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Volumn 269, Issue 6, 2011, Pages 626-635

Vaccination against type 1 diabetes

Author keywords

Autoantibodies; GAD65; IA 2; Insulin; ZnT8 transporter

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; CYCLOSPORIN; DIAMYD; GLUTAMATE DECARBOXYLASE 65; IMMUNOSUPPRESSIVE AGENT; INSULIN; MONOCLONAL ANTIBODY CD3; PREDNISOLONE; RITUXIMAB; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ZINC TRANSPORTER;

EID: 79956277614     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2011.02386.x     Document Type: Article
Times cited : (12)

References (62)
  • 1
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • DPT-1
    • DPT-1. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Eng J Med 2002; 346: 1685-91.
    • (2002) N Eng J Med , vol.346 , pp. 1685-1691
  • 2
    • 72249122333 scopus 로고    scopus 로고
    • Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1
    • Orban T, Sosenko JM, Cuthbertson D et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2009; 32: 2269-74.
    • (2009) Diabetes Care , vol.32 , pp. 2269-2274
    • Orban, T.1    Sosenko, J.M.2    Cuthbertson, D.3
  • 3
    • 0027078251 scopus 로고
    • Pancreatic beta cells in insulin-dependent diabetes
    • Pipeleers D, Ling Z. Pancreatic beta cells in insulin-dependent diabetes. Diabetes Metab Rev 1992; 8: 209-27.
    • (1992) Diabetes Metab Rev , vol.8 , pp. 209-227
    • Pipeleers, D.1    Ling, Z.2
  • 4
    • 0023750455 scopus 로고
    • Factors influencing the magnitude, duration, and rate of fall of B-cell function in type 1 (insulin-dependent) diabetic children followed for two years from their clinical diagnosis
    • Wallensteen M, Dahlquist G, Persson B et al. Factors influencing the magnitude, duration, and rate of fall of B-cell function in type 1 (insulin-dependent) diabetic children followed for two years from their clinical diagnosis. Diabetologia 1988; 31: 664-9.
    • (1988) Diabetologia , vol.31 , pp. 664-669
    • Wallensteen, M.1    Dahlquist, G.2    Persson, B.3
  • 5
    • 70449480577 scopus 로고    scopus 로고
    • Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
    • Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H et al. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 2009; 361: 2143-52.
    • (2009) N Engl J Med , vol.361 , pp. 2143-2152
    • Pescovitz, M.D.1    Greenbaum, C.J.2    Krause-Steinrauf, H.3
  • 6
    • 55249110198 scopus 로고    scopus 로고
    • GAD treatment and insulin secretion in recent-onset type 1 diabetes
    • Ludvigsson J, Faresjo M, Hjorth M et al. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med 2008; 359: 1909-20.
    • (2008) N Engl J Med , vol.359 , pp. 1909-1920
    • Ludvigsson, J.1    Faresjo, M.2    Hjorth, M.3
  • 7
    • 77956882292 scopus 로고    scopus 로고
    • Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies
    • Porksen S, Laborie LB, Nielsen L et al. Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies. BMC Endocr Disord 2010; 10: 16.
    • (2010) BMC Endocr Disord , vol.10 , pp. 16
    • Porksen, S.1    Laborie, L.B.2    Nielsen, L.3
  • 9
    • 58149168752 scopus 로고    scopus 로고
    • Diabetes classification: grey zones, sound and smoke: Action LADA 1
    • Leslie RD, Kolb H, Schloot NC et al. Diabetes classification: grey zones, sound and smoke: Action LADA 1. Diabetes Metab Res Rev 2008; 24: 511-9.
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 511-519
    • Leslie, R.D.1    Kolb, H.2    Schloot, N.C.3
  • 10
    • 34347272254 scopus 로고    scopus 로고
    • Multiple factors affect the loss of measurable C-peptide over 6years in newly diagnosed 15- to 35-year-old diabetic subjects
    • Jensen RA, Gilliam LK, Torn C et al. Multiple factors affect the loss of measurable C-peptide over 6years in newly diagnosed 15- to 35-year-old diabetic subjects. J Diabetes Complications 2007; 21: 205-13.
    • (2007) J Diabetes Complications , vol.21 , pp. 205-213
    • Jensen, R.A.1    Gilliam, L.K.2    Torn, C.3
  • 11
    • 79959616082 scopus 로고    scopus 로고
    • Closed-loop insulin delivery: from bench to clinical practice
    • Feb 22. [Epub ahead of print].
    • Hovorka R. Closed-loop insulin delivery: from bench to clinical practice. Nat Rev Endocrinol 2011 Feb 22. [Epub ahead of print].
    • (2011) Nat Rev Endocrinol
    • Hovorka, R.1
  • 13
    • 33746468259 scopus 로고    scopus 로고
    • Current status of clinical islet cell transplantation
    • Lakey JR, Mirbolooki M, Shapiro AM. Current status of clinical islet cell transplantation. Methods Mol Biol 2006; 333: 47-104.
    • (2006) Methods Mol Biol , vol.333 , pp. 47-104
    • Lakey, J.R.1    Mirbolooki, M.2    Shapiro, A.M.3
  • 14
    • 77951168859 scopus 로고    scopus 로고
    • Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells
    • Vendrame F, Pileggi A, Laughlin E et al. Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes 2010; 59: 947-57.
    • (2010) Diabetes , vol.59 , pp. 947-957
    • Vendrame, F.1    Pileggi, A.2    Laughlin, E.3
  • 15
    • 57749203195 scopus 로고    scopus 로고
    • GAD65 autoimmunity-clinical studies
    • Uibo R, Lernmark A. GAD65 autoimmunity-clinical studies. Adv Immunol 2008; 100: 39-78.
    • (2008) Adv Immunol , vol.100 , pp. 39-78
    • Uibo, R.1    Lernmark, A.2
  • 16
    • 0023097680 scopus 로고
    • The role of immunotherapy in type I diabetes mellitus
    • Geffner ME, Lippe BM. The role of immunotherapy in type I diabetes mellitus. West J Med 1987; 146: 337-43.
    • (1987) West J Med , vol.146 , pp. 337-343
    • Geffner, M.E.1    Lippe, B.M.2
  • 17
    • 0023252955 scopus 로고
    • Immune intervention studies in insulin-dependent diabetes mellitus
    • Skyler JS. Immune intervention studies in insulin-dependent diabetes mellitus. Diabetes Metab Rev 1987; 3: 1017-35.
    • (1987) Diabetes Metab Rev , vol.3 , pp. 1017-1035
    • Skyler, J.S.1
  • 18
    • 76749126708 scopus 로고    scopus 로고
    • Immunomodulation for type 1 diabetes mellitus
    • Skyler JS. Immunomodulation for type 1 diabetes mellitus. Int J Clin Pract Suppl 2010; 166: 59-63.
    • (2010) Int J Clin Pract Suppl , vol.166 , pp. 59-63
    • Skyler, J.S.1
  • 19
    • 0023849461 scopus 로고
    • Factors associated with early remission of type I diabetes in children treated with cyclosporine
    • Bougneres PF, Carel JC, Castano L et al. Factors associated with early remission of type I diabetes in children treated with cyclosporine. N Engl J Med 1988; 318: 663-70.
    • (1988) N Engl J Med , vol.318 , pp. 663-670
    • Bougneres, P.F.1    Carel, J.C.2    Castano, L.3
  • 20
    • 0023709376 scopus 로고
    • Cyclosporin-induced remission of IDDM after early intervention. Association of 1yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group
    • Cyclosporin-induced remission of IDDM after early intervention. Association of 1yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group. Diabetes 1988; 37: 1574-82.
    • (1988) Diabetes , vol.37 , pp. 1574-1582
  • 21
    • 0025909735 scopus 로고
    • Follow-up of cyclosporin A treatment in type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects
    • Martin S, Schernthaner G, Nerup J et al. Follow-up of cyclosporin A treatment in type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects. Diabetologia 1991; 34: 429-34.
    • (1991) Diabetologia , vol.34 , pp. 429-434
    • Martin, S.1    Schernthaner, G.2    Nerup, J.3
  • 22
    • 67749100757 scopus 로고    scopus 로고
    • Anti-CD3 mAbs for treatment of type 1 diabetes
    • Kaufman A, Herold KC. Anti-CD3 mAbs for treatment of type 1 diabetes. Diabetes Metab Res Rev 2009; 25: 302-6.
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 302-306
    • Kaufman, A.1    Herold, K.C.2
  • 23
    • 0037100387 scopus 로고    scopus 로고
    • Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope
    • Jaume JC, Parry SL, Madec AM, Sonderstrup G, Baekkeskov S. Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope. J Immunol 2002; 169: 665-72.
    • (2002) J Immunol , vol.169 , pp. 665-672
    • Jaume, J.C.1    Parry, S.L.2    Madec, A.M.3    Sonderstrup, G.4    Baekkeskov, S.5
  • 24
    • 41949090941 scopus 로고    scopus 로고
    • Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein
    • Steed J, Gilliam LK, Harris RA, Lernmark A, Hampe CS. Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein. J Immunol Methods 2008; 334: 114-21.
    • (2008) J Immunol Methods , vol.334 , pp. 114-121
    • Steed, J.1    Gilliam, L.K.2    Harris, R.A.3    Lernmark, A.4    Hampe, C.S.5
  • 26
    • 77953924891 scopus 로고    scopus 로고
    • Immunology of beta-cell destruction
    • La Torre D, Lernmark A. Immunology of beta-cell destruction. Adv Exp Med Biol 2010; 654: 537-83.
    • (2010) Adv Exp Med Biol , vol.654 , pp. 537-583
    • La Torre, D.1    Lernmark, A.2
  • 28
    • 0036673437 scopus 로고    scopus 로고
    • GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes
    • Hampe CS, Kockum I, Landin-Olsson M et al. GAD65 antibody epitope patterns of type 1.5 diabetic patients are consistent with slow-onset autoimmune diabetes. Diabetes Care 2002; 25: 1481-2.
    • (2002) Diabetes Care , vol.25 , pp. 1481-1482
    • Hampe, C.S.1    Kockum, I.2    Landin-Olsson, M.3
  • 29
    • 34247574292 scopus 로고    scopus 로고
    • GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination
    • Bekris LM, Jensen RA, Lagerquist E et al. GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination. Diabet Med 2007; 24: 521-6.
    • (2007) Diabet Med , vol.24 , pp. 521-526
    • Bekris, L.M.1    Jensen, R.A.2    Lagerquist, E.3
  • 30
    • 67049159857 scopus 로고    scopus 로고
    • Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
    • Patterson CC, Dahlquist GG, Gyurus E, Green A, Soltesz G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009; 373: 2027-33.
    • (2009) Lancet , vol.373 , pp. 2027-2033
    • Patterson, C.C.1    Dahlquist, G.G.2    Gyurus, E.3    Green, A.4    Soltesz, G.5
  • 32
    • 77956262741 scopus 로고    scopus 로고
    • Virus infections and type 1 diabetes risk
    • Roivainen M, Klingel K. Virus infections and type 1 diabetes risk. Curr Diab Rep 2010; 10: 350-6.
    • (2010) Curr Diab Rep , vol.10 , pp. 350-356
    • Roivainen, M.1    Klingel, K.2
  • 33
    • 78649321907 scopus 로고    scopus 로고
    • Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies
    • Schlosser M, Mueller PW, Torn C, Bonifacio E, Bingley PJ. Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies. Diabetologia 2010; 53: 2611-20.
    • (2010) Diabetologia , vol.53 , pp. 2611-2620
    • Schlosser, M.1    Mueller, P.W.2    Torn, C.3    Bonifacio, E.4    Bingley, P.J.5
  • 34
    • 77954949830 scopus 로고    scopus 로고
    • Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia
    • Bonifacio E, Yu L, Williams AK et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab 2010; 95: 3360-7.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3360-3367
    • Bonifacio, E.1    Yu, L.2    Williams, A.K.3
  • 35
    • 58149467464 scopus 로고    scopus 로고
    • Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence
    • Bonifacio E, Mayr A, Knopff A, Ziegler AG. Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence. Diabetologia 2009; 52: 185-92.
    • (2009) Diabetologia , vol.52 , pp. 185-192
    • Bonifacio, E.1    Mayr, A.2    Knopff, A.3    Ziegler, A.G.4
  • 36
    • 78650070483 scopus 로고    scopus 로고
    • Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)
    • Stene LC, Oikarinen S, Hyoty H et al. Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes 2011; 59: 3174-80.
    • (2011) Diabetes , vol.59 , pp. 3174-3180
    • Stene, L.C.1    Oikarinen, S.2    Hyoty, H.3
  • 37
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial
    • Nanto-Salonen K, Kupila A, Simell S et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet 2008; 372: 1746-55.
    • (2008) Lancet , vol.372 , pp. 1746-1755
    • Nanto-Salonen, K.1    Kupila, A.2    Simell, S.3
  • 38
    • 49249134526 scopus 로고    scopus 로고
    • Children developing type 1 diabetes before 6years of age have increased linear growth independent of HLA genotypes
    • Larsson HE, Hansson G, Carlsson A et al. Children developing type 1 diabetes before 6years of age have increased linear growth independent of HLA genotypes. Diabetologia 2008; 51: 1623-30.
    • (2008) Diabetologia , vol.51 , pp. 1623-1630
    • Larsson, H.E.1    Hansson, G.2    Carlsson, A.3
  • 39
    • 34548783929 scopus 로고    scopus 로고
    • The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design
    • The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes 2007; 8: 286-98.
    • (2007) Pediatr Diabetes , vol.8 , pp. 286-298
  • 40
    • 34548397755 scopus 로고    scopus 로고
    • Screening for insulitis in adult autoantibody-positive organ donors
    • In't Veld P, Lievens D, De Grijse J et al. Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 2007; 56: 2400-4.
    • (2007) Diabetes , vol.56 , pp. 2400-2404
    • In't Veld, P.1    Lievens, D.2    De Grijse, J.3
  • 41
    • 8844259795 scopus 로고    scopus 로고
    • Autoimmune epitopes: autoepitopes
    • Mackay IR, Rowley MJ. Autoimmune epitopes: autoepitopes. Autoimmun Rev 2004; 3: 487-92.
    • (2004) Autoimmun Rev , vol.3 , pp. 487-492
    • Mackay, I.R.1    Rowley, M.J.2
  • 42
    • 44849112223 scopus 로고    scopus 로고
    • T cells in the pathogenesis of type 1 diabetes
    • Mallone R, van Endert P. T cells in the pathogenesis of type 1 diabetes. Curr Diab Rep 2008; 8: 101-6.
    • (2008) Curr Diab Rep , vol.8 , pp. 101-106
    • Mallone, R.1    van Endert, P.2
  • 44
    • 0026046093 scopus 로고
    • Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10
    • Karlsen AE, Hagopian WA, Grubin CE et al. Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc Natl Acad Sci U S A 1991; 88: 8337-41.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 8337-8341
    • Karlsen, A.E.1    Hagopian, W.A.2    Grubin, C.E.3
  • 45
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993; 366: 72-5.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 46
    • 0027368141 scopus 로고
    • Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
    • Kaufman DL, Clare-Salzler M, Tian J et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 1993; 366: 69-72.
    • (1993) Nature , vol.366 , pp. 69-72
    • Kaufman, D.L.1    Clare-Salzler, M.2    Tian, J.3
  • 47
    • 16144361909 scopus 로고    scopus 로고
    • Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
    • Tian J, Clare-Salzler M, Herschenfeld A et al. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med 1996; 2: 1348-53.
    • (1996) Nat Med , vol.2 , pp. 1348-1353
    • Tian, J.1    Clare-Salzler, M.2    Herschenfeld, A.3
  • 48
    • 0031831753 scopus 로고    scopus 로고
    • Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice
    • Tisch R, Liblau RS, Yang XD, Liblau P, McDevitt HO. Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice. Diabetes 1998; 47: 894-9.
    • (1998) Diabetes , vol.47 , pp. 894-899
    • Tisch, R.1    Liblau, R.S.2    Yang, X.D.3    Liblau, P.4    McDevitt, H.O.5
  • 49
    • 0031784202 scopus 로고    scopus 로고
    • Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology
    • Plesner A, Worsaae A, Dyrberg T, Gotfredsen C, Michelsen BK, Petersen JS. Immunization of diabetes-prone or non-diabetes-prone mice with GAD65 does not induce diabetes or islet cell pathology. J Autoimmun 1998; 11: 335-41.
    • (1998) J Autoimmun , vol.11 , pp. 335-341
    • Plesner, A.1    Worsaae, A.2    Dyrberg, T.3    Gotfredsen, C.4    Michelsen, B.K.5    Petersen, J.S.6
  • 50
    • 28444486947 scopus 로고    scopus 로고
    • Immunomodulation with human recombinant autoantigens
    • Lernmark A, Agardh CD. Immunomodulation with human recombinant autoantigens. Trends Immunol 2005; 26: 608-12.
    • (2005) Trends Immunol , vol.26 , pp. 608-612
    • Lernmark, A.1    Agardh, C.D.2
  • 51
    • 21344461521 scopus 로고    scopus 로고
    • Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes
    • Agardh CD, Cilio CM, Lethagen A et al. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications 2005; 19: 238-46.
    • (2005) J Diabetes Complications , vol.19 , pp. 238-246
    • Agardh, C.D.1    Cilio, C.M.2    Lethagen, A.3
  • 52
    • 67349116493 scopus 로고    scopus 로고
    • GAD65 vaccination: 5years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes
    • Agardh CD, Lynch KF, Palmer M, Link K, Lernmark A. GAD65 vaccination: 5years of follow-up in a randomised dose-escalating study in adult-onset autoimmune diabetes. Diabetologia 2009; 52: 1363-8.
    • (2009) Diabetologia , vol.52 , pp. 1363-1368
    • Agardh, C.D.1    Lynch, K.F.2    Palmer, M.3    Link, K.4    Lernmark, A.5
  • 53
    • 44449135894 scopus 로고    scopus 로고
    • The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes
    • Oak S, Gilliam LK, Landin-Olsson M et al. The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes. Proc Natl Acad Sci U S A 2008; 105: 5471-6.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5471-5476
    • Oak, S.1    Gilliam, L.K.2    Landin-Olsson, M.3
  • 54
    • 78049525235 scopus 로고    scopus 로고
    • Changes in GAD65Ab-specific antiidiotypic antibody levels correlate with changes in C-peptide levels and progression to islet cell autoimmunity
    • Ortqvist E, Brooks-Worrell B, Lynch K et al. Changes in GAD65Ab-specific antiidiotypic antibody levels correlate with changes in C-peptide levels and progression to islet cell autoimmunity. J Clin Endocrinol Metab 2010; 95: E310-8.
    • (2010) J Clin Endocrinol Metab , vol.95
    • Ortqvist, E.1    Brooks-Worrell, B.2    Lynch, K.3
  • 55
    • 77953432137 scopus 로고    scopus 로고
    • The role of immunomodulation therapy in autoimmune diabetes
    • Ludvigsson J. The role of immunomodulation therapy in autoimmune diabetes. J Diabetes Sci Technol 2009; 3: 320-30.
    • (2009) J Diabetes Sci Technol , vol.3 , pp. 320-330
    • Ludvigsson, J.1
  • 56
    • 79953756466 scopus 로고    scopus 로고
    • Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial
    • Ludvigsson J, Hjorth M, Cheramy M et al. Extended evaluation of the safety and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes: a randomised controlled trial. Diabetologia 2011; 54: 634-40.
    • (2011) Diabetologia , vol.54 , pp. 634-640
    • Ludvigsson, J.1    Hjorth, M.2    Cheramy, M.3
  • 57
    • 77956614531 scopus 로고    scopus 로고
    • GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response
    • Cheramy M, Skoglund C, Johansson I, Ludvigsson J, Hampe CS, Casas R. GAD-alum treatment in patients with type 1 diabetes and the subsequent effect on GADA IgG subclass distribution, GAD65 enzyme activity and humoral response. Clin Immunol 2010; 137: 31-40.
    • (2010) Clin Immunol , vol.137 , pp. 31-40
    • Cheramy, M.1    Skoglund, C.2    Johansson, I.3    Ludvigsson, J.4    Hampe, C.S.5    Casas, R.6
  • 58
    • 78651374710 scopus 로고    scopus 로고
    • GAD-alum treatment induces GAD65-specific CD4+ CD25highFOXP3+ cells in type 1 diabetic patients
    • Hjorth M, Axelsson S, Ryden A, Faresjo M, Ludvigsson J, Casas R. GAD-alum treatment induces GAD65-specific CD4+ CD25highFOXP3+ cells in type 1 diabetic patients. Clin Immunol 2010; 138: 117-26.
    • (2010) Clin Immunol , vol.138 , pp. 117-126
    • Hjorth, M.1    Axelsson, S.2    Ryden, A.3    Faresjo, M.4    Ludvigsson, J.5    Casas, R.6
  • 59
    • 79953220761 scopus 로고    scopus 로고
    • Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes
    • Fourlanos S, Perry C, Gellert SA et al. Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes. Diabetes 2011; 60: 1237-45.
    • (2011) Diabetes , vol.60 , pp. 1237-1245
    • Fourlanos, S.1    Perry, C.2    Gellert, S.A.3
  • 60
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1
    • Skyler JS, Krischer JP, Wolfsdorf J et al. Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1. Diabetes Care 2005; 28: 1068-76.
    • (2005) Diabetes Care , vol.28 , pp. 1068-1076
    • Skyler, J.S.1    Krischer, J.P.2    Wolfsdorf, J.3
  • 61
    • 34249786263 scopus 로고    scopus 로고
    • Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials
    • Schloot NC, Meierhoff G, Lengyel C et al. Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials. Diabetes Metab Res Rev 2007; 23: 276-85.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 276-285
    • Schloot, N.C.1    Meierhoff, G.2    Lengyel, C.3
  • 62
    • 79551693086 scopus 로고    scopus 로고
    • Type 1 diabetes vaccine development: animal models vs. humans
    • Epub ahead of print].
    • Boettler T, Herrath MV. Type 1 diabetes vaccine development: animal models vs. humans. Hum Vaccin 2011; 7. [Epub ahead of print].
    • (2011) Hum Vaccin , vol.7
    • Boettler, T.1    Herrath, M.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.