The neonatal Fc receptor is expressed by human retinal pigment epithelial cells and is downregulated by tumour necrosis factor-alpha

British Journal of Ophthalmology

Volumn 95, Issue 6, 2011, Pages 864-868

  Van Bilsen, Kiki ^a   Van Hagen, P Martin ^a   Bastiaans, Jeroen ^a,b   Van Meurs, Jan C ^b   Missotten, Tom ^b   Kuijpers, Robert W ^a   Hooijkaas, Herbert ^a   Dingjan, Gemma M ^a   Baarsma, G Seerp ^b   Dik, Willem A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ROTTERDAM EYE HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; FC RECEPTOR; GAMMA INTERFERON; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EYE INFLAMMATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

BETA 2-MICROGLOBULIN; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; DOWN-REGULATION; EPITHELIAL CELLS; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HT29 CELLS; HUMANS; RECEPTORS, FC; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79956345472     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjo.2010.187930     Document Type: Article

References (24)

1. Simister NE, Mostov KE. An Fc receptor structurally related to MHC class I antigens. Nature 1989;337:184-7. (Pubitemid 19025381)
2. Akilesh S, Christianson GJ, Roopenian DC, et al. Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism. J Immunol 2007;179:4580-8.
3. Chaudhury C, Mehnaz S, Robinson JM, et al. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 2003;197:315-22. (Pubitemid 36184238)
4. Ward ES, Zhou J, Ghetie V, et al. Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans. Int Immunol 2003;15:187-95. (Pubitemid 36267110)
5. Ghetie V, Hubbard JG, Kim JK, et al. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol 1996;26:690-6. (Pubitemid 26091401)
6. Wani MA, Haynes LD, Kim J, et al. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc Natl Acad Sci U S A 2006;103:5084-9.
7. Bitonti AJ, Dumont JA. Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway. Adv Drug Deliv Rev 2006;58:1106-18. (Pubitemid 44709269)
8. Schlachetzki F, Zhu C, Pardridge WM. Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier. J Neurochem 2002;81:203-6. (Pubitemid 34808868)
9. Cauza K, Hinterhuber G, Dingelmaier-Hovorka R, et al. Expression of FcRn, the MHC class I-related receptor for IgG, in human keratinocytes. J Invest Dermatol 2005;124:132-9. (Pubitemid 40100961)
10. Liu X, Ye L, Christianson GJ, et al. NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences. J Immunol 2007;179:2999-3011.
11. Kim H, Fariss RN, Zhang C, et al. Mapping of the neonatal Fc receptor in the rodent eye. Invest Ophthalmol Vis Sci 2008;49:2025-9.
12. Kim H, Robinson SB, Csaky KG. FcRn receptor-mediated pharmacokinetics of therapeutic IgG in the eye. Mol Vis 2009;15:2803-12.
13. Dik WA, Nadel B, Przybylski GK, et al. Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL. Blood 2007;110:388-92. (Pubitemid 47026860)
14. van Steensel L, Paridaens D, Schrijver B, et al. Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy. Invest Ophthalmol Vis Sci 2009;50:3091-8.
15. Israel EJ, Taylor S, Wu Z, et al. Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology 1997;92:69-74. (Pubitemid 27380883)
16. Zhu X, Meng G, Dickinson BL, et al. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol 2001;166:3266-76. (Pubitemid 33117326)
17. Kobayashi N, Suzuki Y, Tsuge T, et al. FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells. Am J Physiol Renal Physiol 2002;282:F358-65.
18. de Ridder D, van der Linden CE, Schonewille T, et al. Purity for clarity: the need for purification of tumor cells in DNA microarray studies. Leukemia 2005;19:618-27. (Pubitemid 40528351)
19. Brito BE, O'Rourke LM, Pan Y, et al. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 1999;40:2583-9. (Pubitemid 29455487)
20. Oh H, Takagi H, Takagi C, et al. The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes. Invest Ophthalmol Vis Sci 1999;40:1891-8. (Pubitemid 29365148)
21. Sfikakis PP, Theodossiadis PG, Katsiari CG, et al. Effect of infliximab on sight-threatening panuveitis in Behcet's disease. Lancet 2001;358:295-6. (Pubitemid 32738970)
22. Lindstedt EW, Baarsma GS, Kuijpers RW, et al. Anti-TNF-alpha therapy for sight threatening uveitis. Br J Ophthalmol 2005;89:533-6. (Pubitemid 40569703)
23. Fekkar A, Bodaghi B, Touafek F, et al. Comparison of immunoblotting, calculation of the Goldmann-Witmer coefficient, and real-time PCR using aqueous humor samples for diagnosis of ocular toxoplasmosis. J Clin Microbiol 2008;46:1965-7. (Pubitemid 351831828)
24. Lux A, Llacer H, Heussen FM, et al. Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions. Br J Ophthalmol 2007;91:1318-22. (Pubitemid 47492865)