Gambogenic acid induced apoptosis in human nasopharyngeal carcinoma CNE-1 cells and effect of p-p38 and p-ERK1/2 protein

Chinese Pharmacological Bulletin

Volumn 27, Issue 3, 2011, Pages 355-359

  Yan, Feng Gen ^a   Li, Qing Lin ^a  

^a ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; CNE 1 cells; ERK1 2; Gambogenic acid; p ERK1 2; p p38; p38

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYTOCHROME C; GAMBOGENIC ACID; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; MICROSCOPE; MITOCHONDRION; NASOPHARYNX CARCINOMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EID: 79956257429     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Li Q L, Cheng H, Zhu G Q, et al. Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing and cell cycle arresting [J]. Biol Pharm Bull, 2010,33(3):415-20.
2. Zhao Y, Tang F Q, Zeng L, et al. Apoptosis regulated by (-)-epigallocatechin-3-gallate in nasopharyngeal carcinoma cells using apoptosis cDNA expression array [J]. Chin Pharmacol Bull, 2002,18(3):255-9. (Pubitemid 34786861)
3. Tang X D, Zhou K Y, Zhu Q F, et al. Effects of homoharringtonine on inhibition of proliferation and induction of apoptosis of nasopharyngeal carcinoma cells CNE-2Z [J]. Chin Pharmacol Bull, 2003,19(1):63-6.
4. Yu M C, Yuan J M. Epidemiology of nasopharyngeal carcinoma [J]. Semin Cancer Biol, 2002,12(6):421-9.
5. Marcus K J, Tishler R B. Head and neck carcinomas across the age spectrum: epidemiology, therapy, and late effects [J]. Semin Radial Oncol, 2010,20(1):52-7.
6. Cheng H, Peng D Y, Wang X S, et al. Antitumor effects of neogambogic acid both in vivo and in vitro [J]. Chin Tradit Herb Drugs, 2008,39(2):236-40. (Pubitemid 351492708)
7. Lin M L, Lu Y C, Chung J G, et al. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway [J]. Cancer Lett, 2010,291(1):46-58.
8. Ting C M, Lee Y M, Wong C K, et al. 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways [J]. Biochem Pharmacol, 2010,79(6):825-41.
9. Lee Y M, Ting C M, Cheng Y K, et al. Mechanisms of 2-methoxyestradiol- induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells [J]. Cancer Lett, 2008,268(2):295-307.
10. Zhang Y J, Hao J, Liu S X, et al. Regulatory effect of p38MAPK signal pathway on the apoptosis of human esophageal cancer cells induced by valdecoxib [J]. Chin Pharmacol Bull, 2009,25(4):497-501.
11. Lü J, Zhou L S, Shao G, et al. Effects of sodium vanadate on p-ERK1/2 prote in expression in human esophageal cancer cell line EC109[J]. Chin Pharmacol Bull, 2009,25(10):1398-9.
12. Hu W, Kavanagh J J. Anticancer therapy targeting the apoptotic pathway [J]. Lancet Oncol, 2003,4(12):721-9. (Pubitemid 37527207)
13. Tsuruo T, Naito M, Tomida A, et al. Molecular targeting therapy of cancer : drug resistance, apoptosis and survival signal [J]. Cancer Sci, 2003,94(1):15-21. (Pubitemid 36575852)