Effects of resistance and aerobic exercise on physical function, bone mineral density, OPG and RANKL in older women

Experimental Gerontology

Volumn 46, Issue 7, 2011, Pages 524-532

  Marques, Elisa A ^a   Wanderley, Flávia ^a   Machado, Leandro ^a   Sousa, Filipa ^a   Viana, João L ^b   Moreira Gonçalves, Daniel ^a   Moreira, Pedro ^a   Mota, Jorge ^a   Carvalho, Joana ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Age; Biomarkers; Bone mass; Exercise; Fall risk

Indexed keywords

LACTASE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

ACCELEROMETRY; AEROBIC EXERCISE; AGED; ARTICLE; BODY COMPOSITION; BODY EQUILIBRIUM; BONE DENSITY; CONTROLLED STUDY; DIETARY INTAKE; FALL RISK; FEMALE; FEMUR; GREATER TROCHANTER; HIP; HUMAN; HUMAN EXPERIMENT; MUSCLE STRENGTH; NORMAL HUMAN; PHYSICAL ACTIVITY; PHYSICAL CAPACITY; PRIORITY JOURNAL; RESISTANCE TRAINING; VOLUNTEER;

AGED; AGED, 80 AND OVER; BODY COMPOSITION; BONE DENSITY; ENERGY INTAKE; EXERCISE; FEMALE; HUMANS; MIDDLE AGED; MUSCLE STRENGTH; OSTEOPROTEGERIN; PATIENT COMPLIANCE; POSTURAL BALANCE; RANK LIGAND; RESISTANCE TRAINING;

EID: 79956327851     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.02.005     Document Type: Article

References (63)

1. Abrahamova D., Hlavacka F. Age-related changes of human balance during quiet stance. Physiol. Res. 2008, 57:957-964.
2. Bacsi K., Kosa J.P., Lazary A., Balla B., Horvath H., Kis A., Nagy Z., Takacs I., Lakatos P., Speer G. LCT 13910C/T polymorphism, serum calcium, and bone mineral density in postmenopausal women. Osteoporos. Int. 2009, 20:639-645.
3. Bailey C.A., Brooke-Wavell K. Exercise for optimising peak bone mass in women. Proc. Nutr. Soc. 2008, 67:9-18.
4. Bemben D.A., Bemben M.G. Dose-response effect of 40weeks of resistance training on bone mineral density in older adults. Osteoporos. Int. 2010, 10.1007/s00198-00010-01182-00199.
5. Bohannon R.W. One-legged balance test times. Percept. Mot. Skills 1994, 78:801-802.
6. Bonaiuti D., Shea B., Iovine R., Negrini S., Robinson V., Kemper H.C., Wells G., Tugwell P., Cranney A. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst. Rev. 2002, CD000333.
7. Borer K.T. Physical activity in the prevention and amelioration of osteoporosis in women: interaction of mechanical, hormonal and dietary factors. Sports Med. 2005, 35:779-830.
8. Borg G., Hassmen P., Lagerstrom M. Perceived exertion related to heart rate and blood lactate during arm and leg exercise. Eur. J. Appl. Physiol. Occup. Physiol. 1987, 56:679-685.
9. Boyce B.F., Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch. Biochem. Biophys. 2008, 473:139-146.
10. Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
11. Brooke-Wavell K., Jones P.R., Hardman A.E., Tsuritan, Yamada Y. Commencing, continuing and stopping brisk walking: effects on bone mineral density, quantitative ultrasound of bone and markers of bone metabolism in postmenopausal women. Osteoporos. Int. 2001, 12:581-587.
12. Browner W.S., Lui L.Y., Cummings S.R. Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women. J. Clin. Endocrinol. Metab. 2001, 86:631-637.
13. Chodzko-Zajko W.J., Proctor D.N., Fiatarone Singh M.A., Minson C.T., Nigg C.R., Salem G.J., Skinner J.S. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med. Sci. Sports Exerc. 2009, 41:1510-1530.
14. Copeland J.L., Esliger D.W. Accelerometer assessment of physical activity in active, healthy older adults. J Aging Phys. Act. 2009, 17:17-30.
15. Enattah N.S., Sulkava R., Halonen P., Kontula K., Jarvela I. Genetic variant of lactase-persistent C/T-13910 is associated with bone fractures in very old age. J. Am. Geriatr. Soc. 2005, 53:79-82.
16. Esen H., Buyukyazi G., Ulman C., Taneli F., Ari Z., Gozlukaya F., Tikiz H. Do walking programs affect C-reactive protein, osteoprotegerin and soluble receptor activator of nuclear factor-kappa beta ligand?. Turk. J. Biochem. Turk. Biyokimya Dergisi. 2009, 34:178-186.
17. Freedson P.S., Melanson E., Sirard J. Calibration of the Computer Science and Applications, Inc. accelerometer. Med. Sci. Sports Exerc. 1998, 30:777-781.
18. Gillespie L.D., Robertson M.C., Gillespie W.J., Lamb S.E., Gates S., Cumming R.G., Rowe B.H. Interventions for preventing falls in older people living in the community. Cochrane Database Syst. Rev. 2009, CD007146.
19. Haykowsky M., McGavock J., Vonder Muhll I., Koller M., Mandic S., Welsh R., Taylor D. Effect of exercise training on peak aerobic power, left ventricular morphology, and muscle strength in healthy older women. J. Gerontol. A Biol. Sci. Med. Sci. 2005, 60:307-311.
20. Henwood T.R., Taaffe D.R. Short-term resistance training and the older adult: the effect of varied programmes for the enhancement of muscle strength and functional performance. Clin. Physiol. Funct. Imaging 2006, 26:305-313.
21. Jorgensen H.L., Kusk P., Madsen B., Fenger M., Lauritzen J.B. Serum osteoprotegerin (OPG) and the A163G polymorphism in the OPG promoter region are related to peripheral measures of bone mass and fracture odds ratios. J. Bone Miner. Metab. 2004, 22:132-138.
22. Kim C.H., You L., Yellowley C.E., Jacobs C.R. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone 2006, 39:1043-1047.
23. Kohrt W.M., Ehsani A.A., Birge S.J. Effects of exercise involving predominantly either joint-reaction or ground-reaction forces on bone mineral density in older women. J. Bone Miner. Res. 1997, 12:1253-1261.
24. Kohrt W.M., Bloomfield S.A., Little K.D., Nelson M.E., Yingling V.R. American College of Sports Medicine Position Stand: physical activity and bone health. Med. Sci. Sports Exerc. 2004, 36:1985-1996.
25. Lane N.E. Epidemiology, etiology, and diagnosis of osteoporosis. Am. J. Obstet. Gynecol. 2006, 194:S3-S11.
26. Lanyon L.E. Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone 1996, 18:37S-43S.
27. Lanyon L., Skerry T. Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J. Bone Miner. Res. 2001, 16:1937-1947.
28. Latash M.L., Ferreira S.S., Wieczorek S.A., Duarte M. Movement sway: changes in postural sway during voluntary shifts of the center of pressure. Exp. Brain Res. 2003, 150:314-324.
29. Lau E., Al-Dujaili S., Guenther A., Liu D., Wang L., You L. Effect of low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts. Bone 2010, 46:1508-1515.
30. Liegibel U.M., Sommer U., Tomakidi P., Hilscher U., Van Den Heuvel L., Pirzer R., Hillmeier J., Nawroth P., Kasperk C. Concerted action of androgens and mechanical strain shifts bone metabolism from high turnover into an osteoanabolic mode. J. Exp. Med. 2002, 196:1387-1392.
31. Manini T., Marko M., VanArnam T., Cook S., Fernhall B., Burke J., Ploutz-Snyder L. Efficacy of resistance and task-specific exercise in older adults who modify tasks of everyday life. J. Gerontol. A Biol. Sci. Med. Sci. 2007, 62:616-623.
32. Martyn-St James M., Carroll S. Progressive high-intensity resistance training and bone mineral density changes among premenopausal women: evidence of discordant site-specific skeletal effects. Sports Med. 2006, 36:683-704.
33. Martyn-St James M., Carroll S. Meta-analysis of walking for preservation of bone mineral density in postmenopausal women. Bone 2008, 43:521-531.
34. Mazumdar S., Liu K.S., Houck P.R., Reynolds C.F. Intent-to-treat analysis for longitudinal clinical trials: coping with the challenge of missing values. J. Psychiatr. Res. 1999, 33:87-95.
35. Messier S.P., Royer T.D., Craven T.E., O'Toole M.L., Burns R., Ettinger W.H. Long-term exercise and its effect on balance in older, osteoarthritic adults: results from the Fitness, Arthritis, and Seniors Trial (FAST). J. Am. Geriatr. Soc. 2000, 48:131-138.
36. Misic M.M., Valentine R.J., Rosengren K.S., Woods J.A., Evans E.M. Impact of training modality on strength and physical function in older adults. Gerontology 2009, 55:411-416.
37. Mori T., Okimoto N., Sakai A., Okazaki Y., Nakura N., Notomi T., Nakamura T. Climbing exercise increases bone mass and trabecular bone turnover through transient regulation of marrow osteogenic and osteoclastogenic potentials in mice. J. Bone Miner. Res. 2003, 18:2002-2009.
38. Nakata Y., Ohkawara K., Lee D.J., Okura T., Tanaka K. Effects of additional resistance training during diet-induced weight loss on bone mineral density in overweight premenopausal women. J. Bone Miner. Metab. 2008, 26:172-177.
39. Nalbant O., Toktas N., Toraman N.F., Ogus C., Aydin H., Kacar C., Ozkaya Y.G. Vitamin E and aerobic exercise: effects on physical performance in older adults. Aging Clin. Exp. Res. 2009, 21:111-121.
40. Notomi T., Okazaki Y., Okimoto N., Saitoh S., Nakamura T., Suzuki M. A comparison of resistance and aerobic training for mass, strength and turnover of bone in growing rats. Eur. J. Appl. Physiol. 2000, 83:469-474.
41. Obermayer-Pietsch B.M., Bonelli C.M., Walter D.E., Kuhn R.J., Fahrleitner-Pammer A., Berghold A., Goessler W., Stepan V., Dobnig H., Leb G., Renner W. Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J. Bone Miner. Res. 2004, 19:42-47.
42. Orr R., Raymond J., Fiatarone Singh M. Efficacy of progressive resistance training on balance performance in older adults: a systematic review of randomized controlled trials. Sports Med. 2008, 38:317-343.
43. Pajala S., Era P., Koskenvuo M., Kaprio J., Tormakangas T., Rantanen T. Force platform balance measures as predictors of indoor and outdoor falls in community-dwelling women aged 63-76years. J. Gerontol. A Biol. Sci. Med. Sci. 2008, 63:171-178.
44. Palombaro K.M. Effects of walking-only interventions on bone mineral density at various skeletal sites: a meta-analysis. J. Geriatr. Phys. Ther. 2005, 28:102-107.
45. Rhodes E.C., Martin A.D., Taunton J.E., Donnelly M., Warren J., Elliot J. Effects of one year of resistance training on the relation between muscular strength and bone density in elderly women. Br. J. Sports Med. 2000, 34:18-22.
46. Rikli R.E., Jones C.J. Development and validation of a functional fitness test for community-residing older adults. J. Aging Phys. Activ. 1999, 7:129-161.
47. Rubenstein L.Z. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing 2006, 35(Suppl 2):ii37-ii41.
48. Rubin C.T., Bain S.D., McLeod K.J. Suppression of the osteogenic response in the aging skeleton. Calcif. Tissue Int. 1992, 50:306-313.
49. Rubin J., Murphy T., Nanes M.S., Fan X. Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am. J. Physiol. Cell Physiol. 2000, 278:C1126-C1132.
50. Rubin J., Murphy T.C., Zhu L., Roy E., Nanes M.S., Fan X. Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK. J. Biol. Chem. 2003, 278:34018-34025.
51. Ryan A.S., Ivey F.M., Hurlbut D.E., Martel G.F., Lemmer J.T., Sorkin J.D., Metter E.J., Fleg J.L., Hurley B.F. Regional bone mineral density after resistive training in young and older men and women. Scand. J. Med. Sci. Sports 2004, 14:16-23.
52. Saunders M.M., Taylor A.F., Du C., Zhou Z., Pellegrini V.D., Donahue H.J. Mechanical stimulation effects on functional end effectors in osteoblastic MG-63 cells. J. Biomech. 2006, 39:1419-1427.
53. Sherrington C., Whitney J.C., Lord S.R., Herbert R.D., Cumming R.G., Close J.C. Effective exercise for the prevention of falls: a systematic review and meta-analysis. J. Am. Geriatr. Soc. 2008, 56:2234-2243.
54. Silverman N.E., Nicklas B.J., Ryan A.S. Addition of aerobic exercise to a weight loss programme increases BMD, with an associated reduction in inflammation in overweight postmenopausal women. Calcif. Tissue Int. 2009, 84:257-265.
55. Singh J.A., Schmitz K.H., Petit M.A. Effect of resistance exercise on bone mineral density in premenopausal women. Joint Bone Spine 2009, 76:273-280.
56. Stengel S.V., Kemmler W., Pintag R., Beeskow C., Weineck J., Lauber D., Kalender W.A., Engelke K. Power training is more effective than strength training for maintaining bone mineral density in postmenopausal women. J. Appl. Physiol. 2005, 99:181-188.
57. Stern A., Laughlin G.A., Bergstrom J., Barrett-Connor E. The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor kappaB legend with bone mineral density in older adults: the Rancho Bernardo study. Eur. J. Endocrinol. 2007, 156:555-562.
58. Tamura K., Dudley J., Nei M., Kumar S. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol. Biol. Evol. 2007, 24:1596-1599.
59. Tarpenning K.M., Hawkins S.A., Marcell T.J., Wiswell R.A. Endurance exercise and leg strength in older women. J Aging Phys. Act. 2006, 14:3-11.
60. Vogel T., Brechat P.H., Lepretre P.M., Kaltenbach G., Berthel M., Lonsdorfer J. Health benefits of physical activity in older patients: a review. Int. J. Clin. Pract. 2009, 63:303-320.
61. Warner S.E., Shea J.E., Miller S.C., Shaw J.M. Adaptations in cortical and trabecular bone in response to mechanical loading with and without weight bearing. Calcif. Tissue Int. 2006, 79:395-403.
62. Watts N.B. Fundamentals and pitfalls of bone densitometry using dual-energy X-ray absorptiometry (DXA). Osteoporos. Int. 2004, 15:847-854.
63. Ziegler S., Niessner A., Richter B., Wirth S., Billensteiner E., Woloszczuk W., Slany J., Geyer G. Endurance running acutely raises plasma osteoprotegerin and lowers plasma receptor activator of nuclear factor kappa B ligand. Metabolism 2005, 54:935-938.