Human CD4+CD25+ cells in combination with CD34+ cells and thymoglobulin to prevent anti-hematopoietic stem cell T cell alloreactivity

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 1, 2011, Pages 61-68

  Mahmud, Dolores ^a   Nicolini, Benedetta ^a   van den Dries, Lennert ^a   Mahmud, Nadim ^a   Arpinati, Mario ^b   Rondelli, Damiano ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

ATG; CD34; Hematopoietic stem cells; Regulatory T cells; T cell alloreactivity

Indexed keywords

CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; THYMOCYTE ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; CD34 ANTIGEN; CYTOKINE; LYMPHOCYTE ANTIBODY;

ALLOGENEIC STEM CELL TRANSPLANTATION; ALLOIMMUNITY; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CD34 T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CLONOGENESIS; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA MATCHING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOMAGNETIC SEPARATION; IMMUNOREACTIVITY; IMMUNOREGULATION; IN VITRO STUDY; NONOBESE DIABETIC MOUSE; PERIPHERAL BLOOD STEM CELL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; UMBILICAL CORD BLOOD; ANIMAL; CULTURE TECHNIQUE; CYTOLOGY; GRAFT REJECTION; HISTOCOMPATIBILITY; IMMUNOSUPPRESSIVE TREATMENT; METABOLISM; METHODOLOGY; MOUSE; MOUSE MUTANT; TRANSPLANTATION;

ANIMALS; ANTIGENS, CD34; ANTILYMPHOCYTE SERUM; CELL CULTURE TECHNIQUES; COCULTURE TECHNIQUES; CYTOKINES; GRAFT REJECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY; HUMANS; IMMUNOSUPPRESSION; MICE; MICE, SCID; T-LYMPHOCYTES, REGULATORY;

EID: 79956196213     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2010.08.004     Document Type: Article

References (28)

1. Mattason J, Ringden O, Storb S. Graft failure after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2008;14(Suppl 1):165-170.
2. Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med. 1998;339:1186-1193.
3. Rondelli D, Andrews RG, Hansen JA, Ryncarz R, Faerber MA, Anasetti C. Alloantigen presenting function of normal human CD34+ hematopoietic cells. Blood. 1996;88:2619-2675.
4. Rondelli D, Anasetti C, Fortuna A, et al. T cell alloreactivity induced by normal G-CSF-mobilized CD34+ blood cells. Bone Marrow Transplant. 1998;21:1183-1191.
5. Rondelli D, Lemoli RM, Ratta M, et al. Rapid induction of CD40 on a subset of granulocyte colony-stimulating factor-mobilized CD34(+) blood cells identifies myeloid committed progenitors and permits selection of non immunogenic CD40(-) progenitor cells. Blood. 1999;94:2293-2300.
6. Abbasian J, Mahmud D, Mahmud N, et al. Allogeneic T cells induce rapid CD34+ cell differentiation into CD11c+CD86+ cells with direct and indirect antigen-presenting function. Blood. 2006;108:203-208.
7. Arpinati M, Terragna C, Chirumbolo G, et al. Human CD34(+) blood cells induce T-cell unresponsiveness to specific alloantigens only under costimulatory blockade. Exp Hematol. 2003; 31:31-38.
8. Glennie S, Soeiro I, Dyson PJ, Lam EW, Dazzi F. Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood. 2005;105:2821-2827.
9. Tolar J, Hippen KL, Blazar BR. Immune regulatory cells in umbilical cord blood: T regulatory cells and mesenchymal stromal cells. Br J Haematol. 2009;147:200-206.
10. Joffre O, Santolaria T, Calise D, et al. Prevention of acute and chronic allograft rejection with CD4+CD25+FoxP3+ regulatory T Lymphocytes. Nat Med. 2008;14:88-92.
11. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531-562.
12. Albert MH, Liu Y, Anasetti C, Yu XZ. Antigen- dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation. Eur J Immunol. 2005;35:2598-2607.
13. Finke J, Bethge WA, Schmoor C, et al. Standard graft-versushost disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial. Lancet Oncol. 2009;10:855-864.
14. Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N. A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+FoxP3 regulatory T cells. J Am Soc Nephrol. 2006;17:2844-2853.
15. Feng X, Kajigaya S, Solomou EE, et al. Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25 high FoxP3+ regulatory T cells in vitro. Blood. 2008;111: 3675-3683.
16. Hoffmann P, Boeld TJ, Eder R, et al. Isolation of CD4+CD25+ regulatory T cells for clinical trials. Biol Blood Marrow Transplant. 2006;12:267-274.
17. Di Ianni M, Del Papa B, Cecchini D, et al. Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications. Clin Exp Immunol. 2009;156: 246-253.
18. Kakhniashvili I, Filicko J, Kraft WK, Flomenberg N. Heterogeneous clearance of antithymocyte globulin after CD34+ selected allogeneic hematopoietic progenitor cell transplantation. Biol Blood Marrow Transplant. 2005;11:609-618.
19. Waller EK, Langston AA, Lonial S, et al. Pharmacokinetics and pharmacodynamics of anti-thymocyte globulin in recipients of partially HLA-matched blood hematopoietic progenitor cell transplantation. Biol Blood Marrow Transplant. 2003;9:460-471.
20. LaCorcia G, Swistak M, Lawendowski C, et al. Polyclonal rabbit antithymocyte globulin exhibits consistent immunosuppressive capabilities beyond cell depletion. Transplantation. 2009;87: 966-974.
21. Richter G, Hayden-Ledbetter M, Irgang M, et al. Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells. J Biol Chem. 2001; 276:45686-45693.
22. Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol. 2007;8:1353-1362.
23. Nguyen VH, Shashidhar S, Chang DS, et al. The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation. Blood. 2008;11:945-953.
24. Urbieta M, Barao I, Jones M, et al. Hematopoietic progenitor cell regulation by CD4+CD25+ T cells. Blood. 2010 Mar 3 [Epub ahead of print].
25. Liu Z, Fang Y, Wang X, Wang P, Yun P, Xu H. Upregulation of molecules associated with T-regulatory function by thymoglobulin pretreatment of human CD4+ cells. Transplantation. 2008;86:1419-1426.
26. Menning A, Hopken HE, Siegmund K, Lipp M, Hamann A, Huehn J. Distinctive role of CCR7 in migration and functional activity of nai{dotless}̈ve and effector/memory-like Treg subsets. Eur J Hematol. 2007;37:1575-1583.
27. Koenecke C, Czeloth N, Bubke A, et al. Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD. Eur J Immunol. 2009;39:3091-3096.
28. Di Ianni M, Falzetti F, Carotti A, et al. Adoptive immunotherapy with Tregs prevents GvHD and favours immune reconstitution after HLA haploidentical transplants for hematological malignancies. Blood. 2009;114:4 (abstr.)