Eliminating blood transfusions: New aspects and perspectives

Anesthesiology

Volumn 93, Issue 1, 2000, Pages 242-255

  Spahn, Donat R ^a,b   Casutt, Mattias ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Acute normovolemic hemodilution; Anesthesia techniques; Cell salvage; Preoperative autologous donation

Indexed keywords

ERYTHROPOIETIN;

BLEEDING; BLOOD TRANSFUSION REACTION; DISEASE TRANSMISSION; ERYTHROCYTE TRANSFUSION; GRAFT VERSUS HOST REACTION; HEMODILUTION; HUMAN; IMMUNOMODULATION; INFECTION; PRIORITY JOURNAL; REVIEW;

EID: 0033918205     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200007000-00035     Document Type: Review

References (194)

1. Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP: Transfusion medicine: First of two parts - blood transfusion. N Engl J Med 1999; 340:438-47
2. Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP: Transfusion medicine: Second of two parts - blood conservation. N Engl J Med 1999; 340:525-33
3. Vamvakas EC, Carven JH: Allogeneic blood transfusion, hospital charges, and length of hospitalization: A study of 487 consecutive patients undergoing colorectal cancer resection. Arch Pathol Lab Med 1998; 122:145-51
4. Jensen LS, Grunnet N, Hanberg Sorensen F, Jorgensen J: Cost-effectiveness of blood transfusion and white cell reduction in elective colorectal surgery. Transfusion 1995; 35:719-22
5. Blumberg N, Kirkley SA, Heal JM: A cost analysis of autologous and allogeneic transfusions in hip-replacement surgery. Am J Surg 1996; 171:324-30
6. Birchard K: Ireland's blood shortage reaches crisis (letter). Lancet 1998; 351:1567
7. Keipert PE: Perfluorochemical emulsions: Future alternatives to transfusion. Blood Subst Princ Meth Prod Clin Trials 1998; 2:127-56
8. Randal J: "Look back" program initiated for hepatitis C infection [news]. J Natl Cancer Inst 1999; 91:907
9. Heddle N, Kelton JG, Smaill F, Foss K, Everson J, Janzen C, Walker C Jones M, Hammons D: A Canadian hospital-based HIV/hepatitis C look-back notification program. Can Med Assoc J 1997; 157:149-54
10. Long A, Spurll G, Demers H, Goldman M: Targeted hepatitis C lookback Quebec, Canada. Transfusion 1999; 39:194-200
11. AuBuchon JP: Public health, public trust, and public decision making: Making hepatitis C virus lookback work. Transfusion 1999; 39:123-7
12. Fitzgerald RD, Martin CM, Dietz GE, Doig GS, Potter RF, Sibbald WJ: Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats. Crit Care Med 1997; 25:726-32
13. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G Tweeddale M, Schweitzer I, Yetisir E, and the Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999; 340: 409-17
14. Ely EW, Bernard GR: Transfusions in critically ill patients. N Engl J Med 1999; 340:467-8
15. Carson JL, Duff A, Berlin JA, Lawrence VA, Poses RM, Huber EC, Ohara DA, Noveck H, Strom BL: Perioperative blood transfusion and postoperative mortality. JAMA 1998; 279:199-205
16. Greenburg AG: Benefits and risks of blood transfusion in surgical patients. World J Surg 1996; 20:1189-93
17. Tremper KK: Perfluorochemical "blood substitutes": Indications for an oxygen carrying colloid. ANESTHESIOLOGY 1999; 91:1185-7
18. Sielenkämper AW, Chin Yee IH, Martin CM, Sibbald WJ: Diaspirin crosslinked hemoglobin improves systemic oxygen uptake in oxygen supply-dependent septic rats. Am J Respir Crit Care Med 1997; 156:1066-72
19. Marik PE Sibbald WJ: Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 1993; 269:3024-9
20. Purdy FR, Tweeddale MG, Merrick PM: Association of mortality with age of blood transfused in septic ICU patients. Can J Anaesth 1997; 44:1256-61
21. Cantaloube JF, Gallian P, Biagini P, Attoui H, Escher J, Zappitelli JP, Delord Y, de Micco P, de Lamballerie X: Prevalence of GB virus type C/hepatitis G virus RNA and anti-E2 among blood donors in Southeastern France. Transfusion 1999; 39:95-102
22. Lefrèere JJ, Roudot Thoraval F, Morand Joubert L, Brassard Y, Parnet Mathieu F, Mariotti M, Agis F, Rouet G, Lerable J, Lefevre G, Girot R, Loiseau P: Prevalence of GB virus type C/hepatitis G virus RNA and of anti-E2 in individuals at high or low risk for blood-borne or sexually transmitted viruses: Evidence of sexual and parenteral transmission. Transfusion 1999; 39:83-94
23. Itoh K, Hirakawa K, Okamoto H, Ukita M, Tanaka H, Sawada N, Tsuda F Miyakawa Y, Mayumi M: Infection by an unenveloped DNA virus associated with non-A to -G hepatitis in Japanese blood donors with or without elevated ALT levels. Transfusion 1999; 39:522-6
24. Ukita M, Okamoto H, Kato N, Miyakawa Y, Mayumi M: Excretion into bile of a novel unenveloped DNA virus (TT virus) associated with acute and chronic non-A-G hepatitis. J Infect Dis 1999; 179:1245-8
25. Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H, Miyakwa Y, Mayumi M: Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol Res 1998; 10:1-16
26. Kobayashi M, Chayama K, Arase Y, Tsubota A, Suzuki Y, Koida I, Saitoh S, Murashima N, Ikeda K, Koike H, Hashimoto M, Kumada H: Prevalence of TT virus before and after blood transfusion in patients with chronic liver disease treated surgically for hepatocellular carcinoma. J Gastroenterol Hepatol 1999; 14:358-63
27. Prati D, Lin YH, De Mattei C, Liu JK, Farma E, Ramaswamy L, Zanella A, Lee H, Rebulla P, Allain JP, Sirchia G, Chen B: A prospective study on TT virus infection in transfusion-dependent patients with beta-thalassemia. Blood 1999; 93:1502-5
28. Blackbourn DJ, Ambroziak J, Lennette E, Adams M, Ramachandran B, Levy JA: Infectious human herpesvirus 8 in a healthy North American blood donor. Lancet 1997; 349:609-11
29. Simmonds P: Transfusion virology: Progress and challenges. Blood Rev 1998; 12:171-7
30. Dobroszycki J, Herwaldt BL, Boctor F, Miller JR, Linden J, Eberhard ML, Yoon JJ, Ali NM, Tanowitz HB, Graham F, Weiss LM, Wittner M: A cluster of transfusion-associated babesiosis cases traced to a single asymptomatic donor. JAMA 1999; 281:927-30
31. Moor AC, Dubbelman TM, VanSteveninck J, Brand A: Transfusion-transmitted diseases: Risks, prevention and perspectives. Eur J Haematol 1999; 62:1-18
32. Transfusion-transmitted malaria-Missouri and Pennsylvania, 1996-1998. MMWR Morb Mortal Wkly Rep 1999; 48:253-6
33. Turner ML, Ironside JW: New-variant Creutzfeldt-Jakob disease: The risk of transmission by blood transfusion. Blood Rev 1998; 12: 255-68
34. Blumberg N, Heal JM: Blood transfusion immunomodulation: The silent epidemic. Arch Pathol Lab Med 1998; 122:117-9
35. Vamvakas EC: Transfusion-associated cancer recurrence and postoperative infection: Meta-analysis of randomized, controlled clinical trials. Transfusion 1996; 36:175-86
36. Klein HG: Immunomodulatory aspects of transfusion. ANESTHESIOLOGY 1999; 91:861-5
37. Amato AC, Pescatori M: Effect of perioperative blood transfusions on recurrence of colorectal cancer: Meta-analysis stratified on risk factors. Dis Colon Rectum 1998; 41:570-85
38. Innerhofer P, Walleczek C, Luz G, Hobisch Hagen P, Benzer A, Stockl B, Hessenberger G, Nussbaumer W, Schobersberger W: Transfusion of buffy coat-depleted blood components and risk of postoperative infection in orthopedic patients. Transfusion 1999; 39:625-32
39. Triulzi DJ, Vanek K, Ryan DH, Blumberg N: A clinical and immunologic study of blood transfusion and postoperative bacterial infection in spinal surgery. Transfusion 1992; 32:517-24
40. Carson JL, Altman DG, Duff A, Noveck H, Weinstein MP, Sonnenberg FA, Hudson JI, Provenzano G: Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion 1999; 39:694-700
41. Houbiers JG, van de Velde CJ, van de Watering LM, Hermans J, Schreuder S, Bijnen AB, Pahlplatz P, Schattenkerk ME, Wobbes T, de Vries JE, Klementschitsch P, van de Maas AH, Brand A: Transfusion of red cells is associated with increased incidence of bacterial infection after colorectal surgery: A prospective study. Transfusion 1997; 37: 126-34
42. Heiss MM, Mempel W, Jauch KW, Delanoff C, Mayer G, Mempel M, Eissner HJ, Schildberg FW: Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgery. Lancet 1993; 342:1328-33
43. Tartter PI, Mohandas K, Azar P, Endres J, Kaplan J, Spivack M: Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery. Am J Surg 1998; 176:462-6
44. El Oakley R, Paul E, Wong PS, Yohana A, Magee P, Walesby R, Wright J: Mediastinitis in patients undergoing cardiopulmonary bypass: Risk analysis and midterm results. J Cardiovasc Surg Torino 1997; 38:595-600
45. Ryan T, McCarthy JF, Rady MY, Serkey J, Gordon S, Starr NJ, Cosgrove DM: Early bloodstream infection after cardiopulmonary bypass: Frequency rate, risk factors, and implications. Crit Care Med 1997; 25:2009-14
46. Murphy PJ, Connery C, Hicks GL, Blumberg N: Homologous blood transfusion as a risk factor for postoperative infection after coronary artery bypass graft operations. J Thorac Cardiovasc Surg 1992; 104:1092-9
47. Vamvakas EC, Carven JH: Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: Effect of the length of storage of transfused red cells. Transfusion 1999; 39:701-10
48. Opelz G, Vanrenterghem Y, Kirste G, Gray DW, Horsburgh T, Lachance JG, Largiader F, Lange H, Vujaklija Stipanovic K, Alvarez Grande J, Schott W, Hoyer J, Schnuelle P, Descoeudres C, Ruder H, Wujciak T, Schwarz V: Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 1997; 63: 964-7
49. Jensen LS, Kissmeyer Nielsen P, Wolff B, Qvist N: Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgery. Lancet 1996; 348: 841-5
50. van de Watering LMG, Hermans J, Houbiers JGA, van den Borek PJ, Bouter H, Boer F, Harvey MS, Huysmans HA, Brand A: Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: A randomized clinical trial. Circulation 1998; 97:562-8
51. Jensen LS: Benefits of leukocyte-reduced blood transfusions in surgical patients. Curr Opin Hematol 1998; 5:376-80
52. Blajchman MA: Transfusion-associated immunomodulation and universal white cell reduction: Are we putting the can before the horse? Transfusion 1999; 39:665-70
53. Kopko PM, Holland PV: Transfusion-related acute lung injury. Br J Haematol 1999; 105:322-9
54. Silliman CC, Voelkel NF, Allard JD, Elzi DJ, Tuder RM, Johnson JL, Ambruso DR: Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest 1998;
55. Silliman CC, Paterson AJ, Dickey WO, Stroneck DF, Popovsky MA, Caldwell SA, Ambruso DR: The association of biologically active lipids with the development of transfusion-related acute lung injury: A retrospective study. Transfusion 1997; 37:719-26
56. Vamvakas EC, Moore SB: Blood transfusion and postoperative septic complications. Transfusion 1994; 34:714-27
57. Healy JC, Frankforter SA, Graves BK, Reddy RL, Beck JR: Preoperative autologous blood donation in total-hip arthroplasty: A cost-effectiveness analysis. Arch Pathol Lab Med 1994; 118:465-70
58. Bierbaum BE, Callaghan JJ, Galante JO, Rubash HE, Tooms RE, Welch RB: An analysis of blood management in patients having a total hip or knee arthroplasty. J Bone Joint Surg Am 1999; 81:2-10
59. Bengtsson A, Bengtson JP: Autologous blood transfusion: Preoperative blood collection and blood salvage techniques. Acta Anaesthesiol Scand 1996; 40:1041-56
60. Thomas MJ, Gillon J, Desmond MJ: Consensus conference on autologous transfusion: Preoperative autologous donation. Transfusion 1996; 36:633-9
61. Etchason J, Petz L, Keeler E, Calhoun L, Kleinman S, Snider C, Fink A, Brook R: The cost effectiveness of preoperative autologous blood donations. N Engl J Med 1995; 332:719-24
62. Murphy P, Heal JM, Blumberg N: Infection or suspected infection after hip replacement surgery with autologous or homologous blood transfusions. Transfusion 1991; 31:212-7
63. Goh M, Kleer CG, Kielczewski P, Wojno KJ, Kim K, Oesterling JE: Autologous blood donation prior to anatomical radical retropubic prostatectomy: Is it necessary? Urology 1997; 49:569-73
64. Popovsky MA, Whitaker B, Arnold NL: Severe outcomes of allogeneic and autologous blood donation: Frequency and characterization. Transfusion 1995; 35:734-7
65. Trouern-Trend JJ, Cable RG, Badon SJ, Newman BH, Popovsky MA: A case-controlled multicenter study of vasovagal reactions in blood donors: Influence of sex, age, donation status, weight, blood pressure, and pulse. Transfusion 1999; 39:316-20
66. Hillyer CD, Hart KK, Lackey DA, Lin LS, Bryan JA: Comparable safety of blood collection in "high-risk" autologous donors versus non-high-risk autologous and directed donors in a hospital setting. Am J Clin Pathol 1994; 102:275-7
67. Gandini G, Franchini M, Bertuzzo D, Olzer D, Crocco I, De Gironcoli M, Aprili G: Preoperative autologous blood donation by 1073 elderly patients undergoing elective surgery: A safe and effective practice. Transfusion 1999; 39:174-8
68. Kasper SM, Ellering J, Stachwitz P, Lynch J, Grunenberg R, Buzello W: All adverse events in autologous blood donors with cardiac disease are not necessarily caused by blood donation. Transfusion 1998; 38:669-73
69. The National Blood Resource Education Program Expert Panel: The use of autologous blood. JAMA 1990; 263:414-7
70. Ferguson KJ, Strauss RG, Toy PT: Physician recommendation as the key factor in patients' decisions to participate in preoperative autologous blood donation programs: Preoperative Autologous Blood Donation Study Group. Am J Surg 1994; 168:2-5
71. Chun TY, Martin S, Lepor H: Preoperative recombinant human erythropoietin injection versus preoperative autologous blood donation in patients undergoing radical retropubic prostatectomy. Urology 1997; 50:727-32
72. Miller RD, von Ehrenburg W: Controversies in transfusion medicine: Indications for autologous and allogeneic transfusion should be the same: con. Transfusion 1995; 35:450-2
73. Gould SA, Forbes JM: Controversies in transfusion medicine: Indications for autologous and allogeneic transfusion should be the same: pro. Transfusion 1995; 35:446-9
74. Domen RE: Adverse reactions associated with autologous blood transfusion: Evaluation and incidence at a large academic hospital. Transfusion 1998; 38:296-300
75. Linden JV, Kruskall MS: Autologous blood: Always safer? Transfusion 1997; 37:455-6
76. Goldman M, Remyprince S, Trepanier A, Decary F: Autologous donation error rates in canada. Transfusion 1997; 37:523-7
77. Red blood cell transfusions contaminated with Yersinia enterocolitica - United States, 1991-1996, and initiation of a national study to detect bacteria-associated transfusion reactions. MMWR Morb Mortal Wkly Rep 1997; 46:553-5
78. Goodnough LT, Monk TG, Andriole GL: Current concepts: Erythropoietin therapy. N Engl J Med 1997; 336:933-8
79. Mercuriali F, Inghilleri G: Management of preoperative anaemia. Br J Anaesth 1998; 81(suppl 1):56-61
80. Major A, Mathez Loic F, Rohling R, Gautschi K, Brugnara C: The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin. Br J Haematol 1997; 98:292-4
81. Eschbach JW, Abdulhadi MH, Browne JK, Delano BG, Downing MR, Egrie JC, Evans RW, Friedman EA, Graber SE, Haley NR, Korbet S, Krantz SB, Lundin AP, Nissenson AR, Ogden DA, Paganini EP, Rader B, Rutsky EA, Stivelman J, Stone WJ, Teschan P, Van Stone JC, Van Wyck DB, Zuckerman K, Adamson JW: Recombinant human erythropoietin in anemic patients with end-stage renal disease: Results of a phase III multicenter clinical trial. Ann Intern Med 1989; 111:992-1000
82. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW: Correction of the anemia of end-stage renal disease with recombinant human erythropoietin: Results of a combined phase I and II clinical trial [see comments]. N Engl J Med 1987; 316:73-8
83. Goodnough LT, Despotis GJ, Parvin CA: Erythropoietin therapy in patients undergoing cardiac operations. Ann Thorac Surg 1997; 64:1579-80
84. Sowade O, Warnke H, Scigalla P, Sowade B, Franke W, Messinger D, Gross J: Avoidance of allogeneic blood transfusions by treatment with epoetin beta (recombinant human erythropoietin) in patients undergoing open heart surgery. Blood 1997; 89:411-8
85. Weiskopf RB: Mathematical analysis of isovolemic hemodilution indicates that it can decrease the need for allogeneic blood transfusion. Transfusion 1995; 35:37-41
86. Helm RE, Klemperer JD, Rosengart TK, Gold JP, Peterson P, DeBois W, Altorki NK, Lang S, Thomas S, Isom OW, Krieger KH: Intraoperative autologous blood donation preserves red cell mass but does not decrease postoperative bleeding. Ann Thorac Surg 1996; 62:1431-41
87. Kochamba GS, Pfeffer TA, Sintek CF, Khonsari S: Intraoperative autotransfusion reduces blood loss after cardiopulmonary bypass. Ann Thorac Surg 1996; 61:900-3
88. Kahraman S, Altunkaya KH, Celebioglu B, Kanbak M, Pasaoglu I, Erdem K: The effect of acute normovolemic hemodilution on homologous blood requirements and total estimated red blood cell volume lost. Acta Anaesthesiol Scand 1997; 41:614-7
89. Herregods L, Moerman A, Foubert L, Denblauwen N, Mortier E, Poelaert J, Strays M: Limited intentional normovolemic hemodilution: ST segment changes and use of homologous blood products in patients with left main coronary artery stenosis. J Cardiothorac Vasc Anesth 1997; 11:18-23
90. Nash PA, Schrepferman CG, Rowland RG, Young J, Foster RS, Birhle R, Donohue JP: The impact of pre-donated autologous blood and intra-operative isovolaemic haemodilution on the outcome of transfusion in patients undergoing radical retropubic prostatectomy. Br J Urol 1996; 77:856-60
91. Lisander B, Jonsson R, Nordwall A: Combination of blood-saving methods decreases homologous blood requirements in scoliosis surgery. Anaesth Intensive Care 1996; 24:555-8
92. Schmied H, Schiferer A, Sessler DI, Meznik C: The effects of red-cell scavenging, hemodilution, and active warming on allogenic blood requirements in patients undergoing hip or knee arthroplasty. Anesth Analg 1998; 86:387-91
93. Gillon J, Thomas MJ, Desmond MJ: Consensus conference on autologous transfusion: Acute normovolaemic haemodilution. Transfusion 1996; 36:640-3
94. Bryson GL, Laupacis A, Wells GA: Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion? A meta-analysis. The International Study of Perioperative Transfusion. Anesth Analg 1998; 86:9-15
95. Monk TG, Goodnough LT, Brecher ME, Colberg JW, Andriole GL, Catalona WJ: A prospective randomized comparison of three blood conservation strategies for radical prostatectomy. ANESTHESIOLOGY 1999; 91:24-33
96. Goodnough LT, Monk TG, Brecher ME: Acute normovolemic hemodilution should replace the preoperative donation of autologous blood as a method of autologous-blood procurement. Transfusion 1998; 38:473-6
97. Brecher ME, Goodnough LT, Monk T: The value of oxygen-carrying solutions in the operative setting, as determined by mathematical modeling. Transfusion 1999; 39:396-402
98. Spahn DR: Blood substitutes: Artificial oxygen carriers: Perfluorocarbon emulsions. Crit Care 1999; 3:R93-7
99. Stehling L: Autologous transfusion, Anesthesia. Edited by Miller RD. Philadelphia, Churchill Livingston, 1999, pp 1645-62
100. Spahn DR, Leone BJ, Reves JG, Pasch T: Cardiovascular and coronary physiology of acute isovolemic hemodilution: A review of nonoxygen-carrying and oxygen-carrying solutions. Anesth Analg 1994; 78:1000-21
101. Spahn DR, Schmid ER, Seifert B, Pasch T: Hemodilution tolerance in patients with coronary artery disease who are receiving chronic beta-adrenergic blocker therapy. Anesth Analg 1996; 82:687-94
102. Spahn DR, Seifert B, Pasch T, Schmid ER. Haemodilution tolerance in patients with mitral valve regurgitation. Anaesthesia 1998; 53:20-4
103. Spahn DR, Zollinger A, Schlumpf RB, Stöhr S, Seifert B, Schmid ER, Pasch T: Hemodilution tolerance in elderly patients without known cardiac disease. Anesth Analg 1996; 82:681-6
104. Laxenaire MC, Charpentier C, Feldman L: Réactions anaphylactoï'des aux substituts colloïdaux du plasma: Incidence, facteurs de risque, mécanismes. Enquête prospective multicentrique française. Ann Fr Anesth Reanim 1994; 13:301-10
105. Laxenaire MC, Le Groupe d'études des reactions anaphylactoïdes peranesthésiques: Epidémiologie des réactions anaphylactoïdes peranesthésiques: Quatrième enquête multicentrique (juillet 1994-décembre 1996). Ann Fr Anesth Reanim 1999; 18:796-809
106. Egli GA, Zollinger A, Seifert B, Popovic D, Pasch T, Spahn DR: Effect of progressive haemodilution with hydroxyethyl starch, gelatin and albumin on blood coagulation: An in vitro thrombelastography study. Br J Anaesth 1997; 78:684-9
107. Desmond MJ, Thomas MJ, Gillon J, Fox MA: Consensus conference on autologous transfusion. Perioperative red cell salvage. Transfusion 1996; 36:644-51
108. National Heart, Lung, and Blood Institute Expert Panel on the use of Autologous Blood. Transfusion alert: Use of autologous blood. Transfusion 1995; 35:703-11
109. Huët C, Salmi LR, Fergusson D, Koopman-van Gemert AW, Rubens F, Laupacis A, International Study of Perioperative Transfusion (ISPOT) Investigators: A meta-analysis of the effectiveness of cell salvage to minimize perioperative allogeneic blood transfusion in cardiac and orthopedic surgery. Anesth Analg 1999; 89:861-9
110. Halpern NA, Alicea M, Seabrook B, Spungen AM, McElhinney AJ, Greenstein RJ: Cell saver autologous transfusion: Metabolic consequences of washing blood with normal saline. J Trauma 1996; 41: 407-15
111. Halpern NA, Alicea M, Seabrook B, Spungen A, Greenstein R: Isolyte S, a physiologic multielectrolyte solution, is preferable to normal saline to wash cell saver salvaged blood: Conclusions from a prospective, randomized study in a canine model. Crit Care Med 1997; 25:2031-8
112. Linden JV, Kaplan HS, Murphy MT: Fatal air embolism due to perioperative blood recovery. Anesth Analg 1997; 84:422-6
113. Napier JAF, Bruce M, Chapman J, Duguid JKM, Kelsey PR, Knowles SM, Murphy MF, Williamson LM, Wood JK, Lee D, Contreras M, Cross N, Desmond MJ, Gillon J, Lardy A, Williams FG: Guidelines for autologous transfusion perioperative haemodilution and cell salvage. Br J Anaesth 1997; 78:768-71
114. Hansen E, Wolff N, Knuechel R, Ruschoff J, Hofstaedter F, Taeger K: Tumor cells in blood shed from the surgical field. Arch Surg 1995; 130:387-93
115. Hansen E, Knuechel R, Altmeppen J, Taeger K: Blood irradiation for intraoperative autotransfusion in cancer surgery: Demonstration of efficient elimination of contaminating tumor cells. Transfusion 1999; 39:608-15
116. Kongsgaard UE, Wang MY, Kvalheim G: Leucocyte depletion filter removes cancer cells in human blood. Acta Anaesthesiol Scand 1996; 40:118-20
117. Edelman MJ, Potter P, Mahaffey KG, Frink R, Leidich RB: The potential for reintroduction of tumor cells during intraoperative blood salvage: Reduction of risk with use of the RC-400 leukocyte depletion filter. Urology 1996; 47:179-81
118. Müller M, Kuhn DF, Hinrichs B, Schindler E, Dreyer T, Hirsch C, Schaffer R, Hempelmann G: Ist die Elimination von Osteosarkomzellen durch "maschinelle Autotransfusion" und Leukozyten-Depletionsfilter möglich? Anaesthesist 1996; 45:834-8
119. Hansen E, Altmeppen J, Hansen K, Taeger K: Leukocyte depletion filters do not eliminate cancer cells contaminated blood (abstract). Transfusion 1999; 39(suppl):S239-P
120. Hansen E, Altmeppen J, Taeger K: Autologous haemotherapy in malignant diseases. Baillière's Clin Anaesth 1997; 11:335-50
121. Fidler IJ, Talmadge JE: Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell. Cancer Res 1986; 46:5167-71
122. Friedman BA, Burns TL, Schork MA: A study of blood utilization by diagnosis, month of transfusion, and geographic region of the United States. Transfusion 1979; 19:511-25
123. Munoz JJ, Birkmeyer NJ, Birkmeyer JD, O'Connor GT, Dacey LJ: Is epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery? A meta-analysis. Circulation 1999; 99: 81-9
124. Laupacis A, Fergusson D: Drugs to minimize perioperative blood loss in cardiac surgery: Meta-analyses using perioperative blood transfusion as the outcome. The International Study of Peri-operative Transfusion (ISPOT) Investigators. Anesth Analg 1997; 85:1258-67
125. Alderman EL, Levy JH, Rich JB, Nili M, Vidne B, Schaff H, Uretzky G, Pettersson G, Thiis JJ, Hantler CB, Chaitman B, Nadel A: Analyses of coronary graft patency after aprotinin use: Results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial. J Thorac Cardiovasc Surg 1998; 116:716-30
126. Rich JB: The efficacy and safety of aprotinin use in cardiac surgery. Ann Thorac Surg 1998; 66:86-11
127. Peters DC, Noble S: Aprotinin: An update of its pharmacology and therapeutic use in open heart surgery and coronary artery bypass surgery. Drugs 1999; 57:233-60
128. Levy JH: Hemostatic agents and their safety. J Cardiothorac Vasc Anesth 1999; 13:6-11
129. Hendrikx M, Jiang H, Gutermann H, Toelsie J, Renard D, Briers A, Pauwels JL, Mees U: Release of cardiac troponin I in antegrade crystalloid versus cold blood cardioplegia. J Thorac Cardiovasc Surg 1999; 118:452-9
130. Lentschener C, Benhamou D, Mercier FJ, Boyerneumann C, Naveau S, Smadja C, Wolf M, Franco D: Aprotinin reduces blood loss in patients undergoing elective liver resection. Anesth Analg 1997; 84: 875-81
131. Capdevila X, Calvet Y, Biboulet P, Biron C, Rubenovitch J, d'Athis F: Aprotinin decreases blood loss and homologous transfusions in patients undergoing major orthopedic surgery. ANESTHESIOLOGY 1998; 88:50-7
132. Hiippala ST, Strid LJ, Wennerstrand MI, Arvela JVV, Niemela HM, Mantyla SK, Kuisma RP, Ylinen JE: Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 1997; 84:839-44
133. Kaspar M, Ramsay MA, Nguyen AT, Cogswell M, Hurst G, Ramsay KJ: Continuous small-dose tranexamic acid reduces fibrinolysis but not transfusion requirements during orthotopic liver transplantation. Anesth Analg 1997; 85:281-5
134. Garcia-Huete L, Domenech P, Sabate A, Martinez Brotons F, Jaurrieta E, Figueras J: The prophylactic effect of aprotinin on intraoperative bleeding in liver transplantation: A randomized clinical study. Hepatology 1997; 26:1143-8
135. Kurz A, Sessler DI, Lenhardt R, for the Study of Wound Infection and Temperature Group: Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. N Engl J Med 1996; 334:1209-15
136. Bock M, Müller J, Bach A, Bohrer H, Martin E, Motsch J: Effects of preinduction and intraoperative warming during major laparotomy. Br J Anaesth 1998; 80:159-163
137. Schmied H, Kurz A, Sessler DI, Kozek S, Reiter A: Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty. Lancet 1996; 347:289-92
138. Barone JE, Tucker JB, Cecere J, Yoon MY, Reinhard E, Blabey RG, Lowenfels AB: Hypothermia does not result in more complications after colon surgery. Am Surg 1999; 65:356-9
139. Valeri CR, Khabbaz K, Khuri SF, Marquardt C, Ragno G, Feingold H, Gray AD, Axford T: Effect of skin temperature on platelet function in patients undergoing extracorporeal bypass. J Thorac Cardiovasc Surg 1992; 104:108-16
140. Michelson AD, MacGregor H, Barnard MR, Kestin AS, Rohrer MJ, Valeri CR: Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. Thromb Haemost 1994; 71:633-40
141. Michelson AD, Barnard MR, Khuri SF, Rohrer MJ, MacGregor H, Valeri CR: The effects of aspirin and hypothermia on platelet function in vivo. Br J Haematol 1999; 104:64-8
142. Sinclair S, James S, Singer M: Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: Randomised controlled trial. Br Med J 1997; 315: 909-12
143. McLoughlin TM, Fontana JL, Alving B, Mongan PD, Bunger R: Profound normovolemic hemodilution: Hemostatic effects in patients and in a porcine model. Anesth Analg 1996; 83:459-65
144. Ruttmann TG, James MF, Viljoen JF: Haemodilution induces a hypercoagulable state. Br J Anaesth 1996; 76:412-4
145. Janvrin SB, Davies G, Greenhalgh RM: Postoperative deep vein thrombosis caused by intravenous fluids during surgery. Br J Surg 1980; 67:690-3
146. Tuman KJ, Spiess BD, McCarthy RJ, Ivankovich AD: Effects of progressive blood loss on coagulation as measured by thrombelastography. Anesth Analg 1987; 66:856-63
147. Ruttmann TG, James MFM, Aronson I: In vivo investigation into the effects of haemodilution with hydroxyethyl starch (200/0.5) and normal saline on coagulation. Br J Anaesth 1998; 80:612-6
148. Mortelmans YJ, Vermaut G, Verbruggen AM, Arnout JM, Vermylen J, Van Aken H, Mortelmans LA: Effects of 6% hydroxyethyl starch and 3% modified fluid gelatin on intravascular volume and coagulation during intraoperative hemodilution. Anesth Analg 1995; 81:1235-42
149. Strauss RG, Stansfield C, Henriksen RA, Villhauer PJ: Pentastarch may cause fewer effects on coagulation than hetastarch. Transfusion 1988; 28:257-60
150. Karoutsos S, Nathan N, Lahrimi A, Grouille D, Feiss P, Cox DJ: Thrombelastogram reveals hypercoagulability after administration of gelatin solution. Br J Anaesth 1999; 82:175-7
151. Hobisch-Hagen P, Wirleittner B, Mair J, Luz G, Innerhofer P, Frischhut B, Ulmer H, Schobersberger W: Consequences of acute normovolaemic haemodilution on haemostasis during major orthopedic surgery. Br J Anaesth 1999; 82:503-9
152. Habler OP, Kleen MS, Hutter JW, Podtschaske AH, Tiede M, Kemming GI, Welte MV, Corso CO, Batra S, Keipert PE, Faithfull NS, Messmer KF: Effects of hyperoxic ventilation on hemodilution-induced changes in anesthetized dogs. Transfusion 1998; 38:135-44
153. Zollinger A, Hager P, Singer T, Friedl HP, Pasch T, Spahn DR: Extreme hemodilution due to massive blood loss in tumor surgery. ANESTHESIOLOGY 1997; 87:985-7
154. Boldt J, Weber A, Mailer K, Papsdorf M, Schuster P: Acute normovolaemic haemodilution vs controlled hypotension for reducing the use of allogeneic blood in patients undergoing radical prostatectomy. Br J Anaesth 1999; 82:170-4
155. Williams-Russo P, Sharrock NE, Mattis S, Liguori GA, Mancuso C, Peterson MG, Hollenberg J, Ranawat C, Salvati E, Sculco T: Randomized trial of hypotensive epidural anesthesia in older adults. ANESTHESIOLOGY 1999; 91:926-35
156. Ramos HC, Todo S, Kang Y, Felekouras E, Doyle HR, Starzl TE: Liver transplantation without the use of blood products. Arch Surg 1994; 129:528-32
157. Dupont J, Messiant F, Declerck N, Tavernier B, Jude B, Durinck L, Pruvot FR, Scherpereel P: Liver transplantation without the use of fresh frozen plasma. Anesth Analg 1996; 83:681-6
158. Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA: Human cardiovascular and metabolic response to acute, severe isovolemic anemia. JAMA 1998; 279:217-21
159. -1. ANESTHESIOLOGY 2000; 92:407-13
160. Hebert PC, Hu LQ, Biro GP: Review of physiologic mechanisms in response to anemia. Can Med Assoc J 1997; 156:827-40
161. Spahn DR, Schmid ER: Haemodilution in cardiac and vascular surgery. Curr Opin Anaesthesiol 1996; 9:54-61
162. Kleen M, Habler O, Hutter J, Podtschaske A, Tiede M, Kemming G, Welte M, Corso C, Messmer K: Effects of hemodilution on gastric regional perfusion and intramucosal pH. Am J Physiol 1996; 271:H1849-55
163. Haisjackl M, Luz G, Sparr H, Germann R, Salak N, Friesenecker B, Deusch E, Meusburger S, Hasibeder W: The effects of progressive anemia on jejunal mucosal and serosal tissue oxygenation in pigs. Anesth Analg 1997; 84:538-44
164. Tomiyama Y, Jansen K, Brian JE, Todd MM: Hemodilution, cerebral O2 delivery, and cerebral blood flow: A study using hyperbaric oxygenation. Am J Physiol 1999; 276:H1190-6
165. Woodson RD, Auerbach S: Effect of increased oxygen affinity and anemia on cardiac output and its distribution. J Appl Physiol 1982; 53:1299-306
166. Bauer R, Iijima T, Hossmann KA: Influence of severe hemodilution on brain function and brain oxidative metabolism in the cat. Intensive Care Med 1996; 22:47-51
167. van Woerkens EC, Trouwborst A, Duncker DJ, Koning MM, Boomsma F, Verdouw PD: Catecholamines and regional hemodynamics during isovolemic hemodilution in anesthetized pigs. J Appl Physiol 1992; 72:760-9
168. Fan FC, Chen RY, Schuessler GB, Chien S: Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog. Am J Physiol 1980; 238:H545-52
169. Crystal GJ, Rooney MW, Salem MR: Regional hemodynamics and oxygen supply during isovolemic hemodilution alone and in combination with adenosine-induced controlled hypotension. Anesth Analg 1988; 67:211-8
170. Tu YK, Liu HM: Effects of isovolemic hemodilution on hemodynamics, cerebral perfusion, and cerebral vascular reactivity. Stroke 1996; 27:441-5
171. Sungurtekin H, Cook DJ, Orszulak TA, Daly RC, Mullany CJ: Cerebral response to hemodilution during hypothermie cardiopulmonary bypass in adults. Anesth Analg 1999; 89:1078-83
172. Dong WK, Bledsoe SW, Chadwick HS, Shaw CM, Hornbein TF: Electrical correlates of brain injury resulting from severe hypotension and hemodilution in monkeys. ANESTHESIOLOGY 1986; 65:617-25
173. Kee DB, Wood JH: Experimental isovolemic haemodilution-induced augmentation of carotid blood flow and oxygen transport through graded carotid stenoses. Neurol Res 1991; 13:205-8
174. Wood JH, Simeone FA, Kron RE, Snyder LL: Experimental hypervolemic hemodilution: Physiological correlations of cortical blood flow, cardiac output, and intracranial pressure with fresh blood viscosity and plasma volume. Neurosurgery 1984; 14:709-23
175. Casutt M, Seifert B, Pasch T, Schmid ER, Turina MI, Spahn DR: Factors influencing the individual effects of blood transfusion on oxygen delivery and oxygen consumption. Crit Care Med 1999; 27:2194-2200
176. Hebert PC, Wells G, Marshall J, Martin C, Tweeddale M, Pagliarello G, Blajchman M: Transfusion requirements in critical care: A pilot study. Canadian Critical Care Trials Group. JAMA 1995; 273: 1439-44
177. Nelson AH, Fleisher LA, Rosenbaum SH: Relationship between postoperative anemia and cardiac morbidity in high-risk vascular patients in the intensive care unit. Crit Care Med 1993; 21:860-6
178. Hogue CW, Goodnough LT, Monk TG: Perioperative myocardial ischemic episodes are related to hematocrit level in patients undergoing radical prostatectomy. Transfusion 1998; 38:924-31
179. Weiskopf RB: Red cell transfusion outcome studies require a prospective, randomized design. Transfusion 1999; 39:657-60
180. Raby KE, Goldman L, Creager MA, Cook EF, Weisberg MC, Whittemore AD, Selwyn AP: Correlation between preoperative ischemia and major cardiac events after peripheral vascular surgery. N Engl J Med 1989; 321:1296-300
181. Raby KE, Brull SJ, Timimi F, Akhtar S, Rosenbaum S, Naimi C, Whittemore AD: The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery. Anesth Analg 1999; 88:477-82
182. Wallace A, Layug B, Tateo I, Li J, Hollenberg M, Browner W, Miller D, Mangano DT: Prophylactic atenolol reduces postoperative myocardial ischemia. ANESTHESIOLOGY 1998; 88:7-17
183. Mangano DT, Layug EL, Wallace A, Tateo I: Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery: Multicenter Study of Perioperative Ischemia Research Group. N Engl J Med 1996; 335:1713-20
184. Mangano DT: Adverse outcomes after surgery in the year 2001 - A continuing odyssey. ANESTHESIOLOGY 1998; 88:561-4
185. Badner NH, Knill RL, Brown JE, Novick TV, Gelb AW: Myocardial infarction after noncardiac surgery. ANESTHESIOLOGY 1998; 88:572-8
186. Johnson RG, Thurer RL, Kruskall MS, Sirois C, Gervino EV, Critchlow J, Weintraub RM: Comparison of two transfusion strategies after elective operations for myocardial revascularization. J Thorac Cardiovasc Surg 1992; 104:307-14
187. A Report by the American Society of Anesthesiologists Task Force on Blood Component Therapy: Practice guidelines for blood component therapy. ANESTHESIOLOGY 1996; 84:732-47
188. Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela Cantos F, Ergin MA: Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesth Analg 1999; 88:312-9
189. Despotis GJ, Grishaber JE, Goodnough LT: The effect of an intraoperative treatment algorithm on physicians' transfusion practice in cardiac surgery [see comments]. Transfusion 1994; 34:290-6
190. Despotis GJ, Santoro SA, Spitznagel E, Kater KM, Cox JL, Barnes P, Lappas DG: Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg 1994; 107:271-9
191. Despotis GJ, Levine V, Saleem R, Spitznagel E, Joist JH: Use of point-of-care test in identification of patients who can benefit from desmopressin during cardiac surgery: A randomised controlled trial. Lancet 1999; 354:106-10
192. Gould SA, Moore EE, Hoyt DB, Burch JM, Haenel JB, Garcia J, DeWoskin R, Moss GS: The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. J Am Coll Surg 1998; 187:113-20
193. Spahn DR, van Bremt R, Theilmeier G, Reibold JP, Welte M, Heinzerling H, Birck K, Keipert PE, Messmer K, Perflubron Emulsion Study Group: Perflubron emulsion delays blood transfusion in orthopedic surgery. ANESTHESIOLOGY 1999; 91:1195-1208
194. Helm RE, Rosengart TK, Gomez M, Klemperer JD, DeBois WJ, Velasco F, Gold JP, Altorki NK, Lang S, Thomas S, Isom OW, Krieger KH: Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion. Ann Thorac Surg 1998; 65:125-36