Proteolysis of milk fat globule membrane proteins during in vitro gastric digestion of milk

Journal of Dairy Science

Volumn 94, Issue 6, 2011, Pages 2762-2770

  Ye, A ^a   Cui, J ^a   Singh, H ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

Hydrolysis rate; Milk fat globule membrane (MFGM); Pepsin; Simulated gastric fluid (SGF)

Indexed keywords

BUTYROPHILIN; GLYCOLIPID; GLYCOPROTEIN; MEMBRANE PROTEIN; PEPSIN A; PEPTIDE; XANTHINE OXIDASE;

ANIMAL; ARTICLE; DIGESTION; METABOLISM; MILK; MILK FAT GLOBULE; PH; PHYSICAL CHEMISTRY; STOMACH;

ANIMALS; DIGESTION; GLYCOLIPIDS; GLYCOPROTEINS; HYDROGEN-ION CONCENTRATION; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MILK; PEPSIN A; PEPTIDES; PHYSICOCHEMICAL PHENOMENA; STOMACH; XANTHINE OXIDASE;

EID: 79956278976     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2010-4099     Document Type: Article

References (18)

1. Armand M., Borel P., Ythier P., Dutot G., Melin C., Senft M., Lafont H., Lairon D. Effects of droplet size, triacylglycerol composition, and calcium on the hydrolysis of complex emulsions by pancreatic lipase-An in vitro study. J. Nutr. Biochem. 1992, 7:333-341.
2. Armand M., Pasquier B., Andre M., Borel P., Senft M., Peyrot J. Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am. J. Clin. Nutr. 1999, 70:1096-1106.
3. Berton A., Sebban-Kreuzer C., Rouvellac S., Lopez C., Crenon I. Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules. Mol. Nutr. Food Res. 2009, 53:1592-1602.
4. Beysseriat M., Decker E.A., McClements D.J. Preliminary study of the influence of dietary fiber on the properties of oil-in-water emulsions passing through an in vitro human digestion model. Food Hydrocoll 2006, 20:800-809.
5. Borel P., Armand M., Pasquier B., Senft M., Dutot G., Melin C., Lafont H., Lairon D. Digestion and absorption of tube-feeding emulsions with different droplet sizes and compositions in the rat. JPEN J. Parenter. Enteral Nutr. 1994, 18:534-543.
6. Ekmekcioglu C.A. Physiological approach for preparing and conducting intestinal bioavailability studies using experimental systems. Food Chem 2002, 76:225-229.
7. Kalantzi L., Goumas K., Kalioras V., Abrahamsson B., Dressman J.B., Reppas C. Characterization of the human upper gastrointestinal contents under conditions simulating bioavailability/bioequivalence studies. Pharm. Res. 2006, 23:165-176.
8. Lindahl A., Ungell A.L., Knutson L., Lennernas H. Characterization of fluids from the stomach and proximal jejunum in men and women. Pharm. Res. 1997, 14:497-502.
9. Mather I.H. A review and proposed nomenclature for major proteins of the milk-fat globule membrane. J. Dairy Sci. 2000, 83:203-247.
10. Mun S., Decker E.A., McClements D.J. Influence of emulsifier type on in vitro digestibility of lipid droplets by pancreatic lipase. Food Res. Int. 2007, 40:770-781.
11. Patton S., Keenan T.W. Milk-fat globule membrane. Biochim. Biophys. Acta 1975, 415:273-309.
12. Sarkar A., Goh K., Singh P., Singh H. Behaviour of an oil-in-water emulsion stabilized by beta-lactoglobulin in an in vitro gastric model. Food Hydrocoll. 2009, 23:1563-1569.
13. Singh H., Ye A., Horne D. Structuring food emulsions in the gastrointestinal tract to modify lipid digestion. Prog. Lipid Res. 2009, 48:92-100.
14. Staggers J.E., Hernell O., Stafford R.J., Carey M.C. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings. Biochemistry 1990, 29:2028-2040.
15. Simulated intestinal fluid. United States Pharmacopeia and National Formulary 1995, United States Pharmacopeial Convention, United States Pharmacopeial Convention, Rockville, MD, Page 2053. 23rd ed.
16. Ye A., Cui J., Singh H. Effect of the fat globule membrane on in vitro digestion of milk fat globules with pancreatic lipase. Int. Dairy J. 2010, 20:822-829.
17. Ye A., Singh H., Anema S. High pressure-induced interactions between the milk fat globule membrane proteins and skim milk proteins in whole milk. J. Dairy Sci. 2004, 87:4013-4022.
18. Ye A., Singh H., Taylor M.W., Anema S. Characterization of protein components of natural and heat-treated milk fat globule membranes. Int. Dairy J. 2002, 12:393-402.