Single- and double-chained truncated jaspine B analogues: Asymmetric synthesis, biological evaluation and theoretical study of an unexpected 5-endo-dig process

Tetrahedron

Volumn 67, Issue 23, 2011, Pages 4253-4262

  Salma, Yahya ^a,b   Ballereau, Stéphanie ^b   Ladeira, Sonia ^c   Lepetit, Christine ^d   Chauvin, Remi ^d   Andrieu Abadie, Nathalie ^a   Génisson, Yves ^b  

^a CANCER RESEARCH CENTER OF TOULOUSE   (France)

^b Université Paul Sabatier Toulouse III   (France)

^c UNIVERSITÉ PAUL SABATIER   (France)

^d LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

Author keywords

5 endo dig; Apoptosis; Furan; Sphingolipid; Sphingomyelin synthase

Indexed keywords

4 (DIMETHYLAMINO) 2 OCTYLTETRA HYDROFURAN 3 OL; 4 (HEXYLAMINO) 2 OCTYLTETRA HYDROFURAN 3 OL; 4 AMINO 2 (4 FLUOROPHENETHYL)TETRAHYDROFURAN 3 OL; 4 AMINO 2 (OCTYL)TETRAHYDROFURAN 3 OL; ALIPHATIC COMPOUND; AMIDE; AMINE; ANTINEOPLASTIC AGENT; CERAMIDE; JASPINE B DERIVATIVE; LEWIS ACID; N (4 HYDROXY 5 OCTYLTETRA HYDROFURAN 3 YL)OCTANAMIDE; NATURAL PRODUCT; NUCLEOPHILE; POTASSIUM ION; SPHINGOLIPID; SPHINGOMYELIN; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ACIDITY; ALKALINITY; APOPTOSIS; ARTICLE; ASYMMETRIC SYNTHESIS; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CULTURE MEDIUM; CYCLIZATION; DRUG SCREENING; LIPOPHILICITY; PRIORITY JOURNAL; SAPONIFICATION;

EID: 79956129293     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2011.04.027     Document Type: Article

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