Cytokines and culture medium have a major impact on human in vitro T-cell differentiation

Blood Cells, Molecules, and Diseases

Volumn 47, Issue 1, 2011, Pages 72-78

  Six, Emmanuelle M ^a,b   Benjelloun, Fatine ^a,b,e   Garrigue, Alexandrine ^a,b   Bonhomme, Delphine ^a,b   Morillon, Estelle ^a,b   Rouiller, Julien ^a,b   Cacavelli, Laure ^c   Blondeau, Johanna ^c   Beldjord, Kheira ^b,c,d   Hacein Bey Abina, Salima ^a,b,c   Cavazzana Calvo, Marina ^a,b,c   André Schmutz, Isabelle ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d CNRS   (France)

^e HÔPITAL JEAN VERDIER   (France)

Author keywords

Lymphopoiesis; Notch; OP9 Delta1; T cell development; Thymopoiesis

Indexed keywords

INTERLEUKIN 7; STEM CELL FACTOR;

ALPHA BETA T LYMPHOCYTE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL PROLIFERATION; CELL STRAIN OP9 DELTA1; CONTROLLED STUDY; CULTURE MEDIUM; GAMMA DELTA T LYMPHOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; PRIORITY JOURNAL; STROMA CELL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; CYTOKINES; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN-7; STEM CELL FACTOR; STROMAL CELLS; T-LYMPHOCYTES;

MURINAE;

EID: 79956325710     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2011.04.001     Document Type: Article

References (31)

1. Radtke F., Wilson A., Stark G., et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 1999, 10:547-558.
2. Pui J.C., Allman D., Xu L., et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 1999, 11:299-308.
3. Maillard I., Fang T., Pear W.S. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu. Rev. Immunol. 2005, 23:945-974.
4. Hozumi K., Negishi N., Suzuki D., et al. Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat. Immunol. 2004, 5:638-644.
5. Schmitt T.M., Ciofani M., Petrie H.T., Zuniga-Pflucker J.C. Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J. Exp. Med. 2004, 200:469-479.
6. Jenkinson E.J., Franchi L.L., Kingston R., Owen J.J. Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: application in the production of chimeric thymus rudiments. Eur. J. Immunol. 1982, 12:583-587.
7. Schmitt T.M., Zuniga-Pflucker J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 2002, 17:749-756.
8. De Smedt M., Hoebeke I., Plum J. Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells Mol. Dis. 2004, 33:227-232.
9. La Motte-Mohs R.N., Herer E., Zuniga-Pflucker J.C. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 2005, 105:1431-1439.
10. Ikawa T., Hirose S., Masuda K., et al. An essential developmental checkpoint for production of the T cell lineage. Science 2010, 329:93-96.
11. Broudy V.C. Stem cell factor and hematopoiesis. Blood 1997, 90:1345-1364.
12. Lyman S.D., Jacobsen S.E. c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood 1998, 91:1101-1134.
13. Wolins N.E., Quaynor B.K., Skinner J.R., et al. OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis. J. Lipid Res. 2006, 47:450-460.
14. Balciunaite G., Ceredig R., Fehling H.J., Zuniga-Pflucker J.C., Rolink A.G. The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. Eur. J. Immunol. 2005, 35:1292-1300.
15. Huang J., Garrett K.P., Pelayo R., et al. Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation. J. Immunol. 2005, 175:4858-4865.
16. Six E.M., Bonhomme D., Monteiro M., et al. A human postnatal lymphoid progenitor capable of circulating and seeding the thymus. J. Exp. Med. 2007, 204:3085-3093.
17. Deftos M.L., Huang E., Ojala E.W., Forbush K.A., Bevan M.J. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 2000, 13:73-84.
18. Osborne B., Miele L. Notch and the immune system. Immunity 1999, 11:653-663.
19. Stier S., Cheng T., Dombkowski D., Carlesso N., Scadden D.T. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 2002, 99:2369-2378.
20. Petrie H.T., Zuniga-Pflucker J.C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol. 2007, 25:649-679.
21. Weerkamp F., Baert M.R., Brugman M.H., et al. Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential. Blood 2006, 107:3131-3137.
22. Garcia-Peydro M., de Yebenes V.G., Toribio M.L. Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates. J. Immunol. 2006, 177:3711-3720.
23. Karsunky H., Merad M., Cozzio A., Weissman I.L., Manz M.G. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J. Exp. Med. 2003, 198:305-313.
24. Wils E.J., Braakman E., Verjans G.M., et al. Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation. J. Immunol. 2007, 178:3551-3557.
25. Yang L., Bryder D., Adolfsson J., et al. Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood 2005, 105:2717-2723.
26. Fry T.J., Sinha M., Milliron M., et al. Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution. Blood 2004, 104:2794-2800.
27. Offner F., Kerre T., De Smedt M., Plum J. Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy. Br. J. Haematol. 1999, 104:801-808.
28. Patel E., Wang B., Lien L., et al. Diverse T-cell differentiation potentials of human fetal thymus, fetal liver, cord blood and adult bone marrow CD34 cells on lentiviral Delta-like-1-modified mouse stromal cells. Immunology 2009, 128:e497-e505.
29. Cavazzana-Calvo M., Fischer A. Gene therapy for severe combined immunodeficiency: are we there yet?. J. Clin. Invest. 2007, 117:1456-1465.
30. Hacein-Bey-Abina S., Le Deist F., Carlier F., et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N. Engl. J. Med. 2002, 346:1185-1193.
31. Lagresle-Peyrou C., Six E.M., Picard C., et al. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat. Genet. 2009, 41:106-111.