The anti-inflammatory and antibacterial basis of human omental defense: Selective expression of cytokines and antimicrobial peptides

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Chandra, Abhijit ^a   Srivastava, Ritesh Kumar ^b,c   Kashyap, Mahendra Pratap ^b,c   Kumar, Raj ^d   Srivastava, Rajeshwar Nath ^a   Pant, Aditya Bhushan ^b  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^c NATIONAL CHEMICAL LABORATORY   (India)

^d Geisinger Health Geisinger Commonwealth School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; PEPTIDE; PEPTIDE HBD 1; PEPTIDE HBD 2; PEPTIDE HNP1-3; POLYPEPTIDE ANTIBIOTIC AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; ANTIMICROBIAL CATIONIC PEPTIDE;

ADIPOCYTE; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; MOLECULAR DYNAMICS; NONHUMAN; OMENTUM; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; VALIDATION STUDY; WESTERN BLOTTING; WOUND HEALING; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; INFLAMMATION; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROTEIN SYNTHESIS;

ADIPOCYTES; ANTI-INFLAMMATORY AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; OMENTUM; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 79956346743     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020446     Document Type: Article

References (33)

1. Liebermann-Meffert D, (2000) The greater omentum: anatomy, embryology, and surgical applications. Surg Clin North Am 80: 275-293.
2. Disen DL, Skinner M, (2008) Spontaneous sealing of a neonatal intestinal perforation by the omentum. J Ped Surg 43: 2308-2310.
3. Zhang QX, Magovern CJ, Mack CA, Budenbender KT, Ko W, et al. (1997) Vascular endothelial growth factor is the major angiogenic factor in omentum: mechanism of the omentum-mediated angiogenesis. J Surg Res 67 (2): 147-154.
4. Litbarg NO, Gudehithlu KP, Sethupathi P, Arruda JA, Dunea G, et al. (2007) Activated omentum becomes rich in factors that promote healing and tissue regeneration. Cell Tissue Res 328: 487-497.
5. Paslakis G, Keuneke C, Groene HJ, Schroppel B, Schmid H, et al. (2010) The putative role of human peritoneal adipocytes in the fight against bacteria: synthesis of the antimicrobial active peptide DEFA1-3. Nephron Exp Nephrol 115 (4): e96-100.
6. Shimutsoma M, Takahashi T, Kawata M, Dux K, (1991) Cellular subsets of the milkynspots in human greater omentum. Cell Tissue Res 264: 599-601.
7. Fain JN, Bahouth SW, Madan AK, (2004) TNFα release by the nonfat cells of human adipose tissue. Intl J Obes Relat Metab Disord 28: 616-622.
8. Fain JN, Bahouth SW, Madan AK, (2005) Involvement of multiple signaling pathways in the post-bariatric induction of IL-6 and IL-8 mRNA and release in human visceral adipose tissue. Biochem Pharmacol 69: 1315-1324.
9. Fain JN, Cheema P, Tichansky DS, Madan AK, (2010) The inflammatory response seen when human omental adipose tissue explants are incubated in primary culture is not dependent upon albumin and is primarily in the nonfat cells. J Inflamm 7: 4.
10. Bassols J, Ortega FJ, Moreno-Navarrete JM, Peral B, Ricart W, et al. (2009) Study of the proinflammatory role of human differentiated omental adipocytes. J Cell Biochem 107: 1107-1117.
11. Zhu S, Sun F, Li W, Cao Y, Wang C, et al. (2011) Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes. Mol Cell Biochem In press.
12. Ouchi N, Parker JL, Lugus JJ, Walsh K, (2011) Adipokines in inflammation and metabolic disease. Nat Rev Immunol 11 (2): 85-97.
13. Maenhaut N, Van de Voorde J, (2011) Regulation of vascular tone by adipocytes. BMC Med 9: 25.
14. Puma F, Fedeli C, Ottavi P, Porcaro G, Battista Fonsi G, et al. (2003) Laparoscopic omental flap for the treatment of major sternal wound infection after cardiac surgery. J Thorac Cardiovasc Surg 126: 1998-2002.
15. Yoshida K, Ohshima H, Murakami F, Tomida Y, Matsuura A, et al. (1997) Omental transfer as a method of preventing residual persistent subcutaneous infection after mediastinitis. Ann Thorac Surg 63: 858-860.
16. Kuniyoshi Y, Koja K, Miyagi K, Uezu T, Yamashiro S, et al. (2005) Graft for Mycotic thoracic aortic aneurysm; omental wrapping to prevent infection. Asian Cardio Vasc Thorac Annals 13: 11-16.
17. Melzig MF, Loose R, (1995) Investigations into the mechanism of toxicity of lipopolysaccharide (LPS) in bovine aortic endothelial cells. Pharmiziee 50: 558-560.
18. Mattacks CA, Pond CM, (1999) Interactions of noradrenalin and tumor necrosis factor, interleukin 4 and interleukin 6 in the control of lipolysis from adipocytes around lymph nodes. Cytokine 11: 334-346.
19. Bender TO, Riesenhuber A, Endemann M, Herkner K, Witowski J, et al. (2007) Correlation between HSP-72 expression and IL-8 secretion in human mesothelial cells. Int J Artif Organs 30: 199-203.
20. Kim CS, Park HS, Kawada T, Kim JH, Lim D, et al. (2006) Circulatinglevels of MCP-1 and IL 8 are elevated in human obese subjects and associated with obesity related parameters. Int J Obes 30: 1347-1355.
21. Sopasakis VR, Nagaev I, Smith U, (2005) Cytokine release from adipose tissue of nonobese individuals. International Journal of Obesity 29: 1144-1147.
22. Schroder K, Hertzog PJ, Ravasi T, Hume DA, (2004) Interferon-γ an overview of signals, mechanisms and functions. J Leukoc Biol 75: 163-189.
23. Delbridge LM, O'Riordan MX, (2007) Innate recognition of intracellular bacteria. Curr Opin Immunol 19 (1): 10-16.
24. Greenbaum D, Colangelo C, Williams K, Gerstein Mark, (2003) Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biology 4: 117.
25. Stanley AC, Lacy P, (2010) Pathways for Cytokine Secretion. Physiology 25: 218-229.
26. Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, et al. (2000) The Lipopolysaccharide-activatedtoll reseptor(TLR) 4 induces synthesisof the closely related receptorTLR2 in adipocytes. J Biol Chem 275: 24255-24263.
27. Elsbach P, (2003) What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses? J Clin Invest 111: 1643-1645.
28. Oudhoff MJ, Blaauboer ME, Nazmi K, Scheres N, Bolscher JG, et al. (2010) The role of salivary histatin and the human cathelicidin LL-37 in wound healing and innate immunity. Biol Chem 391: 541-548.
29. Sewter CP, Digby JE, Blows F, Prins J, O'Rahilly S, (1999) Regulation of tumor necrosis factor- alpha release from human adipose tissue in vitro. J Endocrinol 163: 33-38.
30. Maury E, Ehala-Aleksejev K, Guiot Y, Detry R, Vandenhooft A, et al. (2007) Adipokines oversecreted by omental adipose tissue in human obesity. Am J Physiol Endocrinol Metab 293: E656-E665.
31. Srivastava RK, Lohani M, Pant AB, Rahman Q, (2010) Cyto-Genotoxicity of Amphibole Asbestos Fibers in Cultured Human Lung Epithelial Cell Line: Role of surface iron. Toxicol Ind Health 26: 575-582.
32. Kashyap MP, Singh AK, Siddiqui MA, Kumar V, Tripathi VK, et al. (2010) Caspase cascade regulated mitochondria mediated apoptosis in Monocrotophos exposed PC12 cells. Chem Res Toxicol 23: 1663-1672.
33. Kashyap MP, Singh AK, Kumar V, Tripathi VK, Srivastava RK, et al. (2010) Monocrotophos induced apoptotic changes in PC12 cells: involvement of xenobiotic metabolizing cytochrome P450s. PLOs One. PLoS ONE 6 (3): e17757.