Measurement of vasoactive metabolites (hydroxyeicosatetraenoic and epoxyeicosatrienoic acids) in uterine tissues of normal and compromised human pregnancy

Journal of Hypertension

Volumn 28, Issue 12, 2010, Pages 2429-2437

  Pearson, Timothy ^a,c   Zhang, Ji Hong ^a,d   Arya, Pratibha ^a   Warren, Averil Y ^a   Ortori, Catherine ^a   Fakis, Apostolos ^b   Khan, Raheela N ^a   Barrett, David A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b DERBY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Eicosanoids; Human; Intrauterine growth restriction; Massspectrometry; Preeclampsia; Pregnancy

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; 5 HYDROXYICOSATETRAENOIC ACID; EPOXYICOSATRIENOIC ACID; HYDROXYICOSATETRAENOIC ACID; EPOXIDE;

AMNION; ARTICLE; CHORION; CONTROLLED STUDY; CORRELATION ANALYSIS; DECIDUA; FEMALE; HUMAN; HUMAN TISSUE; INTRAUTERINE GROWTH RETARDATION; LABOR; LIQUID CHROMATOGRAPHY; MYOMETRIUM; PLACENTA; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TISSUE LEVEL; TROPHOBLAST; UTERUS; METABOLISM;

CHROMATOGRAPHY, LIQUID; EPOXY COMPOUNDS; FEMALE; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; PREGNANCY; TANDEM MASS SPECTROMETRY; UTERUS;

EID: 79956318134     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32833e86aa     Document Type: Article

References (47)

1. Patel L, Sullivan MH, Elder MG. Production of epoxygenase metabolite by human reproductive tissues. Prostaglandins 1989; 38:615-624. (Pubitemid 20026278)
2. Saeed SA, Mitchell MD. Formation of arachidonate lipoxygenase metabolites by human fetal membranes, uterine decidua vera and placenta. Prostaglandins Leukot Med 1982; 8:635-640. (Pubitemid 12123351)
3. Zhang JH, Pearson T, Matharoo-Ball B, Ortori CA, Warren AY, Khan R, Barrett DA. Quantitative profiling of epoxyeicosatrienoic, hydroxyeicosatetraenoic, and dihydroxyeicosatetraenoic acids in human intrauterine tissues using liquid chromatography/electrospray ionization tandem mass spectrometry. Anal Biochem 2007; 365:40-51. (Pubitemid 46617468)
4. Schafer WR, Zahradnik HP, Arbogast E, Wetzka B, Werner K, Breckwoldt M. Arachidonate metabolism in human placenta, fetal membranes, decidua and myometrium: Lipoxygenase and cytochrome P450 metabolites as main products in HPLC profiles. Placenta 1996; 17:231-238. (Pubitemid 26166914)
5. Larsen BT, Gutterman DD, Hatoum OA. Emerging role of epoxyeicosatrienoic acids in coronary vascular function. Eur J Clin Invest 2006; 36:293-300.
6. Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, et al. The antiinflammatory effect of laminar flow: The role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A 2005; 102:16747-16752. (Pubitemid 41688848)
7. Michaelis UR, Fisslthaler B, Barbosa-Sicard E, Falck JR, Fleming I, Busse R. Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxiainduced endothelial cell migration and angiogenesis. J Cell Sci 2005; 118:5489-5498. (Pubitemid 43079290)
8. Campbell WB, Harder DR. Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone. Circ Res 1999; 84:484-488. (Pubitemid 29120015)
9. Archer SL, Gragasin FS, Wu X, Wang S, McMurtry S, Kim DH, et al. Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. Circulation 2003; 107:769-776. (Pubitemid 36222608)
10. Oltman CL, Weintraub NL, VanRollins M, Dellsperger KC. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ Res 1998; 83:932-939. (Pubitemid 28503082)
11. Zhang Y, Oltman CL, Lu T, Lee HC, Dellsperger KC, VanRollins M. EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. Am J Physiol Heart Circ Physiol 2001; 280:H2430-2440.
12. Maier KG, Roman RJ. Cytochrome P450 metabolites of arachidonic acid in the control of renal function. Curr Opin Nephrol Hypertens 2001; 10:81-87. (Pubitemid 32102227)
13. Earley S, Heppner TJ, Nelson MT, Brayden JE. TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circ Res 2005; 97:1270-1279.
14. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002; 82:131-185. (Pubitemid 34654217)
15. Ma YH, Harder DR, Clark JE, Roman RJ. Effects of 12-HETE on isolated dog renal arcuate arteries. Am J Physiol 1991; 261:H451-H456.
16. Imig JD. Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases. Am J Physiol Renal Physiol 2005; 289:F496- 503. (Pubitemid 41208461)
17. Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371:75-84.
18. Roberts JM, Cooper DW. Pathogenesis and genetics of preeclampsia. Lancet 2001; 357:53-56.
19. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 1986; 93:1049-1059. (Pubitemid 16004866)
20. Friedman SA, Taylor RN, Roberts JM. Pathophysiology of preeclampsia. Clin Perinatol 1991; 18:661-682.
21. Jonsdottir LS, Arngrimsson R, Geirsson RT, Sigvaldason H, Sigfusson N. Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet Gynecol Scand 1995; 74:772-776. (Pubitemid 26002174)
22. Wilson BJ, Watson MS, Prescott GJ, Sunderland S, Campbell DM, Hannaford P, Smith WC. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: Results from cohort study. BMJ 2003; 326:845.
23. Williams B, Poulter NR, Brown MJ, Davis M, McInnes GT, Potter JF, et al. British Hypertension Society guidelines for hypertension management 2004 (BHS-IV): summary. BMJ 2004; 328:634-640. (Pubitemid 38340037)
24. Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ. Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. Am J Physiol 1996; 270:F822- 832. (Pubitemid 26178768)
25. Gebremedhin D, Ma YH, Imig JD, Harder DR, Roman RJ. Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. J Vasc Res 1993; 30:53-60. (Pubitemid 23072294)
26. Sarkis A, Roman RJ. Role of cytochrome P450 metabolites of arachidonic acid in hypertension. Curr Drug Metab 2004; 5:245-256. (Pubitemid 38735779)
27. Harder DR, Campbell WB, Roman RJ. Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res 1995; 32:79-92.
28. Ashworth JR, Baker PN, Warren AY, Johnson IR. Mechanisms of endothelium-dependent relaxation in myometrial resistance vessels and their alteration in preeclampsia. Hypertens Pregnancy 1999; 18:57-71. (Pubitemid 29149858)
29. Kenny LC, Baker PN, Kendall DA, Randall MD, Dunn WR. Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and preeclampsia. Clin Sci (Lond) 2002; 103:67-73. (Pubitemid 34729126)
30. McCarthy AL, Woolfson RG, Raju SK, Poston L. Abnormal endothelial cell function of resistance arteries from women with preeclampsia. Am J Obstet Gynecol 1993; 168:1323-1330. (Pubitemid 23122189)
31. Fisslthaler B, Fleming I, Busse R. EDHF: A cytochrome P450 metabolite in coronary arteries. Semin Perinatol 2000; 24:15-19. (Pubitemid 30115264)
32. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 1996; 78:415-423. (Pubitemid 26072547)
33. Capdevila JH, Falck JR. The CYP P450 arachidonic acid monooxygenases: From cell signaling to blood pressure regulation. Biochem Biophys Res Commun 2001; 285:571-576. (Pubitemid 32924808)
34. Roman RJ, Alonso-Galicia M. P-450 eicosanoids: A novel signaling pathway regulating renal function. News Physiol Sci 1999; 14:238-242.
35. Roman RJ, Maier KG, Sun CW, Harder DR, Alonso-Galicia M. Renal and cardiovascular actions of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids. Clin Exp Pharmacol Physiol 2000; 27:855-865.
36. Arbogast E, Schafer W, Zahradnik HP. Alterations of intrauterine eicosanoid production in pregnancy-induced hypertension: Decreased production of 12-hydroxyeicosatetraenoic acid in the placenta. Prostaglandins 1996; 51:125-137.
37. Mitchell MD, Koenig JM. Increased production of 15- hydroxyeicosatetraenoic acid by placentae from pregnancies complicated by pregnancy-induced hypertension. Prostaglandins Leukot Essent Fatty Acids 1991; 43:61-62.
38. Johnson RD, Polakoski KL,Huang X, Sadovsky Y, Nelson DM. The release of 15-hydroxyeicosatetraenoic acid by human placental trophoblast is increased in preeclampsia. Am J Obstet Gynecol 1998; 178:54-58. (Pubitemid 28302794)
39. Pearson T, Warren AY, Barrett DA, Khan RN. Detection of EETs and HETEgenerating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function. Am J Physiol Endocrinol Metab 2009; 297:E647-656.
40. Young A, Thomson AJ, Ledingham M, Jordan F, Greer IA, Norman JE. Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term. Biol Reprod 2002; 66:445-449. (Pubitemid 34101843)
41. Spector AA, Fang X, Snyder GD, Weintraub NL. Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Prog Lipid Res 2004; 43:55-90. (Pubitemid 37433867)
42. Yu Z, Huse LM, Adler P, Graham L, Ma J, Zeldin DC, Kroetz DL. Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. Mol Pharmacol 2000; 57:1011-1020. (Pubitemid 30253386)
43. Catella F, Lawson JA, Fitzgerald DJ, FitzGerald GA. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension. Proc Natl Acad Sci U S A 1990; 87:5893-5897.
44. Huang H, Chang HH, Xu Y, Reddy DS, Du J, Zhou Y, et al. Epoxyeicosatrienoic acid inhibition alters renal hemodynamics during pregnancy. Exp Biol Med (Maywood) 2006; 231:1744-1752. (Pubitemid 44865993)
45. Sharma M, McCarthy ET, Reddy DS, Patel PK, Savin VJ, Medhora M, Falck JR. 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier. Prostaglandins Other Lipid Mediat 2009; 89:43-51.
46. Greiss FC Jr, Anderson SG. Uterine blood flow during labor. Clin Obstet Gynecol 1968; 11:96-109.
47. Brar HS, Platt LD, DeVore GR, Horenstein J, Medearis AL. Qualitative assessment of maternal uterine and fetal umbilical artery blood flow and resistance in laboring patients by Doppler velocimetry. Am J Obstet Gynecol 1988; 158:952-956.