Characterisation of granule structure and strength made in a high shear granulator

Powder Technology

Volumn 192, Issue 2, 2009, Pages 184-194

  Rahmanian, N ^a   Ghadiri, M ^a   Jia, X ^a   Stepanek, F ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cyclomix; High shear mixer granulator; Porosity; Strength characterisation; Structure characterisation; X ray micro tomography

Indexed keywords

CYCLOMIX; HIGH SHEAR MIXER GRANULATOR; STRENGTH CHARACTERISATION; STRUCTURE CHARACTERISATION; X-RAY MICRO-TOMOGRAPHY;

CALCIUM; DIAGNOSTIC RADIOGRAPHY; ETHYLENE GLYCOL; GRANULATION; MIXERS (MACHINERY); POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POROSITY; SPEED; TOMOGRAPHY;

GRANULATORS;

EID: 62549138222     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.12.016     Document Type: Article

References (62)

1. Capes C.E. Particle size enlargement. Handbook of Powder Technology vol. 1 (1980), Elsevier, Amsterdam
2. Pietsch, W., 1991. Size enlargement by agglomeration. Wiley; Aarau; Salle and Sauerländer, Chichester.
3. Ennis B., and Litster J. Principles of size enlargement. In: Green D., and Perry R. (Eds). Perry's Chemical Engineers (1997), Mc Graw Hill, New York Handbook-7th Edition
4. Litster J., and Ennis B. The science and engineering of granulation process (2004), Kluwer academic publishers, Dordrecht, The Netherlands
5. Parikh D.M. Handbook of pharmaceutical granulation technology. 2nd ed. (2005), Taylor and Francis Informa Publications 191-228
6. Newitt D.M., and Conway-Jones J.M. A contribution to the theory and practise of granulation. Trans. Inst. Chem Eng. 36 (1958) 422-441
7. Kapur P.C., and Fuerstenau D.W. A coalescence model for granulation. Ind. Eng. Chem. Process Des. Dev. 8 (1969) 56-62
8. Iveson S.M., Litster J.D., and Ennis J.D. Fundamental studies of granule consolidation: part 1. Effects of binder viscosity and binder content. Powder Technol. 88 (1996) 15-20
9. Knight P.C., Instone T., Peason J.M.K., and Hounslow M.J. An investigation into kinetics of liquid distribution and growth in high shear mixer agglomeration. Powder Technol. 97 (1998) 246-257
10. Knight P.C., Johansen A., Kristensen P.C., Schaefer P.C., and Seville J.P.K. An investigation of the effects on agglomeration of changing the speed of a mechanical mixer. Powder Technol. 110 (2000) 204-209
11. Scott A., Hounslow M.J., and Instone T. Direct evidence of heterogeneity during high shear granulation. Powder Technol. 113 (2000) 205-213
12. Johansen A., and Schaefer T. Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer. Eur. J. Pharm. Sci 12 (2001) 297-309
13. Stepanek F., and Rajniak P. Droplet morphologies on particles with macroscopic surface roughness. Langmuir 22 (2006) 917-923
14. Golchert D., Moreno R., Ghadiri M., and Litster J. Effect of granule morphology on breakage behaviour during compression. Powder Technol. 143-144 (2004) 84-96
15. Stepanek F. Computer-aided product design: granule dissolution. Chem. Eng. Res. Des. 82 A11 (2004) 1458-1466
16. Jia X., and Williams R.A. Agglomerates-structures and their dissolution behaviour. Fifth World Congress on Particle Technology, 23-27 April, Florida, USA (2006)
17. Jia X., and Williams R.A. A hybrid mesoscale modelling approach to dissolution of granules and tablets. Chem. Eng. Res. Des. 85 (2007) 1027-1038
18. Kohlus R. Quantification of granule structure. International Congress on Particle Technology, Nuremberg, Germany (2001)
19. Farber L., Tardos G.I., and Michaels J.N. Use of X-ray tomography to study the porosity and morphology of granules. Powder Technol. 132 (2003) 57-63
20. Kosek J., Stepanek F., and Marek M. Modelling of transport and transformation processes in porous and multiphase bodies. Adv. Chem. Eng. 30 (2005) 137-203
21. Stepanek F., and Ansari M.A. Computer simulation of granule microstructure formation. Chem. Eng. Sci. 60 (2005) 4019-4029
22. Barrera-Medrano D., Reynolds G.K., Bonstall J., Salman A.D., and Hounslow M.J. An X-ray tomography study of the effect of processing time on granulation structure in high shear melt granulation. Fifth World Congress on Particle Technology, 23-27 April, Florida, USA (2006)
23. Russ, J.C. and Dehoff, R.T.D. 2000. Particle sterelogy, 2nd ed., Kulwer Academic Publishing/Plenum, New York, pp. 300-306.
24. Adler P.M. Porous media: Geometry and Transports (1992), Butterworth-Heinemann, Boston
25. Kohout M., Grof Z., and Stepanek F. Pore-scale modelling and tomographic visualisation of drying in granular media. J. Colloid Interface Sci. 299 (2006) 342-351
26. Barrot D., Corriveau J., Giordano P., Mandayam S., and Sukumaran B. Three-dimensional shape descriptors and tomographic reconstruction techniques for granular materials. Fifth World Congress on Particle Technology, 23-27 April, Florida, USA (2006)
27. Lowell S., Shields J.E., Thomas M.A., and Thommes M. Characterisation of porous solids and powders: surface area, pore size and density. Chapter 14: Vaccum volumetric measurement (2004), Kulwer Academic Publishers
28. Stanley-wood N.G., and Shubair M.S. The influence of binder concentration on the intra- and intergranular porosity of pharmaceutical granules. Powder Technol. 22 (1979) 153-160
29. Klobes P., Reisemeier H., Meyer K., and Goebbels J. Rock porosity determination by combination of X-ray computerized tomography with mercury porosimetry. Fresenius J. Anal. Chem. 357 (1997) 543-547
30. Gregg S.J., and Sing K.S.W. Adsorption, Surface Area and Porosity (1982), Academic Press, New York
31. Thielmann F., Naderi M., Ansari M.A., and Stepanek F. The effect of primary particle surface energy on agglomeration rate in fluidised-bed wet granulation. Powder Technol. 181 (2008) 160-168
32. Hancock B.D., and Mullarney M.P. X-ray micro-tomography of solid dosage forms. Pharmaceutical Technol 29 4 (2005) 92-100
33. Garboczi E.J. Three-dimensional mathematical analysis of particle shape using X-ray tomography and spherical harmonics: application to aggregates used in concrete. Cem. Concr. Res. 32 (2002) 1621-1638
34. Subero J., and Ghadiri M. Breakage patterns of agglomerates. Powder Technol. 120 3 (2001) 232-243
35. Salman A.D., Fu J., Gorham A.D., and Hounslow M.J. Impact breakage of fertiliser granules. Powder Technol. 130 1-3 (2003) 359-366
36. Antonyuk S., Khanal M., Tomas J., Heinrich S., and Mörl L. Impact breakage of spherical granules: experimental study and DEM simulation. Chem. Eng. Process. 45 10 (2006) 838-856
37. Hassanpour A., Antony S.J., and Ghadiri M. Effect of size ratio on the behaviour of agglomerates embedded in a bed of particles subjected to shearing: DEM analysis. Chem. Eng. Sci. 62 (2007) 935-942
38. Rahmanian N., Ghadiri M., Ding Y., and Jia X. Influence of scale-up of high shear mixer granulators on the strength and properties of granules. PARTEC 2007, 27-29 March, Nuremberg, Germany (2007)
39. Rahmanian N., Ghadiri M., and Ding Y. Effect of scale of operation on granule strength in high shear granulators. Chem. Eng. Sci. 63 4 (2008) 915-923
40. Stepanek F., Marek M., Kubíček M., and Adler P.M. Computer-aided screening of adsorbents and porous catalyst carriers. Comput. Aided Chem. Eng. 8 (2000) 667-672
41. Hassanpour A., Kwan C.C., Ng B.H., Rahmanian N., Ding Y.L., Antony S.J., Jia X.D., and Ghadiri M. Effect of granulation scale-up on the structure and strength of granules. Third International Granulation Workshop, University of Sheffield, 27-29 June 2007 (2007)
42. Kwan C.C., Hare C., Ding Y., Williams R.A., and Ghadiri M. How granule characteristics change when high shear mixer granulator are scale-up. Fifth World Congress on Particle Technology, 23-27 April, Florida, USA (2006)
43. Eliassi A., Modarres H., and Mansoori G.A. Densities of polyethyleneglycol and water mixtures in the 298.15-328.15 K temperature range. J. Chem. Eng. Data 43 (1998) 719-721
44. Ansari M.A., and Stepanek F. The effect of granule microstructure on dissolution rate. Powder Technology 181 (2008) 104-114
45. Giesche H. Mercury porsosimetry: a general (practical) overview. Part. Part. Syst. Charact. 23 (2006) 9-19
46. McCullough E. Photon attenuation in computed tomography. Med. Phys. 2 6 (1975) 307-320
47. Brooks R.A., and Di Chiro G. Theory of image reconstruction in computer tomography. Radiology 117 (1975) 561-572
48. Brooks R.A., and Di Chiro G. Principles of computer assisted tomography (CAT) in radiographic in radio isotopic imaging. Phys. Med. Biol. 21 5 (1976) 689-732
49. McCullough E., and Payne J.T. X-ray transmission computed tomography. Med. Phys. 4 2 (1977) 85-98
50. Panton D.M. Mathematical reconstruction techniques in computer tomography. Mathnce 6 (1981) 87-102
51. Kak A.C., and Slaney M. Principles of computerised tomography (1988), IEEE press, Piscataway, N.J.
52. Endoh, S., 2006. Particle shape charcaterisation. In Powder Technology Handbook, CRC press, Taylor and Francis Group, Florida.
53. Witt W., Köhler U., and List J. Direct imaging of very fast particles opens the application of powerful (dry) dispersion for size and shape characterisation. PARTEC 2004, Nuremberg, Germany (2004)
54. Witt W., Köhler U., and List J. Current limits of particle size and shape analysis with high speed image analysis. PARTEC 2007, 27-29 March, Nuremberg, Germany (2007)
55. Arns C.H., Knackstedt M.A., Pinczewski V.W., and Mecke K.R. Euler-Poincar ́e characteristics of classes of disordered media. Physical Review E 63 (2001) 031112
56. Hilfer R. Review on scale dependent characterization of the microstructure of porous media. Transport in Porous Media 46 (2002) 373-390
57. Arns C.H., Knackstedt M.A., and Mecke K.R. Characterisation of irregular spatial structures by parallel sets and integral geometric measures. Colloids and Surfaces A: Physicochemical and Engineering Aspects 241 (2004) 351-372
58. Roberts A.P., and Torquato S. Chord distribution functions of three dimensional random media: approximate first-passage times of Gaussian processes. Physical Review E 59 (1999) 4953-4963
59. Adler P.M. The method of reconstructed porous media. Current Topics in the Physics of Fluids 1 (1994) 277-306
60. Adler P.M., and Thovert J.F. Real porous media: local geometry and macroscopic properties. Applied Mechanics Reviews 51 9 (1998) 537-585
61. Mecke K.R., and Stoyan D. Morphological characterization of point patterns. Biometrical Journal 47 (2005) 473-488
62. Gabbott I.P., Barrera-Medrano D., Reynolds G.K., Bonsall J., Hounslow M.J., and Salman A.D. Effect of binder ratio on granule strength, dissolution and structure. Fifth World Congress on Particle Technology, 23-27 April, Florida, USA (2006)