메뉴 건너뛰기




Volumn 4, Issue 1, 2010, Pages 40-47

Vitamin D, Insulin Resistance, and Type 2 Diabetes

Author keywords

Insulin resistance; Insulin secretion; Type 2 diabetes; Vitamin D; Vitamin D receptor

Indexed keywords


EID: 79956111707     PISSN: 19329520     EISSN: 19329563     Source Type: Journal    
DOI: 10.1007/s12170-009-0071-2     Document Type: Article
Times cited : (11)

References (42)
  • 1
    • 54049148081 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention, Atlanta, GA: US Department of Health and Human Services
    • Centers for Disease Control and Prevention: National Diabetes Fact Sheet: United States 2007. Atlanta, GA: US Department of Health and Human Services; 2007.
    • (2007) National Diabetes Fact Sheet: United States 2007
  • 2
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: principles of pathogenesis and therapy
    • Stumvoll M, Goldstein BJ, van Haeften TW: Type 2 diabetes: principles of pathogenesis and therapy. Lancet 2005, 365: 1333-1346.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 3
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections
    • King H, Aubert RE, Herman WH: Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 1998, 21: 1414-1431.
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 4
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, et al.: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27: 1047-1053.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3
  • 5
    • 0027953703 scopus 로고
    • Insulin action, diabetogenes, and the cause of type II diabetes
    • Kahn CR: Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994, 43: 1066-1084.
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 6
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Banting lecture 1988
    • Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988, 37: 1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 7
    • 1642281100 scopus 로고    scopus 로고
    • Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    • Holick MF: Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr 2004, 79: 362-371.
    • (2004) Am J Clin Nutr , vol.79 , pp. 362-371
    • Holick, M.F.1
  • 8
    • 34447514029 scopus 로고    scopus 로고
    • Deficiency
    • This review focuses on the nature of vitamin D deficiency and summarized evidence linking vitamin deficiency to a wide variety of chronic diseases, including common cancers, autoimmune, cardiovascular, and infectious diseases. In addition, the author emphasizes the epidemic of vitamin D deficiency and the importance of adequate vitamin D by synthesis in the skin or from dietary and supplemental sources for overall health and well being throughout life
    • •• Holick MF: Vitamin D deficiency. N Engl J Med 2007, 357: 266-281. This review focuses on the nature of vitamin D deficiency and summarized evidence linking vitamin deficiency to a wide variety of chronic diseases, including common cancers, autoimmune, cardiovascular, and infectious diseases. In addition, the author emphasizes the epidemic of vitamin D deficiency and the importance of adequate vitamin D by synthesis in the skin or from dietary and supplemental sources for overall health and well being throughout life.
    • (2007) N Engl J Med , vol.357 , pp. 266-281
    • Holick, M.F.1    Vitamin, D.2
  • 9
    • 49449100141 scopus 로고    scopus 로고
    • From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health
    • Norman AW: From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008, 88: 491S-499S.
    • (2008) Am J Clin Nutr , vol.88
    • Norman, A.W.1
  • 10
    • 58149346072 scopus 로고    scopus 로고
    • Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000
    • Forouhi NG, Luan J, Cooper A, et al.: Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes 2008, 57: 2619-2625.
    • (2008) Diabetes , vol.57 , pp. 2619-2625
    • Forouhi, N.G.1    Luan, J.2    Cooper, A.3
  • 11
    • 50549084247 scopus 로고    scopus 로고
    • Serum vitamin D and subsequent occurrence of type 2 diabetes
    • This study combined data from two nested case-control studies from two Finnish cohorts to provide prospective evidence on the relation of serum vitamin D with type 2 diabetes incidence. The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes
    • • Knekt P, Laaksonen M, Mattila C, et al.: Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology 2008, 19: 666-671. This study combined data from two nested case-control studies from two Finnish cohorts to provide prospective evidence on the relation of serum vitamin D with type 2 diabetes incidence. The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes.
    • (2008) Epidemiology , vol.19 , pp. 666-671
    • Knekt, P.1    Laaksonen, M.2    Mattila, C.3
  • 12
    • 35148824474 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes
    • Mattila C, Knekt P, Mannisto S, et al.: Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 2007, 30: 2569-2570.
    • (2007) Diabetes Care , vol.30 , pp. 2569-2570
    • Mattila, C.1    Knekt, P.2    Mannisto, S.3
  • 13
    • 0027478740 scopus 로고
    • Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer
    • Hollis BW, Kamerud JQ, Selvaag SR, et al.: Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer. Clin Chem 1993, 39: 529-533.
    • (1993) Clin Chem , vol.39 , pp. 529-533
    • Hollis, B.W.1    Kamerud, J.Q.2    Selvaag, S.R.3
  • 14
    • 0022192485 scopus 로고
    • Improved radioimmunoassay for vitamin D and its use in assessing vitamin D status
    • Hollis BW, Napoli JL: Improved radioimmunoassay for vitamin D and its use in assessing vitamin D status. Clin Chem 1985, 31: 1815-1819.
    • (1985) Clin Chem , vol.31 , pp. 1815-1819
    • Hollis, B.W.1    Napoli, J.L.2
  • 15
    • 0036287888 scopus 로고    scopus 로고
    • Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994
    • Nesby-O'Dell S, Scanlon KS, Cogswell ME, et al.: Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2002, 76: 187-192.
    • (2002) Am J Clin Nutr , vol.76 , pp. 187-192
    • Nesby-O'Dell, S.1    Scanlon, K.S.2    Cogswell, M.E.3
  • 16
    • 63849098416 scopus 로고    scopus 로고
    • Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004
    • This national population-based study evaluated US population trends in vitamin D insufficiency by age, sex, and ethnicity strata comparing serum 25[OH]D levels from NHANES-III, collected during 1988 through 1994, with NHANES data collected from 2001 through 2004 (NHANES 2001-2004). The results showed a marked decrease in serum 25(OH)D levels with racial/ethnic differences, indicating a growing epidemic of vitamin D insufficiency in the US general population
    • • Ginde AA, Liu MC, Camargo CA Jr: Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med 2009, 169: 626-632. This national population-based study evaluated US population trends in vitamin D insufficiency by age, sex, and ethnicity strata comparing serum 25[OH]D levels from NHANES-III, collected during 1988 through 1994, with NHANES data collected from 2001 through 2004 (NHANES 2001-2004). The results showed a marked decrease in serum 25(OH)D levels with racial/ethnic differences, indicating a growing epidemic of vitamin D insufficiency in the US general population.
    • (2009) Arch Intern Med , vol.169 , pp. 626-632
    • Ginde, A.A.1    Liu, M.C.2    Camargo Jr, C.A.3
  • 17
    • 0023792789 scopus 로고
    • Low circulating vitamin D in obesity
    • Liel Y, Ulmer E, Shary J, et al.: Low circulating vitamin D in obesity. Calcif Tissue Int 1988, 43: 199-201.
    • (1988) Calcif Tissue Int , vol.43 , pp. 199-201
    • Liel, Y.1    Ulmer, E.2    Shary, J.3
  • 18
    • 0033847865 scopus 로고    scopus 로고
    • Decreased bioavailability of vitamin D in obesity
    • (Published erratum appears in Am J Clin Nutr 2003, 77: 1342.)
    • Wortsman J, Matsuoka LY, Chen TC, et al.: Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000, 72: 690-693. (Published erratum appears in Am J Clin Nutr 2003, 77: 1342.).
    • (2000) Am J Clin Nutr , vol.72 , pp. 690-693
    • Wortsman, J.1    Matsuoka, L.Y.2    Chen, T.C.3
  • 19
    • 1642317096 scopus 로고    scopus 로고
    • The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults
    • Parikh SJ, Edelman M, Uwaifo GI, et al.: The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004, 89: 1196-1199.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 1196-1199
    • Parikh, S.J.1    Edelman, M.2    Uwaifo, G.I.3
  • 20
    • 34347266963 scopus 로고    scopus 로고
    • The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis
    • This systematic review and meta-analysis summarized observational studies and clinical trials through January 2007 for vitamin D and calcium and outcomes related to glucose homeostasis. The results showed a relatively consistent association between low vitamin D status, calcium or dairy intake, and prevalent type 2 diabetes or metabolic syndrome, although most observational studies were cross-sectional and intervention studies were short in duration, included few subjects, used a variety of formulations of vitamin D and calcium, or did post hoc analyses
    • •• Pittas AG, Lau J, Hu FB, Dawson-Hughes B: The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007, 92: 2017-2029. This systematic review and meta-analysis summarized observational studies and clinical trials through January 2007 for vitamin D and calcium and outcomes related to glucose homeostasis. The results showed a relatively consistent association between low vitamin D status, calcium or dairy intake, and prevalent type 2 diabetes or metabolic syndrome, although most observational studies were cross-sectional and intervention studies were short in duration, included few subjects, used a variety of formulations of vitamin D and calcium, or did post hoc analyses.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2017-2029
    • Pittas, A.G.1    Lau, J.2    Hu, F.B.3    Dawson-Hughes, B.4
  • 21
    • 0019302750 scopus 로고
    • Vitamin D deficiency inhibits pancreatic secretion of insulin
    • Norman AW, Frankel JB, Heldt AM, Grodsky GM: Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 1980, 209: 823-825.
    • (1980) Science , vol.209 , pp. 823-825
    • Norman, A.W.1    Frankel, J.B.2    Heldt, A.M.3    Grodsky, G.M.4
  • 22
    • 0037364216 scopus 로고    scopus 로고
    • Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor
    • Zeitz U, Weber K, Soegiarto DW, et al.: Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. Faseb J 2003, 17: 509-511.
    • (2003) Faseb J , vol.17 , pp. 509-511
    • Zeitz, U.1    Weber, K.2    Soegiarto, D.W.3
  • 23
    • 60249087200 scopus 로고    scopus 로고
    • Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults
    • Liu E, Meigs JB, Pittas AG, et al.: Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr 2009, 139: 329-334.
    • (2009) J Nutr , vol.139 , pp. 329-334
    • Liu, E.1    Meigs, J.B.2    Pittas, A.G.3
  • 24
    • 2442526414 scopus 로고    scopus 로고
    • Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction
    • Chiu KC, Chu A, Go VL, Saad MF: Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004, 79: 820-825.
    • (2004) Am J Clin Nutr , vol.79 , pp. 820-825
    • Chiu, K.C.1    Chu, A.2    Go, V.L.3    Saad, M.F.4
  • 25
    • 33644826159 scopus 로고    scopus 로고
    • Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    • Liu S, Song Y, Ford ES, et al.: Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U. S. women. Diabetes Care 2005, 28: 2926-2932.
    • (2005) Diabetes Care , vol.28 , pp. 2926-2932
    • Liu, S.1    Song, Y.2    Ford, E.S.3
  • 26
    • 33646475087 scopus 로고    scopus 로고
    • Vitamin D and calcium intake in relation to type 2 diabetes in women
    • Pittas AG, Dawson-Hughes B, Li T, et al.: Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006, 29: 650-656.
    • (2006) Diabetes Care , vol.29 , pp. 650-656
    • Pittas, A.G.1    Dawson-Hughes, B.2    Li, T.3
  • 27
    • 0036303244 scopus 로고    scopus 로고
    • Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians
    • Ogunkolade BW, Boucher BJ, Prahl JM, et al.: Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes 2002, 51: 2294-2300.
    • (2002) Diabetes , vol.51 , pp. 2294-2300
    • Ogunkolade, B.W.1    Boucher, B.J.2    Prahl, J.M.3
  • 28
    • 0036123536 scopus 로고    scopus 로고
    • Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study
    • Oh JY, Barrett-Connor E: Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism 2002, 51: 356-359.
    • (2002) Metabolism , vol.51 , pp. 356-359
    • Oh, J.Y.1    Barrett-Connor, E.2
  • 29
    • 0037783945 scopus 로고    scopus 로고
    • The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men
    • Ortlepp JR, Metrikat J, Albrecht M, et al.: The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men. Diabet Med 2003, 20: 451-454.
    • (2003) Diabet Med , vol.20 , pp. 451-454
    • Ortlepp, J.R.1    Metrikat, J.2    Albrecht, M.3
  • 30
    • 0034894334 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset
    • Ye WZ, Reis AF, Dubois-Laforgue D, et al.: Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur J Endocrinol 2001, 145: 181-186.
    • (2001) Eur J Endocrinol , vol.145 , pp. 181-186
    • Ye, W.Z.1    Reis, A.F.2    Dubois-Laforgue, D.3
  • 31
    • 0025237467 scopus 로고
    • A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1, 25-dihydroxyvitamin D3
    • Sone T, Marx SJ, Liberman UA, Pike JW: A unique point mutation in the human vitamin D receptor chromosomal gene confers hereditary resistance to 1, 25-dihydroxyvitamin D3. Mol Endocrinol 1990, 4: 623-631.
    • (1990) Mol Endocrinol , vol.4 , pp. 623-631
    • Sone, T.1    Marx, S.J.2    Liberman, U.A.3    Pike, J.W.4
  • 32
    • 27244447854 scopus 로고    scopus 로고
    • Promoter and 3′-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study
    • Fang Y, van Meurs JB, d'Alesio A, et al.: Promoter and 3′-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study. Am J Hum Genet 2005, 77: 807-823.
    • (2005) Am J Hum Genet , vol.77 , pp. 807-823
    • Fang, Y.1    van Meurs, J.B.2    d'Alesio, A.3
  • 33
    • 0347763681 scopus 로고    scopus 로고
    • Vitamin D receptor gene polymorphisms and association with type 2 diabetes mellitus in a Polish population
    • Malecki MT, Frey J, Moczulski D, et al.: Vitamin D receptor gene polymorphisms and association with type 2 diabetes mellitus in a Polish population. Exp Clin Endocrinol Diabetes 2003, 111: 505-509.
    • (2003) Exp Clin Endocrinol Diabetes , vol.111 , pp. 505-509
    • Malecki, M.T.1    Frey, J.2    Moczulski, D.3
  • 34
    • 0029152846 scopus 로고
    • Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians
    • Boucher BJ, Mannan N, Noonan K, et al.: Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 1995, 38: 1239-1245.
    • (1995) Diabetologia , vol.38 , pp. 1239-1245
    • Boucher, B.J.1    Mannan, N.2    Noonan, K.3
  • 35
    • 0022640891 scopus 로고
    • Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man
    • Gedik O, Akalin S: Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 1986, 29: 142-145.
    • (1986) Diabetologia , vol.29 , pp. 142-145
    • Gedik, O.1    Akalin, S.2
  • 36
    • 0028350615 scopus 로고
    • Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus
    • Orwoll E, Riddle M, Prince M: Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1994, 59: 1083-1087.
    • (1994) Am J Clin Nutr , vol.59 , pp. 1083-1087
    • Orwoll, E.1    Riddle, M.2    Prince, M.3
  • 37
    • 0030860090 scopus 로고    scopus 로고
    • No effect of calcitriol on insulin-mediated glucose uptake in healthy subjects
    • Fliser D, Stefanski A, Franek E, et al.: No effect of calcitriol on insulin-mediated glucose uptake in healthy subjects. Eur J Clin Invest 1997, 27: 629-633.
    • (1997) Eur J Clin Invest , vol.27 , pp. 629-633
    • Fliser, D.1    Stefanski, A.2    Franek, E.3
  • 38
    • 58149216055 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men
    • 3supplementation improves postprandial insulin sensitivity (oral glucose insulin sensitivity) in apparently healthy men likely to have insulin resistance (centrally obese but nondiabetic)
    • 3supplementation improves postprandial insulin sensitivity (oral glucose insulin sensitivity) in apparently healthy men likely to have insulin resistance (centrally obese but nondiabetic).
    • (2009) Diabet Med , vol.26 , pp. 19-27
    • Nagpal, J.1    Pande, J.N.2    Bhartia, A.3
  • 39
    • 34147190196 scopus 로고    scopus 로고
    • The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults
    • This post-hoc analysis using the data from a double-blind, randomized, controlled trial showed that supplementation with calcium and vitamin D may attenuate increases in glycemia and insulin resistance in healthy, older adults with impaired fasting glucose
    • • Pittas AG, Harris SS, Stark PC, Dawson-Hughes B: The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care 2007, 30: 980-986. This post-hoc analysis using the data from a double-blind, randomized, controlled trial showed that supplementation with calcium and vitamin D may attenuate increases in glycemia and insulin resistance in healthy, older adults with impaired fasting glucose.
    • (2007) Diabetes Care , vol.30 , pp. 980-986
    • Pittas, A.G.1    Harris, S.S.2    Stark, P.C.3    Dawson-Hughes, B.4
  • 40
    • 65549137566 scopus 로고    scopus 로고
    • Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
    • Zittermann A, Frisch S, Berthold HK, et al.: Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 2009, 89: 1321-1327.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1321-1327
    • Zittermann, A.1    Frisch, S.2    Berthold, H.K.3
  • 41
    • 48649108658 scopus 로고    scopus 로고
    • Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative
    • 3(400 IU daily) supplementation did not reduce the risk of developing diabetes over 7 years of follow-up among 33, 951 participants free of diabetes at baseline
    • 3(400 IU daily) supplementation did not reduce the risk of developing diabetes over 7 years of follow-up among 33, 951 participants free of diabetes at baseline.
    • (2008) Diabetes Care , vol.1 , pp. 701-707
    • de Boer, I.H.1    Tinker, L.F.2    Connelly, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.