Up-regulation of interleukin-2 mRNA in children with idiopathic nephrotic syndrome

Pediatric Nephrology

Volumn 19, Issue 10, 2004, Pages 1115-1121

  Shimoyama, Hironobu ^a   Nakajima, Mitsuru ^a   Naka, Hiroyuki ^a   Maruhashi, Yoshiyuki ^a   Akazawa, Hideki ^a   Ueda, Taku ^a   Nishiguchi, Masayuki ^a   Yamoto, Yoko ^a   Kamitsuji, Hidekazu ^b   Yoshioka, Akira ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b NARA MEDICAL UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cytokines; Idiopathic nephrotic syndrome; Interleukin 2; mRNA; Real time PCR assay

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELLULAR DISTRIBUTION; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE LOCATION; HUMAN; HYPOTHESIS; IDIOPATHIC DISEASE; IMMUNE RESPONSE; MALE; MONONUCLEAR CELL; NEPHROTIC SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; QUANTITATIVE ANALYSIS; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; UPREGULATION;

CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-4; MALE; NEPHROTIC SYNDROME; RNA, MESSENGER; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 4844226349     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-004-1569-y     Document Type: Article

References (26)

1. Neuhaus TJ, Shah V, Callard RE, Barratt TM (1999) T-lymphocyte activation in steroid-sensitive nephrotic syndrome in childhood. Nephrol Dial Transplant 10: 1348-1352
2. Cho BS, Yoon SR, Jang JY, Pyun KH, Lee CE (1999) Upregulation of interleukin-4 and CD23/Fc epsilon RII in minimal change nephrotic syndrome. Pediatr Nephrol 13:199-204
3. Frank C, Herrmann M, Fernandez S, Dirnecker D, Boswald M, Kolowos W, Ruder H, Haas JP (2000) Dominant T cells in idiopathic nephrotic syndrome of childhood. Kidney Int 57: 510-517
4. Daniel V, Trautmann Y, Konrad M, Nayir A, Scharer K (1997) T-lymphocyte populations, cytokines and other growth factors in serum and urine of children with idiopathic nephrotic syndrome. Clin Nephrol 47:289-297
5. Stachowski J, Barth C, Michalkiewicz J, Krynicki T, Jarmolinski T, Runowski D, Lewandowska-Stachowiak M, Zaniew M, Warzywoda A, Bortkiewicz E, Dobosz M, Maciejewski J, Baldamus CA (2000) Th1/Th2 balance and CD45-positive T cell subsets in primary nephrotic syndrome. Pediatr Nephrol 14:779-785
6. Lama G, Luongo I, Tirino G, Borriello A, Carangio C, Salsano ME (2002) T-lymphocyte populations and cytokines in childhood nephrotic syndrome. Am J Kidney Dis 39:958-965
7. Brodehl J (1991) The treatment of minimal change nephrotic syndrome: lessons learned from multicentre co-operative studies. Eur J Pediatr 150:380-387
8. Melvin T, Bennett W (1991) Management of nephrotic syndrome in childhood. Drugs 42:30-51
9. Tejani A, Suthanthiran M, Pomrantz A (1991) A randomized controlled trial of low-dose prednisone and ciclosporin versus high-dose prednisone in nephrotic syndrome of children. Nephron 59:96-99
10. Neuhaus TJ, Wadhwa M, Callard R, Barratt TM (1995) Increased IL-2, IL-4 and interferon-gamma (IFN-gamma) in steroid-sensitive nephrotic syndrome. Clin Exp Immunol 100: 475-479
11. Stefanovic V, Golubovic E, Mitic-Zlatkovic M, Vlahovic P, Jovanovic O, Bogdanovic R (1998) Interleukin-12 and interferon-gamma production in childhood idiopathic nephrotic syndrome. Pediatr Nephrol 12:463-466
12. Matsumoto K, Kanmatsuse K (2001) Elevated interleukin-18 levels in the urine of nephrotic patients. Nephron 88:334-339
13. Bustos C, Gonzalez E, Muley R, Alonso JL, Egido J (1994) Increase of tumour necrosis factor alpha synthesis and gene expression in peripheral blood mononuclear cells of children with idiopathic nephrotic syndrome. Eur J Clin Invest 24:799-805
14. Hinoshita F, Noma T, Tomura S, Shiigai T, Yata J (1990) Decreased production and responsiveness of interleukin 2 in lymphocytes of patients with nephrotic syndrome. Nephron 54:122-126
15. Suranyi MG, Guasch A, Hall BM, Myers BD (1993) Elevated levels of tumor necrosis factor-alpha in the nephrotic syndrome in humans. Am J Kidney Dis 21:251-259
16. A report of the International Study of Kidney Disease in Children (1981) The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. J Pediatr 98:561-564
17. Powrie F, Coffman RL (1993) Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol Today 14:270-274
18. Romagnani S (1995) Biology of human TH1 and TH2 cells. J Clin Immunol 15:121-129
19. Kunzendorf U, Tran TH, Bulfone-Paus S (1998) The Th1-Th2 paradigm in 1998: law of nature or rule with exceptions. Nephrol Dial Transplant 13:2445-2448
20. Laflam PF, Haraguchi S, Garin EH (2002) Cytokine mRNA profile in lipoid nephrosis: evidence for increased IL-8 mRNA stability. Nephron 91:620-626
21. Stordeur P, Poulin LF, Craciun L, Zhou L, Schandene L, Lavareille A de, Goriely S, Goldman M (2002) Cytokine mRNA quantification by real-time PCR. J Immunol Methods 259:55-64
22. Yap HK, Cheung W, Murugasu B, Sim SK, Seah CC, Jordan SC (1999) Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse. J Am Soc Nephrol 10:529-537
23. Sahali D, Pawlak A, Valanciute A, Grimbert P, Lang P, Remy P, Bensman A, Guellen G (2002) A novel approach to investigation of the pathogenesis of active minimal-change nephrotic syndrome using subtracted cDNA library screening. J Am Soc Nephrol 13:1238-1247
24. Hirano T, Akashi T, Keira T, Oka K, Ihoya N, Yoshida (2000) Clinical impact of cyclosporine cellular pharmacodynamics in minimal change nephrotic syndrome. Clin Pharmacol Ther 68:532-540
25. Briggs WA, Han SH, Miyakawa H, Burdick JF, Kwon HM (1999) Effects of glucocorticoids and cyclosporine on IL-2 and I kappa B alpha mRNA expression in human peripheral blood mononuclear cells. J Clin Pharmacol 39:119-124
26. Fujimoto S, Yamamoto Y, Hisanaga S, Yokota N, Eto T (1992) Recombinant interleukin-2 alone did not induce proteinuria with changes in anionic sites of the glomerular basement membrane in rats. Nephron 61:117-118