Visualization and analysis of superparamagnetic iron oxide nanoparticles in the inner ear by light microscopy and energy filtered TEM

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 7, Issue 3, 2011, Pages 360-369

  Thaler, Marlene ^a,d   Roy, Soumen ^b,d   Fornara, Andrea ^c   Bitsche, Mario ^b   Qin, Jian ^c   Muhammed, Mamoun ^c   Salvenmoser, Willi ^d   Rieger, Gunde ^b,d   Fischer, Anneliese Schrott ^b   Glueckert, Rudolf ^b  

^a CARL ZEISS SMT AG   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^d UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Energy filtered transmission electron microscopy; Human temporal bone; Iron oxide nanoparticles; Organotypic inner ear explant culture

Indexed keywords

CROSS-LINKED HYDROGELS; ENERGY FILTERED TEM; ENERGY FILTERED TRANSMISSION ELECTRON MICROSCOPY; HUMAN TEMPORAL BONE; IMAGING MODES; IN-VITRO TESTS; INNER EAR; IRON OXIDE NANOPARTICLE; IRON OXIDE NANOPARTICLES; LIGHT MICROSCOPY; PLURONICS; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; TEMPORAL BONE; VISUALIZATION AND ANALYSIS;

BONE; COPOLYMERIZATION; COPOLYMERS; DRUG DELIVERY; HYDROGELS; IRON; NANOPARTICLES; SUPERPARAMAGNETISM; TRANSMISSION ELECTRON MICROSCOPY; VISUALIZATION;

IRON OXIDES;

FERRIC FERROCYANIDE; POLOXAMER; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CADAVER; CONTROLLED STUDY; CROSS LINKING; ENERGY FILTERED TRANSMISSION ELECTRON MICROSCOPY; EXPLANT; HUMAN; HYDROGEL; INNER EAR; MICROSCOPY; MOUSE; NONHUMAN; TEMPORAL BONE; TISSUE CHARACTERIZATION; VISCOSITY;

ANIMALS; EAR, INNER; ENDOSOMES; FERRIC COMPOUNDS; FERROCYANIDES; HUMANS; MAGNETITE NANOPARTICLES; MICE; MICE, INBRED C57BL; MICROSCOPY, ENERGY-FILTERING TRANSMISSION ELECTRON; ORGAN CULTURE TECHNIQUES; RATS;

EID: 79956340120     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2010.11.005     Document Type: Article

References (24)

1. Rask-Andersen H., Schrott-Fischer A., Pfaller K., Glueckert R. Perilymph/modiolar communication routes in the human cochlea. Ear Hear 2006, 27:457-465.
2. Lange G. 27 years experiences with transtympanic aminoglycoside treatment of Meniere's disease. Laryngorhinootologie 1995, 74:720-723.
3. Takemura K., Komeda M., Yagi M., Himeno C., Izumikawa M., Doi T., et al. Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig. Hear Res 2004, 196:58-68.
4. Arnold W., Senn P., Hennig M., Michaelis C., Deingruber K., Scheler R., et al. Novel slow- and fast-type drug release round-window microimplants for local drug application to the cochlea: An experimental study in guinea pigs. Audiol Neurootol 2005, 10:53-63.
5. Park H., Shalaby W.S.W., Park H. Biodegradable hydrogels for drug delivery 1993, Technomic Publishing Company Inc., Pennsylvania, USA.
6. Gouveris H., Selivanova O., Mann W. Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensorineural hearing loss after failure of intravenous steroid and vasoactive therapy. Eur Arch Otorhinolaryngol 2005, 262:131-134.
7. Silverstein H., Rosenbery S., Arruda J., Deams D. Direct round window membrane application of gentamicin in the treatment of Meniere's disease. Otolaryngology. Otolaryngol Head Neck Surg 1999, 120(5):649-655.
8. Hoffer M.E., Balough B., Henderson J., DeCicco M., Wester D., O'Leary M.J., et al. Use of sustained release vehicles in the treatment of Meniere's disease. Otolaryngol Clin North Am 1997, 30:1159-1166.
9. Na H.B., Song I.C.H.T. Inorganic Nanoparticles for MRI Contrast Agents. Advanced Materials 2009, 21:2133-2148.
10. Qin J., Laurent S., Jo Y.S., Roch A., Mikhaylova M., Bhujwalla Z.M., et al. A High-Performance Magnetic Resonance Imaging T2 Contrast Agent. Advanced Material 2007, 19:1874-1878.
11. Fornara A., Johansson P., Petersson K., Gustafsson S., Qin J.O.E., Ilver D., et al. Tailored Magnetic Nanoparticles for Direct and Sensitive Detection of Biomolecules in Biological Samples. Nano Letters 2008, 8(10):3423-3428.
12. Gupta A.K., Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005, 26:3995-4021.
13. Kopke R.D., Wassel R.A., Mondalek F., Grady B., Chen K., Liu J., et al. Magnetic nanoparticles: Inner ear targeted molecule delivery and middle ear implant. Audiol Neurootol 2006, 11:123-133.
14. Barnes A.L., Wassel R.A., Mondalek F., Chen K., Dormer K.J., Kopke R.D. Magnetic characterization of superparamagnetic nanoparticles pulled through model membranes. Biomagn Res Technol 2007, 5:1.
15. Rill R.L., Locke B.R., Liu Y., van Winkle D.H. Electrophoresis in lyotropic polymer liquid crystals. Proc Acad Sci U S A 1998, 95(4):1534-1539.
16. Qin J., Asempah I., Laurent S., Fornara A., Muller R.N., Muhammed M. Injectable superparamagnetic ferrogels for controlled release of hydrophobic drugs. Adv Mater 2009, 21:1354-1357.
17. Ding D., Stracher A., Salvi R.J. Leupeptin protects cochlear and vestibular hair cells from gentamicin ototoxicity. Hear Res 2002, 164:115-126.
18. Romeis B., Böck P. Mikroskopische Technik. Urban & Fischer bei Elsevier 1989, 17.
19. Bauer R. Electron Spectroscopic Imaging: An advanced technique for imaging and analysis in transmission electron microscopy. Methods Microbiol 1988, 20:113-146.
20. Egerton R.F. Electron Energy Loss Spectroscopy in the Electron Microscope 1986, 410. Plenum Press, New York.
21. Hofer F., Grogger W., Kothleitner G., Warbichler P. Quantitative analysis of EFTEM elemental distribution images. Ultramicroscopy 1997, 67:83-103.
22. Ferrati S., Mack A., Chiappini C., Liu X., Bean A.J., Ferrari M., et al. Intracellular trafficking of silicon particles and logic-embedded vectors. Nanoscale 2010, 2:1512-1520.
23. Sundstrom L., Pringle A., Morrison B., Bradley M. Organotypic cultures as tools for functional screening in the CNS. Drug Discov Today 2005, 10(14):993-1000.
24. Roy S., Johnston A.H., Newman T.A., Glueckert R., Dudas J., Bitsche M Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neurotrophin-derived peptide ligand: Potential tool for drug delivery. Int J Pharm 2010, 390(2):214-224.