Reduction of spasticity with repetitive transcranial magnetic stimulation in patients with spinal cord injury

Neurorehabilitation and Neural Repair

Volumn 24, Issue 5, 2010, Pages 435-441

  Kumru, Hatice ^a   Murillo, Narda ^a   Vidal Samso, Joan ^a   Valls Sole, Josep ^b   Edwards, Dylan ^c,d   Pelayo, Raul ^a   Valero Cabre, Antoni ^c,e   Tormos, Josep Maria ^a   Pascual Leone, Alvaro ^a,c  

^a University Institute affiliated with the Autonomous University of Barcelona   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Neurophysiological examination; Repetitive TMS; Spasticity; Spinal cord injury

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BICEPS BRACHII MUSCLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MOTOR CORTEX; MOTOR PERFORMANCE; MUSCLE SPASM; MUSCLE TONE; NEUROMUSCULAR FUNCTION; NEUROPHYSIOLOGY; PYRAMIDAL TRACT; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SPASTICITY; SPINAL CORD INJURY; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME; VISUAL ANALOG SCALE; WITHDRAWAL REFLEX;

ACTION POTENTIALS; ADOLESCENT; ADULT; AGED; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEG; MALE; MIDDLE AGED; MUSCLE SPASTICITY; MUSCLE, SKELETAL; PAIN MEASUREMENT; PYRAMIDAL TRACTS; REFLEX; SPINAL CORD INJURIES; TRANSCRANIAL MAGNETIC STIMULATION; YOUNG ADULT;

EID: 77953212384     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968309356095     Document Type: Article

References (26)

1. Frigon A., Rossignol S. Functional plasticity following spinal cord lesions. Prog Brain Res. 2006 ; 157: 231-260.
2. Elbasiouny SM, Moroz D., Bakr MM, Mushahwar VK Management of spasticity after spinal cord injury: Current techniques and future directions [published online ahead of print September 1, 2009]. Neurorehabil Neural Repair. doi:10.1177/1545968309343213.
3. Abbruzzese G. The medical management of spasticity. Eur J Neurol. 2002 ; 9: 30-34.
4. Adams MM, Hicks AL Spasticty after spinal cord injury. Spinal Cord. 2005 ; 43: 577-586.
5. Decq P. Pathophysiology of spasticity. Neurochirurgie. 2003 ; 49: 163-184.
6. Dietz V., Sinkjaer T. Spastic movement disorder: impaired reflex function and altered muscle mechanics. Lancet Neurol. 2007 ; 6: 725-733.
7. Wassermann EM, Lisanby SH Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin Neurophysiol. 2001 ; 112: 1367-1377.
8. Pascual-Leone A., Valls-Sole J., Wassermann EM, Hallett M. Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain. 1994 ; 117: 847-858. (Pubitemid 24281845)
9. Pascual-Leone A., Tormos JM, Keenan J., Tarazona F., Canete C., Catala MD Study and modulation of human cortical excitability with transcranial magnetic stimulation. J Clin Neurophysiol. 1998 ; 5: 333-343.
10. Siebner HR, Rothwell J. Transcranial magnetic stimulation: new insights into representational cortical plasticity. Exp Brain Res. 2003 ; 148: 1-16.
11. Berardelli A., Inghilleri M., Rothwell JC, et al. Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp Brain Res. 1998 ; 122: 79-84.
12. Romero JR, Anschel D., Sparing R., Gangitano M., Pascual-Leone A. Subthreshold low frequency repetitive transcranial magnetic stimulation selectively decreases facilitation in the motor cortex. Clin Neurophysiol. 2002 ; 113: 101-107. (Pubitemid 34093861)
13. Perez MA, Lungholt BK, Nielsen JB Short-term adaptations in spinal cord circuits evoked by repetitive transcranial magnetic stimulation: possible underlying mechanisms. Exp Brain Res. 2005 ; 162: 202-212.
14. Quartarone A., Bagnato S., Rizzo V., et al. Distinct changes in cortical and spinal excitability following high-frequency repetitive TMS to the human motor cortex. Exp Brain Res. 2005 ; 161: 114-124.
15. Valero-Cabre A., Oliveri M., Gangitano M., Pascual-Leone A. Modulation of spinal cord excitability by subthreshold repetitive transcranial magnetic stimulation of the primary motor cortex in humans. Neuroreport. 2001 ; 12: 3845-3848.
16. Centonze D., Koch G., Versace V., et al. Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis. Neurology. 2007 ; 68: 1045-1050.
17. Valle AC, Dionisio K., Pitskel NB, et al. Low and high frequency repetitive transcranial magnetic stimulation for the treatment of spasticity. Dev Med Child Neurol. 2007 ; 49: 534-538.
18. Marino RJ, Barros T., Biering-Sorensen F., et al. ASIA Neurological Standards Committee 2002. International standards for neurological classification of spinal cord injury. J Spinal Cord Med. 2003 ; 26 (suppl 1). S50 - S56.
19. Bohannon RW, Smith MB Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther. 1987 ; 67: 206-207.
20. Nielsen JF, Sinkjaer T., Jakobsen J. Treatment of spasticity with repetitive magnetic stimulation: a double-blind placebo-controlled study. Mult Scler. 1996 ; 2: 227-232.
21. Pierrot-Deseilligny E., Burke D. The Circuitry of the Human Spinal Cord: Its Role in Motor Control and Movement Disorders. Cambridge, UK: Cambridge University Press ; 2005.
22. Peinemann A., Reimer B., Loer C., et al. Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex. Clin Neurophysiol. 2004 ; 115: 1519-1526.
23. Baumer T., Lange R., Liepert J., et al. Repeated premotor rTMS lead to cumulative changes of motor cortex excitability in humans. Neuroimage. 2003 ; 20: 550-560.
24. Buhmann C., Gorsler A., Baumer T., et al. Abnormal excitability of premotor-motor connections in de novo Parkinsong's disease. Brain. 2004 ; 127: 2732-2746.
25. Nielsen JF, Sinkjaer T. Long-lasting depression of soleus motoneurons excitability following repetitive magnetic stimuli of the spinal cord in multiple sclerosis patients. Mult Scler. 1997 ; 3: 18-30.
26. Siebner HR, Peller M., Willoch F., et al. Lasting cortical activation after repetitive TMS of the motor cortex: a glucose metabolic study. Neurology. 2000 ; 54: 956-963.