Insulin-mediated upregulation of KCa3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 1, 2011, Pages 51-57

  Su, Xing Li ^a,b   Wang, Yan ^a   Zhang, Wei ^a   Zhao, Li Mei ^a   Li, Gui Rong ^c   Deng, Xiu Ling ^a,d  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b XI'AN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

ERK1 2; Insulin; Intermediate conductance Ca 2+ activated K + channel; Migration; Proliferation; VSMCs

Indexed keywords

INSULIN; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCA3.1 CHANNEL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA WALL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HORMONE ACTION; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; FLAVONOIDS; IMIDAZOLES; INSULIN; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

RATTUS;

EID: 79956320554     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.03.014     Document Type: Article

References (39)

1. Semenkovich C.F. Insulin resistance and atherosclerosis. J Clin Invest 2006, 116:1813-1822.
2. Avena R., Mitchell M.E., Neville R.F., Sidawy A.N. The additive effects of glucose and insulin on the proliferation of infragenicular vascular smooth muscle cells. J Vasc Surg 1998, 28:1033-1038.
3. Goetze S., Kintscher U., Kawano H., Kawano Y., Wakino S., Fleck E., Hsueh W.A., Law R.E. Tumor necrosis factor alpha inhibits insulin-induced mitogenic signaling in vascular smooth muscle cells. J Biol Chem 2000, 275:18279-18283.
4. Wang C.C., Gurevich I., Draznin B. Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. Diabetes 2003, 52:2562-2569.
5. Isenovic E.R., Fretaud M., Dobutovic B., Sudar E., Smiljanic K., Zaric B., Trpkovic A., Marche P. A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin-stimulated proliferation of vascular smooth muscle cells. Cell Biol Int 2009, 33:386-392.
6. Xi X.P., Graf K., Goetze S., Hsueh W.A., Law R.E. Inhibition of MAP kinase blocks insulin-mediated DNA synthesis and transcriptional activation of c-fos by Elk-1 in vascular smooth muscle cells. FEBS Lett 1997, 417:283-286.
7. Isenovic E.R., Fretaud M., Koricanac G., Sudar E., Velebit J., Dobutovic B., Marche P. Insulin regulation of proliferation involves activation of Akt and Erk1/2 signaling pathways in vascular smooth muscle cells. Exp Clin Endocrinol Diabetes 2009, 117:214-219.
8. DeCoursey T.E., Chandy K.G., Gupta S., Cahalan M.D. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?. Nature 1984, 307:465-468.
9. Jager H., Dreker T., Buck A., Giehl K., Gress T. Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro. Mol Pharmacol 2004, 65:630-638.
10. Ouadid-Ahidouch H., Roudbaraki M., Delcourt P., Ahidouch A., Joury N., Prevarskaya N. Functional and molecular identification of intermediate-conductance Ca2+-activated K+ channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol 2004, 287:C125-C134.
11. Neylon C.B., Avdonin P.V., Larsen M.A., Bobik A. Rat aortic smooth muscle cells expressing charybdotoxin-sensitive potassium channels exhibit enhanced proliferative responses. Clin Exp Pharmacol Physiol 1994, 21:117-120.
12. Shepherd M.C., Duffy S.M., Harris T., Cruse G., Schuliga M., Brightling C.E., Neylon C.B., Bradding P., Stewart A.G. KCa3.1 Ca2+-activated K+ channels regulate human airway smooth muscle proliferation. Am J Respir Cell Mol Biol 2007, 37:525-531.
13. Deng X.L., Lau C.P., Lai K., Cheung K.F., Lau G.K., Li G.R. Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. Cell Prolif 2007, 40:656-670.
14. Tao R., Lau C.P., Tse H.F., Li G.R. Regulation of cell proliferation by intermediate-conductance Ca2+-activated potassium and volume-sensitive chloride channels in mouse mesenchymal stem cells. Am J Physiol Cell Physiol 2008, 295:C1409-C1416.
15. Neylon C.B., Lang R.J.Fu.Y., Bobik A., Reinhart P. Molecular cloning and characterization of the intermediate-conductance Ca2+-activated K+ channel in vascular smooth muscle: relationship between KCa channel diversity and smooth muscle cell function. Circ Res 1999, 85:e33-e43.
16. Si H., Grgic I., Heyken W.T., Maier T., Hoyer J., Reusch H.P., Kohler R. Mitogenic modulation of Ca2+-activated K+ channels in proliferating A7r5 vascular smooth muscle cells. Br J Pharmacol 2006, 148:909-917.
17. Tharp D.L., Wamhoff B.R., Turk J.R., Bowles D.K. Upregulation of intermediate-conductance Ca2+-activated K+ channel (IKCa1) mediates phenotypic modulation of coronary smooth muscle. Am J Physiol Heart Circ Physiol 2006, 291:H2493-H2503.
18. Kohler R., Wulff H., Eichler I., Kneifel M., Neumann D., Knorr A., Grgic I., Kampfe D., Si H., Wibawa J., Real R., Borner K., Brakemeier S., Orzechowski H.D., Reusch H.P., Paul M., Chandy K.G., Hoyer J. Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation 2003, 108:1119-1125.
19. Toyama K., Wulff H., Chandy G., Azam P., Raman G., Saito T., Fujiwara Y. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest 2008, 118:3025-3037.
20. Wang Y., Zhang H.T., Su X.L., Deng X.L., Yuan B.X., Zhang W., Wang X.F., Yang Y.B. Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance. Curr Neurovas Res 2010, 7:75-84.
21. Zhang F., Ye C., Li G., Ding W., Zhou W., Zhu H., Chen G., Luo T., Guang M., Liu Y., Zhang D., Zheng S., Yang J., Gu Y., Xie X., Luo M. The rat model of type-2 diabetic mellitus and its glycometabolism characters. Experimental Animal 2003, 52:401-407.
22. Reed M.J., Meszaros K., Entes L.J., Claypool M.D., Pinkett J.G., Gadbois T.M., Reaven G.M. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 2000, 49:1390-1394.
23. Srinivasan K., Viswanad B., Asrat L., Kaul C.L., Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 2005, 52:313-320.
24. McNeish A.J., Sandow S.L., Neylon C.B., Chen M.X., Dora K.A., Garland C.J. Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery. Stroke 2006, 37:1277-1282.
25. Kingsley K., Huff J.L., Rust W.L., Carroll K., Martinez A.M., Fitchmun M., Plopper G.E. ERK1/2 mediates PDGF-BB stimulated vascular smooth muscle cell proliferation and migration on laminin-5. Biochem Biophys Res Commun 2002, 293:1000-1006.
26. Li G.R., Deng X.L., Sun H., Chung S.S., Tse H.F., Lau C.P. Ion channels in mesenchymal stem cells from rat bone marrow. Stem Cells 2006, 24:1519-1528.
27. Kanno Y., Kuroki A., Minamida M., Kaneiwa A., Okada K., Tomogane K., Takeuchi K., Ueshima S., Matsuo O., Matsuno H. The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation. Thromb Res 2008, 123:336-341.
28. Jia G., Mitra A.K., Cheng G., Gangahar D.M., Agrawal D.K. Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits. J Surg Res 2007, 142:137-142.
29. Sowers J.R., Epstein M., Frochlich E.D. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001, 37:1053-1059.
30. Nigro J., Osman N., Dart A.M., Little P.J. Insulin resistance and atherosclerosis. Endocr Rev 2006, 27:242-259.
31. Bansilal S., Farkouh M.E., Fuster V. Role of insulin resistance and hyperglycemia in the development of atherosclerosis. Am J Cardiol 2007, 99:6B-14B.
32. Hodroj W., Legedz L., Foudi N., Cerutti C., Bourdillon M.C., Feugier P., Beylot M., Randon J., Bricca G. Increased insulin-stimulated expression of arterial angiotensinogen and angiotensin type 1 receptor in patients with type 2 diabetes mellitus and atheroma. Arterioscler Thromb Vasc Biol 2007, 27:525-531.
33. Schwab A., Hanley P., Fabian A., Stock C. Potassium channels keep mobile cells on the go. Physiology (Bethesda) 2008, 23:212-220.
34. Kaiser N., Tur-Sinai A., Hasin M., Cerasi E. Binding, degradation, and biological activity of insulin in vascular smooth muscle cells. Am J Physiol 1985, 249:E292-E298.
35. Banskota N.K., Taub R., Zellner K., Olsen P., King G.L. Characterization of induction of protooncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-I. Diabetes 1989, 38:123-129.
36. Johansson G.S., Arngvist H.J. Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin-IGF-I receptors in vascular smooth muscle cells. Am J Physiol Endocrinol Metab 2006, 291:E1124-E1130.
37. Banskota N.K., Taub R., Zellner K., King G.L. Insulin, insulin-like growth factor I and platelet-derived growth factor interact additively in the induction of the protooncogene c-myc and cellular proliferation in cultured bovine aortic smooth muscle cells. Mol Endocrinol 1989, 3:1183-1190.
38. Kobayashi T., Kamata K. Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats. Am J Physiol Heart Circ Physiol 2002, 283:H1761-H1768.
39. Bornfeldt K.E., Skottner A., Arnqvist H.J. In-vivo regulation of messenger RNA encoding insulin-like growth factor-I (IGF-I) and its receptor by diabetes, insulin and IGF-I in rat muscle. J Endocrinol 1992, 135:203-211.