The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON

Anticancer Research

Volumn 31, Issue 4, 2011, Pages 1153-1160

  Silva, Scott R ^a,c   Zaytseva, Yekaterina Y ^c   Jackson, Lindsey N ^d   Lee, Eun Y ^b,c   Weiss, Heidi L ^a,c   Bowen, Kanika A ^d   Townsend Jr , Courtney M ^d   Evers, B Mark ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Carcinoid; PTEN; Serotonin

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SEROTONIN; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARCINOID; CARCINOID CELL LINE BON; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SYNTHESIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARCINOID TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MICE; MICE, NUDE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA, SMALL INTERFERING; SEROTONIN; TUMOR CELLS, CULTURED;

EID: 79956102477     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after 'carcinoid': epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 26: 3063-3072, 2008.
2. Pinchot SN, Holen K, Sippel RS and Chen H: Carcinoid tumors. Oncologist 13: 1255-1269, 2008.
3. Berger M, Gray JA and Roth BL: The expanded biology of serotonin. Annu Rev Med 60: 355-366, 2009.
4. Walther DJ and Bader M: A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 66: 1673-1680, 2003. (Pubitemid 37249312)
5. Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P and Sundin A: Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 9: 61-72, 2008.
6. Modlin IM, Kidd M, Drozdov I, Siddique ZL and Gustafsson BI: Pharmacotherapy of neuroendocrine cancers. Expert Opin Pharmacother 9: 2617-2626, 2008.
7. Pitt SC, Davis R, Kunnimalaiyaan M and Chen H: AKT and PTEN expression in human gastrointestinal carcinoid tumors. Am J Transi Res 1: 291-299, 2009.
8. Voortman J, Lee JH, Killian JK, Suuriniemi M, Wang Y, Lucchi M, Smith WI Jr., Meltzer P and Giaccone G: Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors. Proc Natl Acad Sci USA 107: 13040-13045, 2010.
9. Bunney TD and Katan M: Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer 10: 342-352, 2010.
10. Chalhoub N and Baker SJ: PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4: 127-150, 2009.
11. Evers BM, Ishizuka J, Townsend CM Jr. and Thompson JC: The human carcinoid cell line, BON. A model system for the study of carcinoid tumors. Ann N Y Acad Sci 733: 393-406, 1994.
12. Evers BM, Townsend CM Jr., Upp JR, Allen E, Hurlbut SC, Kim SW, Rajaraman S, Singh P, Reubi JC and Thompson JC: Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth. Gastroenterology 101: 303-311, 1991.
13. Evers BM, Ishizuka J, Townsend CM Jr., Rajaraman S and Thompson JC: Expression of neurotensin messenger RNA in a human carcinoid tumor. Ann Surg 214: 448-454; discussion 454-445, 1991.
14. Germano PM, Lieu SN, Xue J, Cooke HJ, Christofi FL, Lu Y and Pisegna JR: PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells. J Mol Neurosci 39: 391-401, 2009.
15. Jeng YJ, Townsend CM Jr., Nagasawa S, Chuo S, Kern K, Yanaihara N, Ferrar RS, Hill FL, Thompson JC and Greeley GH, Jr.: Regulation of pancreastatin release from a human pancreatic carcinoid cell line in vitro. Endocrinology 128: 220-225, 1991.
16. Jackson LN, Chen LA, Larson SD, Silva SR, Rychahou PG, Boor PJ, Li J, Defreitas G, Stafford WL, Townsend CM, Jr. and Evers BM: Development and characterization of a novel in vivo model of carcinoid syndrome. Clin Cancer Res 15: 2747-2755, 2009.
17. Silva SR, Bowen KA, Rychahou PG, Jackson LN, Weiss HL, Lee EY, Townsend CM, Jr. and Evers BM: VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis. Int J Cancer 128: 1045-1056, 2011.
18. Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R and Woscholski R: A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol 1: 780-790, 2006.
19. Bowen KA, Silva SR, Johnson JN, Doan HQ, Jackson LN, Gulhati P, Qiu S, Riall TS and Evers BM: An analysis of trends and growth factor receptor expression of GI carcinoid tumors. J Gastrointest Surg 13: 1773-1780, 2009.
20. Abelev GI and Lazarevich NL: Control of differentiation in progression of epithelial tumors. Adv Cancer Res 95: 61-113, 2006. (Pubitemid 44066524)
21. Hill R and Wu H: PTEN, stem cells, and cancer stem cells. J Biol Chem 284: 11755-11759, 2009.
22. Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H and Ball DW: Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling. J Clin Endocrinol Metab 90: 4350-4356, 2005. (Pubitemid 41058218)
23. Alenina N, Bashammakh S and Bader M: Specification and differentiation of serotonergic neurons. Stem Cell Rev 2: 5-10, 2006.
24. Dolmazon V, Alenina N, Markossian S, Mancip J, van de Vrede Y, Fontaine E, Dehay C, Kennedy H, Bader M, Savatier P and Bernat A: Forced expression of LIM homeodomain transcription factor lb enhances differentiation of mouse embryonic stem cells into serotonergic neurons. Stem Cells Dev 20: 301-311, 2011.
25. Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, Gilcrease MZ, Krishnamurthy S, Lee JS, Fridlyand J, Sahin A, Agarwal R, Joy C, Liu W, Stivers D, Baggerly K, Carey M, Lluch A, Monteagudo C, He X, Weigman V, Fan C, Palazzo J, Hortobagyi GN, Nolden LK, Wang NJ, Valero V, Gray JW, Perou CM and Mills GB: Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 69: 4116-4124, 2009.
26. Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH and Evers BM: Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci USA 105: 20315-20320, 2008.
27. Rotte A, Pasham V, Bhandaru M, Eichenmuller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ and Lang F: Regulation of gastric acid secretion by PKB/Akt2. Cell Physiol Biochem 25: 695-704, 2010.
28. Rotte A, Pasham V, Eichenmuller M, Yang W, Qadri SM, Bhandaru M and Lang F: Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3. J Gastroenterol 45: 1022-1032, 2010.
29. Pai VP, Marshall AM, Hernandez LL, Buckley AR and Horseman ND: Altered serotonin physiology in human breast cancers favors paradoxical growth and cell survival. Breast Cancer Res 11: R81, 2009.
30. Pai VP and Horseman ND: Biphasic regulation of mammary epithelial resistance by serotonin through activation of multiple pathways. J Biol Chem 283: 30901-30910, 2008.
31. Stull MA, Pai V, Vomachka AJ, Marshall AM, Jacob GA and Horseman ND: Mammary gland homeostasis employs serotonergic regulation of epithelial tight junctions. Proc Natl Acad Sci USA 104: 16708-16713, 2007. (Pubitemid 350211081)
32. Brabletz T, Jung A, Spaderna S, Hlubek F and Kirchner T: Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 5: 744-749, 2005. (Pubitemid 41486367)
33. Kulke MH, Lenz HJ, Meropol NJ, Posey J, Ryan DP, Picus J, Bergsland E, Stuart K, Tye L, Huang X, Li JZ, Baum CM and Fuchs CS: Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 26: 3403-3410, 2008.
34. Yao JC, Phan A, Hoff PM, Chen HX, Charnsangavej C, Yeung SC, Hess K, Ng C, Abbruzzese JL and Ajani JA: Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J Clin Oncol 26: 1316-1323, 2008.