An adaptive confirmatory trial with interim treatment selection: Practical experiences and unbalanced randomization

Statistics in Medicine

Volumn 30, Issue 13, 2011, Pages 1541-1554

  Heritier, Stephane ^a,b   Lô, Serigne N ^a   Morgan, Caroline C ^c  

^a George Institute   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Cardinal Systems   (France)

Author keywords

Closed testing procedure; Combination function; Gatekeeping; Multiplicity; Non inferiority; Signed root likelihood ratio test

Indexed keywords

ACCURACY; ADAPTIVE CONFIRMATORY TRIAL; ARTICLE; CALCULATION; CLINICAL RESEARCH; DRUG EFFICACY; DRUG SAFETY; INTERMETHOD COMPARISON; METHODOLOGY; MONTE CARLO METHOD; RANDOMIZATION; SIMULATION; STATISTICAL ANALYSIS; VALIDITY;

CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; MONTE CARLO METHOD; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN;

EID: 79956103128     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.4179     Document Type: Article

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