut J.B., Thurel C., Bussel B. Effect of intrathecal baclofen on the monosynaptic reflex in humans: evidence for a postsynaptic action. J Neurol Neurosurg Psychiatry 1993, 56:515-519.
7. Bernards C.M. Epidural and intrathecal drug movement. Spinal drug delivery 1999, 239-252. Elsevier Science B.V., Amsterdam, Lausanne, New York, Oxford, Shannon, Singapore, Tokyo. T.L. Yaksh (Ed.).
8. Bernards C.M. Cerebrospinal fluid and spinal cord distribution of baclofen and bupivacaine during slow intrathecal infusion in pigs. Anesthesiology 2006, 105:169-178.
9. Bohannon R.W., Smith M.B. Interrater reliability of a modified Ashworth Scale of muscle spasticity. Phys Ther 1987, 67:206-207.
10. Brennan P.M., Whittle I.R. Intrathecal baclofen therapy for neurological disorders: a sound knowledge base but many challenges remain. Br J Neurosurg 2008, 22:508-519.
11. Brooks V.B. Muscle tone. The neural basis of motor control 1986, 151-159. Oxford University Press, New York, Oxford. V.B. Brooks (Ed.).
12. Burns A.S., Meythaler J.M. Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia. Spinal Cord 2001, 39:413-419.
13. Craven BC, Morris AR. Modified Ashworth scale reliability for measurement of lower extremity spasticity among patients with SCI. Spinal Cord 2009.
14. Curtis D.R., Lodge D., Bornstein J.C., Peet M.J. Selective effects of (-)-baclofen on spinal synaptic transmission in the cat. Exp Brain Res 1981, 42:158-170.
15. Davidoff R.A. Antispasticity drugs: mechanisms of action. Ann Neurol 1985, 17:107-116.
16. Deuschl G., Eisen A. Recommendations for the practice of clinical neurophysiology: guidelines of the international federation of clinical neurophysiology 1999, Elsevier Science B.V., Amsterdam.
17. Elbasiouny SM, Moroz D, Bakr MM, Mushahwar VK. Management of spasticity after spinal cord injury: current techniques and future directions. Neurorehabil Neural Repair 2009.
18. Fleuren J.F., Voerman G.E., Erren-Wolters C.V., Snoek G.J., Rietman J.S., Hermens H.J., Nene A.V. Stop using the Ashworth Scale for the assessment of spasticity. J Neurol Neurosurg Psychiatry 2010, 81:46-52.
19. Francisco G.E. The role of intrathecal baclofen therapy in the upper motor neuron syndrome. Eura Medicophys 2004, 40:131-143.
20. Grabb P.A., Guin-Renfroe S., Meythaler J.M. Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity. Neurosurgery 1999, 45:833-836.
21. Haugh A.B., Pandyan A.D., Johnson G.R. A systematic review of the Tardieu Scale for the measurement of spasticity. Disabil Rehabil 2006, 28:899-907.
22. Hugenholtz H., Nelson R.F., Dehoux E. Intrathecal baclofen - the importance of catheter position. Can J Neurol Sci 1993, 20:165-167.
23. Jones E.G. GABAergic neurons and their role in cortical plasticity in primates. Cereb Cortex 1993, 3:361-372.
24. Kirshblum S. Treatment alternatives for spinal cord injury related spasticity. J Spinal Cord Med 1999, 22:199-217.
25. Kita M., Goodkin D.E. Drugs used to treat spasticity. Drugs 2000, 59:487-495.
26. Kofler M., Donovan W.H., Loubser P.G., Beric A. Effects of intrathecal baclofen on lumbosacral and cortical somatosensory evoked potentials. Neurology 1992, 42:864-868.
27. Kumru H., Vidal J., Kofler M., Benito J., Garcia A., Valls-Sole J. Exaggerated auditory startle responses in patients with spinal cord injury. J Neurol 2008, 255:703-709.
28. Kumru H., Kofler M., Valls-Solé J., Portell E., Vidal J. Brainstem reflexes are enhanced following severe spinal cord injury and reduced by continuous intrathecal baclofen. Neurorehabil Neural Repair 2009, 23:921-927.
29. Kumru H., Murillo N., Vidal J., Valls-Solé J., Edwards D., Pelayo R., Valero-Cabre A., Tormos J.M., Pascual-Leone A. Reduction of spasticity with repetitive transcranial magnetic stimulation in patients with spinal cord injury. Neurorehabil Neural Repair 2010, 24:435-441.
30. Kumru H., Vidal J., Kofler M., Portell E., Valls-Solé J. Alterations in excitatory and inhibitory brainstem interneuronal circuits following severe spinal cord injury. J Neurotrauma 2010, 27:721-728.
31. Lance J.W. The control of muscle tone, reflexes, and movement: Robert Wartenberg lecture. Neurology 1980, 30:1303-1313.
32. Latash M.L., Penn R.D., Corcos D.M., Gottlieb G.L. Short-term effects of intrathecal baclofen in spasticity. Exp Neurol 1989, 103:165-172.
33. Lazorthes Y., Sallerin-Caute B., Verdie J.C., Bastide R., Carillo J.P. Chronic intrathecal baclofen administration for control of severe spasticity. J Neurosurg 1990, 72:393-402.
34. Macdonell R.A., Talalla A., Swash M., Grundy D. Intrathecal baclofen and the H-reflex. J Neurol Neurosurg Psychiatry 1989, 52:1110-1112.
35. Marino R.J., Barros T., Biering-Sorensen F., Burns S.P., Donovan W.H., Graves D.E., Haak M., Hudson L.M., Priebe M.M. ASIA Neurological Standards Committee 2002. International standards for neurological classification of spinal cord injury. J Spinal Cord Med 2003, 26:S50-6.
36. McCall T.D., MacDonald J.D. Cervical catheter tip placement for intrathecal baclofen administration. Neurosurgery 2006, 59:634-639.
37. Meythaler J.M., DeVivo M.J., Hadley M. Prospective study on the use of bolus intrathecal baclofen for spastic hypertonia due to acquired brain injury. Arch Phys Med Rehabil 1996, 77:461-466.
38. Otsuka M., Yanagisawa M. The effects of substance P and baclofen on motoneurones of isolated spinal cord of the newborn rat. J Exp Biol 1980, 89:201-214.
39. Pohl M., Rockstroh G., Rückriem S., Mehrholz J., Pause M., Koch R., Strik H. Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticity. J Neurol 2003, 250:1195-1200.
40. Price G.W., Wilkin G.P., Turnbull M.J., Bowery N.G. Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord?. Nature 1984, 307:71-74.
41. Rothwell J. Investigating reflex pathways and their function. Control of human voluntary movement 1994, 153-216. Chapman and Hall, London. J. Rothwell (Ed.).
42. Sallerin-Caute B., Lazorthes Y., Monsarrat B., Cros J., Bastide R. CSF baclofen levels after intrathecal administration in severe spasticity. Eur J Clin Pharmacol 1991, 40:363-365.
43. Saltuari L., Kronenberg M., Marosi M., Kofler M., Russegger L., Rifici C., Bramanti P., Gerstenbrand F. Long-term intrathecal baclofen treatment in supraspinal spasticity. Acta Neurol (Napoli) 1992, 47:195-207.
44. Sheean G. The pathophysiology of spasticity. Eur J Neurol 2002, 9(Suppl. 1):3-9.
45. Štetkárová I, Vrba I, Kofler M. The effect of intrathecal baclofen bolus on H-reflex and muscle tone in severe spinal spasticty. In: International symposium on spinal cord motor control: from denervated muscles to neurocontrol of locomotion with the 22nd Dr. Janez Faganel memorial lecture proceedings; 2006. p. 104.
46. Stokic D.S., Yablon S.A., Hayes A. Comparison of clinical and neurophysiologic responses to intrathecal baclofen bolus administration in moderate-to-severe spasticity after acquired brain injury. Arch Phys Med Rehabil 2005, 86:1801-1806.
47. Waldvogel H.J., Faull R.L., Jansen K.L., Dragunow M., Richards J.G., Mohler H., Streit P. GABA, GABA receptors and benzodiazepine receptors in the human spinal cord: an autoradiographic and immunohistochemical study at the light and electron microscopic levels. Neuroscience 1990, 39:361-385.