Whole-genome association study for milk protein composition in dairy cattle

Journal of Dairy Science

Volumn 94, Issue 6, 2011, Pages 3148-3158

  Schopen, G C B ^a   Visker, M H P W ^b   Koks, P D ^b   Mullaart, E ^a   van Arendonk, J A M ^b   Bovenhuis, H ^b  

^a CRV   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

lactalbumin; lactoglobulin; Casein; Genome wide association

Indexed keywords

CASEIN; LACTALBUMIN; LACTOGLOBULIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CATTLE; CHEMISTRY; FEMALE; GENETIC ASSOCIATION; GENETICS; MILK; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; CASEINS; CATTLE; FEMALE; GENOME-WIDE ASSOCIATION STUDY; LACTALBUMIN; LACTOGLOBULINS; MILK; POLYMORPHISM, SINGLE NUCLEOTIDE;

BOS; BOS TAURUS; BOVINAE; FRIESIA;

EID: 79956268263     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2010-4030     Document Type: Article

References (29)

1. Aulchenko Y.S., de Koning D.-J., Haley C. Genomewide rapid association using mixed model and regression: A fast and simple method for genomewide pedigree-based quantitative trait loci association analysis. Genetics 2007, 177:577-585.
2. Beavis W.D. QTL analysis: Power, precision and accuracy. Molecular Dissection of Complex Traits 1994, 145-162. CRC, Boca Raton, FL. A.H. Paterson (Ed.).
3. Bleck G.T., Bremel R.D. Sequence and single-base polymorphisms of the bovine α-lactalbumin 5′-flanking region. Gene 1993, 126:213-218.
4. Bobe G., Beitz D.C., Freeman A.E., Lindberg G.L. Effect of milk protein genotypes on milk protein composition and its genetic parameter estimates. J. Dairy Sci. 1999, 82:2797-2804.
5. Charlier C., Coppieters W., Rollin F., Desmecht D., Agerholm J.S., Cambisano N., Carta E., Dardano S., Dive M., Fasquelle C., Frennet J.-C., Hanset R., Hubin X., Jorgensen C., Karim L., Kent M., Harvey K., Pearce B.R., Simon P., Tama N., Nie H., Vandeputte S., Lien S., Longeri M., Fredholm M., Harvey R.J., Georges M. Highly effective SNP-based association mapping and management of recessive defects in livestock. Nat. Genet. 2008, 40:449-454.
6. Cohen-Zinder M., Seroussi E., Larkin D.M., Loor J.J., Everts-van der Wind A., Lee J.-H., Drackley J.K., Band M.R., Hernandez A.G., Shani M., Lewin H.A., Weller J.I., Ron M. Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Res. 2005, 15:936-944.
7. Emmons D.B., Ernstrom C.A., Lacroix C., Verret P. Predictive formulae for yield of cheese from composition of milk: A review. J. Dairy Sci. 1990, 73:1365-1394.
8. Fitzgerald D.K., Brodbeck U., Kiyosawa I., Mawal R., Colvin B., Ebner K.E. α-Lactalbumin and the lactose synthetase reaction. J. Biol. Chem. 1970, 245:2103-2108.
9. Ganai N.A., Bovenhuis H., van Arendonk J.A.M., Visker M.H.P.W. Novel polymorphisms in the bovine β-lactoglobulin gene and their effects on β-lactoglobulin protein concentration in milk. Anim. Genet. 2009, 40:127-133.
10. Gilmour A.R., Gogel B.J., Cullis B.R., Welham S.J., Thompson R. ASReml User Guide. Release 1.0 2002, VSN International Ltd., Hemel Hempstead, UK.
11. González J.R., Armengol L., Solé X., Guinó E., Mercader J.M., Estivill X., Moreno V. SNPassoc: An R package to perform whole genome association studies. Bioinformatics 2007, 23:644-645.
12. Grisart B., Coppieters W., Farnir F., Karim L., Ford C., Berzi P., Cambisano N., Mni M., Reid S., Simon P., Spelman R., Georges M., Snell R. Positional candidate cloning of a QTL in dairy cattle: Identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. Genome Res. 2002, 12:222-231.
13. Heck J.M.L., Olieman C., Schennink A., van Valenberg H.J.F., Visker M.H.P.W., Meuldijk R.C.R., van Hooijdonk A.C.M. Estimation of variation in concentration, phosphorylation and genetic polymorphism of milk proteins using capillary zone electrophoresis. Int. Dairy J. 2008, 18:548-555.
14. Heck J.M.L., Schennink A., van Valenberg H.J.F., Bovenhuis H., Visker M.H.P.W., van Arendonk J.A.M., van Hooijdonk A.C.M. Effects of milk protein variants on the protein composition of bovine milk. J. Dairy Sci. 2009, 92:1192-1202.
15. Kennedy B.W., Quinton Q., van Arendonk J.A.M. Estimation of effects of single genes on quantitative traits. J. Anim. Sci. 1992, 70:2000-2012.
16. Liu Y., Qin X., Song X.-Z.H., Jiang H., Shen Y., Durbin K.J., Lien S., Kent M.P., Sodeland M., Ren Y., Zhang L., Sodergren E., Havlak P., Worley K.C., Weinstock G.M., Gibbs R.A. Bos taurus genome assembly. BMC Genomics 2009, 10:180-191.
17. Lundén A., Lindersson M. α-Lactalbumin polymorphism in relation to milk lactose. Proc 6th World Congr. Genet. Appl. Livest. Prod. 1998, 47-50. 25.
18. Lundén A., Nilsson M., Janson L. Marked effect of β-lactoglobulin polymorphism on the ratio of casein to total protein in milk. J. Dairy Sci. 1997, 80:2996-3005.
19. Menzies K.K., Lefèvre C., Macmillan K.L., Nicholas K.R. Insulin regulates milk protein synthesis at multiple levels in the bovine mammary gland. Funct. Integr. Genomics 2009, 9:197-217.
20. Ng-Kwai-Hang K.F., Hayes J.F., Moxley J.E., Monardes H.G. Variation in milk protein concentrations associated with genetic polymorphism and environmental factors. J. Dairy Sci. 1987, 70:563-570.
21. R Development Core Team. 2005. R: A language and environment for statistical computing, reference index version 2.2.1. R Foundation for Statistical Computing, Vienna, Austria. http://www.r-project.org/.
22. Schnabel R.D., Kimm J.-J., Ashwell M.S., Sonstegard T.S., Van Tassell C.P., Conner E.E., Taylor J.F. Fine-mapping milk production quantitative trait loci on BTA6: Analysis of the bovine osteopontin gene. Proc. Natl. Acad. Sci. USA 2005, 102:6896-6901.
23. Schopen G.C.B., Heck J.M.L., Bovenhuis H., Visker M.H.P.W., van Valenberg H.J.F., van Arendonk J.A.M. Genetic parameters for major milk proteins in Dutch Holstein-Friesians. J. Dairy Sci. 2009, 92:1182-1191.
24. Schopen G.C.B., Koks P.D., van Arendonk J.A.M., Bovenhuis H., Visker M.H.P.W. Whole genome scan to detect quantitative trait loci for bovine milk protein composition. Anim. Genet. 2009, 40:524-537.
25. Storey J.D., Tibshirani R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA 2003, 100:9440-9445.
26. Van den Berg G., Escher J.T.M., de Koning P.J., Bovenhuis H. Genetic polymorphism of k-casein and β-lactoglobulin in relation to milk composition and processing properties. Neth. Milk Dairy J. 1992, 46:145-168.
27. Visker M.H.P.W., Dibbits B.W., Kinders S.M., Van Valenberg H.J.F., van Arendonk J.A.M., Bovenhuis H. Association of bovine β-casein protein variant I with milk production and milk protein composition. Anim. Genet. 2011, 42:212-218. doi:10.1111/j.1365-2052.2010.02106.x.
28. Wedholm A., Larsen L.B., Lindmark-Månsson H., Karlsson A.H., Andrén A. Effect of protein composition on the cheesemaking properties of milk from individual dairy cows. J. Dairy Sci. 2006, 89:3296-3305.
29. Yu J., Pressoir G., Briggs W.H., Bi I.V., Yamasaki M., Doebley J.F., McMullen M.D., Gaut B.S., Nielsen D.M., Holland J.B., Kresovich S., Buckler E.S. A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. Nat. Genet. 2006, 38:203-208.