Soluble interleukine-2 recptor and MDR1 gene expression levels as inflammatory biomarkers for prediction of steroid response in children with nephrotic syndrome

Iranian Journal of Kidney Diseases

Volumn 5, Issue 3, 2011, Pages 154-161

  Youssef, Doaa Mohammed ^a   Elbehidy, Rabab Mohammed ^a   Abdelhalim, Hosam Salah ^b   Amr, Ghada Elsyde ^b  

^a ZAGAZIG UNIVERSITY   (Egypt)

^b Zagazig University   (Egypt)

Author keywords

Interlekin 2; Multidrug resistant protein 1; Nephrotic syndrome; P glycoprotein 1

Indexed keywords

CYCLOPHOSPHAMIDE; MULTIDRUG RESISTANCE PROTEIN 1; PREDNISONE; SOLUBLE INTERLEUKIN 2 RECEPTOR; BIOLOGICAL MARKER; GLUCOCORTICOID; GLYCOPROTEIN P; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; PREDNISOLONE;

ARTICLE; CASE CONTROL STUDY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG RESPONSE; FEMALE; GENE; GENE EXPRESSION; HUMAN; LYMPHOCYTE; MALE; MULTIDRUG RESISTANT GENE 1 GENE; NEPHROTIC SYNDROME; PREDICTION; PROTEIN BLOOD LEVEL; RELAPSE; REMISSION; SCHOOL CHILD; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG RESISTANCE; FOLLOW UP; GENETICS; METABOLISM; POLYMERASE CHAIN REACTION; PROGNOSIS;

BIOLOGICAL MARKERS; CHILD; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MALE; NEPHROTIC SYNDROME; P-GLYCOPROTEIN; POLYMERASE CHAIN REACTION; PREDNISOLONE; PROGNOSIS; REMISSION INDUCTION; RNA, MESSENGER;

EID: 79956335302     PISSN: 17358582     EISSN: 17358604     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Araya C, Diaz L, Wasserfall C, et al. T regulatory cell function in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol. 2009;24:1691-8.
2. Aviles DH, Vehaskari MV, Culotta KS, Manning J, Ochoa AC, Zea AH. T cell CD3 receptor zeta (TCRzeta)-chain expression in children with idiopathic nephrotic syndrome. Pediatr Nephrol. 2009;24:769-73.
3. Shimoyama H, Nakajima M, Naka H, et al. Up-regulation of interleukin-2 mRNA in children with idiopathic nephrotic syndrome. Pediatr Nephrol. 2004;19:1115-21.
4. Funaki S, Takahashi S, Wada N, Murakami H, Harada K. Multiple drug-resistant gene 1 in children with steroid-sensitive nephrotic syndrome. Pediatr Int. 2008;50:159-61.
5. Tsujimura S, Saito K, Nakayamada S, Nakano K, Tanaka Y. Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus. Arthritis Rheum. 2005;52:1676-83.
6. Meijer OC, de Lange EC, Breimer DD, de Boer AG, Workel JO, de Kloet ER. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology. 1998;139:1789-93.
7. Webster JI, Carlstedt-Duke J. Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response. J Steroid Biochem Mol Biol. 2002;82:277-88.
8. Candiano G, Musante L, Carraro M, et al. Apolipoproteins prevent glomerular albumin permeability induced in vitro by serum from patients with focal segmental glomerulosclerosis. J Am Soc Nephrol. 2001;12:143-50.
9. Glassock RJ. Steroid-resistant Nephrotic syndrome. Am J Nephrol. 2004;24:70.
10. Zhu-Wen Y, Qing-Nan H. Strengthening clinical research into childhood steroid-resistant nephrotic syndrome. World J Pediatr. 2006;3:15.
11. Hulton SA, Shah V, Byrne MR, Morgan G, Barratt TM, Dillon MJ. Lymphocyte subpopulations, interleukin-2 and interleukin-2 receptor expression in childhood nephritic syndrome. Pediatr Nephrol. 1994;8:135-9.
12. El-Osta A, Kantharidis P, Zalcberg J. Absolute quantitation of MDR1 transcripts using heterologous DNA standards-validation of the competitive RT-PCR (CRT-PCR) approach. Biotechniques. 1999;26:1114-6, 8-20, 22 passim.
13. [No authors listed]. Consensus statement on management of steroid sensitive nephrotic syndrome. Indian Pediatr. 2001;38:975-86.
14. Nourusis MJ. Statistical package for social sciences base 8.0 for windows. Users guide. Chicago: SPSS; 1997.
15. Hogg RJ, Portman RJ, Milliner D, Lemley KV, Eddy A, Ingelfinger J. Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the National Kidney Foundation conference on proteinuria, albuminuria, risk, assessment, detection, and elimination (PARADE). Pediatrics. 2000;105:1242-9.
16. Farrell RJ, Kelleher D. Glucocorticoid resistance in inflammatory bowel disease. J Endocrinol. 2003;178: 339-46.
17. Tsujimura S, Saito K, Nakayamada S, et al. Transcriptional regulation of multidrug resistance-1 gene by interleukin-2 in lymphocytes. Genes Cells. 2004;9:1265-73.
18. Lama G, Luongo I, Tirino G, Borriello A, Carangio C, Salsano ME. T-lymphocyte populations and cytokines in childhood nephrotic syndrome. Am J Kidney Dis. 2002;39:958-65.
19. Aviles DH, Matti Vehaskari V, Manning J, Ochoa AC, Zea AH. Decreased expression of T-cell NF-kappaB p65 subunit in steroid-resistant nephrotic syndrome. Kidney Int. 2004;66:60-7.
20. McBryde KD, Kershaw DB, Smoyer WE. Pediatric steroid-resistant nephrotic syndrome. Curr Probl Pediatr 2001;31:275-307.
21. Swiatecka-Urban A. Anti-interleukin-2 receptor antibodies for the prevention of rejection in pediatric renal transplant patients: current status. Paediatr Drugs. 2003;5:699-716.
22. Maillefert JF, Maynadie M, Tebib JG, et al. Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. The percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisolone. Br J Rheumatol. 1996;35:430-5.