Elevated circulating CD4 +ICOS +Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic lupus erythematosus

Lupus

Volumn 20, Issue 6, 2011, Pages 620-627

  Liu, Y ^a   Zhu, T ^a   Cai, G ^a   Qin, Y ^a   Wang, W ^a   Tang, G ^a   Zhao, D ^a   Shen, Q ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

anti dsDNA antibodies; FoxP3; inducible co stimulator; interleukin 10; systemic lupus erythematosus

Indexed keywords

COMPLEMENT COMPONENT C3; DOUBLE STRANDED DNA ANTIBODY; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 10; PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; LYMPHOCYTE SUBPOPULATION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; INTERLEUKIN-10; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; TRANSFORMING GROWTH FACTOR BETA; YOUNG ADULT;

EID: 79956159047     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203310392431     Document Type: Article

References (28)

1. Horwitz DA. Regulatory T cells in systemic lupus erythematosus: past, present and future. Arthritis Res Ther. 2008 ; 6: 227-227
2. Mellor-Pita S, Citores MJ, Castejon R, et al. Monocytes and T lymphocytes contribute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus. Cytometry B Clin Cytom. 2009 ; 4: 261-270
3. Enghard P, Langnickel D, Riemekasten G. T cell cytokine imbalance towards production of IFN-gamma and IL-10 in NZB/W F1 lupus-prone mice is associated with autoantibody levels and nephritis. Scand J Rheumatol. 2006 ; 3: 209-216 (Pubitemid 43890741)
4. Ito T, Hanabuchi S, Wang YH, et al. Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity. 2008 ; 6: 870-880
5. Miller AM, Lundberg K, Ozenci V, et al. CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patients. J Immunol. 2006 ; 10: 7398-7405 (Pubitemid 44715110)
6. Strauss L, Bergmann C, Szczepanski MJ, et al. Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression. J Immunol. 2008 ; 5: 2967-2980
7. Gotsman I, Grabie N, Gupta R, et al. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 ; 19: 2047-2055 (Pubitemid 44706881)
8. Herman AE, Freeman GJ, Mathis D, Benoist C. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med. 2004 ; 11: 1479-1489 (Pubitemid 38780403)
9. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 ; 11: 1271-1277 (Pubitemid 13221242)
10. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 1992 ; 6: 630-640
11. Mok CC, Lau CS. Pathogenesis of systemic lupus erythematosus. J Clin Pathol. 2003 ; 7: 481-490 (Pubitemid 36819418)
12. Chun HY, Chung JW, Kim HA, et al. Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol. 2007 ; 5: 461-466
13. Houssiau FA, Lefebvre C, Van den Berghe M, et al. Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity. Lupus. 1995 ; 5: 393-395
14. Bussolati B, Rollino C, Mariano F, Quarello F, Camussi G. IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE). Clin Exp Immunol. 2000 ; 3: 471-476 (Pubitemid 32002209)
15. Gomez D, Correa PA, Gomez LM, et al. Th1/Th2 cytokines in patients with systemic lupus erythematosus: is tumor necrosis factor alpha protective?. Semin Arthritis Rheum. 2004 ; 6: 404-413 (Pubitemid 38887139)
16. Rousset F, Garcia E, Defrance T, et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA. 1992 ; 5: 1890-1893
17. Lauwerys BR, Garot N, Renauld JC, Houssiau FA. Interleukin-10 blockade corrects impaired in vitro cellular immune responses of systemic lupus erythematosus patients. Arthritis Rheum. 2000 ; 9: 1976-1981
18. Chen Y, Cuda C, Morel L. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol. 2005 ; 12: 7692-7702 (Pubitemid 40806274)
19. Yan B, Ye S, Chen G, et al. Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells. Arthritis Rheum. 2008 ; 3: 801-812 (Pubitemid 351364878)
20. Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol. 2007 ; 4: 2579-2588 (Pubitemid 46233461)
21. Bonelli M, Savitskaya A, von Dalwigk K, et al. Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). Int Immunol. 2008 ; 7: 861-868 (Pubitemid 351876312)
22. Bonelli M, Savitskaya A, Steiner CW, et al. Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunol. 2009 ; 3: 1689-1695
23. Allan SE, Crome SQ, Crellin NK, et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol. 2007 ; 4: 345-354 (Pubitemid 46523383)
24. Ziegler SF. FOXP3: not just for regulatory T cells anymore. Eur J Immunol. 2007 ; 1: 21-23 (Pubitemid 46128782)
25. Bonelli M, von Dalwigk K, Savitskaya A, Smolen JS, Scheinecker C. Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis. Ann Rheum Dis. 2008 ; 5: 664-671 (Pubitemid 351571931)
26. Joetham A, Matsubara S, Okamoto M, et al. Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses. J Immunol. 2008 ; 11: 7117-7124
27. Zhou X, Bailey-Bucktrout SL, Jeker LT, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009 ; 9: 1000-1007
28. Vocanson M, Rozieres A, Hennino A, et al. Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of T(h)17/T(h)1 and regulatory T cells. J Allergy Clin Immunol. 2010 ; 2: 280-289