Meta-analyses and adaptive group sequential designs in the clinical development process

Journal of Biopharmaceutical Statistics

Volumn 15, Issue 4, 2005, Pages 537-558

  Jennison, Christopher ^a   Turnbull, Bruce W ^b  

^a University of Bath   (United Kingdom)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Adaptive designs; Clinical trials; Early data review; Flexible design; Group sequential tests; Interim analysis; Meta analysis; Overviews; Sample size re estimation; Systematic reviews; Two stage procedure; Variance spending

Indexed keywords

CLINICAL RESEARCH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; HUMAN; MATHEMATICAL ANALYSIS; META ANALYSIS; PRIORITY JOURNAL; PROBABILITY; PROCESS DEVELOPMENT; REVIEW; SYSTEMATIC REVIEW; TIME;

ALGORITHMS; CLINICAL TRIALS; CLINICAL TRIALS, PHASE II; CLINICAL TRIALS, PHASE III; DATA INTERPRETATION, STATISTICAL; MULTICENTER STUDIES; RESEARCH DESIGN; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 22044446634     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1081/BIP-200062273     Document Type: Review

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