Simulating Neurocognitive Aging: Effects of a Dopaminergic Antagonist on Brain Activity During Working Memory

Biological Psychiatry

Volumn 67, Issue 6, 2010, Pages 575-580

  Fischer, Håkan ^a   Nyberg, Lars ^c   Karlsson, Sari ^a   Karlsson, Per ^b   Brehmer, Yvonne ^a   Rieckmann, Anna ^a   MacDonald, Stuart W S ^d   Farde, Lars ^b   Bäckman, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

^d UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Aging; antagonist; D1 receptors; dopamine; fMRI; pharmacology; spatial working memory

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; OXYGEN; PLACEBO;

ADULT; AGED; AGING; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPAMINERGIC TRANSMISSION; ELECTROENCEPHALOGRAM; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXYGEN BLOOD LEVEL; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPATIAL MEMORY; TASK PERFORMANCE; WORKING MEMORY;

ADULT; AGED; AGING; ANALYSIS OF VARIANCE; BENZAZEPINES; BRAIN; BRAIN MAPPING; DOPAMINE ANTAGONISTS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; OXYGEN; POSITRON-EMISSION TOMOGRAPHY; SINGLE-BLIND METHOD; SPACE PERCEPTION; YOUNG ADULT;

EID: 76849093512     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.12.013     Document Type: Article

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